@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00770: (2016-06-02 )
MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKYDSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVPISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYNDLLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPVLLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAMLNKGGVHHG
Atome Classification :
(72 SA)
.........10........20........30........40..-...-...50........-----60..-----......70........80........90.......-----.100-----.-----......110.......120.---......130.......140.-......150-------.----.---------.------..--------.--------..----------------------------160.-----.-------------.--------------....170.-----.-.--------------....180.......190..---...-.-.200...-....210-----.---------------...----------------...220...-....230-----.------.------.-..------..240.......250.-......260.......270.......280...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAQHTIDQ
T
Q
V
I
HTKPSALSYK
E
K
T
L
V
M
G
I
L
NVTPDSFSDGGK-Y
D
S
-
L
D
K
A
L
L
H
A
K
E
M
ID-----DG
A
H
-----
I
I
D
IGGESTRP
G
A
E
CV
S
E
D
E
E
M
S
R
V
I
P
V
I
E
R
I
T
K
E
-----LGV
P
-----
I
-----
S
V
D
T
Y
K
A
S
V
A
D
E
A
V
K
A
G
A
S
I
---
I
N
D
I
WGAKHDP
K
M
A
S
VAAEH-NV
P
I
V
L
MH--------N----R---------P------ER--------
N
--------
Y
N
----------------------------
D
L
L
P
-----
D
-------------
M
--------------
L
S
D
L
M
E
S
V
-----
K
-
I
--------------
A
V
EAGVDEK
N
I
I
LDPGIG
F
---
A
K
T
-Y-HD
N
L
A
V
M
-
N
K
L
E
I
FS-----G---------------LGY----------------
P
V
L
L
AT
S
R
K
-
R
F
I
G
R
V
L-----D------L------
P
-
P
E
------ERAEGTG
A
T
V
C
L
GIQK-GC
D
I
V
R
V
H
D
V
K
Q
I
A
R
M
A
K
M
M
D
A
M
L
NKGGVHHG
11
PsiBlast_PDB
95.63
67%
-117
- C3 -
3H2A
4
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
42
PsiBlast_CBE
94.47
67%
-117
- C3 -
3TYD
7
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
7
PsiBlast_PDB
94.39
67%
-117
- C3 -
3H22
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
53
PsiBlast_CBE
94.35
67%
-115
- C3 -
1TX2
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
29
PsiBlast_CBE
94.30
67%
-113
- C3 -
4DB7
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
45
PsiBlast_CBE
94.11
67%
-114
- C3 -
3TYA
7
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
26
PsiBlast_CBE
93.95
67%
-112
- C3 -
4NHV
9
?
B:
[34-295]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
-----
21
PsiBlast_CBE
93.87
67%
-114
- C3 -
4NL1
5
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
--
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
20
PsiBlast_PDB
93.85
67%
-111
- C3 -
3TYD
8
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
44
PsiBlast_CBE
93.68
67%
-113
- C3 -
3TYB
7
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
9
PsiBlast_PDB
93.67
67%
-107
- C3 -
3H24
6
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
16
PsiBlast_PDB
93.59
67%
-113
- C3 -
3H2N
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
33
PsiBlast_CBE
93.54
67%
-122
- C3 -
4DAF
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
6
PsiBlast_PDB
93.47
67%
-111
- C3 -
3H21
4
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
58
PsiBlast_CBE
93.39
67%
-112
- C3 -
3V5O
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
N
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
28
PsiBlast_CBE
93.35
67%
-116
- C3 -
4DB7
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
18
PsiBlast_PDB
93.26
67%
-111
- C3 -
3TYA
5
?
