@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2184: (2016-04-01 )
MRKMAVISLVLLLFLVGCGKEEAAQKPEQKTDKEPKIVATTVAITEIMDKLDLPLVGIPSSSKKLPKRYADVKETGSPMGPDLEIIRMLKPDMVLSTKTLEADLKSGFEGADLEADFLDFTSIASMQTEIKNLGAKFDRIEEATKLNKDLTSDIDQVKSNVAKKKKPTVLILMGVPGSYLVVTEHAYIGDLVKLAGGENVIKDQKVEYLASNTEYLQSANPDIILRAAHGMPAEVVKMFDEEFKTNDIWKHFDAVKNNRVYDLDENLFGMTASLNAPEALKEMEKMLYDN
Atome Classification :
(20 SA)
.........10........20........30.....----...40........50..--......60..------.------.---.---...--70....---....80........90........100-.-------------...-.------------...-110.......120-..--------------------.......130.......140.......150.......160.----.--.-.-...170...-..-..180.......190.......200..---------...-..210.......220-.......230.-..---...---.240...---....250.......260-......---.-270-...-.-....280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
K
M
A
V
I
S
L
V
L
L
L
F
L
VGCG
K
E
E
A
AQKPEQKTDKEP
K
----
I
V
A
T
T
V
A
I
T
E
I
M
D
K
LDL--
P
L
VGIPSSS
K
------
K
------
L
---
P
---
K
R
Y
--
A
D
V
K
ET---GSPMGP
D
L
E
I
I
R
MLKPD
M
V
L
S
T
K
T
L
-
E
-
A
-------------
D
L
K
-S------------GFE-GADLE
A
D
F
L
D
F
---
T
S
--------------------
I
A
S
M
Q
T
E
I
K
N
LG
A
K
F
D
R
I
E
E
A
T
KLN
K
D
L
T
S
D
I
D
Q
V
K
S
N
V
AK----K--K-K-
P
T
V
L
I
L
MGV-PG-
S
Y
L
V
V
TE
H
A
Y
I
G
D
L
V
K
LAGGENV
I
K
D
Q
---------
K
V
E
-
Y
L
ASN
T
E
Y
L
QSANP
D
-
I
I
L
R
AAHGM
P
A
-
E
V
---
V
K
M
---
F
D
E
EFKT---
N
D
I
W
K
H
F
D
A
VKNN
R
V
Y
D-LDENLF---G-M-T-ASL-N-
A
P
E
A
L
K
E
M
E
K
M
LYDN-
21
HHSearch
99.04
53%
-94
- C1 -
2Q8P
1
ISDE_STAAN
A:
[3-260]
--------------------------------
G
E
F
R
----
I
V
P
T
T
V
A
L
T
M
T
L
D
K
L
D
L
--
P
I
V
G
K
P
T
S
Y
K
------
T
------
L
---
P
---
N
R
Y
--
K
D
V
P
E
I
---
G
Q
P
M
E
P
N
V
E
A
V
K
K
L
K
P
T
H
V
L
S
V
S
T
I
-
K
-
D
-------------
E
M
Q
-
P
------------
F
Y
K
-
Q
L
N
M
K
G
Y
F
Y
D
F
---
D
S
--------------------
L
K
G
M
Q
K
S
I
T
Q
L
G
D
Q
F
N
R
K
A
Q
A
K
E
L
N
D
H
L
N
S
V
K
