@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1029: (2016-03-20 )
MSKIVFFDVDGTLVGETKEIPASAKQAIAKLKENGVYVAIATGRGPFMLDEIRKELDINSYICYNGQYVIFEGKEIYAKPLPTESLERLITVASEHEHPIVFSGKDSMRANLPDHDRVTIGMNSIKREYPKVDANYYKGRDIYQCLLFCDESYDAYYREEFKQYGFLRWHDVSVDVCPADGSKAEGIKQMIKKLGFSMKDTYAFGDGLNDIAMLQTVGTGVAMGNGRDEVKAVADYVTSHVDDDGVYNALKQLKLI
Atome Classification :
(20 SA)
.........10....-..-..20........30........40........50...--.-..----..60----.....-...70..--....-...80........90..-....-..100..---.....110----.--..---.---..-..120---.-----..-..------.--..-130--.-...-.------.-..140-........150-.--...---...160----.-.---......170--------..-.---.....180.......190.......200.......210.......220.......230...--.--...240.......250....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
K
I
V
F
F
DVDGTLVG-ET-KEI
P
A
S
A
K
Q
A
I
A
K
L
KEN
G
V
Y
V
A
I
ATGRGP
F
M
L
D
E
I
R
K
--E-LD----IN
S
Y
----
I
C
YN
G
-
Q
Y
V
I
-FE--G
K
E
I
-YAKPL
P
T
E
S
L
E
R
L
I
T
V
A
-SEHE-H
P
I
V
FSG---KDSMRAN-----L--PD---H---D
R
-
V
T
I
G
----
M
-----
N
S
-
I
K
------
R
--EY-PK---V-DAN-Y------Y-K
G
R
D
--
I
Y
Q
C
L
L
F
CDE
S
-
Y
--
D
A
Y
---
Y
R
E
E
F
-----
K
-Q---YG
F
L
R
W
H
D
---------
V
S
-
V
---
D
V
CPADG
S
K
A
E
G
I
K
Q
M
I
K
KLGFSMK
D
T
YAFGDGL
N
D
I
A
M
L
Q
TVGT
G
V
AMGN
G
R
D
E
V
K
A
V
A
D
--
Y
--
V
T
SHVDD
D
G
V
Y
N
A
L
K
Q
LKLI
2
PsiBlast_PDB
95.24
51%
-114
- C1 -
2QYH
5
?
A:
[4-257]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
--
Q
-
L
G
----
I
D
S
F
----
V
S
F
N
G
-
Q
Y
V
V
-
F
E
--
G
N
V
L
-
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
-
H
K
N
G
-
H
P
L
V
F
M
D
---
A
E
K
M
R
A
S
-----
I
--
G
D
---
H
---
P
H
-
I
H
V
S
----
M
-----
A
S
-
L
K
------
F
--
A
H
-
P
P
---
V
-
D
P
L
-
Y
------
Y
-
E
N
K
D
--
I
Y
Q
A
L
L
F
C
R
A
E
-
E
--
E
E
P
---
Y
V
R
N
Y
-----
P
-
E
---
F
R
F
V
R
W
H
D
---------
V
S
-
T
---
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
--
F
--
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
3
PsiBlast_PDB
78.70
30%
-88
- C1 -
1YMQ
3
?
A:
[2-261]
-
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
--
L
-
Q
D
R
NL-
I
D
G
Y
----
I
T
M
N
G
-
A
Y
C
F
-
V
G
--
E
E
V
I
-
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
-
E
K
K
G
-
V
P
C
I
F
V
E
---
E
H
N
I
S
V
C
-----
Q
--
P
N
---
E
---
M
V
-
K
K
I
F
----
Y
-----
D
F
-
L
H
------
V
--
N
V
I
P
T
---
V
-
S
F
E
-
E
------
A
-
S
N
K
E
--
V
I
Q
M
T
P
F
I
T
E
E
-
E
--
E
K
E
---
V
L
P
S
I
-----
P
-
T
---
C
E
I
G
R
W
Y
P
---------
A
F
-
A
---
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
8
PsiBlast_PDB
78.56
31%
-105
- C1 -
3R4C
4
?
