@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2693: (2016-04-06 )
MKAIFITLEGPDGSGKTTVGTLLNQKMTEAGIDFIKTREPGGSPISEKVRNIVLGIGNEEMDPKTEVLLIAGARRQHVVETIRPALAAGKSVLCDRFMDSSLAYQGAGRDMNMEQVLQVNLYAIEDTLPDRTYYLDVPAEVGLARIAANKGREVNRLDKEDITYHEKVQAGYEKVINMFPERFMRVDATKTPEEITETILADILRQLA
Atome Classification :
(60 SA)
.........10.......----.20........-30---..-.-..-.-...40........50....---.---.-.-.60........70........80........90........100.......-110.......120.......130.......140.......150-.......160.......170.......180.......190....---...---200......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
A
I
F
I
T
L
EGPDGSG
K
T
T
----
V
G
T
L
L
N
Q
K
M
T
E
-A----GI-
D
-
F
I
-K-TREPGGS
P
I
S
E
K
V
R
N
I
V
LG---I---G-N-EEMDPKT
E
V
L
L
I
AGA
R
R
Q
H
V
V
E
T
I
R
P
A
L
AA
G
K
S
V
L
C
D
R
FM
D
S
SLAYQGAGR-DM
N
M
E
Q
V
L
Q
V
N
L
Y
A
IEDTLPD
R
T
Y
Y
L
DVPAEV
G
L
A
R
I
AANKGR-EVNRLDKED
I
T
Y
H
E
K
V
Q
A
G
Y
E
K
V
I
N
M
F
P
E
R
F
M
RVDATK
T
P
E
E
I
T
---
E
T
I
---
L
A
D
I
L
R
QLA---
17
PsiBlast_PDB
98.33
48%
-75
- C3 -
2CCG
1
KTHY_STAAM
A:
[24-222]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
R
-
D
Q
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
5
PsiBlast_PDB
97.97
48%
-82
- C3 -
4HEJ
1
KTHY_STAAN
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
------
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
21
PsiBlast_CBE
97.73
48%
-80
- C3 -
4XWA
2
KTHY_STAA1
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
--------
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
32
PsiBlast_CBE
97.48
48%
-70
- C3 -
4DWJ
1
KTHY_STAAM
F:
[28-226]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
R
-
D
Q
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
--
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
14
PsiBlast_PDB
96.81
48%
-71
- C3 -
4DWJ
1
KTHY_STAAM
A:
[28-226]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
R
-
D
Q
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
---
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
22
PsiBlast_CBE
96.70
48%
-77
- C3 -
4QGH
2
KTHY_STAAR
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
--------
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
26
PsiBlast_CBE
96.52
48%
-80
- C3 -
4HLD
1
KTHY_STAAR
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
-------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
27
PsiBlast_CBE
96.45
48%
-79
- C3 -
4HLC
1
KTHY_STAAR
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
-------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
25
PsiBlast_CBE
96.30
48%
-77
- C3 -
4QG7
1
KTHY_STAAR
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
-------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
13
PsiBlast_PDB
95.98
48%
-78
- C3 -
4XWA
1
KTHY_STAA1
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
R
-----
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
7
PsiBlast_PDB
95.88
48%
-74
- C3 -
4HLD
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
---------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
29
PsiBlast_CBE
95.77
48%
