@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0823c: (2016-04-26 )
MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG
Atome Classification :
(20 SA)
.........10........20.......-.30--------.-..--.....40...----.....50.....----------------...------60........--------70.---.-----------.-----.-..--.---.80........90-----------------------..----------------------..----------------------.-...100.....-..110........---------120-------.........130.......140.......150.......160......----.----170.........180..--.....---190.....---------.-------.------200---.--.----.-..-.-------..210.......220....----...230.......240.......250.......260.......270.......280.......290.......300.-......310.......320..-..--...330-.......340.......350.......360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRRRAIQPSP
A
L
R
IGPIELAS
P
V
V
L
AP-MA
G
--------
V
-
T
N
--
V
A
F
R
A
L
C
R
Q
L
----
E
Q
SKVGT
V
S
G
L
Y
----------------
V
C
E
------
M
V
T
A
R
A
L
I
E
R--------HP
V
---
T
-----------
M
-----
H
-
M
T
--T---FSADESP
R
S
L
Q
L
Y
-----------------------
T
V----------------------DP----------------------D-
T
T
Y
A
A
A
R
M
I
AG-EGL
A
-
D
HIDMNFG---------C---------PVPKVTKRGGGAAL
P
F
K
R
R
L
F
G
Q
I
V
A
A
A
V
RATEGTDI
P
V
T
V
K
F
R
IGID----D----A--HHTHLDAGRIAEAE--G
A
A
A
V
---
A
L
H
A
R
T
A
A
---------
Q
-------R------YS----G--T----A-
D
W
-
E
-------
Q
I
A
R
L
K
Q
H
V
R
TIPVLGNGD----IYDAGD
A
L
A
M
MSTTGCD
G
V
V
IGRGCLGR
P
W
L
F
A
E
L
S
A
AFTGSPAPTPP
T
L
G
E
V
A
D
I
I
R
RHG
T
L
L
A
AHFGEDK
G
M
R
D
I
-
R
K
H
I
A
W
Y
LHGFP
A
G
S
A
L
R
R
A
L
-
A
M
--
V
K
T
F
D
E
-
L
D
C
L
L
D
RLDGTVPFPDSATGARGRQGSP
A
R
V
ALPDGWLTDPDDCRVPEGADAMGSGG
22
HHSearch
97.38
30%
-106
- C4 -
1VHN
4
?
A:
[5-309]
---------------------
V
K
V
G
L
A
P
-
M
A
G
--------
Y
-
T
D
--
S
A
F
R
T
L
A
F
E
W
----
G
A
-------
D
F
A
----------------
F
S
E
------
M
V
S
A
K
G
F
L
M
N
--------
S
Q
K
---
T
-----------
E
-----
E
-
L
L
--
P
----
Q
P
H
E
R
N
V
A
V
Q
I
F
-----------------------
G
S
----------------------
E
P
----------------------
N
-
E
L
S
E
A
A
R
I
L
S
E
--
K
-
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
---
V
S
G
K
F
S
V
K
T
R
L
G
W
E
----
K
----
N
----
E
V
E
E
I
Y
R
I
L
V
E
E
--
G
V
D
E
V
---
F
I
H
T
R
T
V
V
---------
Q
-------
S
------
F
T
----
G
--
R
----
A
-
E
W
-
K
-------
A
L
S
V
L
E
K
---
R
I
P
T
F
V
S
G
D
----
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
-
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
--
I
E
E
V
Q
I
-
L
K
E
M
F
Y
N
F
I
K
E
V
E
--------------------------------------------
1
PsiBlast_PDB
94.50
29%
-101
- C4 -
1VHN
4
?