A:
[11-268]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
F
E
T
-
H
K
V
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
L
H
E
I
-
D
--
A
-
V
P
----
Y
D
G
V
----
I
A
L
N
G
A
E
C
V
L
-
R
D
--
G
S
V
I
-
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
L
A
-
R
E
F
D
-
F
A
V
A
L
E
L
---
N
E
G
V
F
V
N
------------------
R
-
L
T
P
T
----
V
-----
E
Q
-
I
A
G
I
----
V
--
E
H
-
P
V
PPV
V
-
D
I
E
E
M
------
F
-
E
R
K
E
--
C
C
Q
L
C
F
Y
F
D
E
E
-
A
--
E
Q
K
---
V
M
P
L
L
-----
S
-
G
---
L
S
A
T
R
W
H
P
---------
L
F
-
A
---
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
--
F
--
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
V
I
112
HHSearch
78.48
30%
-94
- C1 -
2RBK
2
?
A:
[1-261]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
-
F
E
T
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
L
Q
D
-
R
N
L---
I
D
G
Y
----
I
T
M
N
G
-
A
Y
C
F
-
V
G
--
E
E
V
I
-
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
-
E
K
K
G
-
V
P
C
I
F
V
E
---
E
H
N
I
S
V
C
-----
Q
--
P
N
-------
E
M
-
V
K
K
I
----
F
-----
Y
D
-
F
L
------
H
VN
V
I
-
P
T
---
V
-
S
F
E
-
E
------
A
-
S
N
K
E
--
V
I
Q
M
T
P
F
I
T
E
E
-
E
E
-
K
E
----
V
L
P
S
I
-----
P
-
T
---
C
E
I
G
-
R
W
Y
---------
P
A
F
A
---
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
7
PsiBlast_PDB
78.38
30%
-89
- C1 -
2RAV
2
?
A:
[1-261]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
--
L
-
Q
D
R
NL-
I
D
G
Y
----
I
T
M
N
G
-
A
Y
C
F
-
V
G
--
E
E
V
I
-
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
-
E
K
K
G
-
V
P
C
I
F
V
E
---
E
H
N
I
S
V
C
-----
Q
--
P
N
---
E
---
M
V
-
K
K
I
F
----
Y
-----
D
F
-
L
H
------
V
--
N
V
I
P
T
---
V
-
S
F
E
-
E
------
A
-
S
N
K
E
--
V
I
Q
M
T
P
F
I
T
E
E
-
E
--
E
K
E
---
V
L
P
S
I
-----
P
-
T
---
C
E
I
G
R
W
Y
P
---------
A
F
-
A
---
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
4
PsiBlast_PDB
78.14
30%
-87
- C1 -
2RB5
2
?
A:
[1-261]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
--
L
-
Q
D
R
NL-
I
D
G
Y
----
I
T
M
N
G
-
A
Y
C
F
-
V
G
--
E
E
V
I
-
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
-
E
K
K
G
-
V
P
C
I
F
V
E
---
E
H
N
I
S
V
C
-----
Q
--
P
N
---
E
---
M
V
-
K
K
I
F
----
Y
-----
D
F
-
L
H
------
V
--
N
V
I
P
T
---
V
-
S
F
E
-
E
------
A
-
S
N
K
E
--
V
I
Q
M
T
P
F
I
T
E
E
-
E
--
E
K
E
---
V
L
P
S
I
-----
P
-
T
---
C
E
I
G
R
W
Y
P
---------
A
F
-
A
---
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
122
HHSearch
78.06
29%
-102
- C1 -
3R4C
4
?