A:
[34-295]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
-----
2
PsiBlast_PDB
93.26
67%
-110
- C3 -
1TWW
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
54
PsiBlast_CBE
93.24
67%
-114
- C3 -
1TX0
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
48
PsiBlast_CBE
93.21
67%
-117
- C3 -
3H2E
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
----
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
40
PsiBlast_CBE
93.17
67%
-114
- C3 -
3TYE
7
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
-------
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
46
PsiBlast_CBE
93.11
67%
-113
- C3 -
3H2N
5
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
50
PsiBlast_CBE
92.97
67%
-113
- C3 -
3H2A
5
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
31
PsiBlast_CBE
92.91
67%
-112
- C3 -
4DAI
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
55
PsiBlast_CBE
92.83
67%
-112
- C3 -
1TWZ
5
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
19
PsiBlast_PDB
92.82
67%
-112
- C3 -
3TYB
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
10
PsiBlast_PDB
92.78
67%
-110
- C3 -
3H26
4
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
4
PsiBlast_PDB
92.78
67%
-112
- C3 -
1TX0
6
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
14
PsiBlast_PDB
92.72
67%
-107
- C3 -
3H2F
4
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
36
PsiBlast_CBE
92.65
67%
-113
- C3 -
4D8Z
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
41
PsiBlast_CBE
92.59
67%
-111
- C3 -
3TYE
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
------
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
52
PsiBlast_CBE
92.57
67%
-113
- C3 -
3H21
4
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-------
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
30
PsiBlast_CBE
92.45
67%
-116
- C3 -
4DAI
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
32
PsiBlast_CBE
92.23
67%
-119
- C3 -
4DAF
5
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
37
PsiBlast_CBE
92.21
67%
-110
- C3 -
4D8Z
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
5
PsiBlast_PDB
92.20
67%
-105
- C3 -
1TX2
6
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
35
PsiBlast_CBE
92.10
67%
-113
- C3 -
4D9P
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
43
PsiBlast_CBE
92.06
67%
-109
- C3 -
3TYC
7
?
B:
[34-295]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
-----
34
PsiBlast_CBE
92.00
67%
-114
- C3 -
4D9P
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
39
PsiBlast_CBE
91.91
67%
-114
- C3 -
4D8A
5
?
A:
[34-293]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
-------
49
PsiBlast_CBE
91.87
67%
-115
- C3 -
3H2C
7
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-------
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
15
PsiBlast_PDB
91.75
67%
-108
- C3 -
3H2M
5
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
47
PsiBlast_CBE
91.58
67%
-115
- C3 -
3H2M
7
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
38
PsiBlast_CBE
91.28
67%
-117
- C3 -
4D8A
6
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
----------
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
12
PsiBlast_PDB
90.99
67%
-112
- C3 -
3H2C
6
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
---------
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
-
E
S
T
R
------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
17
PsiBlast_PDB
90.83
67%
-111
- C3 -
3H2O
3
?
A:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
8
PsiBlast_PDB
90.63
67%
-102
- C3 -
3H23
5
?
A:
[34-295]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
-----
51
PsiBlast_CBE
90.47
67%
-112
- C3 -
3H24
8
?
B:
[34-294]
------------------
L
N
L
N
E
K
T
L
I
M
G
I
L
N
V
------
D
G
G
S
-
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
-----
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
L
P
-----
I
-----
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
---
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--------
N
----
R
---------
D
------
N
M
--------
N
--------
Y
R
----------------------------
N
L
M
A
-----
D
-------------
M
--------------
I
A
D
L
Y
D
S
I
-----
K
-
I
--------------
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
---
A
K
T
-
P
-
E
Q
N
L
E
A
M
-
R
N
L
E
Q
L
N
-----
V
---------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
-
S
F
I
G
H
V
L
-----
D
------
L
------
P
-
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
-
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
95
HHSearch
82.48
42%
-99
- C3 -
1AJ0
3
DHPS_ECOLI
A:
[6-277]
--------------
Q
G
T
S
L
D
L
-
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
-
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
-----
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
-----
I
-----
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
---
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
--------
M
----
Q
---------
G
------
N
P
--------
K
TM
Q
E
A
P
K
-
Y
D
----------------------------
D
V
F
A
-----
E
-------------
V
--------------
N
R
Y
F
I
E
Q
I
-----
A
-
R
--------------
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
-
A
R
L
A
E
F
H
-----
H
---------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
I
G
Q
L
L
-----
N
------
V
------
G
-
P
S
------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
-
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
----
70
PsiBlast_CBE
81.96
43%
-104
- C3 -
1AJ2
2
DHPS_ECOLI
A:
[17-274]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
-
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
-----
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
-----
I
-----
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
---
I
N
D
I
R
S
L
S
-
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
Q
------
G
----
N
---------
P
------
K
T
MQ
E
A
P
---
K
--------
Y
D
----------------------------
D
V
F
A
-----
E
-------------
V
--------------
N
R
Y
F
I
E
Q
I
-----
A
-
R
--------------
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
-
A
R
L
A
E
F
H
-----
H
---------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
I
G
Q
L
L
-----
N
------
V
------
G
-
P
S
------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
-
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
-------
66
PsiBlast_CBE
81.46
41%
-100
- C3 -
3TYZ
4
?
