@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0091: (2016-04-19 )
MAVTVGVICAIPQELAYLRGVLVDAKRQQVAQILFDSGQLDAHRVVLAAAGMGKVNTGLTATLLADRFGCRTIVFTGVAGGLDPELCIGDIVIADRVVQHDFGLLTDERLRPYQPGHIPFIEPTERLGYPVDPAVIDRVKHRLDGFTLAPLSTAAGGGGRQPRIYYGTILTGDQYLHCERTRNRLHHELGGMAVEMEGGAVAQICASFDIPWLVIRALSDLAGADSGVDFNRFVGEVAASSARVLLRLLPVLTAC
Atome Classification :
(29 SA)
.........10........20.-.......30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160....--...170.....-..180...--...-.-190-.......200.......210.......220.......230.......240.......250...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
V
T
V
G
V
I
CA
I
P
Q
E
L
A
Y
L
R
G
V
L-V
D
A
K
R
Q
Q
V
A
Q
I
L
FDSGQLDA
H
R
V
V
L
A
AAGMGKVNTGL
T
A
T
L
L
A
DRFG
C
R
T
I
V
F
TGVAGGL
D
P
E
L
CI
G
D
I
V
I
A
D
R
V
V
Q
H
D
FGLL
T
D
ERLRPYQPGHIPFIE
P
T
E
RLGYPV
D
P
A
V
I
D
R
V
K
H
R
LDG
F
T
LAPLSTAAGGGGRQ
P
R
I
Y
Y
--
G
T
ILTGD
Q
Y
L
H
-
C
E
R
T
R
N
R
L
--
H
H
E
-L-G
G
M
-
A
V
E
MEG
G
A
V
A
Q
I
C
A
SFD
I
P
W
L
V
I
R
A
L
S
D
L
AGADSGV
D
F
N
R
F
V
G
E
V
A
A
S
S
A
R
V
L
L
R
L
L
P
V
LTAC
24
HHSearch
89.91
32%
-135
- C1 -
4G41
1
?
A:
[4-235]
G
S
M
K
I
G
I
I
A
A
M
E
E
E
L
S
L
L
L
A
N
L
-
L
D
A
Q
E
H
Q
V
L
S
K
T
Y
Y
T
G
R
F
G
K
H
E
L
I
L
V
Q
S
G
V
G
K
V
M
S
A
M
T
V
A
I
L
V
E
H
F
K
A
Q
A
I
I
N
T
G
S
A
G
A
V
A
S
H
L
A
I
G
D
V
V
V
A
D
R
L
V
Y
H
D
V
D
A
T
A
F
G
----
Y
A
Y
G
Q
M
A
G
Q
P
----
L
Y
Y
D
C
D
P
Q
F
V
A
I
F
K
Q
V
L
K
--------------
H
E
K
T
N
G
Q
V
--
G
L
I
A
T
G
D
S
F
V
A
-
G
Q
D
K
I
D
Q
I
--
K
T
A
-
F
S
N
V
L
-
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
A
G
K
P
F
I
V
V
R
A
M
S
D
T
A
A
H
D
A
N
I
T
F
D
Q
F
I
I
E
A
G
K
R
S
A
Q
I
L
M
T
F
L
E
N
L
P
--
10
PsiBlast_PDB
88.46
28%
-143
- C1 -
4BMX
1
MQMTN_HELPY
A:
[21-251]
M
V
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
E
S
L
N
-----
A
L
A
K
E
V
A
N
E
-----------------
Q
H
I
V
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
-------
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
F
L
K
S
M
V
D
E
L
---
28
HHSearch
88.16
33%
-131
- C1 -
3BL6
1
MTNN_STAAM
A:
[2-230]
--
M
M
I
G
I
I
G
A
M
E
E
E
V
T
I
L
K
N
K
L
-
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
----
Y
E
Y
G
Q
I
P
Q
M
P
V
----
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
--------------
Q
Q
Q
L
T
A
K
V
--
G
L
I
V
S
G
D
S
F
I
G
-
S
V
E
Q
R
Q
K
I
--
K
K
A
-
F
P
N
A
M
-
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
---
26
HHSearch
87.38
33%
-132
- C1 -
1ZOS
2
?