Q
K
I
E
N
K
A
A
K
Q---
K
--
K
-
H
-
P
K
V
L
I
L
M
G
V
-
P
G
-
S
Y
L
V
A
T
D
K
S
Y
I
G
D
L
V
K
I
A
G
G
E
N
V
I
K
V
K
---------
D
R
Q
-
Y
I
S
S
N
T
E
N
L
L
N
I
N
P
D
-
I
I
L
R
L
P
H
G
M
P
E
-
E
V
---
K
K
M
---
F
Q
K
E
F
K
Q
---
N
D
I
W
K
H
F
K
A
V
K
N
N
H
V
Y
D
-
L
E
E
V
P
F
---
G
-
I
-
T
-
A
N
V
-
D
-
A
D
K
A
M
T
Q
L
Y
D
L
F
Y
K
--
1
PsiBlast_PDB
98.63
53%
-91
- C1 -
2Q8Q
1
ISDE_STAAN
A:
[4-259]
---------------------------------
E
F
R
----
I
V
P
T
T
V
A
L
T
M
T
L
D
K
L
D
L
--
P
I
V
G
K
P
T
S
Y
K
------
T
------
L
---
P
---
N
R
Y
--
K
D
V
P
E
I
---
G
Q
P
M
E
P
N
V
E
A
V
K
K
L
K
P
T
H
V
L
S
V
S
T
I
-
K
-
D
-------------
E
M
Q
-
P
------------
F
Y
K
-
Q
L
N
M
K
G
Y
F
Y
D
F
---
D
S
--------------------
L
K
G
M
Q
K
S
I
T
Q
L
G
D
Q
F
N
R
K
A
Q
A
K
E
L
N
D
H
L
N
S
V
K
Q
K
I
E
N
K
A
A
K
----
Q
--
K
-
K
H
P
K
V
L
I
L
M
G
V
-
P
G
-
S
Y
L
V
A
T
D
K
S
Y
I
G
D
L
V
K
I
A
G
G
E
N
V
I
K
V
K
---------
D
R
Q
-
Y
I
S
S
N
T
E
N
L
L
N
I
N
P
D
-
I
I
L
R
L
P
H
G
M
P
E
-
E
V
---
K
K
M
---
F
Q
K
E
F
K
Q
---
N
D
I
W
K
H
F
K
A
V
K
N
N
H
V
Y
D
-
L
E
E
V
P
F
---
G
-
I
-
T
-
A
N
V
-
D
-
A
D
K
A
M
T
Q
L
Y
D
L
F
Y
---
2
PsiBlast_PDB
97.83
51%
-94
- C1 -
2Q8P
1
ISDE_STAAN
A:
[4-259]
---------------------------------
E
F
R
----
I
V
P
T
T
V
A
L
T
M
T
L
D
K
L
D
L
--
P
I
V
G
K
P
T
S
Y
K
------
T
------
L
---
P
---
N
R
Y
--
K
D
V
P
E
I
---
G
Q
P
M
E
P
N
V
E
A
V
K
K
L
K
P
T
H
V
L
S
V
S
T
I
-
K
-
D
-------------
E
M
Q
-
P
------------
F
Y
K
-
Q
L
N
M
K
G
Y
F
Y
D
F
---
D
S
--------------------
L
K
G
M
Q
K
S
I
T
Q
L
G
D
Q
F
N
R
K
A
Q
A
K
E
L
N
D
H
L
N
S
V
K
Q
K
I
E
N
K
A
A
K
----
Q
--
K
-
K
H
P
K
V
L
I
L
M
G
V
-
P
G
-
S
Y
L
V
A
T
D
K
S
Y
I
G
D
L
V
K
I
A
G
G
E
N
V
I
K
V
K
---------
D
R
Q
-
Y
I
S
S
N
T
E
N
L
L
N
I
N
P
D
-
I
I
L
R
L
P
H
G
M
P
E
-
E
V
---
K
K
M
---
F
Q
K
E
F
K
Q
---
N
D
I
W
K
H
F
K
A
V
K
N
N
H
V
Y
D
-
L
E
E
V
P
F
---
G
-
I
-
T
-
A
N
V
-
D
-
A
D
K
A
M
T
Q
L
Y
D
L
F
Y
---
23
HHSearch
73.93
20%
-90
- C1 -
2R7A
1
?
