@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3266c: (2016-05-18 )
MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD
Atome Classification :
(23 SA)
.........10........20........------30.-.---..-------...----.------40-....-.....50.--.--.--.--.--...60........70.-.-......80........90........100......--.110.....--..120.......130.......140.......150.......--160....---.-..170........180..----.....190.......200----....-----....----210----.......--220-........230..-----...-----..240-----.....-----..250.......260........270.-......280.......290.......300..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGRS
E
R
L
V
I
TGAGGQL
G
S
H
L
T
A
Q
A
A
REG------R
D
M
-
L
---
A
L
-------TSS----Q------W--DIT
D
-
P
A
A
A
E
R
I
I
--R--H--G--
D
--
V
V
I
N
CAAYTDVDGAES-N-
E
A
V
A
Y
A
VNAT
G
P
Q
H
L
A
R
A
C
A
R
VG
A
R
L
I
H
V
ST
D
Y
V
F
--DGDFGGAEP--RPYEPTDETAPQG
V
Y
A
R
S
KLAG
E
Q
A
V
L
A
AFPE
A
A
V
V
R
T
A
W
V
Y
--TGGT
G
K
D
---
F
-
V
A
V
M
-
R
R
L
AAGHG
R
V
D
V
V----DDQTGS
P
T
Y
V
A
D
L
A
E
A
L
-----
L
A
L
A-----DAGV----R
G
R
----
V
L
HAAN
E
--
G
V
--
V
S
R
F
G
Q
A
R
A
V
F
E
E
-----CGA-----
D
P
Q
RV-----RPVSS-----AQFPRPAPR
S
S
Y
S
A
-
L
SSR
Q
W
ALAG
L
T
-
P
L
R
H
W
R
S
A
L
A
T
A
LAAPANST
S
I
D
RRLPSTRD-
29
HHSearch
91.42
37%
-87
- C1 -
1VL0
2
?
A:
[12-291]
----
H
M
K
I
L
I
T
G
A
N
G
Q
L
G
R
E
I
Q
K
Q
L
K
G
K
N
------
V
E
V
-
I
---
P
T
-------
D
V
Q
----
D
------
L
--
D
I
T
N
-
V
L
A
V
N
K
F
F
--
N
E
K
K
--
P
--
N
--
V
V
I
N
C
A
A
H
T
A
V
D
K
C
E
E
-
Q
-
Y
D
L
A
Y
K
I
N
A
I
G
P
K
N
L
A
A
A
A
Y
S
V
G
A
E
I
V
Q
I
S
T
D
Y
V
F
--
D
G
E
A
----
K
--
E
P
I
T
E
F
D
E
V
N
P
Q
S
A
Y
G
K
T
K
L
E
G
E
N
F
V
K
A
L
N
P
K
Y
Y
I
V
R
T
A
W
L
Y
--
G
D
G
-
N
-
N
---
F
-
V
K
T
M
-
I
N
L
G
K
T
H
D
E
L
K
V
V
----
H
D
Q
V
G
T
P
T
S
T
V
D
L
A
R
V
V
-----
L
K
V
I
-----
D
E
K
-----
N
Y
G
----
T
F
H
C
T
C
K
--
G
I
--
C
S
W
Y
D
F
A
V
E
I
F
R
L
-----
T
G
I
-----
D
V
-
K
V
-----
T
P
C
T
T
-----
E
E
F
P
R
P
A
K
R
P
K
Y
S
V
-
L
R
N
Y
M
L
E
L
T
T
G
D
-
I
T
R
E
W
K
E
S
L
K
E
Y
I
D
L
L
Q
---------------
25
PsiBlast_CBE
90.00
37%
-92
- C1 -
3SC6
5
?
B:
[5-277]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
--
E
I
R
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
----
R
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
---
G
K
Y
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
L
----
Y
G
-----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
---------
A
A
A
A
R
P
K
Y
S
I
-
F
Q
H
N
M
L
R
L
N
G
F
L
-
Q
M
P
S
W
E
E
G
L
-----------------------
24
PsiBlast_CBE
89.91
37%
-90
- C1 -
3SC6
3
?
C:
[5-277]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
--
E
I
R
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
----
R
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
---
G
K
Y
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
L
----
Y
G
-----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
-----
E
E
F
G
A
A
A
A
R
P
K
Y
S
I
-
F
Q
H
N
M
L
R
L
N
G
F
L
-
Q
M
P
S
W
E
E
G
L
-----------------------
22
PsiBlast_CBE
89.20
37%
-92
- C1 -
3SC6
5
?