A:
[5-292]
---------------------
V
K
V
G
L
A
P
-
M
A
G
--------
Y
-
T
D
--
S
A
F
R
T
L
A
F
E
W
----
G
-------
A
D
F
A
----------------
F
S
E
------
M
V
S
A
K
G
F
L
M
N
--------
S
Q
K
---
T
-----------
E
-----
E
-
L
L
--
P
----
Q
P
H
E
R
N
V
A
V
Q
I
F
-----------------------
G
S
----------------------
E
P
----------------------
N
-
E
L
S
E
A
A
R
I
L
S
E
-
K
--
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
S
G
---
K
F
S
V
K
T
R
L
G
W
E
----
K
----
N
--
E
V
E
E
I
--
Y
R
I
L
V
E
E
--
G
V
D
E
V
---
F
I
H
T
R
T
V
V
---------
Q
-------
S
------
F
T
----
G
--
R
----
A
-
E
W
-
K
-------
A
L
S
V
L
E
K
R
---
I
P
T
F
V
S
G
D
----
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
-
D
F
L
R
S
G
K
Y
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
K
--
I
E
--------------------------------------------------------------
42
Fugue
94.06
29%
-108
- C4 -
1VHN
4
?
A:
[5-309]
---------------------
V
K
V
G
L
A
P
M
A
-
G
--------
Y
-
T
D
--
S
A
F
R
T
L
A
F
E
W
----
G
-------
A
D
F
A
----------------
F
S
E
M-----
V
S
A
K
G
F
L
---
M
-------
N
S
Q
---
K
-----------
T
-----
E
-
E
L
--
L
---
P
Q
P
H
E
R
N
V
A
V
Q
I
F
-----------------------
G
S
----------------------
E
P
----------------------
N
-
E
L
S
E
A
A
R
I
L
S
E
-
K
--
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
---
S
G
K
F
S
V
K
T
R
L
G
W
E
----
K
--------
N
E
V
E
E
I
Y
R
I
L
V
E
E
--
G
V
D
E
V
---
F
I
H
T
R
T
V
V
---------
Q
-------
S
------
F
T
----
G
--
R
----
A
-
E
W
-
K
-------
A
L
S
V
L
E
K
---
R
I
P
T
F
V
S
G
D
----
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
S
-
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
-
E
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
I
EE
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
------------------------------------------------
24
HHSearch
91.96
27%
-105
- C4 -
3B0P
1
DUSAL_THET8
A:
[2-318]
-------------------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
-
T
D
--
R
H
F
R
F
L
V
R
Q
V
----
S
L
G
------
V
R
L
----------------
Y
T
E
------
M
T
V
D
Q
A
V
L
R
G
--------
N
R
E
---------------------
R
-
L
L
--
A
---
F
R
P
E
E
H
P
I
A
L
Q
L
A
-----------------------
G
S
----------------------
D
P
----------------------
K
-
S
L
A
E
A
A
R
I
G
E
A
-
F
G
-
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
---
V
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
ET
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
--
G
V
K
V
F
---
V
V
H
A
R
S
A
L
-------------------------------IP
P
----
L
-
R
H
-
D
-------
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
--
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
-
K
G
--
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
--
G
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
E
E
V
G
E
-------------------------------------------
43
Fugue
91.67
27%
-108
- C4 -
3B0P
1
DUSAL_THET8
A:
[2-318]
-------------------
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
-
T
D
--
R
H
F
R
F
L
V
R
Q
V
----
S
L
G
-----
V
R
L
Y
----------------
T
-
E
------
M
T
V
D
Q
A
V
L
R
G
--------
N
-----
R
-----------
E
-----
R
-
L
L
--
A
---
F
R
P
E
E
H
P
I
A
L
Q
L
A
-----------------------
G
S
----------------------
D
P
----------------------
K
-
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
--
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
---
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
--
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
---
V
V
H
A
R
S
A
-------------------------
L
I
----
P
--
P
----
L
-
R
H
-
D
-------
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
