@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1298: (2016-03-24 )
MKLQTTYPSNNYPIFVEHGAIDHISTYIDQFDQSFILIDEHVNQYFADKFDDILSYENVHKVIIPAGEKTKTFEQYQETLEYILSHHVTRNTAIIAVGGGATGDFAGFVAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGAFYRPTAVIYDLDFLKTLPFEQILSGYAEVYKHALLNGESTTQEIEQHFKDREILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEYNHKIAHGHAVMIGIIYQFIVANILFNSNHDIQHYINYLTKLGYPLETITDIDFETIYQYMLSDKKNDKQGVQMVLIKHFGDIVVQHIDQTTLQHACEQLKTYFK
Atome Classification :
(37 SA)
.........10........20.--......--.--30---.......--.40-...----.....50......--------.----.--------60-....--.....70.---.......80......--..90..-......100.......110.......120.....-.-.-130.......140.......150.......160.......170.......180.......190....--...------200....-------------.------.---..--.210...-----....220--........--.230.......240.......----250.---.---.--......260......-------.270..--.-.....-280.......290..-------.....---300--------........310---....-----...320-.......330..-..------....340.......350..-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
Q
T
TYPSNN
Y
P
I
F
V
EHGA
I
D
--
H
I
S
T
Y
I
--
D
--QF---DQ
S
F
I
L
I
--
D
E
H
-
V
N
Q
----
Y
F
A
D
K
F
D
D
I
L
S
YE--------N----
V
--------
H
--
K
V
I
I--PAGEKT
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
HH--VTR
N
T
A
-
I
I
A
VGGGAT
G
D
F
A
G
F
V
A
A
T
L
LRG
V
H
F
I
QV
P
T
T
I
L
-A-H-DSSVGGKVGINSKQGK
N
L
I
G
A
FYR
P
T
A
V
I
Y
D
L
D
F
L
K
TL
P
F
E
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
LLNGES
T
T
Q
E
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------S---LN--
G
M
D
K
Y
I
A
-----KGIET----
K
L
D
I
V
V
AD--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
FG
H
A
V
E----Y--N---H---K--IAHGH
A
V
M
I
G
I
I
Y
Q
F
-------
I
V
A
-
N
I
--L-FNSNH-
D
I
Q
H
Y
I
N
Y
L
T
KLGYP-------
L
E
T
IT---DI---------
D
F
E
T
I
Y
Q
Y
M
LS---DKKN-----DKQGV
Q
-
M
V
L
I
K
H
F
G
-
D
I
V
-
V
Q
------
H
I
D
Q
T
T
L
Q
H
A
C
E
Q
L
K
T
YFK-----
1
PsiBlast_PDB
99.18
91%
-133
- C3 -
1XAG
5
AROB_STAAR
A:
[1-353]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
--
N
--
Q
F
---
D
Q
S
F
L
L
I
--
D
E
Y
-
V
N
Q
----
Y
F
A
N
K
F
D
D
I
L
S
Y
E
--------
N
----
V
--------
H
--
K
V
I
I
--
P
A
G
E
K
T
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
T
A
-
I
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
-
A
-
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------
S
---
L
N
--
G
M
D
K
Y
I
A
-----
K
G
I
E
T
----
K
L
D
I
V
V
A
D
--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
----
Y
--
Y
---
H
---
K
--
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
-------
I
V
A
-
N
A
--
L
-
F
D
S
K
H
-
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
-------
L
D
M
I
T
---
D
L
---------
D
F
E
T
L
Y
Q
Y
M
L
S
---
D
K
K
N
-----
D
K
Q
G
V
Q
-
M
V
L
M
R
Q
F
G
-
D
I
V
-
V
Q
------
H
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
F
------
3
PsiBlast_PDB
97.00
91%
-132
- C3 -
1XAI
3
AROB_STAAR
A:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
--
N
--
Q
F
---
D
Q
S
F
L
L
I
--
D
E
Y
-
V
N
Q
----
Y
F
A
N
K
F
D
D
I
L
S
Y
E
--------
N
----
V
--------
H
--
K
V
I
I
--
P
A
G
E