-79
- C3 -
4EAQ
1
KTHY_STAAM
B:
[28-226]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
--------
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
18
PsiBlast_PDB
95.74
47%
-74
- C3 -
4MQB
2
KTHY_STAAM
A:
[7-205]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
R
-
D
Q
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
--
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
1
PsiBlast_PDB
95.74
48%
-76
- C3 -
2CCJ
5
KTHY_STAAM
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
----
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
----
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
36
PsiBlast_CBE
95.69
48%
-71
- C3 -
2CCG
1
KTHY_STAAM
B:
[24-222]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
------
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
33
PsiBlast_CBE
95.62
48%
-71
- C3 -
4DWJ
1
KTHY_STAAM
D:
[28-226]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
R
-
D
Q
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
---
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
16
PsiBlast_PDB
95.57
48%
-72
- C3 -
4F4I
-
KTHY_STAAM
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
-----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
--
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
23
PsiBlast_CBE
95.42
48%
-79
- C3 -
4QGG
1
KTHY_STAAR
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
-----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
28
PsiBlast_CBE
95.40
48%
-77
- C3 -
4HDC
1
KTHY_STAAN
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
-------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
6
PsiBlast_PDB
95.36
48%
-75
- C3 -
4HLC
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
---------
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
24
PsiBlast_CBE
95.35
48%
-78
- C3 -
4QGA
1
KTHY_STAAR
B:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-
S
-------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
4
PsiBlast_PDB
94.82
48%
-75
- C3 -
4HDC
1
KTHY_STAAN
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
-----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
8
PsiBlast_PDB
94.66
48%
-73
- C3 -
4QG7
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
---------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
9
PsiBlast_PDB
94.58
48%
-73
- C3 -
4QGA
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
---------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
11
PsiBlast_PDB
94.35
48%
-72
- C3 -
4QGG
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
-------------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
3
PsiBlast_PDB
94.29
48%
-75
- C3 -
4GSY
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
-----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
---
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
12
PsiBlast_PDB
94.28
48%
-71
- C3 -
4QGH
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
---------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
--
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
10
