@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1106c: (2016-04-28 )
MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPSLLPAHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDETLPYTDRFNDLYTETKVVAERFVLAQNGVDGMLTCAIRPSGIWGNGDQTMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGWQRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQALTECLPYYVSLFEQMKNEARAEKTAATVKP
Atome Classification :
(24 SA)
.........10........20........30.......--.-------------40-----------......-------.-------.50--.-----.-----.--------.--.-------------------------..--..60........70....--.--...80....---....90........100.......110.......120-.-.......130.-..-..--------..140--------------.-----------.....-------.--.150-..----.....160.......170-.........180.......190---...--.-------------------.-----------...-.---200...---.-.--.-.-210.------......220.......230.......-240.......250...--....260.......270--........280........290.......300.......-.310.......320.......330...-....340.......350.......360----........370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRRMGD
A
S
L
T
T
EL
G
R
V
L
V
TGGA
G
F
V
G
A
N
L
V
T
T
L
LDR
G
--
H
-------------
W
V
-----------
R
S
FDRA-------P-------SL---L-----P-----A--------H--P-------------------------
Q
L
--
E
V
LQGDIT
D
A
D
V
C
A
A
A
V
D
--
G
--
I
D
T
I
F
H
T
A
A
---
I
I
E
LMGGASV
T
D
E
Y
RQ
R
S
F
A
V
NVGG
T
E
N
L
L
H
A
G
Q
R
A--G-
V
Q
R
F
V
Y
TSSN
S
-
V
V
-MG--------GQNI---------------A-----------GGDET-------L--PYT
D
-
R
F
----
N
D
L
Y
T
E
T
K
V
V
A
E
R
F
V
L
---AQNGVD
G
M
L
T
C
A
IRPSGIWG-----N
G
D
--
Q
-------------------
T
-----------
M
F
R
-
K
---
L
F
E
S
V
L
---
K
-
G
--
H
-
V
-
K
V
L
V------GRKSARL
D
N
S
Y
V
H
N
L
I
H
G
F
I
L
A
A
A
H
L-VPDGTAPG
Q
A
Y
F
INDA--EP
I
N
M
F
E
F
A
R
P
V
L
E
A
C
---
G
Q
RWPKMRI-SGP
A
V
R
W
V
M
TGW
Q
R
L
H
F
RFGF-PA
P
L
L
E
P
-
L
A
V
E
R
L
Y
L
D
N
Y
F
S
I
A
K
A
R
R
DLGYEPL
F
-
T
T
Q
Q
A
L
T
E
C
L
P
Y
Y
V
S
L
F
E
Q
M
K
N
E
A
R
A
-----EKTAATVKP
1
PsiBlast_PDB
85.22
26%
-99
* C1 *
3WJ7
2
?
A:
[13-335]
-----------
N
D
V
--
T
L
V
T
G
A
T
G
F
V
G
S
A
V
A
R
V
L
E
E
R
G
--
H
-------------
R
L
-----------
R
L
L
V
R
P
-------
T
-------
S
D
---
R
-----
S
-----
N
--------
I
--
A
-------------------------
E
L
N
A
E
L
A
V
G
D
L
S
D
P
D
T
L
A
P
A
L
K
--
G
--
V
K
I
L
F
H
V
A
A
---
D
Y
R
L
W
----
V
P
D
P
--
E
T
M
M
K
A
N
V
E
G
T
R
N
L
M
L
A
A
L
E
A
--
G
-
V
E
K
I
I
Y
C
S
S
V
A
-
A
L
-
G
L
--------
R
S
D
G
---------------
V
-----------
P
A
D
E
T
-------
T
--
P
V
S
E
S
Q
V
----
I
G
I
Y
K
L
S
K
Y
R
A
E
Q
E
V
L
---
R
L
I
R
E
K
N
L
P
A
I
I
V
N
P
S
T
P
V
G
-----
P
R
D
IK
P
-------------------
T
-----------
P
T
G
-
Q
---
M
I
L
D
C
A
---
S
-
G
--
N
-
M
-
P
A
Y
V
---------
E
T
G
L
N
I
V
H
V
D
D
V
A
E
G
H
A
L
A
L
------
E
R
G
K
I
G
E
K
Y
I
L
G
-
G
--
E
N
I
M
L
G
D
L
F
R
M
V
S
Q
I
A
---
G
V
K
P
P
A
V
K
L
-
K
Q
S
W
L
Y
P
V
A
L
V
S
E
W
L
A
R
G
F
G
I
E
P
R
V
T
R
E
T
-
L
A
M
S
K
K
L
M
--
F
F
S
S
D
K
A
K
K
E
L
G
Y
A
P
-
R
-
P
A
R
D
A
V
T
D
A
I
A
W
F
---------------------------
58
HHSearch
83.65
25%
-84
- C1 -
1R6D
2
?