A:
[2-256]
---------------------------------
A
E
R
----
I
V
V
A
G
G
S
L
T
E
L
I
Y
A
M
G
A
GE
R
V
V
G
V
D
E
T
T
S
-------------
Y
---
P
---
P
E
T
--
A
K
L
P
H
I
---
G
Y
W
K
Q
L
S
S
E
G
I
L
S
L
R
P
D
S
V
I
T
W
Q
D
A
G
P
-
Q
-------------
I
V
L
-
D
------------
Q
L
R
-
A
Q
K
V
N
V
V
T
L
P
R
VP-
A
T
--------------------
L
E
Q
M
Y
A
N
I
R
Q
L
A
K
T
L
Q
V
P
E
Q
G
D
A
L
V
T
Q
I
N
Q
R
L
E
R
V
Q
Q
N
V
A
A
K---
K
--
A
-
P
-
V
K
A
M
F
I
L
S
A
-
G
G
S
A
P
Q
V
A
G
K
G
S
V
A
D
A
I
L
S
L
A
G
A
E
N
V
A
T
H
-----------
Q
Q
-
Y
K
S
Y
S
A
E
S
L
I
A
A
N
P
E
-
V
I
V
V
T
S
Q
M
V
D
G
------------
D
I
N
R
L
R
S
---
I
A
G
I
T
H
T
A
A
W
K
N
Q
R
I
I
T
-
V
D
Q
N
L
I
-----
L
-
G
-
M
G
P
-
R
-
I
A
D
V
V
E
S
L
H
Q
Q
L
W
P
Q
-
22
HHSearch
69.68
19%
-82
- C1 -
2R79
5
?
A:
[1-266]
--------------------------------
L
P
Q
R
----
W
V
S
A
G
G
S
L
S
E
W
V
V
A
L
G
G
ES
K
L
V
G
V
D
T
T
S
-------
Q
------
H
---
P
---
Q
A
L
--
K
Q
L
P
S
V
---
G
Y
Q
R
Q
L
A
A
E
G
V
L
A
L
R
P
D
I
L
I
G
T
E
E
M
G
P
-
P
-------------
P
V
L
-
K
------------
Q
L
E
-
G
A
G
V
R
V
E
T
L
S
A
K--
P
D
--------------------
L
E
A
L
E
S
N
L
K
K
L
G
D
W
L
G
V
P
Q
R
A
E
A
A
E
L
D
Y
R
Q
R
L
R
R
Q
A
D
W
I
A
A
A
Q
KS
Q
--
P
-
A
-
P
G
V
L
L
V
I
G
N
A
G
G
-
Q
L
L
V
A
G
R
N
T
G
G
D
W
V
L
N
R
A
G
A
R
N
L
A
T
H
-----------
E
G
-
Y
K
P
I
S
V
E
A
L
A
A
L
D
P
V
-
A
V
V
I
A
D
R
S
L
E
G
-
D
-----
A
A
---
R
A
A
L
L
K
Q
---
N
P
G
L
A
P
T
R
A
A
R
D
G
R
L
L
V
-
L
D
P
T
L
L
---
V
-
G
-
G
-
L
G
P
-
R
-
L
P
D
G
L
A
A
L
S
A
A
F
Y
P
S
-
25
HHSearch
66.61
21%
-59
- C1 -
3LHS
4
?
A:
[16-294]
--------------------------
T
V
K
V
P
K
D
A
K
R
----
I
V
V
L
E
Y
S
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
D
G
K
------
K
KRI---
I
K
P
V
R
---
E
K
I
--
G
D
Y
T
S
V
---
G
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
-
K
-------------
G
I
N
-
K
------------
E
L
N
-
K
I
A
-
P
T
L
S
L
K
S
FD-
G
D
--------------------
Y
K
Q
N
I
N
S
F
K
T
I
A
K
A
L
N
K
E
K
E
G
E
K
R
L
A
E
H
D
K
L
I
N
K
Y
K
D
E
I
K
F
----
D
--
R
-
N
-
Q
K
V
L
P
A
V
V
A
-
K
A
-
G
L
L
A
H
P
N
Y
S
Y
V
G
Q
F
L
N
E
L
G
F
K
N
A
L
S
D
D
V
T
K
G
L
SKYL
K
G
P
-
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
-
R
M
I
I
M
T
D
H
A
K
K
-
D
-----
S
A
---
E
F
K
K
L
Q
E
---
D
A
T
W
K
K
L
N
A
V
K
N
N
R
V
D
I
-
V
D
R
D
V
W
---
A
-
R
S
R
-
G
L
I
-
S
-
S
E
E
M
A
K
E
L
V
E
L
S
K
K
E
-
45
Fugue
64.67
20%
-81
- C1 -
1N2Z
17
BTUF_ECOLI
A:
[1-245]
--------------------------------