A:
[11-268]
M
I
K
V
L
L
L
D
V
D
G
T
L
L
S
-
F
E
T
H
K
V
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
K
I
V
I
A
T
G
R
A
A
S
D
L
H
E
I
D
---
A
-
V
P
----
Y
D
G
V
----
I
A
L
N
G
-
A
E
C
V
-
L
R
D-
G
S
V
I
-
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
L
A
-
R
E
F
D
-
F
A
V
A
L
E
L
---
N
E
G
V
F
V
N
-----
R
--
L
T
-------
P
T
-
V
-
E
Q
----
I
-----
A
G
-
I
V
EH----
P
--
V
P
-
P
V
---
V
-
D
I
E
-
E
M
-----
F
-
E
R
K
E
--
C
C
Q
L
C
F
Y
F
D
E
E
-
A
E
-
Q
K
----
V
M
P
L
L
-----
S
-
G
---
L
S
A
T
-
R
W
H
---------
P
L
F
A
---
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
--
F
--
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
V
I
5
PsiBlast_PDB
77.65
30%
-88
- C1 -
2RBK
2
?
A:
[1-261]
M
T
K
A
L
F
F
D
I
D
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
--
L
-
Q
D
R
NL-
I
D
G
Y
----
I
T
M
N
G
-
A
Y
C
F
-
V
G
--
E
E
V
I
-
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
-
E
K
K
G
-
V
P
C
I
F
V
E
---
E
H
N
I
S
V
C
-----
Q
--
P
N
---
E
---
M
V
-
K
K
I
F
----
Y
-----
D
F
-
L
H
------
V
--
N
V
I
P
T
---
V
-
S
F
E
-
E
------
A
-
S
N
K
E
--
V
I
Q
M
T
P
F
I
T
E
E
-
E
--
E
K
E
---
V
L
P
S
I
-----
P
-
T
---
C
E
I
G
R
W
Y
P
---------
A
F
-
A
---
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
6
PsiBlast_PDB
77.21
30%
-87
- C1 -
2RAR
2
?
A:
[1-261]
M
T
K
A
L
F
F
D
I
A
G
T
L
V
S
F
E
T
-
H
R
I
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
E
--
L
-
Q
D
R
NL-
I
D
G
Y
----
I
T
M
N
G
-
A
Y
C
F
-
V
G
--
E
E
V
I
-
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
F
C
-
E
K
K
G
-
V
P
C
I
F
V
E
---
E
H
N
I
S
V
C
-----
Q
--
P
N
---
E
---
M
V
-
K
K
I
F
----
Y
-----
D
F
-
L
H
------
V
--
N
V
I
P
T
---
V
-
S
F
E
-
E
------
A
-
S
N
K
E
--
V
I
Q
M
T
P
F
I
T
E
E
-
E
--
E
K
E
---
V
L
P
S
I
-----
P
-
T
---
C
E
I
G
R
W
Y
P
---------
A
F
-
A
---
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
--
Y
--
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
I
9
PsiBlast_PDB
74.29
25%
-86
- C1 -
3FZQ
7
?
A:
[4-274]
L
Y
K
L
L
I
L
D
I
D
G
T
L
R
D
-
E
V
-
Y
G
I
P
E
S
A
K
H
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
S
M
G
T
I
Q
D
D
V
L
--
S
-
L
G
----
V
D
G
Y
----
I
A
G
G
G
-
N
Y
I
Q
-
Y
H
--
G
E
L
L
-
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
L
L
-
K
K
R
E
-
V
A
F
S
I
E
S
---
Q
E
K
V
F
M
N
Q
K
A
K
E
I
--
F
E
---
T
---
M
N
-
Q
L
K
G
----
T
-----
N
S
C
I
N
------
K
--
Q
H
-
I
Q
---
E
-
K
I
T
-
Y
E
NNIEE
Y
-
K
S
Q
D
--
I
H
K
I
C
L
W
S
N
E
K
-
V
--
F
D
E
---
V
K
D
I
L
-----
Q
-
D
---
K
M
E
L
A
Q
R
D
---------
I
S
-
S
Q
Y
Y
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
--
S
--
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
N
I
I
109
HHSearch
74.01
26%
-93
- C1 -
3FZQ
7
?