A:
[1-316]
--------------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD-------
E
V
-----------
I
V
L
D
S
L
-------
T
-------
Y
A
---
G
NRANL
A
-----
P
VDA-----
D
--
P
-------------------------
R
L
--
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
E
L
R
--
G
--
V
D
A
I
V
H
F
A
A
---
E
S
H
V
D
R
S
I
----
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
--
G
-
V
G
R
V
V
H
V
S
T
N
Q
-
V
Y
-
G
S
--------
I
D
S
----------------
G
-----------
S
W
T
E
S
-------
S
--
P
L
E
---
P
----
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
---
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
-----
P
Y
Q
--
H
-------------------
P
EK---------
L
I
P
-
L
---
F
V
T
N
L
L
---
D
-
G
--
G
-
T
-
L
P
L
Y
------
G
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
------
G
R
A
G
E
I
Y
H
I
G
G
G
--
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
---
G
A
D
W
S
S
-----
V
R
--
K
--------
V
A
----
D
---
R
K
--------
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
W
Y
R
E
N
R
G
----------------------
60
HHSearch
82.06
22%
-85
- C1 -
1OC2
4
?
A:
[3-329]
------------
Q
F
K
N
I
I
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
V
Y
N
N
H
--
P
-------------
D
V
H
V
---------
T
V
L
D
K
L
-------
T
-------
Y
A
---
G
NK---
A
NLE--
A
--------
I
LG
D
-------------------------
R
V
--
E
L
V
V
G
D
I
A
D
A
E
L
V
D
K
L
A
A
--
K
--
A
D
A
I
V
H
Y
A
A
---
E
S
H
N
D
N
S
L
----
N
D
P
S
P
F
I
H
T
N
F
I
G
T
Y
T
L
L
E
A
A
R
K
Y
--
D
-
I
-
R
F
H
H
V
S
T
D
E
-
V
Y
-
G
D
--------
L
P
L
R
EDLPGHGEGPG----
E
-----------
K
F
T
A
E
-------
T
--
N
Y
---
N
P
----
S
S
P
Y
S
S
T
K
A
A
S
D
L
I
V
K
---
A
W
V
R
S
F
G
V
K
A
T
I
S
N
C
S
N
N
Y
G
-----
P
Y
Q
--
H
-------------------
I
EK---------
F
I
P
-
R
---
Q
I
T
N
I
L
---
A
-
G
--
I
-
K
-
P
K
L
Y
------
G
E
G
K
N
V
R
D
W
I
H
T
N
D
H
S
T
G
V
W
A
I
L
T
K
------
G
R
M
G
E
T
Y
L
I
G
A
D
--
G
E
K
N
N
K
E
V
L
E
L
I
L
E
K
M
---
G
Q
P
K
D
A
--
Y
--
D
H
--
V
------------------
T
D
R
A
------
G
H
D
L
R
Y
A
I
D
A
S
K
L
R
D
E
L
G
W
T
P
Q
F
T
D
F
S
E
G
L
E
E
T
I
Q
W
Y
T
D
N
Q
D
W
W
--------------------
53
HHSearch
77.54
22%
-74
- C1 -
1ORR
2
RFBE_SALTI
A:
[2-339]
--------------
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
G
--
I
-------------
D
L
-----------
I
V
F
D
N
L
-------
S
-------
R
K
---
G
-----
A
T
D
---
N
L
H
W
L
S
S
--
L
--
G
-------------------------
N
F
--
E
F
V
H
G
D
I
R
N
K
N
D
V
T
R
L
I
T
K
Y
M
--
P
D
S
C
F
H
L
A
G
---
Q
V
A
M
T
T
S
I
----
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
--
N
S
N
C
N
I
I
Y
S
S
T
N
K
-
V
Y
-
G
D
--------
L
E
Q
Y
K
Y
N
E
T
ETRYTCVDKP
N
-----------
G
Y
D
E
S
-------
T
--
Q
L
---
D
F
----
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
---
D
Y
A
R
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
-----
G
R
Q
--
F
-------------------
A
TYDQG------
W
V
G
-
W
---
F
C
Q
K
A
V
E
I
K
N
-
G
IN
K
-
P
-
F
T
I
S
------
G
N
G
K
Q
V
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
----
S
K
I
R
G
N
A
F
N
I
G
G
T
IV
N
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
---
N
I
D
M
R
F
--
T
-
N
L
P
-----------------------
V
R
-----
E
S
D
Q
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
P
K
V
-
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
------------------------
48
HHSearch
75.65
21%
-85
- C1 -
4EGB
19
?