A
A
P
R
----
V
I
T
L
S
P
A
N
T
E
L
A
F
A
A
G
I
--
T
P
V
G
V
S
S
--
Y
SD-----------
Y
---
P
---
P
Q
A
--
Q
K
I
E
Q
V
---
S
T
W
Q
G
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
W
R
G
G
N
A
-
E
-------------
R
Q
V
-
D
------------
Q
L
A
-
S
L
G
I
K
V
M
W
V
D
A
---
T
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
P
Q
P
D
K
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
----
K
--
P
-
K
-
K
R
V
F
L
Q
F
G
I
--
N
-
P
P
F
T
S
G
K
E
S
I
Q
N
Q
V
L
E
V
C
G
G
E
N
I
F
K
D
S
---------
R
V
-P
W
P
Q
V
S
R
E
Q
V
L
A
R
S
P
Q
-
A
I
V
I
T
G
G
P
D
Q
I
-
P
K
---
I
K
Q
---
Y
W
G
-----------
E
Q
L
----
K
I
P
V
I
P
-
L
T
S
D
W
F
---
E
---
R
-
A
S
P
-
R
-
I
I
L
A
A
Q
Q
L
C
N
A
L
S
Q
V
D
46
Fugue
64.17
18%
-62
- C1 -
2CHU
4
?
A:
[10-296]
L
P
I
S
M
S
D
E
G
D
S
F
L
V
K
D
S
L
G
E
N
K
I
P
K
N
P
S
-------
K
----
V
V
I
L
D
L
G
I
L
D
T
F
D
A
L
K
L
--
N
D
K
V
V
G
V
P
A
K
------
N
------
L
---
P
---
K
Y
L
--
Q
Q
F
K
N
K
PSV
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
S
G
R
Q
-
S
-
K
-------------
F
Y
D
-
K
------------
L
K
E
I
A
P
T
L
F
V
G
L
D
N
A
---
N
F
--------------------
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
G
L
E
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
------
D
--
E
-
D
-
K
K
A
L
I
I
L
T
N
-
S
N
-
K
I
S
A
F
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
---------
K
G
K
-
S
I
--
N
S
E
F
I
L
E
K
N
P
D
-
Y
I
F
V
V
D
R
N
V
I
L
-
G
N
---
K
E
R
---
A
Q
G
I
L
D
----
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
-
L
D
P
E
Y
W
YLA
S
-
G
-
N
-
G
L
E
-
S
-
L
K
T
M
I
L
E
I
K
N
A
V
K
---
44
Fugue
63.53
20%
-67
- C1 -
1N2Z
17
BTUF_ECOLI
A:
[1-245]
--------------------------------
A
A
P
R
----
V
I
T
L
S
P
A
N
T
E
L
A
F
A
A
G
I
--
T
P
V
G
V
S
S
Y
S
D
------
Y
----------
P
---
P
Q
A
--
Q
K
I
E
Q
V
---
S
T
W
Q
G
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
W
R
G
G
N
A
-
E
-------------
R
Q
V
-
D
------------
Q
L
A
-
S
L
G
I
K
V
M
W
V
D
A
---
T
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
P
Q
P
D
K
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
----
K
--
P
-
K
-
K
R
V
F
L
Q
F
G
--
I
N
-
P
P
F
T
S
G
K
E
S
I
Q
N
Q
V
L
E
V
C
G
G
E
N
I
F
K
D
S
---------
R
V
P
-
W
P
Q
V
S
R
E
Q
V
L
A
R
S
P
Q
-
A
I
V
I
T
-------------------
G
G
P
D
Q
I
---
P
K
I
K
Q
Y
W
G
E
Q
L
K
I
P
V
I
P
-
L
T
S
D
W
F
---
E
---
R
-
A
S
P
-
R
-
I
I
L
A
A
Q
Q
L
C
N
A
L
S
Q
V
D
33
HHSearch
63.28
19%
-46
* C1 *
3TNY
1
?