K
T
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
T
A
-
I
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
-
A
-
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------
S
---
L
N
--
G
M
D
K
Y
I
A
-----
K
G
I
E
T
----
K
L
D
I
V
V
A
D
--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
----
Y
--
Y
---
H
---
K
--
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
-------
I
V
A
-
N
A
--
L
-
F
D
S
K
H
-
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
-------
L
D
M
I
T
---
D
L
---------
D
F
E
T
L
Y
Q
Y
M
L
S
---
D
K
K
N
-----
D
K
Q
G
V
Q
-
M
V
L
M
R
Q
F
G
-
D
I
V
-
V
Q
------
H
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
-------
21
PsiBlast_CBE
96.90
91%
-133
- C3 -
1XAI
3
AROB_STAAR
B:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
--
N
--
Q
F
---
D
Q
S
F
L
L
I
--
D
E
Y
-
V
N
Q
----
Y
F
A
N
K
F
D
D
I
L
S
Y
E
--------
N
----
V
--------
H
--
K
V
I
I
--
P
A
G
E
K
T
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
T
A
-
I
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
-
A
-
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------
S
---
L
N
--
G
M
D
K
Y
I
A
-----
K
G
I
E
T
----
K
L
D
I
V
V
A
D
--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
----
Y
--
Y
---
H
---
K
--
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
-------
I
V
A
-
N
A
--
L
-
F
D
S
K
H
-
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
-------
L
D
M
I
T
---
D
L
---------
D
F
E
T
L
Y
Q
Y
M
L
S
---
D
K
K
N
-----
D
K
Q
G
V
Q
-
M
V
L
M
R
Q
F
G
-
D
I
V
-
V
Q
------
H
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
-------
22
PsiBlast_CBE
94.49
91%
-141
- C3 -
1XAH
2
AROB_STAAR
B:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
--
N
--
Q
F
---
D
Q
S
F
L
L
I
--
D
E
Y
-
V
N
Q
----
Y
F
A
N
K
F
D
--------------
N
----
V
--------
H
--
K
V
I
I
--
P
A
G
E
K
T
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
T
A
-
I
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
-
A
-
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------
S
---
L
N
--
G
M
D
K
Y
I
A
-----
K
G
I
E
T
----
K
L
D
I
V
V
A
D
--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
----
Y
--
Y
---
H
---
K
--
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
-------
I
V
A
-
N
A
--
L
-
F
D
S
K
H
-
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
-------
L
D
--------------------
T
L
Y
Q
Y
M
L
----------------
G
V
Q
-
M
V
L
M
R
Q
F
G
-
D
I
V
-
V
Q
------
H
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
-------
49
HHSearch
92.72
91%
-140
- C3 -
1XAH
2
AROB_STAAR
A:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
--
N
--
Q
F
---
D
Q
S
F
L
L
I
--
D
E
Y
-
V
N
Q
----
Y
F
A
N
K
F
D
--------------
N
----
V
--------
H
--
K
V
I
I
--
P
A
G
E
K
T
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
T
A
-
I
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
-
A
-
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------
S
---
L
N
--
G
M
D
K
Y
I
A
-----
K
G
I
E
T
----
K
L
D
I
V
V
A
D
--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
----
Y
--
Y
---
H
---
K
--
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