A:
[24-341]
-------------
A
M
N
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
S
Y
ET
Y
-------------
K
I
-----------
I
N
F
D
A
L
-------
T
-------
Y
S
GNL
N
NV---
K
-----
S
IQD-----
H
--
P
-------------------------
N
Y
--
Y
F
V
K
G
E
I
Q
N
G
E
L
L
E
H
V
I
K
E
R
D
--
V
Q
V
I
V
N
F
A
A
---
E
S
-------------
I
P
F
Y
D
T
N
V
I
G
T
V
T
L
L
E
L
V
K
K
Y
--
P
-
H
I
K
L
V
Q
V
S
T
D
E
-
V
Y
-
G
S
--------
L
G
K
T
---------------
G
-----------
R
F
T
E
E
-------
T
--
P
L
A
---
P
----
N
S
P
Y
S
S
S
K
A
S
A
D
M
I
A
L
---
A
Y
Y
K
T
Y
Q
L
P
V
I
V
T
R
C
S
N
N
Y
G
-----
P
Y
Q
--
Y
-------------------
P
EK---------
L
I
P
-
L
---
M
V
T
N
A
L
---
E
-
G
--
K
-
K
-
L
P
L
Y
------
G
D
G
L
N
V
R
D
W
L
H
V
T
D
H
C
S
A
I
D
V
V
L
H
K
------
G
R
V
G
E
V
Y
N
I
G
G
N
--
N
E
K
T
N
V
E
V
V
E
Q
I
I
T
L
L
---
G
K
T
K
K
D
--
I
E
Y
V
T
-----------------
D
-------------
G
H
D
R
R
Y
A
I
N
A
E
K
M
K
N
E
F
D
W
E
P
K
Y
-
T
F
E
Q
G
L
Q
E
T
V
Q
W
Y
E
K
N
E
E
W
W
--------------------
77
Fugue
73.88
20%
-74
- C1 -
1QRR
4
SQD1_ARATH
A:
[2-391]
--------------
K
R
V
M
V
I
G
G
D
G
Y
C
G
W
A
T
A
L
H
L
S
K
K
N
--
Y
-------------
E
V
-----------
C
I
V
D
N
L
-------
V
-------
R
R
---
L
-----
F
-----
D
--------
H
--
Q
L
GLESL
T
P
I
A
S
I
H
D
R
I
S
R
W
K
A
L
TG
K
S
I
--
E
L
Y
V
G
D
I
C
D
F
E
F
L
A
E
S
F
K
--
S
F
E
P
D
S
V
V
H
F
G
E
---
Q
-
R
S
A
P
Y
S
M
I
D
R
S
R
A
V
Y
T
Q
H
N
N
V
I
G
T
L
N
V
L
F
A
I
K
E
F
--
G
-
E
E
C
H
L
V
K
L
G
T
M
-
G
E
-
Y
G
--------
T
P
N
I
---------------
D
IEEG
Y
I
T
I
T
H
N
G
R
T
D
T
-------
L
--
P
Y
P
K
-
Q
A
----
S
S
F
Y
H
L
S
K
V
H
D
S
H
N
I
A
---
F
T
C
K
A
W
G
I
R
A
T
D
L
N
Q
G
V
V
Y
G
-----
V
K
T
--
D
ETEMHEEL
R
N
R
L
D
YDAVFG
T
-----------
A
L
N
-
R
---
F
C
V
Q
A
A
---
V
-
G
--
H
-
P
-
L
T
V
Y
------
G
K
G
G
Q
T
R
G
Y
L
D
I
R
D
T
V
Q
C
V
E
I
A
I
A
N
P
-
A
K
A
G
E
---
F
R
V
F
N
Q
F
T
--
E
Q
F
S
V
N
E
L
A
S
L
V
T
K
A
G
---
S
K
L
G
L
D
V
K
-----------------
K
M
T
V
P
N
-
P
R
V
E
A
E
E
---------
H
Y
Y
N
A
K
H
T
K
L
M
E
L
G
L
E
P
H
Y
-
L
S
D
S
L
L
D
S
L
L
N
F
A
V
Q
F
K
D
R
V
D
T
K
Q
I
M
PSVSW
K
K
I
G
V
K
T
K
S
6
PsiBlast_PDB
73.32
29%
-96
- C1 -
2P4H
-
VESTR_MEDSA
X:
[6-276]
--------------
G
R
V
C
V
T
G
G
T
G
F
L
G
S
W
I
I
K
S
L
L
E
N
G
--
Y
-------------
S
V
-----------
N
T
T
I
R
A
DRDVSFL
T
-------
N
L
---
P
-----
G
-----
A
--------
S
--
E
-------------------------
K
L
--
H
F
F
N
A
D
L
S
N
P
D
S
F
A
A
A
I
E
--
G
--
C
V
G
I
F
H
T
A
S
---
P
I
----------
E
I
V
T
K
R
---
T
V
D
G
A
L
G
I
L
K
A
C
V
N
S
--
K
T
V
K
R
F
I
Y
T
S
S
G
S
-
A
V
S
F
N
--------
G
K
D
K
---------------
D
-----------
V
L
D
E
S
DWSDVDL
L
--
R
S
V
K
-
P
F
----
G
W
N
Y
A
V
S
K
T
L
A
E
K
A
V
L
EFG
E
Q
N
G
I
D
--
V
V
T
L
I
L
P
F
I
V
---------
G
--
R
-------------------
F
-----------
V
C
P
-
K
---
L
P
D
S
I
E
---
K
-
A
--
L
-
V
-
L
V
L
-------
G
K
K
E
-
Q
I
G
V
T
R
F
H
-
M
V
H
V
D
D
V
A
R
A
H
I
Y
L
L
E
N
S
V
P
G
G
R
Y
----------
N
C
S
P
F
I
V
P
I
E
E
M
S
QLL
S
A
K
Y
P
E
Y
Q
I
---------------------------------------------------------------------------------------------------
64
HHSearch
72.56
23%
-80
- C1 -
3KO8
2
?
