@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3168: (2016-05-17 )
MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVTVESGVDSTGMSSETIILTARWQQDGRSIQQKLVARVAPAAEDVPVFPTYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVAWMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH
Atome Classification :
(20 SA)
-.....-....10........20........30......-.---.---40........50......-..60.......-.70........80........90...-.....100.......110.......120.---......130......--.-140.......150.......160....-----...170.......180.-------.-.....190....-...200...--....210---.-.---.--------.-------------..-------.220...-....230.....-..240.......250.......260----.-........270.......280..-------.....290.-...-------.----..300.......310.......-------320---------------.----------------.---......330.......340.......350...----....360.......370......-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MANEP-A
I
G
A
I
D
R
L
Q
RSSRDV
T
T
L
P
A
V
I
S
R
W
L
S
S
VLPG-G---A---A
P
E
V
T
V
ESGVDSTGMSS
E
-
T
I
I
L
T
A
R
W
Q
QD-
G
R
S
I
Q
Q
K
L
V
A
R
VAPAAEDVPVFPTYR-LD
H
Q
F
E
V
I
R
L
V
G
E
L
TDVPVP
R
V
R
W
I
ETTG---DVLG
T
P
F
F
L
M
D
Y
V
E
G--V-VPPDVM
P
Y
TFGDNWFADA
P
A
E
R
Q
R
Q
L
Q
-----
D
A
T
V
A
A
L
A
T
L
H
SIPN
A
Q
-------
N
-
T
F
S
F
L
TQGRTSD-
T
T
L
H
R
H
F
N
W
--
V
R
S
W
Y
D
F
---
A
-
V
---E--------G-------------IG-------RS
P
L
L
E
R
-
T
F
E
W
L
Q
SHWPD
D
-
A
AARE
P
V
L
L
WGDARV
G
N
V
L
Y
RDF------Q-
P
V
A
V
L
D
W
E
M
V
AL
G
P
R
E
L
D
V
A
W
M
I
-------
F
A
H
R
V
F
Q
E
L
-
A
G
L-------A----TLPG
L
P
E
V
M
R
E
D
D
V
R
A
T
Y
Q
A
LT-------G-V---------------E----------------L---G
D
L
H
W
F
Y
VYS
G
V
M
W
A
C
V
F
M
RTGARRVHFGEIE----KPD
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
LGEEH-----------------
1
PsiBlast_PDB
99.66
100%
-145
- C1 -
3ATS
5
Y3168_MYCTU
A:
[1-357]
-----------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
-
G
---
A
---
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
-
T
I
I
L
T
A
R
W
Q
Q
D
-
G
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
E
D
V
P
V
F
P
T
Y
R
-
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
---
D
V
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
V
M
P
Y
T
F
G
D
N
W
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
-----
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
A
Q
-------
N
-
T
F
S
F
L
T
-----
D
-
T
T
L
H
R
H
F
N
W
--
V
R
S
W
Y
D
F
---
A
-
V
---
E
--------
G
-------------
I
G
-------
R
S
P
L
L
E
R
-
T
F
E
W
L
Q
S
H
W
P
D
D
-
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
-
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
-------
F
A
H
R
V
F
Q
E
L
-
A
G
L
-------
A
----
T
L
P
G
L
P
E
V
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
-------
G
-
V
---------------
E
----------------
L
---
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
H
F
G
E
I
E
----
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
-----------------
10
Fugue
99.53
99%
-144
- C1 -
3ATS
5
Y3168_MYCTU
A:
[1-357]
-----------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
-
G
---
A
---
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
-
T
I
I
L
T
A
R
W
Q
Q
D
-
G
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
E
D
V
P
V
F
P
T
Y
R
-
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
---
D
V
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
V
M
P
Y
T
F
G
D
N
W
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
-----
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
A
Q
-------
N
-
T
F
S
F
L
-----
T
D
-
T
T
L
H
R
H
F
N
W
--
V
R
S
W
Y
D
F
---
A
-
V
---
E
--------
G
-------------
I
G
-------
R
S
P
L
L
E
R
-
T
F
E
W
L
Q
S
H
W
P
D
D
-
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