A:
[27-296]
--------------------------
K
T
E
V
P
A
N
P
K
R
----
V
V
I
L
T
N
E
G
T
E
A
L
L
E
L
G
V
--
K
P
V
G
A
V
K
S
W
T
GDP---
W
------
Y
---
P
HIK
D
K
M
--
K
D
V
K
V
V
---
G
D
E
G
Q
V
N
V
E
T
I
A
S
L
K
P
D
L
I
I
G
N
K
M
R
-
H
-
E
-------------
K
V
Y
-
E
------------
Q
L
K
-
A
I
A
-
P
T
V
F
S
E
T
----
L
--------------------
R
G
E
W
K
D
N
F
K
F
Y
A
K
A
L
N
K
E
K
E
G
Q
K
V
V
A
D
Y
E
S
R
M
K
D
L
K
G
K
L
G
D
----
K
VN
Q
-
E
-
I
S
M
V
R
F
M
---
P
G
-
D
V
R
I
Y
H
G
D
T
F
S
G
V
I
L
K
E
L
G
F
K
R
P
G
D
Q
N
KD-------
D
F
A
-
E
R
N
V
S
K
E
R
I
S
A
M
D
G
D
-
V
L
F
Y
F
T
F
D
K
G
N
E
K
K
---
G
S
E
---
L
E
K
E
Y
I
N
---
D
P
L
F
K
N
L
N
A
V
K
N
G
K
A
Y
K
-
V
D
D
V
I
W
---
N
-
T
-
A
G
G
V
I
-
A
-
A
N
L
L
L
D
D
I
E
K
R
F
V
---
24
HHSearch
62.87
19%
-69
- C1 -
3MD9
4
HMUT_YERPE
A:
[2-254]
---------------------------------
A
E
R
----
I
V
T
I
G
G
D
V
T
E
I
A
Y
A
L
G
A
GD
E
I
V
A
R
D
S
T
S
-------
Q
------
Q
---
P
---
Q
A
A
--
Q
K
L
P
D
V
---
G
Y
M
R
T
L
N
A
E
G
I
L
A
M
K
P
T
M
L
L
V
S
E
L
A
-
Q
P
S
-------------
L
V
L
-
T
------------
Q
I
A
-
S
S
G
V
N
V
V
T
V
P
G
Q--
T
T
--------------------
P
E
S
V
A
M
K
I
N
A
V
A
T
A
L
H
Q
T
E
K
G
Q
K
L
I
E
D
Y
Q
Q
R
L
A
A
V
N
K
T
P
---------
L
-
P
-
V
K
V
L
F
V
M
S
H
-
G
G
L
T
P
M
A
A
G
Q
N
T
A
A
D
A
M
I
R
A
A
G
G
S
N
A
M
Q
G
----------
F
S
R
-
Y
R
P
L
S
Q
E
G
V
I
A
S
A
P
D
-
L
L
L
I
T
T
D
G
V
K
A
-
L
------
G
---
S
S
E
N
I
W
K
---
L
P
G
M
A
L
T
P
A
G
K
H
K
R
L
L
V
-
V
D
D
M
A
L
-----
L
-
G
-
F
G
L
-
E
-
T
P
Q
V
L
A
Q
L
R
E
K
M
E
Q
M
-
32
HHSearch
62.80
20%
-68
- C1 -
1N2Z
15
BTUF_ECOLI
A:
[1-244]
--------------------------------
A
A
P
R
----
V
I
T
L
S
P
A
N
T
E
L
A
F
A
A
G
I
--
T
P
V
G
V
S
S
Y
S
D
-------------
Y
---
P
---
P
Q
A
--
Q
K
I
E
Q
V
---
S
T
W
Q
G
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
W
R
G
G
-
N
A
E
-------------
R
Q
V
-
D
------------
Q
L
A
-
S
L
G
I
K
V
M
W
V
D
A
---
T
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
P
Q
P
D
K
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