B:
[20-279]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
-----
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
-----
L
-----
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
---
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
MQ------
G
----
Q
---------
P
------
K
N
MQHSP---
Y
--------
Y
D
----------------------------
D
L
M
T
-----
D
-------------
I
--------------
N
R
F
F
Q
H
H
I
-----
E
-
R
--------------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
-
A
H
L
S
E
L
H
-----
H
---------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
V
G
Q
L
L
-----
N
------
V
------
P
-
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
-
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
K
-----
71
PsiBlast_CBE
81.23
43%
-100
- C3 -
1AJ0
3
DHPS_ECOLI
A:
[17-274]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
-
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
-----
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
V
W
-----
I
-----
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
---
I
N
D
I
R
S
L
S
-
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
Q
------
G
----
N
---------
P
------
K
T
M
Q
E
A
P
---
K
--------
Y
D
----------------------------
D
V
F
A
-----
E
-------------
V
--------------
N
R
Y
F
I
E
Q
I
-----
A
-
R
--------------
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
S
H
N
Y
S
L
L
-
A
R
L
A
E
F
H
-----
H
---------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
I
G
Q
L
L
-----
N
------
V
------
G
-
P
S
------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
-
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
-------
67
PsiBlast_CBE
81.21
41%
-98
- C3 -
3TYZ
4
?
A:
[20-278]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
-----
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
-----
L
-----
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
---
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q
------
G
----
Q
---------
P
------
K
N
MQH
S
P
---
Y
--------
Y
D
----------------------------
D
L
M
T
-----
D
-------------
I
--------------
N
R
F
F
Q
H
H
I
-----
E
-
R
--------------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
-
A
H
L
S
E
L
H
-----
H
---------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
V
G
Q
L
L
-----
N
------
V
------
P
-
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
-
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------
91
HHSearch
80.68
43%
-108
- C3 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
-----------------------
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
-
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
-----
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
------
Q
G
I
T
-----
V
-----
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
---
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
--------
W
----
R
---------
A
------
V
S
ADTPHVPV
R
--------
Y
G
----------------------------
N
V
V
A
-----
E
-------------
V
--------------
R
A
D
L
L
A
S
V
-----
A
-
D
--------------
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
---
A
K
T
-
A
-
Q
H
N
W
A
I
L
-
H
A
L
P
E
L
V
-----
A
---------------
T
G
I
----------------
P
V
L
V
G
A
S
R
K
-
R
F
L
G
A
L
L
-----
A
------
G
PDGVMR
P
-
T
D
------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
-
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
-----
65
PsiBlast_CBE
80.41
41%
-98
- C3 -
3TZF
2
?
A:
[20-278]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
-----
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
-----
L
-----
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
---
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q
------
G
----
Q
---------
P
------
K
N
MQH
S
P
---
Y
--------
Y
D
----------------------------
D
L
M
T
-----
D
-------------
I
--------------
N
R
F
F
Q
H
H
I
-----
E
-
R
--------------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
-
A
H
L
S
E
L
H
-----
H
---------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
V
G
Q
L
L
-----
N
------
V
------
P
-
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
-
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------
64
PsiBlast_CBE
80.00
41%
-100
- C3 -
3TZF
3
?