A:
[1-310]
--------------
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
-------------
E
V
-----------
V
V
V
D
N
L
-------
S
-------
S
G
---
R
-----
R
-----
E
FV------
N
--
P
-------------------------
S
A
--
E
L
H
V
R
D
L
K
D
Y
S
-
W
G
A
-
G
I
--
K
--
G
D
V
V
F
H
F
A
A
---
N
P
E
V
R
L
S
----
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
--
G
-
V
R
T
V
V
F
A
S
S
S
T
-
V
Y
-
G
D
--------
A
D
V
----------------
I
-----------
P
T
P
E
E
-------
E
--
P
Y
K
---
P
----
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
---
T
Y
A
R
L
F
G
V
R
C
L
A
V
R
Y
A
N
V
V
G
-----
P
R
L
--
R
-------------------
H
G----------
V
I
Y
-
D
---
F
I
M
K
L
R
---
R
-
N
--
P
N
V
-
L
E
V
L
----------
Q
R
K
S
Y
L
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
-
E
E
-
M
D
A
P
F
L
A
L
N
V
G
N
V
--
D
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
---
G
L
R
P
E
I
--
R
-
L
V
--------------------------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
P
T
M
-
T
S
A
E
A
V
K
K
T
A
E
D
L
A
K
E
L
-----------------------
61
HHSearch
71.68
21%
-81
- C1 -
2HUN
1
?
A:
[3-324]
-------------
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
D
W
-------------
E
V
-----------
I
N
I
D
K
L
-------
G
-------
Y
G
---
S
NP---
A
NLK--
D
LED-----
D
--
P
-------------------------
R
Y
--
T
F
V
K
G
D
V
A
D
Y
E
L
V
K
E
L
V
R
--
K
--
V
D
G
V
V
H
L
A
A
---
E
S
H
V
D
R
S
I
----
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N-
P
-
E
V
R
F
V
H
V
S
T
D
E
-
V
Y
-
G
D
--------
I
L
K
----------------
G
-----------
S
F
T
E
N
-------
D
--
R
L
M
---
P
----
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
---
G
W
T
R
T
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
-----
P
Y
Q
--
F
-------------------
P
EK---------
L
I
P
-
K
---
T
I
I
R
A
S
---
L
-
G
--
L
-
K
-
I
P
I
Y
------
G
T
---
V
R
D
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
------
G
E
S
R
E
I
Y
N
I
S
A
G
--
E
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
---
G
K
G
E
E
L
--
I
-
E
L
V
--
E
--------------
D
---
R
P
--------
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
E
W
W
W
K
P
L
V
D
E
--------------
56
HHSearch
70.70
20%
-85
- C1 -
4LW8
1
?
A:
[15-322]
----------
G
R
P
S
R
R
A
F
V
T
G
L
T
G
F
T
G
R
Y
M
A
E
R
L
Q
A
A
G
--
Y
-------------
D
V
-----------
W
G
T
V
A
P
-------
G
-------
T
P
---
R
-----
P
-----
A
DPA-----
F
--
A
-------------------------
Q
C
--
T
L
L
P
V
D
L
L
D
A
E
A
M
R
A
A
A
A
D
A
R
--
P
D
A
V
V
H
L
A
A
---
R
A
-----------
E
P
S
Q
T
Y
A
V
N
I
V
G
T
R
N
L
L
A
A
L
S
G
L
DR
R
-
P
S
A
V
L
L
A
S
S
A
N
-
I
Y
-
G
N
--------
S
T
A
----------------
G
-----------
V
L
D
E
T
-------
V
--
A
P
A
---
P
----
A
N
D
Y
A
V
S
K
L
A
M
E
Y
A
A
K
---
L
W
A
D
--
R
L
P
I
V
I
A
R
P
F
N
Y
T
G
-----
V
G
Q
--
S
-------------------
D
AY---------
L
L
P
-
K
---
L
V
A
H
Y
A
---
R
-
N
--
A
-
P
-
R
I
S
L
------
G
N
L
D
V
S
R
D
F
S
D
V
R
D
V
T
A
A
Y
L
K
L
I
E
A
------
A
P
A
G
E
T
F
N
V
C
S
E
--
R
A
Y
S
L
K
E
V
L
A
M
L
S
R
I
A
---
G
Y
V
I
D
V
--
T
-
I
D
P
--
R
-------------------
F
V
R
-----
H
N
E
V
K
S
L
S
G
S
R
D
K
L
R
R
A
V
G
E
L
P
V
T
-
P
L
D
E
T
L
R
W
M
V
D
A
M
R
A
A
------------------------
10
PsiBlast_PDB
69.65
27%
-82
- C1 -
1R66
3
?