E:
[5-277]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
--
E
IR
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
----
R
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
---
G
K
Y
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
L
----
Y
G
-----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
-----
E
E
F
---
A
A
R
P
K
Y
S
I
-
F
Q
H
N
M
L
R
L
N
G
F
L
-
Q
M
P
S
W
E
E
G
L
-----------------------
1
PsiBlast_PDB
88.87
37%
-87
- C1 -
1VL0
2
?
A:
[14-283]
------
K
I
L
I
T
G
A
N
G
Q
L
G
R
E
I
Q
K
Q
L
K
G
K
N
------
V
E
V
-
I
---
P
T
-------
D
V
Q
----
D
------
L
--
D
I
T
N
-
V
L
A
V
N
K
F
F
N
E
K
--
K
--
P
--
N
--
V
V
I
N
C
A
A
H
T
A
V
D
K
C
E
E
-
Q
-
Y
D
L
A
Y
K
I
N
A
I
G
P
K
N
L
A
A
A
A
Y
S
V
G
A
E
I
V
Q
I
S
T
D
Y
V
F
--
D
G
E
----
A
K
--
E
P
I
T
E
F
D
E
V
N
P
Q
S
A
Y
G
K
T
K
L
E
G
E
N
F
V
K
A
L
N
P
K
Y
Y
I
V
R
T
A
W
L
Y
----
G
D
G
N
N
---
F
-
V
K
T
M
-
I
N
L
G
K
T
H
D
E
L
K
V
V
----
H
D
Q
V
G
T
P
T
S
T
V
D
L
A
R
V
V
-----
L
K
V
I
-----
D
E
K
N
----
Y
G
-----
T
F
H
C
T
C
K
--
G
I
--
C
S
W
Y
D
F
A
V
E
I
F
R
L
-----
T
G
I
-----
D
V
-
K
V
-----
T
P
C
T
T
-----
E
E
F
P
R
P
A
K
R
P
K
Y
S
V
-
L
R
N
Y
M
L
E
L
T
T
G
D
-
I
T
R
E
W
K
E
S
L
-----------------------
23
PsiBlast_CBE
87.25
37%
-88
- C1 -
3SC6
3
?
D:
[5-277]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
--
E
IR
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
----
R
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
---
G
K
Y
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
L
----
Y
G
-----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
-----
E
E
F
G
A
A
A
A
R
P
K
Y
S
I
-
F
Q
H
N
M
L
R
L
N
G
F
L
-
Q
M
P
S
W
E
E
G
L
-----------------------
2
PsiBlast_PDB
86.81
37%
-87
- C1 -
3SC6
3
?
A:
[5-277]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
--
E
I
R
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
----
R
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
---
G
K
Y
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
L
----
Y
G
-----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
-----
E
E
F
G
A
A
A
A
R
P
K
Y
S
I
-
F
Q
H
N
M
L
R
L
N
G
F
L
-
Q
M
P
S
W
E
E
G
L
-----------------------
3
PsiBlast_PDB
86.58
34%
-84
- C1 -
4WPG
3
?
A:
[5-279]
-----
E
M
I
L
I
T
G
S
N
G
Q
L
G
T
E
L
R
Y
L
L
D
E
R
G
------
V
D
Y
-
V
---
A
V
-------
D
V
A
----
E
------
M
--
D
I
T
N
-
E
D
K
V
E
A
V
F
--
A
--
Q
--
V
--
K
PT
L
V
Y
H
C
A
A
Y
T
A
V
D
A
A
E
D
-
E
G
K
A
L
N
E
A
I
N
V
T
G
S
E
N
I
A
K
A
C
G
K
Y
G
A
T
L
V
Y
I
S
T
D
Y
V
F
--
D
G
N
----
K
P
VG
Q
E
W
V
E
T
D
H
P
D
P
K
T
E
Y
G
R
T
K
R
L
G
E
L
A
V
E
R
Y
A
E
H
F
Y
I
I
R
T
A
W
V
F
---
G
N
Y
G
K
N
---
F
-
V
F
T
M
-
E
Q
L
A
E
N
H
S
R
L
T
V
V
----
N
D
Q
H
G
R
P
T
W
T
R
T
L
A
E
F
M
-----
C
Y
L
T
-----
E
N
Q
K
----
A
F
G
----
Y
Y
H
L
S
N
D
--
A
K
ED
T
T
W
Y
D
F
A
K
E
I
L
K
D
-----
K
A
V
-----
E
---
V
-----
V
P
V
D
S
-----
S
A
F
P
A
K
A
K
R
P
L
N
S
T
-
M
N
L
D
K
A
K
A
T
G
F
V
--
I
P
T
W
Q
E
A
L
-----------------------
21
PsiBlast_CBE
86.41
37%
-87
- C1 -
3SC6
2
?