A:
[4-273]
L
Y
K
L
L
I
L
D
I
D
G
T
L
R
D
-
E
V
-
Y
G
I
P
E
S
A
K
H
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
S
M
G
T
I
Q
D
D
V
L
--
S
-
L
G
----
V
D
G
Y
----
I
A
G
G
G
-
N
Y
I
Q
-
Y
H
--
G
E
L
L
-
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
L
L
-
K
K
R
E
-
V
A
F
S
I
E
S
---
Q
E
K
V
F
M
N
-----
Q
--
K
A
---
K
E
I
F
E
T
-
M
N
Q
L
----
K
GT---
N
S
-
C
I
NKQHIQ
E
--
K
I
-
T
Y
---
E
N
N
I
E
-
E
------
Y
-
K
S
Q
D
--
I
H
K
I
C
L
W
S
N
E
K
-
V
F
-
D
E
----
V
K
D
I
L
-----
Q
-
D
KME
L
A
Q
R
-
D
I
S
---------
S
Q
Y
Y
---
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
--
S
--
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
N
I
-
1
PsiBlast_PDB
71.99
51%
-12
- C1 -
2PQ0
-
?
A:
[4-257]
--
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
--
Q
-
L
G
----
I
D
S
F
----
V
S
F
N
G
-
Q
Y
V
V
-
F
E
--
G
N
V
L
-
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
-
H
K
N
G
-
H
P
L
V
F
M
D
---
A
E
K
M
R
A
S
-----
I
--
G
D
---
H
---
P
H
-
I
H
V
S
----
M
-----
A
S
-
L
K
------
F
--
A
H
-
P
P
---
V
-
D
P
L
-
Y
------
Y
-
E
N
K
D
--
I
Y
Q
A
L
L
F
C
R
A
E
-
E
--
E
E
P
---
Y
V
R
N
Y
-----
P
-
E
---
F
R
F
V
R
W
H
D
---------
V
S
-
T
---
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
--
F
--
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
10
PsiBlast_PDB
71.89
26%
-97
- C1 -
4DW8
4
?
A:
[6-268]
--
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
--
E
-
L
R
----
M
N
E
F
GGFI
L
S
Y
N
G
-
G
E
I
I
N
W
E
--
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
L
-
S
I
L
T
Y
D
G
---
A
E
I
V
T
E
N
S----
L
--
D
P
---
Y
---
V
Q
-
K
E
A
F
----
L
-----
N
K
-
M
A
I
-----
R
--
E
T
-
N
D
---
F
-
L
T
D
-
I
------
T
---
L
P
--
V
A
K
C
L
I
V
G
D
A
G
-
K
--
L
I
P
---
V
E
S
E
L
C
I
R
LQ
G
-
K
---
I
N
V
F
R
S
E
P
---------
Y
F
-
L
---
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
--
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
---
121
HHSearch
70.83
51%
-9
- C1 -
2PQ0
-
?
A:
[2-257]
G
R
K
I
V
F
F
D
I
D
G
T
L
L
D
-
E
Q
-
K
Q
L
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
K
--
Q
-
L
G
----
I
D
S
F
----
V
S
F
N
G
-
Q
Y
V
V
-
F
E
--
G
N
V
L
-
Y
K
Q
P
L
R
R
E
K
V
R
A
L
T
E
E
A
-
H
K
N
G
-
H
P
L
V
F
M
D
---
A
E
K
M
R
A
S
-----
I
--
G
D
---
H
---
P
H
-
I
H
V
S
----
M
-----
A
S
-
L
K
------
F
A-
H
P
-
P
V
---
D
-
P
L
Y
--------
Y
-
E
N
K
D
--
I
Y
Q
A
L
L
F
C
R
A
E
E
E
--
E
P
----
Y
V
R
N
Y
-----
P
-
E
---
F
R
F
V
-
R
W
H
---------
D
V
S
T
---
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
--
F
--
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
L
Q
L
I
11
PsiBlast_PDB
70.37
25%
-86
- C1 -
3NIW
2
?