A:
[2-269]
---------------
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
V
I
V
L
D
S
L
T
-----------
Y
A
G
N
R
A
---------------
N
L
---
A
-----
P
VD---
A
--------
D
--
P
-------------------------
R
L
--
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
E
L
R
--
G
--
V
D
A
I
V
H
F
A
A
ESH
V
D
R
S
I
A
G
A
S
V
F
T
E
-------
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
--
G
-
V
G
R
V
V
H
V
S
T
D
E
-
V
Y
------------
G
S
I
---------------
D
-----------
S
G
S
W
T
-------
E
--
S
S
P
L
-
E
P
----
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
---
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
PY---
Q
H
P
--
E
-------------------
K
-----------
L
I
P
-
L
---
F
V
T
N
L
L
---
D
-
G
--
G
-
T
-
L
P
L
Y
------
G
D
G
A
N
V
--
R
E
W
V
H
T
D
D
H
C
R
G
I
A
---
L
-
V
L
A
G
G
R
A
G
E
I
Y
H
I
G
G
G
--
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
---
G
A
D
W
S
S
V
R
----------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.68
28%
-93
- C1 -
1SB8
2
?
A:
[31-261]
-----------------
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
-------------
K
V
V
G
L
D
NFATGH
Q
R
N
L
D
E
V
-------
R
-------
S
L
---
V
-----
S
-----
E
--------
K
Q
W
S
-------------------------
N
F
--
K
F
I
Q
G
D
I
R
N
L
D
D
C
N
N
A
C
A
--
G
--
V
D
Y
V
L
H
Q
A
A
---
L
G
S
V
--
P
R
S
I
N
D
P
I
--
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
--
K
-
V
Q
S
F
T
Y
A
A
S
S
S
-
T
Y
-
G
D
--------
H
P
G
L
---------------
P
-----------
K
V
E
D
T
-------
I
G
K
P
L
S
P
----------
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
---
V
F
S
R
C
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
G
RRQDP
N
G
A
Y-
A
-------------------
A
-----------
V
I
P
-
K
---
W
T
S
S
M
I
---
Q
-
G
--
D
-
D
-
V
Y
I
N
------
G
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.47
28%
-81
- C1 -
1R6D
2
?
A:
[2-269]
---------------
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
V
I
V
L
D
S
L
T
-----------
Y
A
G
N
R
A
---------------
N
L
---
A
-----
P
VD---
A
--------
D
--
P
-------------------------
R
L
--
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
E
L
R
--
G
--
V
D
A
I
V
H
F
A
A
ESH
V
D
R
S
I
A
G
A
S
V
F
T
E
-------
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
--
G
-
V
G
R
V
V
H
V
S
T
N
Q
-
V
Y
------------
G
S
I
---------------
D
-----------
S
G
S
W
T
-------
E
--
S
S
P
L
-
E
P
----
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
---
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
PY---
Q
H
P
--
E
-------------------
K
-----------
L
I
P
-
L
---
F
V
T
N
L
L
---
D
-
G
--
G
-
T
-
L
P
L
Y
------
G
D
G
A
N
V
--
R
E
W
V
H
T
D
D
H
C
R
G
I
A
---
L
-
V
L
A
G
G
R
A
G
E
I
Y
H
I
G
G
G
--
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
---
G
A
D
W
S
S
V
R
----------------------------------------------------------------------------------------------------
68
HHSearch
68.41
20%
-83
- C1 -
4ZRM
3
?