F
H
L
K
R
--
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
-----
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
--
G
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
E
E
V
G
E
-------------------------------------------
8
PsiBlast_PDB
89.07
29%
-94
- C4 -
3B0U
3
DUSAL_THET8
X:
[8-306]
-------------------------
V
A
P
-
M
V
D
--------
R
-
T
D
--
R
H
F
R
F
L
V
R
Q
---------
V
S
L
G
V
R
L
Y
-----------------
T
E
------
M
T
V
D
Q
A
V
L
R
G
--------
N
-----
R
-----------
E
-----
R
-
L
L
--
A
---
F
R
P
E
E
H
P
I
A
L
Q
L
A
-----------------------
G
S
----------------------
D
P
----------------------
K
-
S
L
A
E
A
A
R
I
--
G
-
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
---
M
G
E
A
V
R
V
P
V
T
V
K
M
R
L
G
L
-----
E
----
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
--
A
E
A
G
V
KVF
V
V
H
A
R
S
A
L
---------
L
-------
A
------
L
S
----
T
--
K
----
A
-
N
R
-
E
IPPLRHD
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
F
H
L
K
R
--
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
F
G
--
L
P
R
R
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
--
G
R
S
L
Q
A
-
L
D
-------------------------------------------------------
44
Fugue
88.86
25%
-86
- C4 -
4BFA
6
DUSC_ECOLI
A:
[22-338]
-------------------
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
-
W
L
A
E
N
A
A
R
A
V
E
-
L
G
-
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
----
H
I
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
----
N
L
S
R
V
V
K
Y
N
E
P
R
M
P
--
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
--
L
N
N
S
P
D
-
I
A
R
A
I
Q
A
I
D
I
E
K
L
--------------------------------------------
7
PsiBlast_PDB
87.73
29%
-98
- C4 -
3B0P
1
DUSAL_THET8
A:
[8-306]
-------------------------
V
A
P
-
M
V
D
--------
R
-
T
D
--
R
H
F
R
F
L
V
R
Q
---------
V
S
L
G
V
R
L
Y
-----------------
T
E
------
M
T
V
D
Q
A
V
L
R
G
--------
N
-----
R
-----------
E
-----
R
-
L
L
--
A
---
F
R
P
E
E
H
P
I
A
L
Q
L
A
-----------------------
G
S
----------------------
D
P
----------------------
K
-
S
L
A
E
A
A
R
I
--
G
-
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
---
M
G
E
A
V
R
V
P
V
T
V
K
M
R
L
G
L
-----
E
----
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
--
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
L
--------------------------------------------IPPLR
H
D
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
F
H
L
K
R
--
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
F
G
--
L
P
R
R
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
--
G
R
S
L
Q
A
-
L
D
-------------------------------------------------------
9
PsiBlast_PDB
87.66
28%
-91
- C4 -
3B0V
1
DUSAL_THET8
C:
[29-327]
-------------------------
V
A
P
-
M
V
D
--------
R
-
T
D
--
R
H
F
R
F
L
V
R
Q
---------
V
S
L
G
V
R
L
Y
-----------------
T
E
------
M
T
V
D
Q
A
V
L
R
G
--------
N
-----
R
-----------
E
-----
R
-
L
L
--
A
---
F
R
P
E
E
H
P
I
A
L
Q
L
A
-----------------------
G
S
----------------------
D
P
----------------------
K
-
S
L
A
E
A
A
R
I
--
G
-
E
A
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
---
M
G
E
A
V
R
V
P
V
T
V
K
M
R
L
G
L
-----
E
----
G
--
K
E
T
Y
R
G
L
A
Q
S
V
E
A
M
--
A
E
A
G
V
KVF
V
V
H
A
R
S
A
L
---------
L
-------
A
------
L
S
----
T
--
K
----
A
-
N
R
-
E
IPPLRHD
W
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
----
I
R
S
L
E
E
A
L
F
H
L
K
R
--
V
D
G
V
M
L
G
R
A
V
Y
E
D
P
F
V
L
E
E
A
D
R
R
V
F
G
--
L
P
R
R
P
S
R
L
E
V
A
---
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
--
G
R
S
L
Q
A
-
L
D