-------
I
V
A
-
N
A
--
L
-
F
D
S
K
H
-
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
-------
L
D
-------------------------------------------
G
V
Q
-
M
V
L
M
R
Q
F
G
-
D
I
V
-
V
Q
------
H
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
-------
2
PsiBlast_PDB
92.72
91%
-140
- C3 -
1XAH
2
AROB_STAAR
A:
[1-352]
M
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
--
N
--
Q
F
---
D
Q
S
F
L
L
I
--
D
E
Y
-
V
N
Q
----
Y
F
A
N
K
F
D
--------------
N
----
V
--------
H
--
K
V
I
I
--
P
A
G
E
K
T
K
T
---
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
T
A
-
I
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
-
A
-
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
S
A
T
Q
D
I
E
Q
--
H
F
K
------
D
--
R
E
I
L
-------------
Q
------
S
---
L
N
--
G
M
D
K
Y
I
A
-----
K
G
I
E
T
----
K
L
D
I
V
V
A
D
--
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
----
Y
--
Y
---
H
---
K
--
I
P
H
G
H
A
V
M
V
G
I
I
Y
Q
F
-------
I
V
A
-
N
A
--
L
-
F
D
S
K
H
-
D
I
S
H
Y
I
Q
Y
L
I
Q
L
G
Y
P
-------
L
D
-------------------------------------------
G
V
Q
-
M
V
L
M
R
Q
F
G
-
D
I
V
-
V
Q
------
H
V
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
-------
4
PsiBlast_PDB
76.09
33%
-120
- C3 -
3OKF
9
AROB_VIBCH
A:
[40-389]
---------
R
S
Y
P
I
S
I
G
A
G
L
F
A
--
N
P
A
L
L
S
--
L
--
S
A
---
K
Q
K
V
V
I
V
--
T
N
H
T
V
A
P
----
L
Y
A
P
A
I
I
S
L
L
D
H
I
--------
G
----
C
--------
Q
--
H
A
L
L
E
L
P
D
G
E
Q
Y
K
T
---
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
D
V
V
-
V
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
-
S
-
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
--
Q
M
-----------
E
A
L
-------------
Y
------
A
---
L
D
E
Q
A
L
T
Y
A
I
A
-----
R
C
C
Q
I
----
K
A
E
V
V
A
Q
D
--
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
--
G
---
N
---
W
--
L
-
H
G
E
A
V
S
A
G
T
V
M
A
A
-------
K
T
A
-
Q
L
Q
G
L
-
I
D
A
S
Q
--
F
E
R
I
L
A
I
L
K
K
A
H
L
P
-------
V
R
T
P
E
---
N
M
---------
T
F
A
D
F
M
Q
H
M
M
R
---
D
K
K
V
-----
L
A
G
E
L
R
-
L
V
L
P
T
S
I
G
T
S
A
V
-
V
K
------
G
V
P
E
A
V
I
A
Q
A
I
E
Y
C
R
T
--------
52
HHSearch
75.71
33%
-110
- C3 -
3OKF
9
AROB_VIBCH
A:
[34-389]
---
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
--
N
-
P
A
L
L
SL
S
--
A
K
---
Q
K
V
V
I
V
T
--
N
H
T
-
V
A
P
----
L
Y
A
P
A
I
I
S
L
L
D
H
I
--------
G
----
C
--------
Q
H
A
L
L
E
L
--
P
D
G
E
Q
Y
K
T
---
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
D
V
V
-
V
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
-
S
Q
V
-
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
--
Q
M
E
------
A
--
L
Y
A
--------------
L
------
D
---
E
Q
--
A
L
T
Y
A
I
A
-----
R
C
C
Q
I
----
K
A
E
V
V
A
Q
D
--
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
----
A
--
H
---
M
GYG
N
--
W
L
H
G
E
A
V
S
A
G
T
V
M
A
A
-------
K
T
A
-
Q
L
--
Q
-
G
L
I
D
A
S
Q
F
E
R
I
L
A
I
L
K
K
A
H
L
P
-------
V
R
T
P
E
---
N
M
---------
T
F
A
D
F
M
Q
H
M
M
R
---
D
K
K
V
-----
L
A
G
E
L
R
-
L
V
L
P
T
S
I
G
-
T
S
A
-
V
V
K
-----
G
V
P
E
A
V
I
A
Q
A
I
E
Y
C
R
T
--------
23
PsiBlast_CBE
75.47
33%
-125
- C3 -
3OKF
6