F:
[5-277]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
--
E
IR
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
----
R
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
---
G
K
Y
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
L
----
Y
G
-----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
-----
E
E
F
G
A
A
A
A
R
P
K
Y
S
I
-
F
Q
H
N
M
L
R
L
N
G
F
L
-
Q
M
P
S
W
E
E
G
L
-----------------------
45
HHSearch
84.56
34%
-82
- C1 -
4WPG
3
?
A:
[2-288]
--
P
L
L
E
M
I
L
I
T
G
S
N
G
Q
L
G
T
E
L
R
Y
L
L
D
E
R
G
------
V
D
Y
-
V
---
A
V
-------
D
V
A
----
E
------
M
--
D
I
T
N
-
E
D
K
V
E
A
V
F
--
A
Q
V
K
--
P
--
T
--
L
V
Y
H
C
A
A
Y
T
A
V
D
A
A
E
D
E
G
-
K
A
L
N
E
A
I
N
V
T
G
S
E
N
I
A
K
A
C
G
K
Y
G
A
T
L
V
Y
I
S
T
D
Y
V
F
--
D
G
N
K
P
V
--
G
--
Q
E
W
V
E
T
D
H
P
D
P
K
T
E
Y
G
R
T
K
R
L
G
E
L
A
V
E
R
Y
A
E
H
F
Y
I
I
R
T
A
W
V
F
--
G
N
Y
-
G
K
N
---
F
-
V
F
T
M
-
E
Q
L
A
E
N
H
S
R
L
T
V
V
----
N
D
Q
H
G
R
P
T
W
T
R
T
L
A
E
F
M
-----
C
Y
L
T
-----
E
N
Q
K
----
A
F
G
----
Y
Y
H
L
S
N
D
AK
E
D
--
T
T
W
Y
D
F
A
K
E
I
L
K
D
-----
K
A
V
-----
E
---
V
-----
V
P
V
D
S
-----
S
A
F
P
A
K
A
K
R
P
L
N
S
T
-
M
N
L
D
K
A
K
A
-
T
G
F
-
V
I
P
T
W
Q
E
A
L
K
A
F
Y
Q
Q
G
L
K
--------------
27
HHSearch
84.07
35%
-85
- C1 -
3SC6
3
?
A:
[5-285]
----
K
E
R
V
I
I
T
G
A
N
G
Q
L
G
K
Q
L
Q
E
E
L
N
P
E
E
------
Y
D
I
-
Y
---
P
F
-------
D
K
K
----
L
------
L
--
D
I
T
N
-
I
S
Q
V
Q
Q
V
V
--
Q
E
I
R
--
P
--
H
--
I
I
I
H
C
A
A
Y
T
K
V
D
Q
A
E
K
-
E
-
R
D
L
A
Y
V
I
N
A
I
G
A
R
N
V
A
V
A
S
Q
L
V
G
A
K
L
V
Y
I
S
T
D
Y
V
F
--
Q
G
D
R
----
P
--
E
G
Y
D
E
F
H
N
P
A
P
I
N
I
Y
G
A
S
K
Y
A
G
E
Q
F
V
K
E
L
H
N
K
Y
F
I
V
R
T
S
W
L
Y
--
G
K
Y
-
G
N
N
---
F
-
V
K
T
M
-
I
R
L
G
K
E
R
E
E
I
S
V
V
----
A
D
Q
I
G
S
P
T
Y
V
A
D
L
N
V
M
I
-----
N
K
L
I
-----
H
T
S
-----
L
Y
G
----
T
Y
H
V
S
N
T
--
G
S
--
C
S
W
F
E
F
A
K
K
I
F
S
Y
-----
A
N
M
-----
K
V
-
N
V
-----
L
P
V
S
T
-----
E
E
F
G
A
A
A
A
R
P
K
Y
S
I
-
F
Q
-
H
N
M
L
R
L
N
G
F
L
Q
M
P
S
W
E
E
G
L
E
R
F
F
I
E
T
K
---------------
4
PsiBlast_PDB
79.61
31%
-82
- C1 -
1KBZ
-
RMLD_SALTY
A:
[2-298]
------
N
I
L
L
F
G
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
------
N
L
I
A
L
---
D
V
-------
H
S
K
----
E
------
F
CG
D
F
S
N
-
P
K
G
V
A
E
T
V
--
R
--
K
L
R
P
--
D
--
V
I
V
N
A
A
A
H
T
A
V
D
K
A
E
S
-
E
-
P
E
L
A
Q
L
L
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
H
Y
S
T
D
Y
V
F
P
G
T
G
D
I
--------
P