PsiBlast_PDB
94.07
48%
-76
- C3 -
4QGF
1
KTHY_STAAR
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-
N
-
D
-
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
2
PsiBlast_PDB
92.94
48%
-74
- C3 -
4GFD
1
KTHY_STAAM
A:
[4-202]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------
G
-----
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
-----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
---
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
15
PsiBlast_PDB
92.03
48%
-73
- C3 -
4EAQ
1
KTHY_STAAM
A:
[28-226]
----
F
I
T
F
E
G
P
E
G
S
G
K
T
T
----
V
I
N
E
V
Y
H
R
L
V
K
------
D
Y
-
D
-
V
I
-
M
-
T
R
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
-------------
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
-
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
G
L
Y
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-------
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
---
E
D
T
---
Y
Q
T
I
I
K
Y
L
----
51
PsiBlast_CBE
90.53
40%
-58
- C3 -
3HJN
3
KTHY_THEMA
A:
[1-192]
---
M
F
I
T
F
E
G
I
D
G
S
G
K
S
T
----
Q
I
Q
L
L
A
Q
Y
L
E
K
-
R
----
G
K
-
K
-
V
I
-
L
-
K
R
E
P
G
G
T
E
T
G
E
K
I
R
K
I
L
L
----------
E
-
E
E
V
T
P
K
A
E
L
F
L
F
L
A
S
R
N
L
L
V
T
E
-
I
K
Q
Y
L
S
E
G
Y
A
V
L
L
D
R
Y
T
D
S
S
V
A
Y
Q
G
F
G
R
-
N
L
G
K
E
I
V
E
E
L
N
D
F
A
T
D
G
L
I
P
D
L
T
F
Y
I
D
V
D
V
E
T
A
L
K
R
----
K
-----
N
R
F
E
K
R
E
--
F
L
E
R
V
R
E
G
Y
L
V
L
A
R
E
H
P
E
R
I
V
V
L
D
G
K
R
S
I
E
E
I
H
---
R
D
V
---
V
R
E
V
K
R
R
-----
52
PsiBlast_CBE
89.91
38%
-55
- C3 -
3N2I
2
KTHY_VIBCH
B:
[26-233]
-
N
A
K
F
I
V
I
E
G
L
E
G
A
G
K
S
T
----
A
I
Q
V
V
V
E
T
L
Q
Q
-
N
----
G
I
-
D
-
H
I
T
R
-
T
R
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
---
E
---
H
P
G
-
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
-
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
G
D
F
K
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
A
---
R
G
R
G
E
L
D
R
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
D
S
V
V
M
-
I
D
A
A
Q
S
I
E
Q
V
T
---
A
D
I
R
R
A
L
Q
D
W
L
S
Q
V
----
53
PsiBlast_CBE
89.50
38%
-56
- C3 -
3N2I
2
KTHY_VIBCH
A:
[25-232]
M
N
A
K
F
I
V
I
E
G
L
E
G
A
G
K
S
T
----
A
I
Q
V
V
V
E
T
L
Q
Q
-
N
----
G
I
-
D
-
H
I
T
R
-
T
R
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
---
E
---
H
P
G
-
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
-
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
G
D
F
K
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
A
---
R
G
--
E
L
D
R
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
D
S
V
V
M
-
I
D
A
A
Q
S
I
E
Q
V
T
---
A
D
I
R
R
A
L
Q
D
W
L
S
Q
-----
113
HHSearch
88.12
38%
-65
- C3 -
3HJN
3
KTHY_THEMA
A:
[1-192]
---
M
F
I
T
F
E
G
I
D
G
S
G
K
S
T
----
Q
I
Q
L
L
A
Q
Y
L
E
K
-
R
----
G
K
-
K
-
V
I
-
L
-
K
R
E
P
G
G
T
E
T
G
E
K
I
R
K
I
L
L
E
---
E
--------
E
V
T
P
K
A
E
L
F
L
F
L
A
S
R
N
L
-
L
V
T
E
I
K
Q
Y
L
S
E
G
Y
A
V
L
L
D
R
Y
T
D
S
S
V
A
Y
Q
G
F
G
R
-
N
L
G
K
E
I
V
E
E
L
N
D
F
A
T
D
G
L
I
P
D
L
T
F
Y
I
D
V
D
V
E
T
A
L
K
R
K
---
N
R
F
------
E
--
K
R
E
F
L
E
R
V
R
E
G
Y
L
V
L
A
R
E
H