AROB_VIBCH
B:
[40-389]
---------
R
S
Y
P
I
S
I
G
A
G
L
F
A
--
N
P
A
L
L
S
--
L
--
S
A
---
K
Q
K
V
V
I
V
--
T
N
H
T
V
A
P
----
L
Y
A
P
A
I
I
S
L
L
D
H
I
--------
G
----
C
--------
Q
--
H
A
L
L
E
L
P
D
G
E
Q
Y
K
T
---
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
D
V
V
-
V
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
-
S
-
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
A
F
F
D
W
L
E
A
--
Q
M
-----------
E
A
L
-------------
Y
------
A
---
L
D
E
Q
A
L
T
Y
A
I
A
-----
R
C
C
Q
I
----
K
A
E
V
V
A
Q
D
--
E
K
E
S
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
Y
--
G
---
N
---
W
--
L
-
H
G
E
A
V
S
A
G
T
V
M
A
A
-------
K
T
A
-
Q
L
Q
G
L
-
I
D
A
S
Q
--
F
E
R
I
L
A
I
L
K
K
A
H
L
P
-------
V
R
T
P
E
---
N
M
---------
T
F
A
D
F
M
Q
H
M
M
R
-------------------
L
V
L
P
T
S
I
G
T
S
A
V
-
V
K
------
G
V
P
E
A
V
I
A
Q
A
I
E
Y
C
R
T
--------
51
HHSearch
72.51
28%
-99
- C3 -
2GRU
8
DOIS_BACCI
A:
[3-367]
-
T
K
Q
I
C
F
A
D
R
C
F
N
F
A
F
G
E
H
V
L
E
--
S
V
E
S
Y
I
--
P
RD
E
F
---
D
Q
Y
I
M
I
S
--
D
S
G
-
V
P
D
----
S
I
V
H
Y
A
A
E
Y
F
G
K
L
A
-------
P
----
V
--------
H
--
I
L
R
F
--
Q
G
G
E
E
Y
K
T
---
L
S
T
V
T
N
L
Q
E
R
A
I
A
L
G
--
A
N
R
R
T
A
-
I
V
A
V
G
G
G
L
T
G
N
V
A
G
V
A
A
G
M
M
F
R
G
I
A
L
I
H
V
P
T
T
F
L
-
A
A
S
-
D
S
V
L
S
I
K
Q
A
V
N
L
T
S
G
K
N
L
V
G
F
Y
Y
P
P
R
F
V
F
A
D
T
R
I
L
S
E
S
P
P
R
Q
V
K
A
G
M
C
E
L
V
K
N
M
L
I
L
E
N
D
N
K
E
F
T
E
D
DL
N
S
A
------
N
-----
V
-------------
Y
------
S
---
P
K
--
Q
L
E
T
F
I
N
-----
F
C
I
S
A
----
K
M
S
V
L
S
E
D
--
I
Y
E
K
K
K
G
L
I
F
E
Y
G
H
T
I
G
H
A
I
E
----
L
--
A
---
E
Q
G-
G
--
I
T
H
G
E
A
I
A
V
G
M
I
Y
A
A
-------
K
I
A
-
N
R
--
M
-
N
L
M
P
E
H
D
V
S
A
H
Y
W
L
L
N
K
I
G
A
L
-------
Q
D
I
P
L
---
K
S
---------
D
P
D
S
I
F
H
Y
L
I
H
---
D
N
K
R
GYIKL
D
E
D
N
L
G
-
M
I
L
L
S
G
V
G
-
K
P
A
-
M
Y
NQTL
L
T
P
V
R
K
T
L
I
K
E
V
I
R
E
G
----------
40
Fugue
72.05
32%
-115
- C3 -
1UJN
-
?
A:
[1-347]
M
Q
R
L
E
V
R
E
P
V
P
Y
P
I
L
V
G
E
G
V
L
K
--
E
V
P
P
L
A
--
G
--
P
------
A
A
L
L
F
--
D
R
R
-
V
E
G
----
F
A
Q
E
V
A
K
A
L
G
V
---------------
R
--------
H
--
L
L
G
L
--
P
G
G
E
A
A
K
S
---
L
E
V
Y
G
K
V
L
S
W
L
A
E
K
G
--
L
P
R
N
A
T
-
L
L
V
V
G
G
G
T
L
T
D
L
G
G
F
V
A
A
T
Y
L
R
G
V
A
Y
L
A
F
P
T
T
T
L
-
A
-
I
V
D
A
S
V
G
G
K
T
G
I
N
L
P
E
G
K
N
L
V
G
A
F
H
F
P
Q
G
V
Y
A
E
L
R
A
L
K
T
L
P
L
P
T
F
K
E
G
L
V
E
A
F
K
H
G
L
I
A
G
D
E
A
L
L
K
V
E
D
--
L
T
P
------
Q
--
S
P
R
------------------------------
L
E
A
F
L
A
-----
R
A
V
A
V
----
K
V
R
V
T
E
E
D
--
P
L
E
K
G
K
R
R
L
L
N
L
G
H
T
L
G
H
A
L
E
----
A
Q
T
R
---
H
---
A
--
L
P
H
G
M
A
V
A
Y
G
L
L
Y
A
A
-------
L
L
G
-
R
A
--
L
--
G
G
E
D
-
L
L
P
P
V
R
R
L
L
L
W
L
S
P
P
---------
P
L
P
---
P
L
---------
A
F
E
D
L
L
P
Y
L
S
L
---
H
---------------
W
V
V
P
L
A
P
G
-
R
L
V
-
V
R
------
P
L
P
E
G
L
L
R
E
A
F
A
A
W
R
E
E
L
K
G
L
GLL
55
HHSearch
71.36
31%
-109
- C3 -
1SG6
2
ARO1_EMENI
A:
[10-391]
--------
L
G
R
E
S
I
I
A
D
F
G
L
W
R
NY
V
A
K
D
L
I
--
S
DC
S
S
---
T
T
Y
V
L
V
T
--
D
T
N
-
I
G
S
----
I
Y
T
P
S
F
E
E
A
F
R
K
R
--------
A
----
A
EITP
S
P
R
L
L
--
I
Y
N
R
--
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