A:
[4-310]
--------------
M
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
-------------
G
V
-----------
I
V
V
D
N
L
-------
S
-------
S
G
---
K
-----
V
-----
E
N-------
L
N-
R
-------------------------
N
A
--
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
R
--
P
E
Y
V
F
H
L
A
A
---
Q
A
S
V
A
I
S
V
----
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
--
G
-
V
K
K
F
I
F
S
S
T
G
G
A
I
Y
-
G
E
--------
N
V
K
V
---------------
F
-----------
P
T
P
E
T
-------
E
--
I
P
---
H
P
----
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
---
F
F
A
R
E
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
Y
G
-----
P
R
Q
--
D
-------------------
P
YGEAG------
V
V
A
-
I
---
F
T
E
R
M
L
---
R
-
G
--
E
-
E
-
V
H
I
F
------
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
A
M
E
K
-------
G
D
N
E
V
F
N
I
G
T
G
--
R
G
T
T
V
N
Q
L
F
K
L
L
K
E
I
T
---
G
Y
D
K
E
P
--
V
-
Y
K
P
--
P
------------------
R
K
--------
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
P
K
V
-
S
L
E
E
G
L
K
L
T
V
E
Y
F
R
K
T
------------------------
51
HHSearch
67.53
19%
-81
- C1 -
4WOK
3
?
A:
[11-333]
-------------
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
G
--
Y
-------------
A
P
-----------
V
V
Y
D
N
L
-------
S
-------
T
G
---
H
-----
Q
-----
S
A-------
V
--
R
-------------------------
W
G
--
D
F
V
E
G
D
I
L
D
Q
A
R
L
V
E
T
M
E
K
Y
A
--
P
V
A
V
I
H
F
A
A
---
S
A
Y
V
G
E
S
V
----
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
--
R
-
T
Q
N
V
I
F
S
S
S
C
A
-
T
Y
-
G
V
--------
P
S
R
----------------
L
-----------
P
I
G
E
G
-------
E
--
A
Q
N
---
P
----
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
A
---
D
Y
A
V
A
Y
G
L
R
Y
V
A
L
R
Y
F
N
A
S
G
-----
A
D
I
--
D
-------------------
G
E
L
G
E
K
H
DPETH
L
I
P
-
R
---
A
M
M
A
A
A
---
G
R
L
--
D
-
V
-
L
E
V
Y
G
DDYET
P
D
G
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
-
K
--
E
A
G
G
N
L
A
V
N
L
G
T
G
--
R
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
---
G
R
S
V
P
V
------
A
--
M
R
-------------
A
--
R
R
A
--------
G
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
D
T
I
I
R
T
A
A
P
H
F
G
L
E
------------------------
67
HHSearch
66.75
17%
-84
- C1 -
1RPN
3
GM4D_PSEAE
A:
[15-333]
--------------
R
S
A
L
V
T
G
I
T
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
G
--
Y
-------------
R
V
-----------
H
G
L
V
A
R
-------
R
-------
S
S
---
D
-----
T
-----
R
W
R
L
R
E
L
GI
E
--
G
-------------------------
D
I
--
Q
Y
E
D
G
D
M
A
D
A
C
S
V
Q
R
A
V
I
K
A
Q
--
P
Q
E
V
Y
N
L
A
A
---
Q
S
F
V
G
A
S
W
----
N
Q
P
V
T
T
G
V
V
D
G
L
G
V
T
H
L
L
E
A
I
R
Q
F
S-
P
-
E
T
R
F
Y
Q
A
S
T
S
E
-
M
F
-
G
L
--------
I
Q
A
----------------
E
-----------
R
Q
D
E
N
-------
T
--
P
F
Y
---
P
----
R
S
P
Y
G
V
A
K
L
Y
G
H
W
I
T
V
---
N
Y
R
E
S
F
G
L
H
A
S
S
G
I
L
F
N
H
E
S
-----
P
L
R
--
G
-------------------
I
EF
V
T
R
------
K
V
T
-
D
---
A
V
A
R
I
K
---
L
-
G
--
K
-
Q
Q
E
L
R
L
------
G
N
V
D
A
K
R
D
W
G
F
A
G
D
Y
V
E
A
M
W
L
M
L
Q
Q
------
D
-
K
A
D
D
Y
V
V
A
T
G
--
V
T
T
T
V
R
D
M
C
Q
I
A
F
E
H
V
---
G
L
D
Y
R
D
F
-
L
-
K
I
D
--
P
A
------------------
F
F
R
-----
P
A
E
V
D
V
L
L
G
N
P
A
K
A
Q
R
V
L
G
W
K
P
R
T
-
S
L
D
E
L
I
R
M
M
V
E
A
D
L
R
R
V
S
----------------------
5
PsiBlast_PDB
66.57
28%
-93
- C1 -
1SB9
2
?