P
E
R
I
V
V
L
D
G
K
R
S
I
E
E
I
H
---
R
D
V
---
V
R
E
V
K
R
R
-----
54
PsiBlast_CBE
87.50
38%
-59
- C3 -
3LV8
8
KTHY_VIBCH
A:
[26-233]
-
N
A
K
F
I
V
I
E
G
L
E
G
A
G
K
S
T
----
A
I
Q
V
V
V
E
T
L
Q
Q
-
N
----
G
I
-
D
-
H
I
T
R
-
T
R
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
---
E
---
H
P
G
-
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
-
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
G
D
F
K
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
--------
E
L
D
R
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
D
S
V
V
M
-
I
D
A
A
Q
S
I
E
Q
V
T
---
A
D
I
R
R
A
L
Q
D
W
L
S
Q
V
----
42
PsiBlast_CBE
87.27
40%
-64
- C3 -
3UWK
1
KTHY_PSEAE
B:
[23-228]
--
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
-------------
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
G
L
P
L
A
E
V
Q
A
G
L
D
R
L
---
L
P
N
L
L
E
R
L
----
109
HHSearch
87.23
37%
-55
- C3 -
3LV8
8
KTHY_VIBCH
A:
[26-230]
-
N
A
K
F
I
V
I
E
G
L
E
G
A
G
K
S
T
----
A
I
Q
V
V
V
E
T
L
Q
Q
-
N
----
G
I
-
D
-
H
I
-
T
R
T
R
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
---
E
---
H
-
P
G
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
-
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
G
D
F
K
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
-----
E
L
---
D
R
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
-
D
S
V
V
M
I
D
A
A
Q
S
I
E
Q
V
T
---
A
D
I
---
R
R
A
L
Q
D
W
L
----
43
PsiBlast_CBE
86.54
40%
-58
- C3 -
3UWK
2
KTHY_PSEAE
A:
[23-227]
--
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
-----
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
G
L
P
L
A
E
V
Q
A
G
L
D
R
L
---
L
P
N
L
L
E
R
-----
44
PsiBlast_CBE
85.28
40%
-64
- C3 -
3UWO
1
KTHY_PSEAE
B:
[11-213]
--
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
---------------
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
G
L
P
L
A
E
V
Q
A
G
L
D
R
L
---
L
P
N
L
L
-------
61
PsiBlast_CBE
85.10
35%
-56
- C3 -
5TMP
1
KTHY_ECOLI
A:
[2-200]
-
R
S
K
Y
I
V
I
E
G
L
E
G
A
G
K
T
T
----
A
R
N
V
V
V
E
T
L
E
Q
-
L
----
G
I
R
D
-
M
V
-
F
-
T
R
E
P
G
G
T
Q
L
A
E
K
L
R
S
L
L
L
D
---
I
KSV
G
-
D
-
E
V
I
T
D
K
A
E
V
L
M
F
Y
A
A
R
V
Q
L
V
E
T
V
I
K
P
A
L
A
N
G
T
W
V
I
G
D
R
H
D
L
S
T
Q
A
Y
Q
G
G
G
R
-
G
I
D
Q
H
M
L
A
T
L
R
D
A
V
L
G
D
F
R
P
D
L
T
L
Y
L
D
V
T
P
E
V
G
L
K
R
A
R
A
R
G
---
E
L
D
R
I
E
Q
E
S
F
D
F
F
N
R
T
R
A
R
Y
L
E
L
A
A
Q
-
D
K
S
I
H
T
I
D
A
T
Q
P
L
E
A
V
M
---
D
A
I
---------------
62
PsiBlast_CBE
84.93
35%
-54
- C3 -
4TMK
1
KTHY_ECOLI
A:
[2-200]
-
R
S
K
Y
I
V
I
E
G
L
E
G
A
G
K
T
T
----
A
R
N
V
V
V
E
T
L
E
Q
-
L
----
G
I
R
D
-
M
V
-
F
-
T
R
E
P
G
G
T
Q
L
A
E
K
L
R
S
L
L
L
D
---
I
KSV
G
-
D
-
E
V
I
T
D
K
A
E
V
L
M
F
Y
A
A
R
V
Q
L
V
E
T
V
I
K
P
A
L
A
N
G
T
W
V
I
G
D
R
H
D
L
S
T
Q
A
Y
Q
G
G
G
R
-
G
I
D
Q
H
M
L
A
T
L
R
D
A
V
L
G
D
F
R
P
D
L
T
L
Y
L
D
V
T
P
E
V
G
L
K
R
A
R
A
R
G
---
E
L
D
R
I
E
Q
E
S
F
D
F
F
N
R
T
R
A
R
Y
L
E
L
A
A
Q
-
D
K
S
I
H
T
I
D
A
T
Q
P
L
E
A
V
M
---
D
A
I
---------------
94
Fugue
84.80
34%
-63
- C3 -
4TMK
1
KTHY_ECOLI
A:
[2-211]
-
R
S
K
Y
I
V
I
E
G
L
E
G
A
G
K
T
T
----