-------------------------------------------------------
23
HHSearch
86.69
25%
-94
* C4 *
4BFA
6
DUSC_ECOLI
A:
[22-335]
-------------------
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
------
Y
D
L
C
----------------
I
T
E
------
F
V
R
V
V
D
Q
L
L
P
--------
V
-
K
---
V
-----------
F
H
R
I
C
P
E
-
L
Q
NA
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
-
W
L
A
E
N
A
A
R
A
V
E
-
L
G
-
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
-
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
---
E
K
K
F
E
I
A
D
A
V
Q
Q
A
--
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
E-
H
----
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
N
L
S
R
V
V
K
Y
N
E
------
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
--
L
N
N
S
P
D
-
I
A
R
A
I
Q
A
I
D
I
-----------------------------------------------
2
PsiBlast_PDB
78.90
31%
-89
- C4 -
4BFA
5
DUSC_ECOLI
A:
[26-254]
-----------------------
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
---
E
L
G
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
H---
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.33
30%
-92
- C4 -
4BF9
1
DUSC_ECOLI
A:
[26-254]
-----------------------
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
---
E
L
G
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
H---
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
-------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.38
30%
-88
- C4 -
4YCO
1
DUSC_ECOLI
A:
[9-237]
-----------------------
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
---
E
L
G
S
-
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
H---
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.15
30%
-85
- C4 -
4YCP
1
DUSC_ECOLI
A:
[9-237]
-----------------------
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
---
E
L
G
S
-
W
G
V
D
L
N
C
G
---------
A
---------
P
-------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
H---
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
-------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.28
31%
-90
- C4 -
4BFA
6
DUSC_ECOLI
B:
[26-254]
-----------------------
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
---
E
L
G
S
-
W
G
V
D
L
N
C
G
----------------------------
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
H---
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
-------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.36
31%
-91
- C4 -
3W9Z
1
DUSC_ECOLI
A:
[3-242]
-----------------------
V
L
L
A
P
-
M
E
G
--------
V
-
L
D
--
S
L
V
R
E
L
L
T
E
V
----
N
D
Y
D
L
C
I
T
E
F
V
R
----------------
V
V
D
------
Q
L
L
P
V
K
V
F
H
R
--------
I
C
P
---
E
-----------
L
-----
Q
-
N
A
--
S
---
R
T
P
S
G
T
L
V
R
V
Q
L
L
-----------------------
G
Q
----------------------
F
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
---
E
L
G
S
-
W
G
V
D
L
N
C
G
---------
C
----------------------
L
L
K
D
P
E
L
I
Y
Q
-
G
A
K
A
M
R
E
A
V
P
A
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
K
K
F
E
I
A
D
A
V
Q
Q
A
---
G
A
T
E
L
---
V
V
H
G
R
T
K
E
---------
Q
-------
G
------
Y
R
----
A
--
E
H---
I
-
D
W
-
Q
-------
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
----
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
I
P
-------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
68.84
24%
-54
- C4 -
4XP7
1
DUS2L_HUMAN
A:
[13-321]
----------------
S
L
C
Y
H
N
K
L
I
L
A
P
-
M
V
R
--------
V
-
G
T
--
L
P
M
R
L
L
A
L
D
Y
----
G
A
------
D
-
I
V
----------------
Y
C
E
EL
I
D
L
K
M
I
Q
C
K
R
V
V
N
E
--------
V
L
S
---
T
VDFVAPDD---
R
-----
V
-
V
F
--
R
T
--
