@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0756: (2016-03-18 )
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFINDLYLNLISDLANINGIDMIDIEWQADIDIEKHQRIIKHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
Atome Classification :
(48 SA)
......-----------...10...-------.....-20........30........40...-.-....50........60...---.....70........80........-90........100..-.....110.......120.......130.......140.......150.......160.......170.....-..180..-.-.....190.......200.......210.......220.......230......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
H
V
E
V
-----------
V
A
TIAPQL-------
S
I
E
E
T
-
L
I
Q
K
I
N
HRID
A
I
D
V
L
E
L
R
I
D
Q
IENV-
T
-
V
D
Q
V
A
E
M
I
T
K
L
K
V
M
Q
D
S
F
K
---
L
L
V
T
Y
R
T
KLQG
G
Y
G
Q
F
I
N
D
L
Y
L
N
L
I
-
S
D
L
ANING
I
D
M
I
D
I
E
-
W
QADI
D
I
E
K
H
Q
R
I
I
K
H
L
Q
Q
YNK
E
V
V
I
S
HHNFESTPP
L
D
E
L
Q
F
I
F
F
K
M
Q
KF
N
P
E
Y
V
K
L
A
V
MPHN
K
N
D
V
L
N
L
L
Q
A
-
M
S
T
-FSD-T-M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
TAQGVFGGA
L
T
YGCIGEPQAPGQ
I
D
V
T
D
L
K
A
Q
V
T
LY---
2
PsiBlast_PDB
98.83
97%
-133
- C5 -
1SFJ
1
AROD_STAAR
A:
[3-238]
--
H
V
E
V
-----------
V
A
T
I
T
P
Q
-----------
E
T
-
L
I
Q
K
I
N
H
R
I
D
A
I
D
V
L
E
L
R
I
D
Q
F
E
N
V
-
T
-
V
D
Q
V
A
E
M
I
T
K
L
-----
S
F
K
---
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
-
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
-
W
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
-
M
S
T
-
F
S
D
-
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
A
Q
V
T
L
Y
---
21
PsiBlast_CBE
98.29
97%
-134
- C5 -
1SFJ
1
AROD_STAAR
B:
[1-238]
M
T
H
V
E
V
-----------
V
A
T
I
T
P
Q
L
-------
Y
--
E
T
-
L
I
Q
K
I
N
H
R
I
D
A
I
D
V
L
E
L
R
I
D
Q
F
E
N
V
-
T
-
V
D
Q
V
A
E
M
I
T
K
L
---
Q
D
S
F
K
---
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
-
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
-
W
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
-
M
S
T
-
F
S
D
-
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
A
Q
V
T
L
Y
---
1
PsiBlast_PDB
97.82
97%
-134
- C5 -
1SFL
-
AROD_STAAR
A:
[3-238]
--
H
V
E
V
-----------
V
A
T
I
T
P
Q
L
----------
E
T
-
L
I
Q
K
I
N
H
R
I
D
A
I
D
V
L
E
L
R
I
D
Q
F
E
N
V
-
T
-
V
D
Q
V
A
E
M
I
T
K
L
K
---
D
S
F
K
---
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
-
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
-
W
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
-
M
S
T
-
F
S
D
-
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
A
Q
V
T
L
Y
---
71
HHSearch
94.58
94%
-122
- C5 -
1SFL
-
AROD_STAAR
A:
[3-237]
--
H
V
E
V
-----------
V
A
T
I
T
P
Q
--------
L
---
E
T
L
I
Q
K
I
N
H
R
I
D
A
I
D
V
L
E
L
R
I
D
Q
F
E
N
V
-
T
-
V
D
Q
V
A
E
M
I
T
K
L
K
---
D
S
F
K
---
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
S
D
L
A
N
I
N
-
G
I
D
M
I
D
I
E
-
W
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
-
M
S
T
-
F
S
D
-
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
A
Q
V
T
L
----
58
PsiBlast_CBE
76.23
33%
-106
- C5 -
3JS3
1
AROD_PEPD6
C:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
53
PsiBlast_CBE
76.18
33%
-115
- C5 -
4H3D
3
AROD_PEPD6
D:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
--
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
60
PsiBlast_CBE
76.03
33%
-107
- C5 -
3JS3
1
AROD_PEPD6
A:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
55
PsiBlast_CBE
75.98
33%
-110
- C5 -
4H3D
3
AROD_PEPD6
B:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
57
PsiBlast_CBE
75.78
33%
-108
- C5 -
3JS3
1
AROD_PEPD6
D:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
46
PsiBlast_CBE
75.67
33%
-98
- C5 -
3NNT
1
AROD_SALTY
B:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
4
PsiBlast_PDB
75.65
33%
-99
- C5 -
3OEX
1
AROD_SALTY
A:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
3
PsiBlast_PDB
75.60
33%
-100
- C5 -
3M7W
2
AROD_SALTY
A:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
23
PsiBlast_CBE
75.54
33%
-97
- C5 -
4GUI
4
AROD_SALTY
B:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
6
PsiBlast_PDB
75.41
33%
-100
- C5 -
4GUI
2
AROD_SALTY
A:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
33
PsiBlast_CBE
75.40
32%
-97
- C5 -
3S42
6
AROD_SALTY
B:
[34-272]
-----
V
-----------
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
-
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
59
PsiBlast_CBE
75.39
33%
-107
- C5 -
3JS3
1
AROD_PEPD6
B:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
31
PsiBlast_CBE
75.36
33%
-99
- C5 -
3M7W
5
AROD_SALTY
C:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
22
PsiBlast_CBE
75.36
33%
-98
- C5 -
4GUJ
3
AROD_SALTY
B:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
5
PsiBlast_PDB
75.35
33%
-96
- C5 -
4GFS
1
AROD_SALTY
A:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
8
PsiBlast_PDB
75.33
32%
-103
- C5 -
3L2I
-
AROD_SALTY
A:
[34-272]
-----
V
-----------
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