A:
[6-268]
--
K
L
I
V
L
D
L
D
G
T
L
T
N
-
S
K
-
K
E
I
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
--
E
-
L
R
----
M
N
E
F
GGFI
L
S
Y
N
G
-
G
E
I
I
N
W
E
--
S
K
E
M
M
Y
E
N
V
L
P
N
E
V
V
P
V
L
Y
E
C
A
R
T
N
H
L
-
S
I
L
T
Y
D
G
---
A
E
I
V
T
E
N
-----
S
--
L
D
P
Y
V
Q
---
K
E
-
A
F
L
N
----
K
-----
M
A
-
I
R
------
E
--
T
N
--------
D
F
L
-
T
------
D
-
I
T
L
P
--
V
A
K
C
L
I
V
G
D
A
G
-
K
--
L
I
P
---
V
E
S
E
L
C
I
RLQ
G
-
K
---
I
N
V
F
R
S
E
P
---------
Y
F
-
L
---
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
--
Y
--
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
---
16
PsiBlast_PDB
70.06
25%
-91
- C1 -
3PGV
9
?
A:
[22-284]
--
Q
V
V
A
S
D
L
D
G
T
L
L
S
-
P
D
-
H
F
L
T
P
Y
A
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
--
N
-
L
G
----
I
R
S
Y
M
---
I
T
S
N
G
-
A
R
V
H
D
S
D
--
G
Q
Q
I
-
F
A
H
N
L
D
R
D
I
A
A
D
L
F
E
I
V
-
R
N
D
---
P
K
I
V
T
N
V
Y
R
E
D
E
W
Y
M
N
-----
R
HR------------
F
-------
F
-----
K
E
-
A
V
------
F
--
N
Y
-
K
L
---
Y
-
E
P
G
-
E
------
L
-
D
P
Q
G
--
I
S
K
V
F
F
T
C
E
------
D
H
E
---
H
L
L
P
L
-----
E
-
Q
---
A
M
N
A
R
W
G
D
R
V
N
V
S
F
STL
T
C
-
L
---
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
E
L
E
--
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
-
118
HHSearch
68.99
24%
-88
- C1 -
3PGV
9
?
A:
[21-284]
-
Y
Q
V
V
A
S
D
L
D
G
T
L
L
S
-
P
D
-
H
F
L
T
P
Y
A
K
E
T
L
K
L
L
T
A
R
G
I
N
F
V
F
A
T
G
R
H
Y
I
D
V
G
Q
I
R
D
--
N
-
L
G
I
---
R
S
Y
M
----
I
T
S
N
G
-
A
R
V
H
-
D
S
D-
G
Q
Q
I
-
F
A
H
N
L
D
R
D
I
A
A
D
L
F
E
I
V
-
R
N
D
P
K
I
V
T
N
V
Y
R
---
E
D
E
W
Y
M
N
-----
R
--
H
R
-------------
F
----
F
-----
K
E
-
A
V
------
F
--
N
Y
-
K
L
---
Y
-
E
P
G
-
E
------
L
-
D
P
Q
G
--
I
S
K
V
F
F
T
C
E
D
H
-
E
HL
L
P
L
E
Q
A
M
N
A
R
W
-----
G
D
R
---
V
N
V
S
-
F
S
T
---------
L
T
C
L
---
E
V
M
A
G
G
V
S
K
G
H
A
L
E
A
V
A
K
M
L
G
Y
T
L
S
D
C
I
A
F
G
D
G
M
N
D
A
E
M
L
S
M
A
G
K
G
C
I
M
A
N
A
H
Q
R
L
K
D
L
H
P
--
E
L
E
V
I
G
S
N
A
D
D
A
V
P
R
Y
L
R
K
L
Y
L
-
115
HHSearch
68.86
26%
-88
- C1 -
1RKQ
2
YIDA_ECOLI
A:
[4-271]