-
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
-------
F
A
H
R
V
F
Q
E
L
-
A
G
L
-------
A
----
T
L
P
G
L
P
E
V
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
-------
G
-
V
---------------
E
----------------
L
---
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
H
F
G
E
I
E
----
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
-----------------
20
HHSearch
98.75
100%
-142
- C1 -
3ATS
5
Y3168_MYCTU
A:
[3-357]
-------------------------
P
A
V
I
S
R
W
L
S
S
V
L
P
G
-
G
---
A
---
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
-
T
I
I
L
T
A
R
W
Q
Q
D
-
G
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
E
D
V
P
V
F
P
T
Y
R
-
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
---
D
V
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
V
M
P
Y
T
F
G
D
N
W
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
-----
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
A
Q
-------
N
-
T
F
S
F
L
T
-----
D
-
T
T
L
H
R
H
F
N
W
--
V
R
S
W
Y
D
F
---
A
-
V
---
E
--------
G
-------------
I
G
-------
R
S
P
L
L
E
R
-
T
F
E
W
L
Q
S
H
W
P
D
D
-
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
-
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
-------
F
A
H
R
V
F
Q
E
L
-
A
G
L
-------
A
----
T
L
P
G
L
P
E
V
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
-------
G
-
V
---------------
E
----------------
L
---
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
H
F
G
E
I
E
----
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
-----------------
2
PsiBlast_PDB
98.67
100%
-146
- C1 -
3ATT
7
Y3168_MYCTU
A:
[1-357]
-----------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
-
G
---
A
---
A
P
E
V
T
V
E
S
G
V
D
S
T
G
M
S
S
E
-
T
I
I
L
T
A
R
W
Q
Q
D
-
G
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
E
D
V
P
V
F
P
T
Y
R
-
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
---
D
V
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
V
M
P
Y
T
F
G
D
N
W
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
-----
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
A
Q
-------
N
-
T
F
S
F
L
T
-----
D
-
T
T
L
H
R
H
F
N
W
--
V
R
S
W
Y
D
F
---
A
-
V
---
E
--------
G
-------------
I
G
-------
R
S
P
L
L
E
R
-
T
F
E
W
L
Q
S
H
W
P
D
D
-
A
A
A
R
E
P
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
------
Q
-
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
-------
F
A
H
R
V
F
Q
E
L
-
A
G
L
-------
A
----
T
L
P
G
L
P
E
V
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
-------
G
-
V
---------------
E
----------------
L
---
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
H
F
G
E
I
E
----
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
-----------------
21
HHSearch
57.46
21%
-117
- C1 -
3DXP
3
?
A:
[20-328]
----------------------
R
F
D
T
E
A
L
E
A
W
M
R
Q
H
V
E
G
-
F
-------
A
G
P
L
S
V
E
--
Q
F
K
G
-
Q
S
N
P
-
T
F
K
L
V
T
P
---------
G
Q
T
Y
V
M
R
A
K
P
G
----------
A
-
I
E
R
E
Y
R
V
M
D
A
L
A
G
-
T
D
V
P
V
A
K
M
Y
A
L
C
E
D
E
---
S
V
I
G
R
A
F
Y
I
M
E
F
V
S
G
--
R
-
V
L
W
D
Q
S
-------
L
-
P
G
M
S
P
A
E
R
T
A
I
Y
-----
D
E
M
N
R
V
I
A
A
M
H
T
V
D
Y
Q
A
-------
I
-
G
L
G
D
Y
G
---
K
P
G
-
N
Y
F
Q
R
Q
I
E
R
--
W
T
K
Q
Y
K
L
---
S
-
E
--------------------------
T
E
-------
S
I
P
A
M
D
S
-
L
M
D
W
L
P
Q
H
I
P
Q
E
--
D
A
D
L
T
S
I
V
H
G
D
Y
R
L
D
N
L
M
F
H
P
T
EP----
R
-
V
L
A
V
L
D
W
E
L
S
T
L
G
H
P
M
G
D
F
G
Y
H
C
-------
M
S
W
H
I
A
P
G
Q
F
R
G
I
-------
A
GLDH
A
A
L
G
I
P
D
E
---
A
S
Y
R
K
L
Y
E
Q
R
T
-------
G
-
R
---------------
P
----------------
I
T--
G
D
W
N
F
Y
L
A
F
S
M
F
R
I
A
G
I
L
Q
G
I
M
K
R
V
V
D
-------------------------------------------------
32
HHSearch
46.04
15%
-108
- C1 -
5FTG
11
?