A:
[1-230]
--
M
K
I
G
I
I
A
A
M
P
E
E
L
A
Y
L
V
Q
H
L
-
D
N
T
Q
E
Q
V
V
L
G
N
T
Y
H
T
G
T
I
A
S
H
E
V
V
L
V
E
S
G
I
G
K
V
M
S
A
M
S
V
A
I
L
A
D
H
F
Q
V
D
A
L
I
N
T
G
S
A
G
A
V
A
E
G
I
A
V
G
D
V
V
I
A
D
K
L
A
Y
H
D
V
D
V
T
A
F
G
----
Y
A
Y
G
Q
M
A
Q
Q
P
----
L
Y
F
E
S
D
K
T
F
V
A
Q
I
Q
E
S
L
S
--------------
Q
L
D
Q
N
W
H
L
--
G
L
I
A
T
G
D
S
F
V
A
-
G
N
D
K
I
E
A
I
--
K
S
H
-
F
P
E
V
L
-
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
L
N
L
P
V
L
V
I
R
A
M
S
D
N
A
N
H
E
A
N
I
F
F
D
E
F
I
I
E
A
G
R
R
S
A
Q
V
L
L
A
F
L
K
A
L
D
--
1
PsiBlast_PDB
86.97
30%
-131
- C1 -
3BL6
1
MTNN_STAAM
A:
[1-230]
-
A
M
M
I
G
I
I
G
A
M
E
E
E
V
T
I
L
K
N
K
L
-
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
----
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
Q
M
P
----
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
Q
Q
Q
L
T
A
--------------
K
V
--
G
L
I
V
S
G
D
S
F
I
G
-
S
V
E
Q
R
Q
K
I
--
K
K
A
-
F
P
N
A
M
-
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
---
30
HHSearch
86.78
34%
-135
- C1 -
4QEZ
2
MTNN_BACAN
B:
[2-230]
---
R
I
A
V
I
G
A
M
E
E
E
V
R
I
L
R
D
K
L
-
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
----
N
Y
E
Y
G
Q
V
P
G
M
P
P
----
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
------------------
Q
V
V
K
--
G
M
I
A
T
G
D
S
F
M
S
-
D
P
N
R
V
A
A
I
--
R
D
K
-
F
E
N
L
Y
-
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
V
K
V
L
E
E
L
---
43
Fugue
86.05
32%
-127
- C1 -
1ZOS
2
?
A:
[1-230]
--
M
K
I
G
I
I
A
A
M
P
E
E
L
A
Y
L
V
Q
H
L
-
D
N
T
Q
E
Q
V
V
L
G
N
T
Y
H
T
G
T
I
A
S
H
E
V
V
L
V
E
S
G
I
G
K
V
M
S
A
M
S
V
A
I
L
A
D
H
F
Q
V
D
A
L
I
N
T
G
S
A
G
A
V
A
E
G
I
A
V
G
D
V
V
I
A
D
K
L
A
Y
H
D
V
----
D
V
T
A
F
G
Y
A
Y
G
Q
M
A
Q
Q
P
L
Y
----
F
E
S
D
K
T
F
V
A
Q
I
Q
E
S
L
S
Q
--------------
L
D
Q
N
W
H
L
--
G
L
I
A
T
G
D
S
F
V
A
-
G
N
D
K
I
E
A
I
--
K
S
H
-
F
P
E
V
L
-
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
L
N
L
P
V
L
V
I
R
A
M
S
D
N
A
N
H
E
A
N
I
F
F
D
E
F
I
I
E
A
G
R
R
S
A
Q
V
L
L
A
F
L
K
A
L
D
--
2
PsiBlast_PDB
84.87
30%
-135
- C1 -
4GMH
3
MTNN_STAAM
A:
[4-230]
----
I
G
I
I
G
A
M
E
E
E
V
T
I
L
K
N
K
L
-
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
----
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
Q
M
P
----
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
Q
Q
Q
L
T
A
--------------
K
V
--
G
L
I
V
S
G
D
S
F
I
G
-
S
V
E
Q
R
Q
K
I
--
K
K
A
-
F
P
N
A
M
-
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
---
25
HHSearch
84.53
30%
-137
- C1 -
4F1W
11
?
A:
[17-247]
--
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
----
Y
E
Y
G
Q
L
P
G
C
P
A
----
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
--------------
E
L
N
L
N
A
V
R
--
G
L
I
V
S
G
D
A
F
I
N
-
G
S
V
G
L
A
K
I
--
R
H
N
-
F
P
D
A
V
-
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
H
-
9
PsiBlast_PDB
84.30
27%
-131
- C1 -
4OJT
2
MQMTN_HELPJ
A:
[1-231]
M
G
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
14
PsiBlast_PDB
83.39
27%
-133
- C1 -
4YNB
4
MQMTN_HELPJ
A:
[19-245]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
18
PsiBlast_PDB
83.33
27%
-134
- C1 -
3NM5
2
MQMTN_HELPJ
A:
[4-230]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
3
PsiBlast_PDB
83.31
30%
-122
- C1 -
1ZOS
2
?