A:
[31-261]
-----------------
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
-------------
K
V
V
G
L
D
NFATGH
Q
R
N
L
D
E
V
-------
R
-------
S
L
---
V
-----
S
-----
E
--------
K
Q
W
S
-------------------------
N
F
--
K
F
I
Q
G
D
I
R
N
L
D
D
C
N
N
A
C
A
--
G
--
V
D
Y
V
L
H
Q
A
A
---
L
G
S
V
--
P
R
S
I
N
D
P
I
--
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
--
K
-
V
Q
S
F
T
Y
A
A
S
S
S
-
T
Y
-
G
D
--------
H
P
G
L
---------------
P
-----------
K
V
E
D
T
-------
I
G
K
P
L
S
P
----------
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
---
V
F
S
R
C
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
G
RRQDP
N
G
A
Y-
A
-------------------
A
-----------
V
I
P
-
K
---
W
T
S
S
M
I
---
Q
-
G
--
D
-
D
-
V
Y
I
N
------
G
D
G
E
T
S
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
65.95
18%
-69
- C1 -
2C5A
13
GME_ARATH
A:
[25-349]
---------
W
P
S
E
N
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
K
H
E
G
--
H
-------------
Y
V
-----------
I
A
S
D
W
K
-------
K
-------
N
E
---
H
-----
M
-----
T
ED------
M
--
F
-------------------------
C
D
--
E
F
H
L
V
D
L
R
V
M
E
N
C
L
K
V
T
E
--
G
--
V
D
H
V
F
N
L
A
A
---
D
M
G
G
M
G
F
I
---
Q
S
N
H
S
V
I
M
Y
N
N
T
M
I
S
F
N
M
I
E
A
A
R
I
N
--
G
-
I
K
R
F
F
Y
A
S
S
A
C
-
I
Y
-
P
E
--------
F
K
Q
L
ETTN-----------
V
-----------
S
L
K
E
S
-------
D
--
A
W
P
A
-
E
P
----
Q
D
A
F
G
L
E
K
L
A
T
E
E
L
C
K
---
H
Y
N
K
D
F
G
I
E
C
R
I
G
R
F
H
N
I
Y
G
-----
P
F
G
--
T
-------------------
W
KGGREK-----
A
P
A
-
A
---
F
C
R
K
A
Q
---
T
-
S
T-
D
-
R
-
F
E
M
W
------
G
D
G
L
Q
T
R
S
F
T
F
I
D
E
C
V
E
G
V
L
R
L
T
K
S
-------
D
F
R
E
P
V
N
I
G
S
D
--
E
M
V
S
M
N
E
M
A
E
M
V
L
S
F
E
---
E
K
K
L
P
I
--
H
-
H
I
P
--
G
------------------
P
E
---------
G
V
R
G
R
N
S
D
N
N
L
I
K
E
K
L
G
W
A
P
N
M
-
R
L
K
E
G
L
R
I
T
Y
F
W
I
K
E
Q
I
E
K
E
K
A
K
G
----------------
54
HHSearch
65.84
16%
-76
- C1 -
2Z1M
2
?
A:
[3-339]
-------------
G
K
R
A
L
I
T
G
I
R
G
Q
D
G
A
Y
L
A
K
L
L
L
E
K
G
--
Y
-------------
E
V
-----------
Y
G
A
D
R
R
-------
S
-------
G
E
---
F
-----
A
S
W
R
L
K
E
L
GI-----
E
--
N
-------------------------
D
V
--
K
I
I
H
M
D
L
L
E
F
S
N
I
I
R
T
I
E
K
V
Q
--
P
D
E
V
Y
N
L
A
A
---
Q
S
F
V
G
V
S
F
----
E
Q
P
I
L
T
A
E
V
D
A
I
G
V
L
R
I
L
E
A
L
R
T
V
K-
P
-
D
T
K
F
Y
Q
A
S
T
S
E
-
M
F
-
G
K
--------
V
Q
E
----------------
I
-----------
P
Q
T
E
K
-------
T
--
P
F
Y
---
P
----
R
S
P
Y
A
V
A
K
L
F
G
H
W
I
T
V
---
N
Y
R
E
A
Y
N
M
F
A
C
S
G
I
L
F
N
H
E
S
-----
P
L
R
--
G
-------------------
I
E----------
F
V
T
R
K
I
T
Y
S
L
A
R
I
K
---
Y
-
G
--
L
Q
D
-
K
L
V
L
------
G
N
L
N
A
K
R
D
W
G
Y
A
P
E
Y
V
E
A
M
W
L
M
M
Q
Q
-------
P
E
P
D
D
Y
V
I
A
T
G
--
E
T
H
T
V
R
E
F
V
E
K
A
A
K
I
A
---
G
F
D
I
E
W
V
G
E
-
G
I
N
--
E
K
G
I
D
--
R
N
T
G
----
K
-
V
I
V
E
V
S
E
E
F
F
R
P
A
E
V
D
I
L
V
G
N
P
E
K
A
M
K
K
L
G
W
K
P
R
T
-
T
F
D
E
L
V
E
I
M
M
E
A
D
L
K
R
V
R
----------------------
76
Fugue
64.28
23%
-82
- C1 -
2P4H
-
VESTR_MEDSA
X:
[5-326]
-------------
K
G
R
V
C
V
T
G
G
T
G
F
L
G
S
W
I
I
K
S
L
L
E
N
G
--
Y
-------------
S
V
-----------
N
T
T
I
R
A
-------
D
RDVSFLT
N
L
---
P
-----
G
-----
A
--------
S
--
E
-------------------------
K
L
--
H
F
F
N
A
D
L
S
N
P
D
S
F
A
A
A
I
E
--
G
--
C
V
G
I
F
H
T
A
----------------