A:
[8-349]
------------------------
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
G
A
W
RGL
R
---
E
D
E
F
H
I
S
--
V
I
R
G
G
L
S
N
M
-
L
F
Q
C
S
L
P
D
T
T
A
T
L
G
D
E
P
R
K
V
L
L
R
L
Y
G
----------
E
A
-
M
V
L
E
S
V
M
F
A
I
L
A
E
-
R
S
L
-
G
P
K
L
Y
G
I
F
P
----------
Q
G
R
L
E
Q
F
I
P
S
--
R
-
R
L
D
T
E
E
-----------
L
S
---
L
P
D
I
S
-----
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
P
F
-------
N
-
K
E
P
----------
K
W
L
F
G
T
M
E
K
--
Y
L
K
E
V
L
R
---
I
-
K
---
F
--------
T
E
E
-----------
S
R
I
K
K
L
H
K
L
L
S
Y
N
L
P
L
-
E
L
E
N
L
R
S
L
L
E
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
RENSEK
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
-------
C
E
W
M
Y
D
Y
S
Y
-
E
K
Y
PF
F
R
A
N
I
R
----
K
Y
P
T
K
K
---
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
-------
Q
-
N
DFENLS
T
E
E
K
S
I
I
K
E
E
M
---------------
L
---
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
------------------------------------------------------
27
HHSearch
45.88
15%
-104
- C1 -
1NW1
1
CKA2_CAEEL
A:
[48-396]
--------------------
T
I
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
-
A
W--
K
TVP
L
E
H
L
R
I
S
--
R
I
K
G
G
M
S
N
M
-
L
F
L
C
R
L
S
E
V
Y
P
P
I
R
N
E
P
N
K
V
L
L
R
V
Y
F
N
P
E
-----
T
E
S
H
-
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
-
G
P
K
L
Y
G
I
F
----------
S
G
G
R
L
E
E
Y
I
P
S
--
R
-
P
L
S
C
H
E
-----------
I
---
S
L
A
H
M
S
-----
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
I
-------
W
-
K
--
E
P
D
--------
Y
L
C
E
A
L
Q
R
--
W
L
K
Q
L
T
G
---
T
-
V
---
D
--------
A
E
H
R
F
D
L
PEECGVS
S
V
-------
N
C
L
D
L
A
R
-
E
L
E
F
L
R
A
H
I
S
L
S
---
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
---------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
-------
I
E
W
T
I
D
Y
D
I
-
D
E
A
-------
P
F
Y
K
I
Q
T
E
N
F
P
E
N
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
-------
G
-
N
---------------
T
RENE
L
Y
K
K
S
E
D
L
----
V
---
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
-----------------------------------------------------
15
Fugue
45.58
13%
-86
- C1 -
3JR1
3
?
A:
[14-309]
N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
Y
Y
F
I
K
------
H
K
E
K
L
Y
S
-
G
---
E
M--
N
E
I
W
L
I
N
D
E
--------------------------
V
Q
T
V
F
V
K
I
N
E
R
S
Y
R
-------
S
M
F
R
A
E
A
D
Q
L
A
L
L
A
K
T
N
S
I
N
V
P
L
V
Y
---
G
I
G
---
N
S
Q
G
H
S
F
L
L
L
E
A
L
N
-----------------------
K
S
K
N
K
Q
S
S
F
-----
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
KYGLD
F
D
T
-
W
L
G
P
I
Y
Q
P
N
D
W
Q
-
T
S
W
A
K
F
F
S
E
NR
I
G
W
Q
L
Q
I
---
C
-
K
---
E
--------
K
-------------
G
L
-------
I
F
G
N
I
D
L
-
I
V
Q
I
V
A
D
T
L
S
K
H
-
N
--
P
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
D
------
K
-
I
F
V
C
N
P
--
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
----------------------------
S
----
L
F
E
P
F
P
-----
T
N
F
Y
Q
R
Y
N
E
I
Y
-------
P
-
L
---------------
E
----------------
E
---
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
K
K
Q