A:
[1-229]
--
M
K
I
G
I
I
A
A
M
P
E
E
L
A
Y
L
V
Q
H
L
-
D
N
T
Q
E
Q
V
V
L
G
N
T
Y
H
T
G
T
I
A
S
H
E
V
V
L
V
E
S
G
I
G
K
V
M
S
A
M
S
V
A
I
L
A
D
H
F
Q
V
D
A
L
I
N
T
G
S
A
G
A
V
A
E
G
I
A
V
G
D
V
V
I
A
D
K
L
A
Y
H
D
----
V
D
V
T
A
F
G
Y
A
Y
G
Q
M
----
A
Q
Q
P
L
Y
F
E
S
D
K
T
F
V
A
Q
I
Q
E
S
L
S
Q
L
--------------
D
Q
N
W
H
L
--
G
L
I
A
T
G
D
S
F
V
A
G
N
D
K
I
E
A
I
K
--
S
H
F
-
P
-
E
V
L
-
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
L
N
L
P
V
L
V
I
R
A
M
S
D
N
A
N
H
E
A
N
I
F
F
D
E
F
I
I
E
A
G
R
R
S
A
Q
V
L
L
A
F
L
K
A
L
---
17
PsiBlast_PDB
83.27
27%
-131
- C1 -
3NM4
4
MQMTN_HELPJ
A:
[4-230]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
32
HHSearch
83.26
31%
-129
- C1 -
4KN5
3
?
A:
[22-252]
-
S
M
R
Y
G
V
I
N
A
M
A
E
E
K
A
A
L
V
D
A
M
-
I
D
E
K
K
T
T
I
A
G
K
L
F
H
H
G
K
I
G
H
V
D
V
V
V
V
E
S
G
I
G
K
V
A
S
A
L
T
T
T
L
L
I
T
N
F
G
V
D
A
V
I
N
S
G
S
A
G
A
L
G
T
D
L
R
I
G
D
I
V
I
A
D
Y
L
A
Y
A
D
A
D
A
R
A
F
G
----
Y
A
Y
G
Q
V
P
Q
Q
P
----
A
R
F
K
A
D
T
D
L
S
N
D
L
S
E
S
Y
E
K
-------------
V
T
D
A
R
L
V
R
--
G
L
V
V
T
S
D
S
F
I
A
-
S
N
E
Q
K
Q
T
I
--
L
T
H
F
P
-
E
A
Q
-
S
A
E
M
E
G
A
S
I
A
Q
V
A
N
Y
F
D
V
P
F
A
V
V
R
A
I
S
D
N
A
N
G
E
A
G
M
T
F
D
D
F
I
V
E
A
G
Q
Q
S
A
Q
V
L
I
N
F
F
E
A
Q
---
15
PsiBlast_PDB
83.23
27%
-131
- C1 -
4YO8
3
MQMTN_HELPJ
A:
[19-245]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
19
PsiBlast_PDB
82.67
27%
-132
- C1 -
3NM6
6
MQMTN_HELPJ
B:
[4-230]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
13
PsiBlast_PDB
82.56
27%
-132
- C1 -
4WKP
3
MQMTN_HELPJ
A:
[19-245]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
11
PsiBlast_PDB
82.37
27%
-131
- C1 -
4WKN
1
MQMTN_HELPJ
A:
[19-245]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
16
PsiBlast_PDB
82.35
27%
-132
- C1 -
4FFS
2
MQMTN_HELPJ
A:
[13-239]
----
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
-----
A
L
A
K
K
I
A
N
E
-----------------
Q
H
I
A
L
K
E
--
G
V
I
A
S
G
D
Q
F
V
H
-
S
K
E
R
K
E
F
L
--
V
S
E
-
F
-
K
A
S
-
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---
34
HHSearch
79.94
31%
-132
* C1 *
4WKB
2
MTNN_VIBC3
A:
[1-231]
--
M
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
-
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
----
Y
E
I
G
Q
M
A
G
Q
P
A
----
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-------------
L
P
N
T
H
A
V
R
--
G
L
I
C
T
G
D
A
F
V
C
-
T
A
E
R
Q
Q
F
I
--
R
Q
H
-
F
P
S
V
V
-
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
K
--
22
PsiBlast_CBE
78.84
31%
-124
- C1 -
4QEZ
2
MTNN_BACAN
A:
[3-226]
----
I
A
V
I
G
A
M
E
E
E
V
R
I
L
R
D
K
L
-
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
----
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
G
M
P
P
----
G
F
K
A
D
E
A
-------------
L
V
A
L
A
E
K
C
M
Q
------
V
V
K
--
G
M
I
A
T
G
D
S
F
M
S
-
D
P
N
R
V
A
A
I
--
R
D
K
-
F
-
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
V
K
V
-------
31
HHSearch
78.81
30%
-123
- C1 -
3EEI
2
?