----
K
--
P
-
K
-
K
R
V
F
L
Q
F
G
I
-
N
--
P
P
F
T
S
G
K
E
S
I
Q
N
Q
V
L
E
V
C
G
G
E
N
I
F
K
D
S
---------
R
V
P
-
W
P
Q
V
S
R
E
Q
V
L
A
R
S
P
Q
-
A
I
V
I
T
G
G
P
D
Q
--------------
I
P
K
I
-----
K
Q
Y
W
G
E
Q
---
L
K
I
P
V
I
P
-
L
T
S
D
-
W
---
F
-
E
-
R
-
A
S
P
-
R
-
I
I
L
A
A
Q
Q
L
C
N
A
L
S
Q
V
-
28
HHSearch
62.73
17%
-67
- C1 -
3PSH
1
Y1472_HAEIN
A:
[11-300]
--------------------------
K
V
T
I
P
D
H
I
N
R
----
A
V
V
L
Q
H
Q
T
L
N
I
A
V
Q
L
D
A
TK
Q
I
V
G
V
L
S
N
W
K
K
Q
L
GKN
Y
V
R
----
L
---
A
---
P
E
L
--
E
N
M
A
M
P
---
G
D
L
N
S
V
N
I
E
S
L
L
A
L
K
P
D
V
V
F
V
T
N
Y
A
-
P
-
S
-------------
E
M
I
-
K
------------
Q
I
S
-
D
V
N
I
P
V
V
A
I
S
L
---
R
T
G
E
VGEKGKL
N
P
T
L
TD
E
D
K
A
Y
N
D
G
L
K
Q
G
I
E
L
I
A
E
V
F
E
K
K
Q
Q
G
D
E
L
V
K
A
A
F
A
N
R
K
L
L
A
D
R
L
G
D
V---
S
--
A
-
D
-
K
R
V
R
T
Y
M
A
N
--
P
-
D
L
G
T
Y
G
S
G
K
Y
T
G
L
M
M
E
H
A
G
A
Y
N
V
A
A
A
T
---------
I
K
G
-
F
K
Q
V
S
L
E
N
V
L
E
W
N
P
A
-
V
I
L
V
Q
D
R
Y
P
D
-------------
V
V
P
Q
I
L
N
---
D
Q
G
W
A
N
I
Q
A
L
K
D
K
K
V
F
L
-
M
P
E
Y
A
K
---
A
W
G
-
Y
-
P
M
P
-
E
A
L
A
L
G
E
V
W
L
A
K
A
L
Y
P
Q
-
7
PsiBlast_PDB
61.81
26%
-45
- C1 -
3LHS
4
?
A:
[11-287]
-------------------------
K
D
E
N
G
T
V
K
V
P
K
DAK
R
I
V
V
L
E
Y
S
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
D
G
K
------
K
KRII
K
P
V
---
R
---
E
K
I
--
G
D
Y
T
S
V
---
G
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
-
K
-------------
G
I
N
-
K
E
L
N
K
I
AP
T
L
S
L
K
S
F
D
-
G
-
D
Y
K
Q
N
I
N
S
F
---
K
T
--------------------
I
A
K
A
L
N
K
E
K
E
-
G
E
K
--
R
L
A
E
H
D
K
L
---
I
N
K
Y
K
D
E
I
K
F
D
R
N
Q
----
K
--
V
-
L
-
P
A
V
V
A
K
A
G
L
------
L
A
H
P
N
Y
S
Y
V
G
Q
F
L
N
E
L
G
F
K
N
A
L
S
D
D
V
T
K
G
L
SKYL
K
G
P
-
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
M
T
D
H
A
----------
K
K
---
D
S
A
E
F
K
K
L
Q
E
D
A
T
W
K
K
L
N
A
V
K
N
N
R
V
D
I
-
V
D
R
D
V
W
---
A
-
R
-
S
-
R
G
L
-
I
-
S
S
E
---
E
M
A
K
E
L
----
6
PsiBlast_PDB
61.81
26%
-43
- C1 -
3EIW
1
?