---------------
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
-------------------
40
HHSearch
45.55
14%
-110
- C1 -
4DA5
2
CHKA_HUMAN
A:
[82-429]
-------------------
Q
P
E
P
R
T
R
R
R
A
Y
L
W
C
K
E
F
L
P
G
-
A
W--
R
GLR
E
D
E
F
H
I
S
--
V
I
R
G
G
L
S
N
M
-
L
F
Q
C
S
L
P
D
T
T
A
T
L
G
D
E
P
R
K
V
L
L
R
L
Y
----------
A
E
A
-
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
-
G
P
K
L
Y
G
I
F
P
----------
Q
G
R
L
E
Q
F
I
P
S
--
R
-
R
L
D
T
E
E
-----------
L
---
S
L
P
D
I
S
-----
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
P
F
-------
N
-
K
E
P
K
----------
W
L
F
G
T
M
E
K
--
Y
L
K
E
V
L
R
---
I
-
K
---
F
TE
E
-----
S
R
I
K
K
L
H
-------
K
L
-------
L
S
Y
N
L
P
L
-
E
L
E
N
L
R
S
L
L
E
S
T
---
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
E
G
RENSEK
Q
-
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
-------
C
E
W
M
Y
D
Y
S
Y
-
E
K
Y
-------
P
F
F
R
A
N
I
R
K
Y
P
T
K
K
Q
Q
L
H
F
I
S
S
Y
L
P
A
F
-------
Q
-
N
---------------
D
FENLS
T
E
E
K
S
I
I
K
E
E
M
L
---
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
-----------------------------------------------------
22
HHSearch
45.33
12%
-94
- C1 -
3SG8
2
?
A:
[5-277]
------------------------
T
F
D
Q
V
E
K
A
I
E
Q
L
Y
P
D
-
F
--------
T
I
N
T
I
E
--
I
S
G
E
G
N
D
C
I
-
A
Y
E
I
N
------------
R
D
F
I
F
K
F
P
K
H
S
R
-----
G
S
T
N
-
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
---
E
T
Y
Q
M
S
F
A
G
F
T
K
I
K
G
--
V
-
P
L
T
P
L
L
-------
L
-
N
N
L
P
K
Q
S
Q
N
Q
A
A
-----
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
-------
F
-
K
S
N
L
V
L
---
D
F
R
-
E
K
I
N
E
D
N
K
K
--
I
K
K
L
L
S
R
---
E
-----------------------------
L
-------
K
G
P
Q
M
K
K
-
V
D
D
F
Y
R
D
I
L
E
N
E
I
Y
F
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
E
K-----
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
-------
E
D
D
E
E
Y
----------------------
G
M
E
F
V
---
S
K
I
L
N
H
Y
K
H
K
D
-------
I
-
P
---------------
T
V
---------------
L
---
E
K
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
------------------------------------------------------------
31
HHSearch
44.77
13%
-84
- C1 -
3JR1
3
?
A:
[18-284]
----------------------
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
-
Y
-------
Y
F
I
K
H
K
E
--
K
L
Y
S
G
E
M
N
E
-
I
W
L
I
N
D
E
---------
V
Q
T
V
F
V
K
I
N
E
R
S
------
Y
R
S
M
-
F
R
A
E
A
D
Q
L
A
L
L
A
K
T
N
S
I
N
V
P
L
V
Y
G
I
G
N
S
------
Q
G
H
S
F
L
L
L
E
A
L
N
K
--
S
-
K
N
K
Q
--------------------
S
S
F
-----
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
---------
K
Y
G
L
D
F
D
T
W
L
G
P
I
Y
Q
P
N
D
W
Q
T
S
--
W
A
K
F
F
S
E
NR-
I
-
G
W
Q
L
Q
--------
I
C
K
E
K
---------
G
L
-------
I
F
G
N
I
D
L
-
I
V
Q
I
V
A
D
T
L
S
K
H
---
N
P
K
P
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
D
--------
K
I
F
V
C
N
-
P
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
S
-------
L
F
--------------------------
E
-
P
F
P
---
T
N
F
Y
Q
R
Y
N
E
I
Y
-------
P
-
L
---------------
E
----------------
E
G
Y
L
E
R
K
L
I
Y
Q
L
Y