M
V
-
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
------
T
--
I
L
K
A
V
R
R
E
V
T
PGEHRFE
G
------
T
---
E
E
--
I
L
K
A
R
I
L
-----
A
S
A
R
H
----
K
A
Y
V
V
S
A
-------
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
----
A
--
I
---
L
---
T
PQ
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
-
G
I
L
K
G
V
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
-------
T
S
L
K
D
A
--
R
I
R
K
L
T
AGKHC
S
V
D
Q
L
M
F
N
M
A
L
---
D
K
K
-------------
I
V
L
L
S
A
I
G
-
T
P
Y
-
E
T
R
A
S
---
V
V
A
N
E
D
I
R
V
V
L
-------------
54
HHSearch
70.91
31%
-107
- C3 -
3QBE
3
AROB_MYCTU
A:
[20-367]
-------
V
D
P
P
Y
P
V
V
I
G
T
G
L
L
D
--
E
L
E
D
L
L
--
A
--
D
R
---
H
K
V
A
V
V
H
--
Q
P
G
-
L
A
E
-----
T
A
E
E
I
R
K
R
L
A
G
K
--------
G
----
V
--------
D
A
H
R
I
E
I
--
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
I
-----
G
R
K
D
A
-
L
V
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
-
G
M
V
-
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
D
P
V
I
L
D
L
I
E
A
--
D
P
Q
------
A
--
A
L
D
--------------
P
------
A
---
G
D
--
V
L
P
E
L
I
R
-----
R
A
I
T
V
----
K
A
E
V
V
A
A
------
S
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
----
R
--
R
E
R-
Y
---
R
--
W
R
H
G
A
A
V
S
V
G
L
V
F
A
A
-------
E
L
A
-
R
L
--
A
-
G
R
L
D
D
A
T
A
Q
R
H
R
T
I
L
S
S
L
G
L
P
-------
V
S
Y
D
P
----
D
---------
A
L
P
Q
L
L
E
I
M
A
G
---
D
K
K
T
-----
R
A
G
V
L
R
-
F
V
V
L
D
G
L
A
-
K
P
G
-
R
M
V
-----
G
P
D
P
G
L
L
V
T
A
Y
A
G
V
C
A
--------
39
Fugue
68.94
29%
-96
- C3 -
1DQS
5
ARO1_EMENI
A:
[4-391]
--
P
T
K
I
S
I
L
G
R
E
S
I
I
A
D
F
G
L
W
R
N-
Y
V
A
K
D
L
--
I
--
S
D
CSS
T
T
Y
V
L
V
T
--
D
T
N
-
I
G
S
----
I
Y
T
P
S
F
E
E
A
F
R
K
R
A
A
EITP
S
P
R
----
L
--------
L
--
I
Y
N
R
--
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
------
T
--
I
L
K
A
-------------
V
R
RRFEG
T
---
E
E
--
I
L
K
A
R
I
L
-----
A
S
A
R
H
----
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
----
A
--
I
L
T-
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
AGK
H
C
---------
S
V
D
Q
L
M
F
N
M
A
L
---
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-
T
P
Y
-
E
T
------
R
A
S
V
V
A
N
E
D
I
R
V
V
L
----------
16
PsiBlast_PDB
67.84
31%
-103
- C3 -
2GRU
8
DOIS_BACCI
A:
[17-342]
--------------
F
G
E
H
-
V
L
E
--
S
V
E
S
Y
I
PR
D
--
E
F
---
D
Q
Y
I
M
I
S
--
D
S
G
-
V
P
D
S
I
V
H
Y
A
A
E
Y
F
G
K
L
A
P
---------------
V
--------
H
--
I
L
R
F
--
Q
G
G
E
E
Y
K
T
---
L
S
T
V
T
N
L
Q
E
R
A
I
A
L
G
--
A
N
R
R
T
A
-
I
V
A
V
G
G
G
L
T
G
N
V
A
G
V
A
A
G
M
M
F
R
G
I
A
L
I
H
V
P
T
T
F
L
A
A
-
S
-
D
S
V
L
S
I
K
Q
A
V
N
L
T
S
G
K
N
L
V
G
F
Y
Y
P
P
R
F
V
F
A
D
T
R
I
L
S
E
S
P
P
R
Q
V
K
A
G
M
C
E
L
V
K
N
M
L
I
L
-
E
N
D
N
K
E
F
T
E
--
D
D
L
------
N
--
S
A
N
V
-------------
Y
------
S
---
P
K
--
Q
L
E
T
F
I
N
-----
F
C
I
S
A
----
K
M
S
V
L
S
E
D
IY
E
K
K
K
G
L
--
I
F
E
Y
G
H
T
I
G
H
A
I
E
----
L
--
A
---
E
---
Q
GG
I
T
H
G
E
A
I
A
V
G
M
I
Y
A
A
-------
K
I
A
-
N
R
--
M
N
L
M
P
E
H
-
D
V
S
A
H
Y
W
L
L
N
K
I
G
A
L
-------
Q
D
I
P
L
---
K
S
---------
D
P
D
S
I
F
H
Y
L
I
H
---
D
N
K
R
GYIKL
D
E
D
N
L
G
-
M
I
L
L
S
G
V
G