B:
[20-279]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
-
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
-----
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
-----
L
-----
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
---
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q
------
G
----
Q
---------
P
------
K
N
MQHSP---
Y
--------
Y
D
----------------------------
D
L
M
T
-----
D
-------------
I
--------------
N
R
F
F
Q
H
H
I
-----
E
-
R
--------------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
-
A
H
L
S
E
L
H
-----
H
---------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
V
G
Q
L
L
-----
N
------
V
------
P
-
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
-
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
K
-----
78
PsiBlast_CBE
79.87
40%
-101
- C3 -
2VEG
2
DHPS_STRR6
A:
[9-292]
-----------------------
K
T
V
I
C
G
I
I
N
V
T
P
----------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
A
S
-----
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
V
L
-----
I
-----
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
---
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
--------
N
P
V
M
A
R
---------
P
------
Q
H
--------
P
--------
S
S
----------------------------
L
I
F
P
-----
H
-------------
F
GFAFTEL
A
D
F
E
T
LP
I
E
E
L
M
E
A
F
F
E
R
A
L
A
-
R
--------------
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
---
G
L
T
-
K
-
K
E
N
L
L
L
L
-
R
D
L
D
K
L
H
-----
Q
---------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
-
R
F
V
I
N
I
L
E
E
N
GF
E
------
V
------
N
-
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
-
G
V
E
V
V
R
V
H
D
V
A
S
-
H
R
M
A
---------------
75
PsiBlast_CBE
78.47
42%
-103
- C3 -
1EYE
2
DHPS1_MYCTU
A:
[8-272]
--------------------------
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
-
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
-----
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
Q
------
G
I
T
-----
V
-----
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
---
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
--------
W
----
R
A
VSADTPHV
P
------
V
R
-----------------
Y
G
----------------------------
N
V
V
A
-----
E
-------------
V
--------------
R
A
D
L
L
A
S
V
-----
A
-
D
--------------
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
---
A
K
T
-
A
-
Q
H
N
W
A
I
L
-
H
A
L
P
E
L
V
-----
A
---------------
T
G
I
----------------
P
V
L
V
G
A
S
R
K
-
R
F
L
G
A
L
L
-----
A
GPDGVM
R
------
P
-
T
D
------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
-
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
-------
68
PsiBlast_CBE
78.21
41%
-102
- C3 -
3TYU
1
?
A:
[20-278]
--------------------------
V
M
G
I
L
N
V
T
P
D
S
-------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
-----
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
V
W
-----
L
-----
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
---
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
M
Q------
G
-----------------------MQHSP---
Y
--------
Y
D
----------------------------
D
L
M
T
-----
D
-------------
I
--------------
N
R
F
F
Q
H
H
I
-----
E
-
R
--------------
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
---
G
K
N
-
L
-
A
H
N
Y
Q
L
L
-
A
H
L
S
E
L
H
-----
H
---------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
-
S
M
V
G
Q
L
L
-----
N
------
V
------
P
-
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
-
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------
92
HHSearch
78.05
41%
-106
- C3 -
2Y5S
13
?
A:
[10-290]
----------
P
L
Q
C
G
R
F
E
L
T
F
E
-
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
-----
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
V
P
-----
L
-----
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
---
I
N
D
I
W
G
F
R
Q
P
-
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
--------
M
----
L
---------
G
------
E
P
--------
Q
TM
Q
V
G
E
PD
Y
G
----------------------------
D
V
V
T
-----
D
-------------
V
--------------
R
D
F
L
A
A
R
A
-----
Q
-
A
--------------
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
-
V
V
D
D
N
Y
A
L
L
-
A
A
L
P
D
T
A
P
A
R
PD
G
---------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
-
S
M
L
G
A
V
I
-----
G
------
G
K-----
P
-
P
L
------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
-
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
------
77
PsiBlast_CBE
77.20
42%
-109
- C3 -
2Y5S
13
?