Y
L
L
N
F
--------------------------------------------------------------
26
HHSearch
44.37
14%
-80
- C1 -
2PPQ
2
KHSE_AGRFC
A:
[8-262]
------------------------
T
E
D
E
L
R
N
F
L
T
Q
-
Y
D
V
-
G
--------
S
L
T
S
Y
K
--
G
I
A
E
---
N
S
-
N
F
L
L
H
T
T
---------
K
D
P
L
I
L
T
L
Y
E
K
--------
K
N
D
-
L
P
F
F
L
G
L
M
Q
H
L
A
A
-
K
G
L
S
C
P
L
P
L
P
R
K
D
G
E
L
L
G
E
L
S
G
R
P
A
A
L
I
S
F
L
E
G
--
M
-
W
L
R
K
P
-------------
E
A
K
----
H
C
-----
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
F
-------
E
-
I
K
R
-
P
N
A
----------
L
S
V
D
G
--
W
K
V
L
W
D
K
---
S
-
E
---
E
--------
R
ADEVE--------
K
G
-------
L
R
E
E
I
R
P
-
E
I
D
Y
L
A
A
H
W
P
K
----
D
L
P
A
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
------
E
-
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
-------
N
A
W
C
F
E
K
D
-----------------
G
A
Y
N
V
T
---
K
G
K
A
L
L
E
G
Y
Q
S
V
R
-------
P
-
L
---------------
S
----------------
E
---
A
E
L
-------------------------------------------------------------------------
23
HHSearch
43.97
11%
-100
- C1 -
4R78
2
?
A:
[21-279]
------------------------
M
E
K
I
I
K
E
K
I
S
S
L
L
S
Q
-
E
-------
E
E
V
L
S
V
E
--
Q
L
-
G
G
M
T
N
Q
-
N
Y
L
A
K
T
T
---------
N
K
Q
Y
I
V
K
F
F
G
K
G
T
E
----
K
L
I
N
-
R
Q
D
E
K
Y
N
L
E
L
L
K
D
-
L
G
L
-
D
V
K
N
Y
L
F
D
I
--------
E
A
G
I
K
V
N
E
Y
I
E
S
--
A
I
T
L
D
S
T
----------------
S
I
K
T
K
F
-----
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
-------
R
-
G
--
E
F
A
--------
P
-
F
E
E
I
K
K
--
Y
E
S
L
I
E
E
---
Q
-
I
---
P
----------------------
Y
A
-------
N
Y
E
S
V
R
N
-
A
V
F
S
L
E
K
R
L
A
D
L
---
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
Q
------
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
-------
L
E
S
E
F
-----------------------
T
S
Q
E
E
---
E
T
F
L
S
H
Y
E
S
D
Q
-------
T
P
V
---------------
S
----------------
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
------------------------------------------------------
28
HHSearch
43.19
15%
-82
- C1 -
3TDW
5
?
A:
[6-276]
--------------------------
L
H
Y
T
T
M
I
M
T
Q
F
P
D
-
I
--------
S
I
Q
S
V
E
--
S
L
G
E
G
F
R
N
Y
-
A
I
L
V
N
------------
G
D
W
V
F
R
F
P
K
S
Q
Q
-----
G
A
D
E
-
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
V
K
V
N
I
P
Q
Y
V
Y
I
G
K
R
-----
S
D
G
N
P
F
V
G
Y
R
K
V
Q
G
--
Q
-
I
L
G
E
D
G
-------
M
-
A
V
L
P
D
D
A
K
D
R
L
A
-----
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
-------
A
-
I
--
S
A
G
V
P
---
V
-
T
N
L
K
N
K
I
L
L
--
L
S
E
A
V
E
D
---
Q
-
V
---
F
--------
P
LLD----------
E
S
-------
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
H
P
V
Y
T
----
R
Y
T
P
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
N
SRQT--
P
-
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
-------
E
D
C
-------------------------
G
E
-
L
F
---
T
R
Q
V
M
A
Y
R
G
E
V
-------
D
-
L
---------------
D
----------------
T
H
I
-
R
K
V
S
L
F
V
T
F
D
Q
V
S
Y
L
L
E
-----------------------------------------------------------
33
HHSearch
42.70
16%
-79
* C1 *
4GKH
6
?