-------------------------------------
38
PsiBlast_CBE
66.88
31%
-108
- C3 -
2GRU
6
DOIS_BACCI
B:
[17-342]
--------------
F
G
E
H
-
V
L
E
--
S
V
E
S
Y
I
PR
D
--
E
F
---
D
Q
Y
I
M
I
S
--
D
S
G
-
V
P
D
SIVH
Y
A
A
E
Y
F
G
K
L
A
P
---------------
V
--------
H
--
I
L
R
F
--
Q
G
G
E
E
Y
K
T
---
L
S
T
V
T
N
L
Q
E
R
A
I
A
L
G
--
A
N
R
R
T
A
-
I
V
A
V
G
G
G
L
T
G
N
V
A
G
V
A
A
G
M
M
F
R
G
I
A
L
I
H
V
P
T
T
F
L
A
A
-
S
-
D
S
V
L
S
I
K
Q
A
V
N
L
T
S
G
K
N
L
V
G
F
Y
Y
P
P
R
F
V
F
A
D
T
R
I
L
S
E
S
P
P
R
Q
V
K
A
G
M
C
E
L
V
K
N
M
L
I
L
-
E
N
D
N
K
E
F
T
E
--
D
D
L
------
N
--
S
A
N
V
-------------
Y
------
S
---
P
K
--
Q
L
E
T
F
I
N
-----
F
C
I
S
A
----
K
M
S
V
L
S
E
D
IY
E
K
K
K
G
L
--
I
F
E
Y
G
H
T
I
G
H
A
I
E
----
L
--
A
---
E
---
Q
GG
I
T
H
G
E
A
I
A
V
G
M
I
Y
A
A
-------
K
I
A
-
N
R
--
M
N
L
M
P
E
H
-
D
V
S
A
H
Y
W
L
L
N
K
I
G
A
L
-------
Q
D
I
P
L
---
K
S
---------
D
P
D
S
I
F
H
Y
L
I
H
---
D
N
-------
D
E
D
N
L
G
-
M
I
L
L
S
G
V
G
-------------------------------------
26
PsiBlast_CBE
64.34
34%
-87
- C3 -
3ZOK
11
DHQS_ACTCH
B:
[24-351]
---------
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
D
L
L
Q
--
R
--
H
V
---
H
G
K
R
V
L
V
VT
N
S
T
-
V
A
P
----
I
Y
L
D
K
V
V
G
A
L
T
N
E
--------
N
PNVS
V
--------
E
--
S
V
I
L
--
P
D
G
E
K
Y
K
N
---
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
C
T
-
F
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
-
A
-
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
F
E
W
Q
E
--
K
N
M
------
P
--
A
L
M
A
-------------
R
------
D
---
P
S
--
A
L
A
Y
A
I
K
-----
R
S
C
E
N
----
K
A
E
V
V
S
L
D
--
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
----
T
--
G
FGY
G
---
Q
--
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
DMSYRLG
W
I
D
-
E
S
--
I
-
V
N
R
A
H
-
N
I
L
Q
Q
A
K
L
P
T
A
---
P
-------
P
E
T
M
T
---------------
V
E
M
F
K
S
V
M
A
V
---
D
K
K
V
-----
A
D
G
L
L
R
-
L
I
L
L
K
----------------------------------------
24
PsiBlast_CBE
64.32
34%
-88
- C3 -
3ZOK
9
DHQS_ACTCH
D:
[24-351]
---------
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
D
L
L
Q
--
R
--
H
V
---
H
G
K
R
V
L
V
VT
N
S
T
-
V
A
P
----
I
Y
L
D
K
V
V
G
A
L
T
N
E
--------
N
PNVS
V
--------
E
--
S
V
I
L
--
P
D
G
E
K
Y
K
N
---
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
C
T
-
F
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
-
A
-
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
F
E
W
Q
E
--
K
N
M
------
P
--
A
L
M
A
-------------
R
------
D
---
P
S
--
A
L
A
Y
A
I
K
-----
R
S
C
E
N
----
K
A
E
V
V
S
L
D
--
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
----
T
--
G
FGY
G
---
Q
--
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
DMSYRLG
W
I
D
-
E
S
--
I
-
V
N
R
A
H
-
N
I
L
Q
Q
A
K
L
P
T
A
---
P
-------
P
E
T
M
T
---------------
V
E
M
F
K
S
V
M
A
V
---
D
K
K
V
-----
A
D
G
L
L
R
-
L
I
L
L
K
----------------------------------------
17
PsiBlast_PDB
64.23
24%
-101
- C3 -
4P53
3
?
A:
[70-396]
-----------------------------------------
R
R
L
I
V
I
--
D
A
T
-
V
R
S
----
L
Y
G
E
Q
L
A
A
Y
L
A
G
H
--------
D
----
V
E
F
------
H
--
L
C
V
I
--
D
A
H
E
S
A
K
V
---
M
E
T
V
F
E
V
V
D
A
M
D
A
F
G