S
P
I
E
I
V
T
K
R
T
V
D
G
A
L
G
I
L
K
A
C
V
N
S
--
K
T
V
K
R
F
I
Y
T
S
S
G
S
-
A
V
-
S
F
NGKDKDVL
D
E
S
D
---------------
W
-----------
S
D
V
D
L
-------
L
--
R
S
V
K
-
P
F
----
G
W
N
Y
A
V
S
K
T
L
A
E
K
A
V
L
---
E
F
G
E
Q
N
G
I
D
V
V
T
L
I
L
P
F
I
V
G
-----
R
F
V
--
C
-------------------
P
-----------
K
L
P
-
D
---
S
I
E
K
A
L
------------
V
L
V
L
------
G
K
K
E
Q
I
--
G
V
T
R
F
H
M
V
H
V
D
D
V
A
R
A
H
I
-
Y
L
L
E
N
S
V
P
G
G
R
Y
N
C
S
P
--
F
I
V
P
I
E
E
M
S
Q
L
L
S
A
K
-------
Y
P
E
Y
Q
I
-
L
T
V
D
E
L
K
E
I
K
G
A
R
L
P
D
L
N
--------------------------
T
K
K
L
V
D
A
G
F
D
F
K
Y
-
T
I
E
D
M
F
D
D
A
I
Q
C
C
K
E
K
G
Y
L
---------------------
21
PsiBlast_CBE
56.53
34%
-91
- C1 -
4IDG
4
?
B:
[22-178]
----------------
I
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
--
R
-------------
T
V
-----------
R
G
F
D
------------------
L
---
R
-----
P
-----
S
--------
G
--
T
-------------------------
G
G
--
E
E
V
V
G
S
L
E
D
G
Q
A
L
S
D
A
I
M
--
G
--
V
S
A
V
L
H
L
G
A
---
F
M
------
S
W
A
P
A
D
R
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
--
G
-
V
R
R
F
V
F
A
S
S
G
E
-
V
Y
-
P
E
--------
N
R
-------------------------------
P
E
F
-------
L
--
P
V
T
E
-
D
H
PLCP
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
---
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
55.08
34%
-89
- C1 -
4ID9
1
?
A:
[22-178]
----------------
I
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
--
R
-------------
T
V
-----------
R
G
F
D
------------------
L
---
R
-----
P
-----
S
--------
G
--
T
-------------------------
G
G
--
E
E
V
V
G
S
L
E
D
G
Q
A
L
S
D
A
I
M
--
G
--
V
S
A
V
L
H
L
G
A
---
F
M
------
S
W
A
P
A
D
R
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
--
G
-
V
R
R
F
V
F
A
S
S
G
E
-
V
Y
-
P
E
--------
N
R
-------------------------------
P
E
F
-------
L
--
P
V
T
E
-
D
H
P
L
C
P
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
---
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
54.62
34%
-89
- C1 -
4IDG
3
?
A:
[22-178]
----------------
I
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
--
R
-------------
T
V
-----------
R
G
F
D
------------------
L
---
R
-----
P
-----
S
--------
G
--
T
-------------------------
G
G
--
E
E
V
V
G
S
L
E
D
G
Q
A
L
S
D
A
I
M
--
G
--
V
S
A
V
L
H
L
G
A
---
F
M
------
S
W
A
P
A
D
R
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
--
G
-
V
R
R
F
V
F
A
S
S
G
E
-
V
Y
-
P
E
--------
N
R
-------------------------------
P
E
F
-------
L
--
P
V
T
E
-
D
H
PLCP
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
---
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.36
34%
-90
- C1 -
4ID9
1
?
B:
[22-178]
----------------
I
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
--
R
-------------
T
V
-----------
R
G
F
D
------------------
L
---
R
-----
P
-----
S
--------
G
--
T
-------------------------
G
G
--
E
E
V
V
G
S
L
E
D
G
Q
A
L
S
D
A
I
M
--
G
--
V
S
A
V
L
H
L
G
A
---
F
M
------
S
W
A
P
A
D
R
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
--
G
-
V
R
R
F
V
F
A
S
S
G
E
-
V
Y
-
P
E
--------
N
R
-------------------------------
P
E
F
-------
L
--
P
V
T
E
-
D
H
P
L
C
P
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
---
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------