A:
[3-233]
-
L
K
T
V
A
V
I
G
A
M
E
Q
E
I
E
L
L
R
E
M
M
-
E
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
----
Y
A
W
G
Q
V
P
Q
L
P
A
----
R
F
A
S
D
G
I
L
I
E
A
A
K
R
A
A
R
-------------
T
F
E
G
A
A
V
E
Q
--
G
L
I
V
S
G
D
R
F
V
H
-
S
S
E
G
V
A
E
I
--
R
K
H
-
F
P
E
V
K
-
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
M
V
A
E
I
V
K
S
L
---
21
PsiBlast_CBE
78.02
31%
-122
- C1 -
4QEZ
2
MTNN_BACAN
C:
[3-226]
----
I
A
V
I
G
A
M
E
E
E
V
R
I
L
R
D
K
L
-
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
----
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
G
M
P
P
----
G
F
K
A
D
E
A
-------------
L
V
A
L
A
E
K
C
M
Q
-----
Q
V
V
K
--
G
M
I
A
T
G
D
S
F
M
S
-
D
P
N
R
V
A
A
I
--
R
D
K
-
F
-
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
V
K
V
-------
5
PsiBlast_PDB
77.82
31%
-124
- C1 -
4QEZ
2
MTNN_BACAN
B:
[3-226]
----
I
A
V
I
G
A
M
E
E
E
V
R
I
L
R
D
K
L
-
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
----
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
G
M
P
P
----
G
F
K
A
D
E
A
-------------
L
V
A
L
A
E
K
C
M
Q
-----
Q
V
V
K
--
G
M
I
A
T
G
D
S
F
M
S
-
D
P
N
R
V
A
A
I
--
R
D
K
-
F
-
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
V
K
V
-------
6
PsiBlast_PDB
72.58
30%
-119
- C1 -
4X24
3
MTNN_VIBC3
A:
[1-230]
--
M
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
-
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
----
A
D
V
T
A
F
G
Y
E
I
G
Q
M
P
--------
G
Q
P
A
A
F
K
A
D
E
K
L
-----------
M
T
V
A
E
Q
A
L
A
Q
L
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
I
C
-
T
A
E
G
Q
Q
F
I
R
-
Q
H
F
-
P
-
S
V
V
-
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
---
7
PsiBlast_PDB
71.98
30%
-121
- C1 -
4WKB
2
MTNN_VIBC3
A:
[1-230]
--
M
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
-
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
----
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
--------
G
Q
P
A
A
F
K
A
D
E
K
L
-----------
M
T
V
A
E
Q
A
L
A
Q
L
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
V
--
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
-
P
-
S
V
V
-
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
---
8
PsiBlast_PDB
70.29
30%
-117
- C1 -
3DP9
2
MTNN_VIBCH
A:
[2-230]
---
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
-
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
----
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
--------
G
Q
P
A
A
F
K
A
D
E
K
L
-----------
M
T
V
A
E
Q
A
L
A
Q
L
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
V
--
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
-
P
-
S
V
V
-
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
---
29
HHSearch
48.14
34%
-51
- C1 -
5DK6
2
MTNN_COLP3
A:
[22-259]
-
S
M
K
A
G
I
I
G
A
M
E
P
E
V
A
I
L
K
E
K
L
-
T
D
A
K
S
T
E
H
A
G
Y
T
F
H
Q
G
Q
L
D
G
S
D
V
V
I
V
Q
S
G
I
G
K
V
A
A
A
L
A
T
A
I
L
I
D
R
F
Q
V
D
Y
V
V
N
T
G
S
A
G
G
F
D
A
S
L
K
V
G
D
I
V
V
S
S
E
V
R
Y
H
D
V
D
L
T
A
F
G
----
Y
E
I
G
Q
L
P
A
N
P
A
----
A
F
M
P
H
D
D
L
V
A
A
A
K
K
G
I
E
Q
L
S
Q
------------
N
I
K
A
V
T
--
G
L
I
T
T
G
D
T
F
M
T
-
K
E
E
D
V
A
K
A
--
R
A
N
-
F
P
T
M
A
-
A
V
E
M
E
G
A
A
I
A
Q
A
C
L
Q
L
K
T
P
F
V
V
I
R
S
L
S
D
I
A
G
K
E
S
P
H
T
F
E
E
Y
L
E
T
A
A
V
N
S
S
Q
L
V
L
N
M
L
G
Q
L
K
G
-