--
V
P
R
R
H
A
P
V
L
A
M
G
G
G
V
L
T
D
I
V
G
L
A
A
S
L
Y
R
R
A
T
P
Y
V
R
I
P
T
T
L
I
-
G
-
M
I
D
A
G
I
G
A
K
T
G
V
N
F
R
E
H
K
N
R
L
G
T
Y
H
P
S
S
L
T
L
I
D
P
G
F
L
A
T
L
D
A
R
H
L
R
N
G
L
A
E
I
L
K
V
A
L
V
K
D
A
E
L
F
D
L
L
E
G
--
H
G
A
------
S
L
V
E
Q
R
M
-------------
Q
------
P
---
G
--------
A
A
L
T
V
L
R
R
A
V
Q
G
----
M
L
E
E
L
Q
P
N
--
L
W
E
H
Q
L
R
R
L
V
D
F
G
H
S
F
S
P
S
V
E
----
M
--
A
A
L-
P
---
E
--
L
L
H
G
E
A
V
C
I
D
M
A
L
S
S
-------
V
L
A
H
H
R
--
G
-
L
L
T
E
A
-
E
L
G
R
V
L
D
V
M
R
L
L
H
L
P
V------
L
H
P
V
C
---
T
P
---------
D
---
L
M
R
A
A
L
A
---
D
T
V
K
-----
H
R
D
G
W
Q
H
M
P
L
P
R
G
I
G
-
D
A
V
F
V
N
------
D
V
T
Q
R
E
I
E
A
A
--------------
5
PsiBlast_PDB
63.83
34%
-87
- C3 -
3ZOK
9
DHQS_ACTCH
A:
[24-351]
---------
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
D
L
L
Q
--
R
--
H
V
---
H
G
K
R
V
L
V
V
T
N
S
T
-
V
A
P
----
I
Y
L
D
K
V
V
G
A
L
T
N
E
--------
N
PN
V
S
V
--------
E
--
S
V
I
L
--
P
D
G
E
K
Y
K
N
---
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
C
T
-
F
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
-
A
-
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
-
D
A
N
F
F
E
W
Q
E
--
K
N
M
------
P
--
A
L
M
A
-------------
R
------
D
---
P
S
--
A
L
A
Y
A
I
K
-----
R
S
C
E
N
----
K
A
E
V
V
S
L
D
--
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
----
T
--
G
F
GY
G
---
Q
--
W
L
H
G
E
A
V
A
A
G
M
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
-
E
S
--
I
-
V
N
R
A
H
-
N
I
L
Q
Q
A
K
L
P
T
A
---
P
-------
P
E
T
M
T
---------------
V
E
M
F
K
S
V
M
A
V
---
D
K
K
V
-----
A
D
G
L
L
R
-
L
I
L
L
K
----------------------------------------
33
PsiBlast_CBE
63.16
34%
-100
- C3 -
1NVA
3
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
-----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
--------
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
31
PsiBlast_CBE
61.86
34%
-83
- C3 -
1NVD
4
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
---------------------------R--
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
10
PsiBlast_PDB
61.06
34%
-98
- C3 -
1NVA
3
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
------
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
----------
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
12
PsiBlast_PDB
60.60
34%
-83
- C3 -
1NVD
4
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
----------------------R--
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
36
PsiBlast_CBE
60.59
34%
-79
- C3 -
1NR5
5
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
28
PsiBlast_CBE
60.58
34%
-84
- C3 -
1NVF
5
ARO1_EMENI
C:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
TILKAV
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
SARH
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
AI--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKDAR
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
MAL
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
8
PsiBlast_PDB
60.57
34%
-103
- C3 -
1NRX
6
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
HR-
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