C
E
R
E
Q
N
R
V
V
F
Q
M
G
-----------------------
T
S
----------------------
D
A
----------------------
E
-
R
A
L
A
V
A
R
L
V
E
--
N
D
-
V
-
A
G
I
D
V
N
M
G
---------
C
---------
P
K
Q
---------
A
L
L
S
D
P
D
K
I
E
K
I
L
S
T
L
V
K
G
---
T
R
R
P
V
T
C
K
I
R
I
L
P
S
----
L
--------
E
D
T
L
S
L
V
K
R
I
E
R
T
--
G
I
A
A
I
---
A
V
H
G
R
K
R
E
---------
E
-------
R
------
P
Q
----
H
--
P
----
V
-
S
C
-
E
-------
V
I
K
A
I
A
D
T
L
-
S
I
P
V
I
A
N
G
G
SHDH
I
Q
Q
Y
S
D
I
E
D
F
R
Q
A
T
A
A
S
S
V
M
V
A
R
A
A
M
W
N
P
S
I
F
L
K
E
G
L
----------
R
P
L
E
E
V
M
Q
K
Y
I
R
Y
A
V
Q
Y
D
N
------
H
Y
T
N
T
-
K
Y
C
L
C
Q
M
L
R
E
Q
L
E
-
S
P
Q
G
R
L
L
-
H
A
--
A
Q
S
S
R
E
-
I
C
E
A
F
G
---------------------------------------------------
37
HHSearch
65.06
16%
-97
- C4 -
1PS9
4
FADH_ECOLI
A:
[8-328]
-----------
P
L
D
L
G
F
T
T
L
K
N
R
V
L
M
G
S
-
M
H
T
--------
G
L
E
E
YP
D
G
A
E
R
L
A
A
F
Y
A
E
R
A
R
H
G
-----
V
A
L
I
----------------
V
S
G
------
G
I
A
P
D
L
T
G
V
G
MEGGAMLN
D
A
S
Q
I
P
H
-----------
H
-----
R
T
I
T
--
E
A
--
V
H
Q
E
G
G
K
I
A
L
Q
I
L
-----------------------
H
T
GRYSYQPHLVAPSALQAPINR
F
V
P
H
ELS
H
E
E
I
L
Q
L
I
----------
D
-
N
F
A
R
C
A
Q
L
A
R
E
-
A
G
-
Y
-
D
G
V
E
V
M
G
S
EGY
L
I
N
E
F
L
T
---------
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
-
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
----
V
EDGG
T
--
F
A
E
T
V
E
L
A
Q
A
I
E
A
A
--
G
A
T
I
I
---
N
T
G
I
G
W
H
E
---------
A
-------
R
IPTIAT
P
V
----
P
--
R
----
G
-
A
F
S
W
-------
V
T
R
K
L
K
G
H
V
-
S
L
P
L
V
T
T
N
R
----
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
--------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.85
17%
-96
- C4 -
3HGJ
2
?
A:
[7-335]
-----------
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
-
M
C
Q
YSATLEGE
V
-
T
D
--
W
H
L
L
H
Y
P
T
R
A
----
L
G
G
-----
V
G
L
I
----------------
L
V
E
------
A
T
A
V
E
P
L
G
R
I
--------
S
P
Y
---
D
LGIWSEDH
L
P
G
L
-----
K
E
L
A
--
R
R
--
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
AGRKAGTARPWEGGKPLGWRVV
G
P
----------------------
S
P
IPFDEGYPVPEPLD
E
A
G
M
E
R
I
L
Q
-
A
F
V
E
G
A
R
R
A
L
R
-
A
G
-
F
-
Q
V
I
E
L
H
M
A
---------
H
GY
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
P
-
R
E
L
P
L
F
V
R
V
S
A
T
D
W
GEGG
W
----
S
--
L
E
D
T
L
A
F
A
R
R
L
K
E
L
--
G
V
D
L
L
---
D
C
S
S
G
G
V
V
---------
L
-------
R
------
V
R
IPLA
P
--
G
----
F
-
Q
V
-
P
-------
F
A
D
A
V
R
K
R
V
-
G
L
R
T
G
A
V
G
L
----
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
---------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
64.20
19%
-78
- C4 -
1EP3
2
PYRDB_LACLM
A:
[4-287]
-------
N
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
-
G
C
F
--------
G
-
F
G
--
E
E
Y
A
K
Y
Y
D
L
N
----
K
L
G
S
I
M
V
--
K
A
T
TLHPRFGNPTPR
V
A
E
T
A
S
G
------
M
L
N
A
I
G
L
Q
N
P
--------
G
L
E
V
--
I
-----------
M
T
----
E
-
K
L
--
P
W
L
N
E
N
F
P
E
L
P
I
I
A
N
V
A
-----------------------
G
S
----------------------
E
E
----------------------
A
-
D
Y
V
A
V
C
A
K
I
G
D
A
A
N
-
V
-
K
A
I
E
L
N
I
S
---------
C
---------
P
N
V
K
----
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
---
S
K
V
P
L
Y
V
K
L
S
P
N
V
T
--------------
D
I
V
P
I
A
K
A
V
E
A
A
--
G
A
D
G
L
---
T
M
I
N
T
L
M
G
V
R
F
D
LKTRQ
P
ILANI
T
G
G
------
L
S
----
G
--
P
AI
K
P
V
-
A
L
-
K
-------
L
I
H
Q
V
A
Q
D
V
-
D
I
P
I
I
G
M
G
G
----
V
A
N
A
Q
D
V
L
E
M
Y
M
-
A
G
A
S
A
V
A
V
G
T
A
N
F
A
D
P
F
V
C
P
K
I
I
D
K
L
---------------------------------------------------------------------------------------------------------------------------------