A:
[11-287]
-------------------------
K
D
E
N
G
T
V
K
V
P
K
DAK
R
I
V
V
L
E
Y
S
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
D
G
K
------
K
KRII
K
P
V
---
R
---
E
K
I
--
G
D
Y
T
S
V
---
G
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
-
K
-------------
G
I
N
-
K
E
L
N
K
I
AP
T
L
S
L
K
S
F
D
-
G
-
D
Y
K
Q
N
I
N
S
F
---
K
T
--------------------
I
A
K
A
L
N
K
E
K
E
-
G
E
K
--
R
L
A
E
H
D
K
L
---
I
N
K
Y
K
D
E
I
K
F
D
R
N
Q
----
K
--
V
-
L
-
P
A
V
V
A
K
A
G
L
------
L
A
H
P
N
Y
S
Y
V
G
Q
F
L
N
E
L
G
F
K
N
A
L
S
D
D
V
T
K
G
L
SKYL
K
G
P
-
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
M
T
D
H
A
----------
K
K
---
D
S
A
E
F
K
K
L
Q
E
D
A
T
W
K
K
L
N
A
V
K
N
N
R
V
D
I
-
V
D
R
D
V
W
---
A
-
R
-
S
-
R
G
L
-
I
-
S
S
E
---
E
M
A
K
E
L
----
8
PsiBlast_PDB
61.40
26%
-46
- C1 -
3LI2
6
?
A:
[11-287]
-------------------------
K
D
E
N
G
T
V
K
V
P
K
DAK
R
I
V
V
L
E
Y
S
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
D
G
K
------
K
KRII
K
P
V
---
R
---
E
K
I
--
G
D
Y
T
S
V
---
G
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
-
K
-------------
G
I
N
-
K
E
L
N
K
I
A
P
T
L
S
L
K
S
F
D
-
G
-
D
Y
K
Q
N
I
N
S
F
---
K
T
--------------------
I
A
K
A
L
N
K
E
K
E
-
G
E
K
--
R
L
A
E
H
D
K
L
---
I
N
K
Y
K
D
E
I
K
F
D
R
N
Q
----
K
--
V
-
L
-
P
A
V
V
A
K
A
G
L
------
L
A
H
P
N
Y
S
Y
V
G
Q
F
L
N
E
L
G
F
K
N
A
L
S
D
D
VTKGLSKYL
K
G
P
-
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
M
T
D
H
A
----------
K
K
---
D
S
A
E
F
K
K
L
Q
E
D
A
T
W
K
K
L
N
A
V
K
N
N
R
V
D
I
-
V
D
R
D
V
W
---
A
-
R
-
S
-
R
G
L
-
I
-
S
S
E
---
E
M
A
K
E
L
----
3
PsiBlast_PDB
60.85
22%
-78
- C1 -
1N4A
1
BTUF_ECOLI
A:
[2-211]
----------------------------------
P
R
----
V
I
T
L
S
P
A
N
T
E
L
A
F
A
A
G
I
--
T
P
V
G
V
-
S
S
Y
S
------
D
------
Y
---
P
---
P
Q
A
--
Q
K
I
E
Q
V
---
S
T
W
Q
G
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
W
R
G
G
-
N
-
A
-------------
E
R
Q
V
D
------------
Q
L
A
-
S
L
G
I
K
V
M
W
V
D
A
---
T
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
P
Q
P
D
K
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
----
K
--
P
-
K
-
K
R
V
F
L
Q
F
G
I
-
N
P
-
P
F
T
S
G
K
E
S
I
Q
-
N
Q
V
L
E
V
C
G
G
E
N
I
F
K
D
S
---------
R
V
P
-
W
P
Q
V
S
R
E
Q
V
L
A
R
S
P
Q
-
A
I
V
--
I
T
G
G
P
D
-
Q
I
---
P
K
I
K
Q
Y
W
G
E
Q
L
K
-----------------------------------------------------------
35
HHSearch
60.80
20%
-57
- C1 -
3GFV
1
YCLQ_BACSU
A:
[27-298]
--------------------------
G
T
K
V
P
K
N
P
K
K
----
V
V
V
F
D
F
G
S
L
D
T
L
D
K
L
G
L
DD
I
V
A
G
L
P
K
Q
V
L
P-----
K
------
Y
---
L
---
S
K
F
KD
D
K
Y
A
D
V
---
G
S
L
K
E
P
D
F
D
K
V
A
E
L
D
P
D
L
I
I
I
S
A
R
Q
---
S
-------------
E
S
Y
-
K
------------
E
F
S
-
K
I
A
-
P
T
I
Y
L
G
V
DTA
K
Y
--------------------
M
E
S
F
K
S
D
A
E
T
I
G
K
I
F
D
K
E
D
K
V
K
D
E
L
A
N
I
D
H
S
I
A
D
V
K
K
T
A
E
K
----
L
--
N
K
N
-
G
L
V
--
I
M
A
N
-
D
G
-
K
I
S
A
F
G
P
K
S
R
Y
G
L
I
H
D
V
F
G
V
A
P
A
D
Q
N
I
KA-------
S
T
H
-
G
Q
S
V
S
Y
E
Y
I
S
K
T
N
P
D
-
Y
L
F
V
I
D
R
G
T
A
I
-
G
E
----
T
S
---
S
T
K
Q
V
V
E
---
N
D
Y
V
K
N
V
N
A
V
K
N
G
H
V
I
Y
-
L
D
S
A
T
W
---
Y
L
S
-
G
-
G
G
L
-
E
S
M
T
Q
M
I
K
E
V
K
D
G
L
E
K
E
-
34
HHSearch
60.69
20%
-55
- C1 -
3MWF
1
?