A:
[21-274]
----------------------
E
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
-----
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
-----
L
N
V
P
-----
L
-----
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
---
I
N
D
I
W
G
F
R
Q
-
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
M
L
------
G
----
E
---------
P
QTM
Q
V
G
E
P
--------
D
--------
Y
G
----------------------------
D
V
V
T
-----
D
-------------
V
--------------
R
D
F
L
A
A
R
A
-----
Q
-
A
--------------
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
V
V
-
D
D
N
Y
A
L
L
-
A
A
L
P
D
T
A
P
A
R
PD
G
---------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
-
S
M
L
G
A
V
I
G----
G
------
K
------
P
-
P
L
------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
-
G
A
A
I
V
R
V
H
D
V
----------------------
72
PsiBlast_CBE
76.97
41%
-119
- C3 -
2DZB
1
?
B:
[27-273]
----------------------
D
R
V
R
L
L
G
V
L
N
L
T
P
D
------------
P
E
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
-----
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
------
L
G
V
P
-----
V
-----
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
---
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
M
P---------------------
A
------
H
A
--------
R
--------
Y
R
----------------------------
D
V
V
A
-----
E
-------------
V
--------------
K
A
F
L
E
A
Q
A
-----
R
-
R
--------------
A
L
S
A
G
V
P
Q
--
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
-
R
R
L
D
E
I
V
-----
A
---------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
-
R
T
I
G
E
L
S
-----
G
------
V
------
E
D
P
A
------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
-
G
V
R
L
L
R
V
H
D
V
R
---------------------
98
HHSearch
76.62
37%
-90
- C3 -
3TR9
4
?
A:
[12-291]
--------
S
F
H
L
R
L
R
D
D
K
R
I
V
F
S
E
P
A
V
M
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
---
L
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
-----
E
G
A
D
-----
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
I
K
K
R
-----
F
P
Q
L
-----
I
-----
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
M
---
I
N
D
Q
R
A
L
Q
L
D
-
D
A
L
T
T
V
S
A
L
-
K
T
P
V
C
L
M
H
--------
F
----
P
---------
S
------
E
T
--------
R
KPGSTT--
H
F
----------------------------
Y
F
L
Q
-----
S
-------------
V
--------------
K
K
E
L
Q
E
S
I
-----
Q
-
R
--------------
C
K
K
A
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GNY
G
K
N
-
V
-
S
E
N
F
Y
L
L
-
N
K
L
P
E
F
V
-----
A
---------------
M
G
L
----------------
P
V
L
S
G
W
S
R
K
-
S
M
I
G
D
V
L
-----
N
------
Q
------
P
-
P
E
------
N
R
L
F
G
S
I
A
A
D
V
L
A
V
Y
H
-
G
A
S
I
I
R
T
H
D
V
K
A
T
R
E
A
I
K
I
A
T
Y
T
R
S
-------
76
PsiBlast_CBE
76.38
42%
-109
- C3 -
2Y5S
9
?
B:
[21-274]
----------------------
E
R
P
L
V
M
G
I
L
N
A
T
P
-----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
-----
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
-
R
P
-----
L
N
V
P
-----
L
-----
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
---
I
N
D
I
W
G
F
R
Q
-
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
M
L
------
G
----
E
---------
P
QTM
Q
V
G
E
P
--------
D
--------
Y
G
----------------------------
D
V
V
T
-----
D
-------------
V
--------------
R
D
F
L
A
A
R
A
-----
Q
-
A
--------------
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
---
G
K
A
V
V
-
D
D
N
Y
A
L
L
-
A
A
L
P
D
T
A
P
A
R
PD
G
---------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
-
S
M
L
G
A
V
I
G----
G
------
K
------
P
-
P
L
------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
-
G
A
A
I
V
R
V
H
D
V
----------------------
74
PsiBlast_CBE
75.54
41%
-110
- C3 -
2DZA
1
?