-
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
---
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
9
PsiBlast_PDB
75.21
32%
-95
- C5 -
3LB0
2
AROD_SALTY
A:
[34-272]
-----
V
-----------
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
-
K
S
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
19
PsiBlast_PDB
75.18
33%
-99
- C5 -
3NNT
1
AROD_SALTY
A:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
61
Fugue
75.17
30%
-95
- C5 -
1QFE
1
AROD_SALTI
A:
[1-252]
M
K
T
V
T
V
KNLIIGEGM
P
K
I
I
V
S
L
M
G
R
-------
D
I
N
S
V
-
K
A
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
-
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
---
L
F
T
G
D
A
D
V
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
-
T
L
E
-
M
Q
Q
H
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
N
A
45
PsiBlast_CBE
75.16
33%
-97
- C5 -
4IUO
1
AROD_SALTY
B:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
54
PsiBlast_CBE
74.89
33%
-116
- C5 -
4H3D
2
AROD_PEPD6
C:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
36
PsiBlast_CBE
74.81
33%
-103
- C5 -
4GUG
1
AROD_SALTY
B:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
----
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
7
PsiBlast_PDB
74.78
33%
-99
- C5 -
4GUJ
2
AROD_SALTY
A:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
20
PsiBlast_PDB
74.72
33%
-97
- C5 -
4IUO
1
AROD_SALTY
A:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
48
PsiBlast_CBE
74.66
34%
-96
- C5 -
1QFE
1
AROD_SALTI
A:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
56
PsiBlast_CBE
74.62
33%
-114
- C5 -
4H3D
3
AROD_PEPD6
A:
[45-252]
------------------------------------------------
C
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
-
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
---
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
-
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
---
E
V
I
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
-
T
N
E
M
F
K
I
-
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
----
13
PsiBlast_PDB
74.49
33%
-98
- C5 -
4GUH
1
AROD_SALTY
A:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
52
PsiBlast_CBE
74.34
34%
-96
- C5 -
1L9W
1
AROD_SALTI
A:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
24
PsiBlast_CBE
74.26
33%
-100
- C5 -
4GFS
4
AROD_SALTY
B:
[36-251]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
---
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
12
PsiBlast_PDB
74.25
33%
-105
- C5 -
4GUG
2
AROD_SALTY
A:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
47
PsiBlast_CBE
74.19
34%
-96
- C5 -
1QFE
1
AROD_SALTI
B:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
50
PsiBlast_CBE
74.01
34%
-92
- C5 -
1L9W
1
AROD_SALTI
C:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
35
PsiBlast_CBE
73.87
33%
-95
- C5 -
4GUH
2
AROD_SALTY
B:
[57-272]
----------------------------------------
E
A
L
A
Y
R
E
A
D
F
D
I
L
E
W
R
V
D
H
F
A
N
V
-
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
---
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
-
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
K
A
---
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
-
T
V
E
-
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
----
43
PsiBlast_CBE
73.80
34%
-95
- C5 -
4CLM
1
AROD_SALTI
B:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
17
PsiBlast_PDB
73.76
34%
-97
- C5 -
4UIO
5
?
A:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
51
PsiBlast_CBE
73.54
34%
-95
- C5 -
1L9W
1
AROD_SALTI
B:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
49
PsiBlast_CBE
73.28
34%
-95
- C5 -
1L9W
1
AROD_SALTI
D:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
16
PsiBlast_PDB
73.22
34%
-95
- C5 -
4CNP
5
AROD_SALTI
A:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
42
PsiBlast_CBE
73.11
34%
-100
- C5 -
4CNN
4
AROD_SALTI
B:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
--------
39
PsiBlast_CBE
72.99
34%
-96
- C5 -
4CNO
1
AROD_SALTI
D:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
--------
41
PsiBlast_CBE
72.93
34%
-101
- C5 -
4CNO
1
AROD_SALTI
B:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
--------
38
PsiBlast_CBE
72.82
34%
-94
- C5 -
4CNP
5
AROD_SALTI
B:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
--------
40
PsiBlast_CBE
72.50
34%
-103
- C5 -
4CNO
1
AROD_SALTI
C:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
DIP
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
--------
14
PsiBlast_PDB
71.98
34%
-99
- C5 -
4CNO
1
AROD_SALTI
A:
[33-244]
----------------------------------------
E
A
L
A
Y
R
E
A
T
F
D
I
L
E
W
R
V
D
H
F
M
D
I
-
A
-
S
T
Q
--
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
-
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
K
A
---
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
-
Q
Q
H
-
Y
-
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
--------