A:
[14-294]
--------------------------
T
T
E
I
K
G
K
P
K
R
----
V
V
T
L
Y
Q
G
A
T
D
V
A
V
S
L
G
V
--
K
P
V
G
A
V
E
S
W
T
QKPKFE
Y
------
I
---
K
---
N
D
L
--
K
D
T
K
I
V
---
G
Q
E
P
A
P
N
L
E
E
I
S
K
L
K
P
D
L
I
V
A
S
K
V
R
-
N
-
E
-------------
K
V
Y
-
D
------------
Q
L
S
-
K
I
A
-
P
T
V
S
T
D
-----
T
--------------------
V
F
K
F
K
D
T
T
K
L
M
G
K
A
L
G
K
E
K
E
A
E
D
L
L
K
K
Y
D
D
K
V
A
A
F
Q
K
D
A
K
A
K
YKD
A
--
W
-
P
-
L
K
A
S
V
V
N
F
R
-
A
D
-
H
T
R
I
Y
A
G
-
G
Y
A
G
E
I
L
N
D
L
G
F
K
R
N
K
D
L
Q
K
Q
V
D
N
G---
K
D
I
-
I
Q
L
T
S
K
E
S
I
P
L
M
N
A
D
-
H
I
F
V
V
K
S
D
P
N
A
-
K
D
A
A
L
V
K
K
---
T
E
S
E
W
T
S
---
S
K
E
W
K
N
L
D
A
V
K
N
N
Q
V
S
D
D
L
D
E
I
T
W
---
N
-
L
-
A
-
G
G
Y
K
S
-
S
L
K
L
I
D
D
L
Y
E
K
L
N
I
E
-
10
PsiBlast_PDB
60.25
27%
-43
- C1 -
3EIX
1
?
A:
[11-287]
-------------------------
K
D
E
N
G
T
V
K
V
P
K
DAK
R
I
V
V
L
E
Y
S
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
D
G
K
------
K
KRII
K
P
V
---
R
---
E
K
I
--
G
D
Y
T
S
V
---
G
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
D
S
S
R
-
H
-
K
GI
N
K
E
L
N
K
I
A
P
T
L
S
L
K
-
S
-------------
F
D
-
G
-
D
Y
K
Q
N
I
N
S
F
---
K
T
--------------------
I
A
K
A
L
N
K
E
K
E
-
G
E
K
--
R
L
A
E
H
D
K
L
---
I
N
K
Y
K
D
E
I
K
F
D
R
N
Q
----
K
--
V
-
L
-
P
A
V
V
A
K
A
G
L
------
L
A
H
P
N
Y
S
Y
V
G
Q
F
L
N
E
L
G
F
K
N
A
L
S
D
D
V
T
K
G
L
SKYL
K
G
P
-
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
M
T
D
H
A
----------
K
K
---
D
S
A
E
F
K
K
L
Q
E
D
A
T
W
K
K
L
N
A
V
K
N
N
R
V
D
I
-
V
D
R
D
V
W
---
A
-
R
-
S
-
R
G
L
I
S
-
S
E
E
M
A
K
E
L
--------