A
I
K
L
I
A
I
D
M
D
G
T
L
L
L
-
P
D
-
H
T
I
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
K
--
E
-
L
H
MEQP
G
D
Y
C
----
I
T
Y
N
G
-
A
L
V
Q
-
K
A
AD
G
S
T
V
-
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
L
S
-
R
E
V
G
-
S
H
F
H
A
L
D
---
R
T
T
L
Y
T
A
-----
N
--
R
D
---
I
---
S
Y
-
Y
-
T
V
----
H
-----
E
S
-
F
V
------
A
T
I
P
L
-
V
F
---
C
-
E
A
E
-
K
M-----
D
-
P
N
T
Q
--
F
L
K
V
M
M
I
D
E
P
A
-
I
L
-
D
Q
A
I
A
R
I
P
Q
E
V
-----
K
E
K
---
Y
T
V
L
-
K
S
A
---------
P
Y
F
L
---
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
--
F
--
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
-
116
HHSearch
67.96
21%
-88
- C1 -
3DNP
1
YHAX_BACSU
A:
[6-275]
-
K
Q
L
L
A
L
N
I
D
G
A
L
L
R
-
S
N
-
G
K
I
H
Q
A
T
K
D
A
I
E
Y
V
K
K
K
G
I
Y
V
T
L
V
T
N
R
H
F
R
S
A
Q
K
I
A
K
--
S
-
L
K
L---
D
A
K
L
----
I
T
H
S
G
-
A
Y
I
A
-
E
K
I-
D
A
P
F
-
F
E
K
R
I
S
D
D
H
T
F
N
I
V
Q
V
L
-
E
S
Y
Q
-
C
N
I
R
L
L
H
---
E
--
K
Y
S
I
-----
G
--
N
K
---
K
KVN
S
N
L
L
G
K
A
----
L
I
H
P
S
D
P
I
-
F
Y
------
P
--
V
Q
-
F
V
---
E
-
S
L
S
-
D
------
L
L
M
D
E
P
VS
A
P
V
I
E
V
Y
T
E
H
D
-
I
Q
-
H
D
I
T
E
T
I
T
K
A
F
-----
P
-
A
---
V
D
V
I
-
R
V
N
---------
D
E
K
L
---
N
I
V
P
K
G
V
S
K
E
A
G
L
A
L
V
A
S
E
L
G
L
S
M
D
D
V
V
A
I
G
H
Q
Y
D
D
L
P
M
I
E
L
A
G
L
G
V
A
M
G
N
A
V
P
E
I
K
R
K
A
D
--
W
--
V
T
R
S
N
D
E
Q
G
V
A
Y
M
M
K
E
Y
F
R
-
119
HHSearch
66.42
23%
-94
- C1 -
1NF2
3
?
A:
[1-262]
M
Y
R
V
F
V
F
D
L
D
G
T
L
L
N
-
D
N
-
L
E
I
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
K
--
K
Y
F
K
R---
T
F
P
T
----
I
A
Y
N
G
-
A
I
V
Y
-
L
P
E-
E
G
V
I
-
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
Y
I
-
K
P
L
N
-
V
H
W
Q
A
Y
I
---
D
D
V
L
Y
S
E
-----
K
--
D
----
N
---
E
E
-
I
K
S
Y
A
R
H
S
N
-----
V
D
-
Y
R
------
V
--
E
P
-
N
L
---
S
-
E
L
---------
V
-
S
K
M
G
--
T
T
K
L
L
L
I
D
T
P
E
-
R
L
-
D
E
L
K
E
I
L
S
E
R
F
-----
K
-
D
V--
V
K
V
F
-
K
S
F
---------
P
T
Y
L
---
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
--
I
--
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
--