W
Q
E
T
D
A
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
A
L
Q
D
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
---
A
G
K
G
N
N
---
F
-
A
K
T
M
-
L
R
L
A
K
E
R
Q
T
L
S
V
I
----
N
D
Q
Y
G
A
P
T
G
A
E
L
L
A
D
C
T
A
H
A
I
R
V
A
L
N
-----
K
P
E
V
----
A
G
-----
L
Y
H
L
V
A
G
--
G
T
--
T
T
W
H
D
Y
A
A
L
V
F
D
E
A
R
K
A
G
I
T
L
-----
A
L
T
E
L
-----
N
A
V
P
T
-----
S
A
Y
P
T
P
A
S
R
P
G
N
S
R
-
L
N
T
E
K
F
Q
R
N
F
D
L
-
I
L
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-----------
7
PsiBlast_PDB
79.19
31%
-83
- C1 -
1N2S
2
RMLD_SALTY
A:
[2-298]
------
N
I
L
L
F
G
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
------
N
L
I
A
L
---
D
V
-------
H
S
K
----
E
------
F
CG
D
F
S
N
-
P
K
G
V
A
E
T
V
--
R
--
K
L
R
P
--
D
--
V
I
V
N
A
A
A
H
T
A
V
D
K
A
E
S
-
E
-
P
E
L
A
Q
L
L
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
H
Y
S
T
D
Y
V
F
P
G
T
G
D
I
--------
P
W
Q
E
T
D
A
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
A
L
Q
D
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
---
A
G
K
G
N
N
---
F
-
A
K
T
M
-
L
R
L
A
K
E
R
Q
T
L
S
V
I
----
N
D
Q
Y
G
A
P
T
G
A
E
L
L
A
D
C
T
A
H
A
I
R
V
A
L
N
-----
K
P
E
V
----
A
G
-----
L
Y
H
L
V
A
G
--
G
T
--
T
T
W
H
D
Y
A
A
L
V
F
D
E
A
R
K
A
G
I
T
L
-----
A
L
T
E
L
-----
N
A
V
P
T
-----
S
A
Y
P
T
P
A
S
R
P
G
N
S
R
-
L
N
T
E
K
F
Q
R
N
F
D
L
-
I
L
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-----------
5
PsiBlast_PDB
77.44
31%
-81
- C1 -
1KC1
3
RMLD_SALTY
A:
[2-298]
------
N
I
L
L
F
G
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
------
N
L
I
A
L
---
D
V
-------
H
S
K
----
E
------
F
CG
D
F
S
N
-
P
K
G
V
A
E
T
V
--
R
--
K
L
R
P
--
D
--
V
I
V
N
A
A
A
H
T
A
V
D
K
A
E
S
-
E
-
P
E
L
A
Q
L
L
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
H
Y
S
T
D
Y
V
F
P
G
T
G
D
I
--------
P
W
Q
E
T
D
A
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
A
L
Q
D
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
---
A
G
K
G
N
N
---
F
-
A
K
T
M
-
L
R
L
A
K
E
R
Q
T
L
S
V
I
----
N
D
Q
Y
G
A
P
T
G
A
E
L
L
A
D
C
T
A
H
A
I
R
V
A
L
N
-----
K
P
E
V
----
A
G
-----
L
Y
H
L
V
A
G
--
G
T
--
T
T
W
H
D
Y
A
A
L
V
F
D
E
A
R
K
A
G
I
T
L
-----
A
L
T
E
L
-----
N
A
V
P
T
-----
S
A
Y
P
T
P
A
S
R
P
G
N
S
R
-
L
N
T
E
K
F
Q
R
N
F
D
L
-
I
L
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-----------
49
Fugue
76.36
30%
-73
- C1 -
1N2S
2
RMLD_SALTY
A:
[1-298]
-----
M
N
I
L
L
F
G