A:
[19-269]
-------------------------------
N
L
D
A
D
L
Y
G
----------
Y
R
W
A
----
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
-------
A
P
E
L
F
L
K
H
G
K
G
S
V
------
A
N
D
-
V
T
D
E
M
V
R
L
N
W
L
T
A
--
F
M
P
L
P
T
I
K
H
F
I
R
T
------
P
D
D
A
W
L
L
T
T
A
I
P
G
--
K
-
T
A
F
Q
V
--------
L
-
E
E
Y
P
-
D
S
G
E
N
I
V
-----
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
-------
C
-
P
F
N
S
D
R
-----
V
-
F
R
L
A
Q
A
Q
S
R
--
M
N
N
G
L
V
D
---
A
-
S
---
D
FD------
D
-------------
E
R
-------
N
G
W
P
V
E
Q
-
V
W
K
E
M
H
K
L
L
P
F
----
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
------
K
-
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
-------
N
C
L
G
E
F
----------------------
S
P
S
L
Q
---
K
R
L
F
Q
K
Y
G
I
D
--------
N
-
P
---------------
D
----------------
M
---
N
K
L
Q
F
H
L
M
L
D
------------------------------------------------------------------
18
Fugue
40.31
12%
-74
- C1 -
3HAM
3
?
A:
[1-299]
------------------------
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
-
I
---
K
---
I
N
E
L
R
Y
L
S
S
----
G
D
D
S
D
-
T
F
L
C
N
------------
E
Q
Y
V
V
K
V
P
K
R
D
------------
S
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K
L
S
Y
Q
I
P
A
V
---
V
Y
Q
S
D
R
F
N
I
M
K
Y
I
K
G
-----------
E
R
I
T
Y
E
Q
Y
H
K
L
S
E
K
E
K
D
A
L
A
-----
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
-------
S
-
V
S
L
F
S
D
A
L
V
N
K
K
-
D
K
F
L
Q
D
K
K
L
--
L
I
S
I
L
E
K
---
E
Q
L
---
L
--------
T
-------------
D
E
-------
M
L
E
H
I
E
T
-
I
Y
E
N
I
L
N
N
--
A
V
-
L
F
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
------
R
-
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
---
F
L
-------
C
L
L
D
C
S
T
D
D
-
F
G
K
-------
E
----
F
G
R
K
V
L
K
Y
Y
Q
H
K
A
P
E
V
A
E
R
K
A
E
-------
L
-
N
---------------
D
----------------
V
---
Y
---------------------
W
S
I
D
Q
I
I
Y
G
Y
----
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
IF---------------
14
Fugue
39.91
12%
-71
- C1 -
2OLC
4
MTNK_BACSU
A:
[5-396]
--------------------
K
T
P
L
Y
E
T
L
N
E
S
S
A
V
A
L
A
V
K
-
L
---
G
---
L
T
L
T
C
Q
E
I
G
---
D
G
N
L
N
Y
-
V
F
H
I
Y
-----------
D
R
A
L
I
I
K
Q
A
V
P
Y
---
W
P
L
T
I
D
R
-
A
R
I
E
S
S
A
L
I
R
Q
G
E
H
V
P
H
L
V
P
R
V
F
Y
S
D
T
E
--------
M
A
V
T
V
M
E
D
L
S
H
LK
I
-
A
R
K
G
L
I
E
G
E
N
Y
P
H
L
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
S
SDY
A
L
E
P
K
V
K
K
Q
L
V
K
Q
F
T
N
P
-------
E
-
L
C
D
I
T
E
R
L
V
F
T
D
-
P
F
F
D
H
D
T
N
D
--
F
E
E
E
L
R
P
---
F
-
V
---
E
--------
K
-------------
L
W
-------
N
N
D
S
V
K
I
-
E
A
A
K
L
K
K
S
F
L
T
-----
S
A
E
T
L
I
H
G
D
L
H
T
G
S
I
F
A
S
E
-------
H
-
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
N
A
L
S
R
D
G
A
D
R
E
-
P
L
Y
-------
E
----
H
V
N
Q
V
W
E
T
F
E
E
T
F
S
E
A
W
Q
K
D
S
L
DVYANID
G
-
Y
---------------
L
----------------
T
---
D
T
L
S
H