-----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
----------
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
35
PsiBlast_CBE
60.43
34%
-100
- C3 -
1NRX
6
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
-----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
----------
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
14
PsiBlast_PDB
60.37
34%
-97
- C3 -
1SG6
2
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
-------
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
------------
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
6
PsiBlast_PDB
60.37
34%
-80
- C3 -
1DQS
5
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
------------------------R--
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
29
PsiBlast_CBE
60.36
34%
-81
- C3 -
1NVF
5
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
TILKAV
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
SARH
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
AI--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKDAR
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
MAL
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
13
PsiBlast_PDB
60.17
34%
-82
- C3 -
1NVF
5
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
32
PsiBlast_CBE
60.16
34%
-76
- C3 -
1NVB
2
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
TILKAV
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
SARH
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
AI--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKDAR
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
MAL
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
11
PsiBlast_PDB
60.11
34%
-76
- C3 -
1NVB
5
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
27
PsiBlast_CBE
60.02
34%
-101
- C3 -
1SG6
2
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
------
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
AL-------------
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
7
PsiBlast_PDB
60.02
34%
-76
- C3 -
1NR5
4
ARO1_EMENI
A:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
E
V
T
-------------
P
------
G
EHR
F
E
--
G
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------
37
PsiBlast_CBE
58.59
34%
-78
- C3 -
1DQS
5
ARO1_EMENI
B:
[78-372]
--------------------------------------------------------------------------------------------------------
P
P
G
E
V
S
K
S
---
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
T
V
-
V
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
-
A
-
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
L
E
E
--
N
A
E
T
I
L
K
A
V
R
--
R
--------------------------------
T
E
E
I
L
K
-----
A
R
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
--
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
--
L
--
T
---
P
---
Q
--
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
-------
E
L
A
-
R
H
--
L
G
I
L
K
G
V
-
A
V
S
R
I
V
K
C
L
A
A
Y
G
L
P
TSLKD
A
R
I
R
K
L
T
---
A
G
---------
K
H
C
S
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
-
I
V
L
L
S
A
I
G
-------------------------------------