B:
[27-273]
----------------------
D
R
V
R
L
L
G
V
L
N
L
T
P
D
S
--------------
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
-----
I
L
D
L
G
A
E
S
T
R
P
---
P
V
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
------
L
G
V
P
-----
V
-----
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
---
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
M
PVPDPAT
M
----
M
---------
A
------
H
A
--------
R
--------
Y
R
----------------------------
D
V
V
A
-----
E
-------------
V
--------------
K
A
F
L
E
A
Q
A
-----
R
-
R
--------------
A
L
S
A
G
V
P
Q
--
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
-
R
R
L
D
E
I
V
-----
A
---------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
-
R
T
I
G
E
L
S
-----
G
------
V
------
E
D
P
A
------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
-
G
V
R
L
L
R
V
H
D
V
R
---------------------
73
PsiBlast_CBE
74.31
41%
-110
- C3 -
2DZB
1
?
A:
[27-273]
----------------------
D
R
V
R
L
L
G
V
L
N
L
T
P
---------------
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
-----
I
L
D
L
G
A
E
S
----------
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
------
L
G
V
P
-----
V
-----
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
---
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
M
PVPDPAT
M
----
M
---------
A
------
H
A
--------
R
--------
Y
R
----------------------------
D
V
V
A
-----
E
-------------
V
--------------
K
A
F
L
E
A
Q
A
-----
R
-
R
--------------
A
L
S
A
G
V
P
Q
--
V
V
L
D
P
G
F
G
F
---
G
K
L
-
L
-
E
H
N
L
A
L
L
-
R
R
L
D
E
I
V
-----
A
---------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
-
R
T
I
G
E
L
S
-----
G
------
V
------
E
D
P
A
------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
-
G
V
R
L
L
R
V
H
D
V
R
---------------------
94
HHSearch
72.87
40%
-90
- C3 -
2BMB
1
FOL1_YEAST
A:
[220-543]
-------------------
I
T
V
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
-
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
V
-----
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
TELPQ
D
K
V
I
-----
L
-----
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
---
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
--------
T
----
R
---------
G
------
D
I
--------
S
TMNRLAH-
Y
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
I
R
-----
N
-------------
V
--------------
G
Q
E
I
G
E
R
Y
-----
I
-
K
--------------
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
---
A
K
T
-
W
-
K
Q
N
L
Q
I
I
-
R
H
I
P
I
L
K
N
----
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
----------------
P
V
L
L
G
P
S
R
K
-
K
F
I
G
H
I
T
-----
K
------
D
------
V
D
A
K
------
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
-
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
------
81
PsiBlast_CBE
65.52
34%
-89
- C3 -
2BMB
1
FOL1_YEAST
A:
[225-540]
------------------------
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
-
I
E
S
Q
L
N
D
I
I
K
L
C
K
-----
D
A
L
Y
LHE
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
-----
T
E
L
P
QDK
V
I
L
-----
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
---
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
T
R
GDISTM
N
----
R
---------
L
------
A
H
--------
Y
--------
E
N
----------------------------
F
A
L
G
-----
D
SIQ
Q
E
F
V
HNTDIQ
Q
--------------
L
D
D
L
K
D
K
T
-----
V
-
L
I
R
N
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
---
A
K
T
-
W
-
K
Q
N
L
Q
I
I
-
R
H
I
P
I
L
K
-----
N
---------------
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
LRNM
P
V
L
L
G
P
S
R
K
-
K
F
I
G
H
I
T
K----
D
------
V
------
D
-
A
K
------
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
-
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
---------
85
PsiBlast_CBE
54.64
32%
-86
- C3 -
3MCO
1
?
A:
[191-442]
------------------------
T
I
R
M
G
I
V
N
L
S
N
Q
S
F
S
D
G
N
F
-
D
D
N
-
Q
R
K
--
L
N
L
D
E
L
I
Q
-----
S
G
A
E
-----
I
I
D
I
G
A
E
S
T
K
P
D
--
P
I
S
I
E
E
E
F
N
K
L
N
E
F
L
E
Y
F
K
S
Q
-----
L
A
N
L
-----
I
YK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
A
K
H
H
D
I
IW
M
I
N
D
V
E
C
N
N
I
E
Q
K
-
A
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
------------------------------------------------------------------------------------------------------
N
--------------
V
C
D
Y
I
E
Q
K
-----
K
Q
I
--------------
L
L
K
H
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
-----
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
-----
R
---------------
L
E
L
----------------
K
A
L
V
G
H
S
R
K
P
S
V
L
G
L
T
K
-----
D
SN----
L
------
A
-
T
L
------
D
R
A
---
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
----------------------
86
PsiBlast_CBE
53.38
32%
-76
- C3 -
3MCN
1
?