A
R
N
V
V
V
E
T
L
E
Q
-
L
----
G
I
-
R
D
M
V
-
F
-
T
R
E
P
G
G
T
Q
L
A
E
K
L
R
S
L
L
L
D
IKS
V
---
G
-
D
-
E
V
I
T
D
K
A
E
V
L
M
F
Y
A
A
R
V
Q
L
V
E
T
V
I
K
P
A
L
A
N
G
T
W
V
I
G
D
R
H
D
L
S
T
Q
A
Y
Q
G
G
G
R
G-
I
D
Q
H
M
L
A
T
L
R
D
A
V
L
G
D
F
R
P
D
L
T
L
Y
L
D
V
T
P
E
V
G
L
K
R
A
R
A
R
G
E
L
---
D
R
I
E
Q
E
S
F
D
F
F
N
R
T
R
A
R
Y
L
E
L
A
A
Q
D
-
K
S
I
H
T
I
D
A
T
-
Q
P
L
E
A
V
---
M
D
A
---
I
R
T
T
V
T
H
W
V
K
E
L
45
PsiBlast_CBE
84.79
40%
-60
- C3 -
3UWO
1
KTHY_PSEAE
A:
[11-215]
--
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
------------
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
G
L
P
L
A
E
V
Q
A
G
L
D
R
L
---
L
P
N
L
L
E
R
-----
50
PsiBlast_CBE
84.22
40%
-54
- C3 -
3HJN
2
KTHY_THEMA
B:
[1-188]
---
M
F
I
T
F
E
G
I
D
G
S
G
K
S
T
----
Q
I
Q
L
L
A
Q
Y
L
E
K
-
R
----
G
K
-
K
-
V
I
-
L
-
K
R
E
P
G
G
T
E
T
G
E
K
I
R
K
I
L
L
----------
E
-
E
E
V
T
P
K
A
E
L
F
L
F
L
A
S
R
N
L
L
V
T
E
-
I
K
Q
Y
L
S
E
G
Y
A
V
L
L
D
R
Y
T
D
S
S
V
A
Y
Q
G
F
G
R
-
N
L
G
K
E
I
V
E
E
L
N
D
F
A
T
D
G
L
I
P
D
L
T
F
Y
I
D
V
D
V
E
T
A
L
K
R
----------
N
R
F
E
K
R
E
--
F
L
E
R
V
R
E
G
Y
L
V
L
A
R
E
H
P
E
R
I
V
V
L
D
G
K
R
S
I
E
E
I
H
---
R
D
V
---
V
R
E
---------
19
PsiBlast_PDB
81.46
43%
-45
- C3 -
4EDH
5
KTHY_PSEAE
A:
[5-189]
-
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
A
A
A
-
R
G
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
20
PsiBlast_PDB
81.22
43%
-54
- C3 -
4ESH
1
KTHY_PSEAE
A:
[4-189]
M
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-----
G
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
48
PsiBlast_CBE
80.96
43%
-52
- C3 -
3UXM
1
KTHY_PSEAE
B:
[3-185]
---
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
----
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
46
PsiBlast_CBE
80.56
43%
-54
- C3 -
3UXM
1
KTHY_PSEAE
D:
[3-185]
---
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
41
PsiBlast_CBE
79.88
43%
-49
- C3 -
4EDH
4
KTHY_PSEAE
B:
[4-189]
M
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
A
-----
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
104
HHSearch
78.71
34%
-56
- C3 -
3V9P
5
KTHY_BURTA
A:
[23-226]
A
R
G
K
F
I
T
F
E
G
I
D
---
K
T
T
----
H
L
Q
W
F
C
D
R
L
Q
E
-
R
L
G
P
A
G
R
-
H
-
V
V
-
V
-
T
R
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
N
---
Q
--------
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
-
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
G
G
F
Q
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
R
G
A
V
R
M
---
P
---
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
---
K
Q
L
---
E
G
V
L
A
A
------
49
PsiBlast_CBE
78.14
43%
-59
- C3 -
3UXM
3
KTHY_PSEAE
A:
[3-185]
---
L
F
V
T
L
E
G
P
E
G
----
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
------
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
40
PsiBlast_CBE
78.07
43%
-48
- C3 -
4GMD
3
KTHY_PSEAE
A:
[5-189]
-
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
-----
A
-
R
G
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
39
PsiBlast_CBE
77.94
43%
-50
- C3 -
4GMD
4
KTHY_PSEAE
B:
[5-189]
-