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
------
N
L
I
-
A
L
D
V
H
S
-------
K
E
F
----
C
------
G
--
D
F
S
N
-
P
K
G
V
A
E
T
V
--
R
--
K
--
L
RP
D
--
V
I
V
N
A
A
A
H
T
A
V
D
K
A
E
S
-
E
-
P
E
L
A
Q
L
L
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
H
Y
S
T
D
Y
V
F
--
P
G
T
G
D
I
------
P
W
Q
E
T
D
A
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
A
L
Q
D
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
---
A
G
K
G
N
N
---
F
-
A
K
T
M
-
L
R
L
A
K
E
R
Q
T
L
S
V
I
----
N
D
Q
Y
G
A
P
T
G
A
E
L
L
A
D
C
T
-----
A
H
A
I
-----
R
V
A
L
N
K
PE
V
A
G
----
L
Y
H
L
V
A
G
--
G
T
--
T
T
W
H
D
Y
A
A
L
V
F
D
E
-----
A
R
K
A
GITL
A
L
T
E
L
-----
N
A
V
P
T
-----
S
A
Y
P
T
P
A
S
R
P
G
N
S
R
-
L
N
T
E
K
F
Q
R
N
F
D
L
-
I
L
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-----------
50
Fugue
75.93
26%
-87
- C1 -
4NDN
1
MAT2B_HUMAN
F:
[15-323]
I
P
N
R
--
R
V
L
V
T
G
A
T
G
L
L
G
R
A
V
H
K
E
F
Q
Q
N
N
------
W
H
A
-
V
---
G
C
GFRRARP
K
F
E
----
Q
------
V
--
N
L
L
D
-
S
N
A
V
H
H
I
I
--
H
--
D
--
F
--
Q
PH
V
I
V
H
C
A
A
-----
E
R
R
P
-
D
-
V
D
A
A
S
Q
L
N
V
D
A
S
G
N
L
A
K
E
A
A
A
V
G
A
F
L
I
Y
I
S
S
D
Y
V
F
--
D
G
T
-----
N
--
P
P
Y
R
E
E
D
I
P
A
P
L
N
L
Y
G
K
T
K
L
D
G
E
K
A
V
L
E
N
N
L
G
A
A
V
L
R
I
P
I
L
Y
--
G
E
V
E
K
L
E
ESA
V
-
T
V
M
F
-
D
K
V
Q
F
S
N
K
S
A
N
M
D
----
H
W
Q
Q
R
F
P
T
H
V
K
D
V
A
T
V
C
-----
R
Q
L
A
-----
E
K
R
M
----
L
D
P
SIKG
T
F
H
W
S
G
N
--
E
Q
--
M
T
K
Y
E
M
A
C
A
I
A
D
A
-----
F
N
L
-----
P
S
S
H
L
-----
R
P
I
T
D
-----
S
--
P
V
L
G
A
Q
R
P
R
N
A
Q
L
D
C
S
K
L
E
T
L
G
I
G
-
Q
R
T
P
F
R
I
G
I
K
E
S
L
W
P
F
L
----
I
D
K
R
W
R
Q
T
V
F
H
6
PsiBlast_PDB
75.62
31%
-78
- C1 -
1KC3
2
RMLD_SALTY
A:
[2-298]
------
N
I
L
L
F
G
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
------
N
L
I
A
L
---
D
V
-------
H
S
K
----
E
------
F
CG
D
F
S
N
-
P
K
G
V
A
E
T
V
--
R
--
K
L
R
P
--
D
--
V
I
V
N
A
A
A
H
T
A
V
D
K
A
E
S
-
E
-
P
E
L
A
Q
L
L
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
H
Y
S
T
D
Y
V
F
PG
T
G
D
I
--------
P
W
Q
E
T
D
A
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
A
L
Q
D
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
---
A
G
K
G
N
N
---
F
-
A
K
T
M
-
L
R
L
A
K
E
R
Q
T
L
S
V
I
----
N
D
Q
Y
G
A
P
T
G
A
E
L
L
A
D
C
T
A
H
A
I
R
V
A
L
N
-----
K
P
E
V
----
A
G
-----
L
Y
H
L
V
A
G
--
G
T
--
T
T
W
H
D
Y
A
A
L
V
F
D
E
A
R
K
A
G
I
T
L
-----
A
L
T
E
L
-----
N
A
V
P
T
-----
S
A
Y
P
T
P