I
F
E
E
A
I
G
F
A
G
C
E
L
I
R
R
T
I
G
L
A
H
V
A
D
L
D
T
IVP
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
EFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
36
HHSearch
39.81
13%
-78
- C1 -
3TM0
4
KKA3_ENTFL
A:
[21-261]
---------------------------------------------------------
D
T
E
G
M
S
P
A
K
-
V
Y
K
L
V
G
E
---------
N
E
N
L
Y
L
K
M
T
D
S
R
Y
K
G
---
T
T
Y
D
-
V
E
R
E
K
D
M
M
L
W
L
E
G
--
K
L
P
V
P
K
V
L
H
F
E
R
H
------
D
G
W
S
N
L
L
M
S
E
A
D
G
--
V
-
L
C
S
E
E
--------
Y
-
E
--
D
E
Q
S
P
E
K
I
I
-----
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
-------
C
-
P
Y
--
T
N
S
--------
L
D
S
R
L
A
E
--
L
D
Y
L
L
N
N
---
D
-
L
---
A
DVDCENWE
E
-------------
D
T
-------
P
F
K
D
P
R
E
-
L
Y
D
F
L
K
T
E
K
P
-----
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
------
K
-
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
-------
R
S
I
R
E
D
I
---------------------
G
E
E
--
Q
Y
V
E
L
F
F
D
L
L
G
I
K
----------
P
---------------
D
----------------
W
---
E
K
I
K
Y
Y
I
L
L
D
E
-----------------------------------------------------------------
34
HHSearch
39.03
13%
-86
- C1 -
1ZYL
-
SRKA_ECOLI
A:
[11-286]
-----------------------
L
H
P
D
T
I
M
D
A
L
F
-
E
H
G
I
-
R
--------
V
D
S
G
L
T
--
P
L
N
-
S
Y
E
N
R
-
V
Y
Q
F
Q
D
E
D
--------
R
R
R
F
V
V
K
F
Y
R
P
E
R
W
----
T
A
D
Q
-
I
L
E
E
H
Q
F
A
L
Q
L
V
N
-
D
E
V
P
V
A
A
P
V
A
F
N
G
Q
T
L
L
-
N
H
Q
G
F
Y
F
A
V
F
P
S
V
G
G
--
R
-
Q
F
E
A
D
-------------
N
I
D
----
Q
M
-----
E
A
V
G
R
Y
L
G
R
M
H
Q
T
G
R
K
Q
-------
L
-
F
I
H
R
P
T
---
I
----
G
L
N
E
Y
L
I
E
--
P
R
K
L
F
E
D
ATL
I
-
P
---
S
--------
G
L
K
-----------
A
A
-------
F
L
K
A
T
D
E
-
L
I
A
A
V
T
A
H
W
R
E
----
D
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
-------
G
--
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
-------
N
G
D
K
A
E
----------------------
Q
R
M
Q
L
---
E
T
I
I
E
A
Y
E
E
F
S
-------
E
-
F
---------------
D
----------------
T
---
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
R
W
A
--------------------------------------------------
30
HHSearch
38.97
17%
-90
- C1 -
3W0O
2
KHYB_ECOLX
A:
[9-235]
--------------------------
T
S
V
E
K
F
L
I
E
K
F
G
S
-
V
----------
S
D
L
M
--
Q
L
S
E
G
E
E
S
R
-
A
F
S
F
D
V
G
---------
G
R
G
Y
V
L
R
V
N
S
C
A
D
--------
G
-
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
-
A
A
L
P
I
P
E
V
L
D
I
G
E
F
S
-----
E
S
L
T
Y
C
I
S
R
R
A
Q
G
--
V
-
T
L
Q
D
L
-------------
P
E
T
E
L
P
A
V
L
-----
Q
P
V
A
E
V
M
D
A
I
A
A
A
D
L
S
Q
-------
T
S
G
F
G
P
F
G
P
-------
Q
G
I
G
Q
Y
T
T
--
W
R
D
F
I
C
A
---
I
-
A
---
D
--------
P
HVYHWQTVMD---
D
T
-------
V
S
A
S
V
A
Q
-
A
L
D
E
L
M
L
W
A
E
D
C
---
P
E
V
R
H
L
V
H
A
D
F
G
S
N
N
V
L
T
D
N
G
------
R
-
I
T
A
V
I
D
W
S
E
A
M
F
G
D
P
L
Y
E
V
A
N
I
F
-------
F
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------