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
---------------
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
55
PsiBlast_CBE
77.65
35%
-54
- C3 -
3V9P
4
KTHY_BURTA
B:
[27-220]
----
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
W
F
C
D
R
L
Q
E
R
L
G
P
-
A
----
G
R
-
H
-
V
V
-
V
-
T
R
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
----------
N
-
Q
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
-
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
G
G
F
Q
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
R
G
A
V
--
R
-
M
P
D
K
F
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
---
K
Q
L
---------------
47
PsiBlast_CBE
77.47
43%
-56
- C3 -
3UXM
3
KTHY_PSEAE
C:
[3-185]
---
L
F
V
T
L
E
G
P
E
G
A
---
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
------
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
56
PsiBlast_CBE
77.33
35%
-51
- C3 -
3V9P
5
KTHY_BURTA
A:
[27-220]
----
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
W
F
C
D
R
L
Q
E
R
L
G
P
-
A
----
G
R
-
H
-
V
V
-
V
-
T
R
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
----------
N
-
Q
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
-
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
G
G
F
Q
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
R
G
A
V
--
R
-
M
P
---
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
---
K
Q
L
---------------
38
PsiBlast_CBE
77.23
43%
-53
- C3 -
4GMD
3
KTHY_PSEAE
C:
[5-189]
-
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
------------
R
--
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
37
PsiBlast_CBE
76.96
43%
-51
- C3 -
4GMD
4
KTHY_PSEAE
D:
[5-189]
-
T
G
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
----
N
R
D
Y
L
A
E
R
L
R
E
-
R
----
G
I
-
E
-
V
Q
-
L
-
T
R
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
---
P
---
S
-
D
-
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
-
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G
D
L
R
P
D
L
T
L
V
F
D
L
P
V
---------------
L
D
R
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------------
59
PsiBlast_CBE
71.43
37%
-57
- C3 -
3LD9
2
KTHY_EHRCR
B:
[21-202]
--
S
M
F
I
T
F
E
G
I
D
G
S
G
K
T
T
----
Q
S
H
L
L
A
E
Y
L
S
E
I
Y
----
G
V
-
N
N
V
V
-
L
-
T
R
E
P
G
G
T
L
L
N
E
S
V
R
N
L
L
F
K
---------
A
-
Q
G
L
D
S
L
S
E
L
L
F
F
I
A
M
R
R
E
H
F
V
K
I
I
K
P
S
L
M
Q
K
K
I
V
I
C
D
R
F
I
D
S
T
I
A
Y
Q
G
Y
G
Q
-
G
I
D
C
S
L
I
D
Q
L
N
D
L
V
I
-
D
V
Y
P
D
I
T
F
I
I
D
V
------------------------
D
M
E
F
Y
Y
R
V
R
D
G
F
Y
D
I
A
K
K
N
P
H
R
-----------------------------------
57
PsiBlast_CBE
71.22
37%
-58
- C3 -
3LD9
2
KTHY_EHRCR
D:
[21-197]
--
S
M
F
I
T
F
E
G
I
D
G
S
G
K
T
T
----
Q
S
H
L
L
A
E
Y
L
S
E
I
Y
----
G
V
-
N
N
V
V
-
L
-
T
R
E
P
G
G
T
L
L
N
E
S
V
R
N
L
L
F
K
---------
A
-
Q
G
L
D
S
L
S
E
L
L
F
F
I
A
M
R
R
E
H
F
V
K
I
I
K
P
S
L
M
Q
K
K
I
V
I
C
D
R
F
I
D
S
T
I
A
Y
Q
G
Y
G
Q
-
G
I
D
C
S
L
I
D
Q
L
N
D
L
V
I
-
D
V
Y
P
D
I
T
F
I
I
D
V
D
-----------------------
D
M
E
F
Y
Y
R
V
R
D
G
F
Y
D
I
A
K
K
N
P
H
R
-----------------------------------