B:
[191-442]
------------------------
T
I
R
M
G
I
V
N
L
S
N
Q
S
F
S
D
G
N
F
-
D
D
N
-
Q
R
K
--
L
N
L
D
E
L
I
Q
-----
S
G
A
E
-----
I
I
D
I
G
A
E
S
T
K
P
D
A
-
P
I
S
I
E
E
E
F
N
K
L
N
E
F
L
E
Y
F
K
S
Q
-----
L
A
N
L
-----
I
YK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
A
K
H
H
D
I
IW
M
I
N
D
V
E
C
N
N
I
E
Q
K
-
A
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
--------
N
--------------------------------------------------------------------------I----
D
-------------
N
--------------
V
C
D
Y
I
E
Q
K
-----
K
Q
I
--------------
L
L
K
H
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
K
--
S
-
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
-----
R
---------------
L
E
L
----------------
K
A
L
V
G
H
S
R
K
P
S
V
L
G
L
-------
D
SN----
L
------
A
-
T
L
------
D
R
A
---
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
----------------------
84
PsiBlast_CBE
52.69
32%
-71
- C3 -
3MCO
1
?
B:
[191-442]
------------------------
T
I
R
M
G
I
V
N
L
S
N
Q
S
F
S
D
G
N
F
-
D
D
N
-
Q
R
K
--
L
N
L
D
E
L
I
Q
-----
S
G
A
E
-----
I
I
D
I
G
A
E
S
T
K
P
D
A
K
P
I
S
I
E
E
E
F
N
K
L
N
E
F
L
E
Y
F
K
S
Q
-----
L
A
N
L
-----
I
YK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
A
K
H
H
D
I
IW
M
I
N
D
V
E
C
N
N
I
E
Q
K
-
A
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
--------
N
--------------------------------------------------------------------------N
A
I
--
D
-------------
N
--------------
V
C
D
Y
I
E
Q
K
-----
K
Q
I
--------------
L
L
K
H
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
K
K
-
S
-
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
-----
R
---------------
L
E
L
----------------
K
A
L
V
G
H
S
R
K
P
S
V
L
G
L
T
K
------------
L
------
A
-
T
L
------
D
R
A
---
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
----------------------
88
PsiBlast_CBE
50.95
32%
-78
- C3 -
4PZV
4
?
A:
[170-421]
------------------------
T
I
R
M
G
I
V
N
L
S
----
S
D
G
N
F
-
D
D
N
-
Q
R
K
--
L
N
L
D
E
L
I
Q
-----
S
G
A
E
-----
I
I
D
I
G
A
E
S
T
K
----
P
I
S
I
E
E
E
F
N
K
L
D
E
F
L
E
Y
F
K
S
Q
-----
L
A
N
L
-----
I
YK
P
L
V
S
I
D
T
R
K
L
E
V
M
Q
K
I
L
A
K
H
H
D
I
IW
M
I
N
D
V
E
C
N
N
I
E
Q
K
-
A
Q
L
I
A
K
Y
-
N
K
K
Y
V
I
I
H
--------
N
----
L
---------
G
------
I
T
--------
D
--------
R
N
----------------------------
Q
Y
L
D
KEN
A
I
D
-------------
N
--------------
V
C
D
Y
I
E
Q
K
-----
K
Q
I
--------------
L
L
K
H
G
I
A
Q
Q
N
I
Y
F
D
I
G
F
G
F
---
G
K
K
-
S
-
D
T
A
R
Y
L
L
E
N
I
I
E
I
K
R
-----
R
---------------
L
E
L
----------------
K
A
L
V
G
H
S
R
K
P
S
V
L
G
L
A
K
-----
D
SN----
L
------
A
-
T
L
------
D
R
A
---
T
R
E
L
S
R
K
L
E
K
L
D
I
D
I
I
R
V
H
K
I
----------------------