A
S
R
P
G
N
S
R
-
L
N
T
E
K
F
Q
R
N
F
D
L
-
I
L
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-----------
9
PsiBlast_PDB
74.10
28%
-94
- C1 -
2YDX
7
MAT2B_HUMAN
A:
[2-267]
----
N
R
R
V
L
V
T
G
A
T
G
L
L
G
R
A
V
H
K
E
F
Q
Q
N
N
------
W
H
A
-
V
---
G
C
G
F
RRARP
K
F
E
----
Q
------
V
--
N
L
L
D
-
S
N
A
V
H
H
I
I
--
H
D
F
Q
--
P
--
H
--
V
I
V
H
C
A
A
E
R
R
P
D
V
V
E
N
-
Q
-
P
D
A
A
S
Q
L
N
V
D
A
S
G
N
L
A
K
E
A
A
A
V
G
A
F
L
I
Y
I
S
S
D
Y
V
F
--
D
----
G
T
N
P
---
P
Y
R
E
E
D
I
P
A
P
L
N
L
Y
G
K
T
K
L
D
G
E
K
A
V
L
E
N
N
L
G
A
A
V
L
R
I
P
I
L
Y
GE
V
E
K
L
E
E
S
---
A
-
V
T
V
M
F
D
K
V
Q
F
S
N
K
S
A
N
M
D
----
H
W
Q
Q
R
F
P
T
H
V
K
D
V
A
T
V
C
-----
R
Q
L
A
E
K
R
M
L
D
P
S
I
----
K
G
T
----
F
H
W
S
G
N
E
--
Q
---
M
T
K
Y
E
M
A
C
A
I
A
D
A
-----
F
N
L
-----
P
S
S
H
L
-----
R
P
I
T
D
S
P
V
L
G
A
Q
R
P
R
N
A
-----------------------------------------------------
10
PsiBlast_PDB
73.72
28%
-88
- C1 -
4KTT
-
MAT2B_HUMAN
E:
[21-286]
----
N
R
R
V
L
V
T
G
A
T
G
L
L
G
R
A
V
H
K
E
F
Q
Q
N
N
------
W
H
A
-
V
---
G
C
G
F
R
RARP
K
F
E
----
Q
------
V
--
N
L
L
D
-
S
N
A
V
H
H
I
I
--
H
D
F
Q
--
P
--
H
--
V
I
V
H
C
A
A
E
R
R
P
D
V
V
E
N
-
Q
-
P
D
A
A
S
Q
L
N
V
D
A
S
G
N
L
A
K
E
A
A
A
V
G
A
F
L
I
Y
I
S
S
D
Y
V
F
--
D
----
G
T
N
P
---
P
Y
R
E
E
D
I
P
A
P
L
N
L
Y
G
K
T
K
L
D
G
E
K
A
V
L
E
N
N
L
G
A
A
V
L
R
I
P
I
L
Y
GE
V
E
K
L
E
E
S
---
A
-
V
T
V
M
F
D
K
V
Q
F
S
N
K
S
A
N
M
D
----
H
W
Q
Q
R
F
P
T
H
V
K
D
V
A
T
V
C
-----
R
Q
L
A
E
K
R
M
L
D
P
S
I
----
K
G
T
----
F
H
W
S
G
N
E
--
Q
---
M
T
K
Y
E
M
A
C
A
I
A
D
A
-----
F
N
L
-----
P
S
S
H
L
-----
R
P
I
T
D
SPVL--
Q
R
P
R
N
A
-----------------------------------------------------
44
HHSearch
70.81
31%
-70
- C1 -
1N2S
2
RMLD_SALTY
A:
[1-297]
-----
M
N
I
L
L
F
G
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
------
N
-
L
-
I
---
A
L
-------
D
V
H
SKEF
C
------
G
--
D
F
S
N
-
P
K
G
V
A
E
T
V
--
R
K
L
R
--
P
--
D
--
V
I
V
N
A
A
A
H
T
A
V
D
K
A
E
S
-
E
-
P
E
L
A
Q
L
L
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
H
Y
S
T
D
Y
V
F
--
P
G
T
G
----
D
--
I
P
W
Q
E
T
D
A
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
A
L
Q
D
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
--
A
G
K
-
G
N
N
---
F
-
A
K
T
M
-
L
R
L
A
K
E
R
Q
T
L
S
V
I
ND
Q
Y
G
A
P
T
G
A
E
L
L
A
D
C
T
A
H
A
I
-----
R
V
A
L
-----
N
K
P
E
----
V
A
G
----
L
Y
H
L
V
A
G
--
G
T
--
T
T
W
H
D
Y
A
A
L
V
F
D
E
-----
A
R
K
-----
A
G
I
T
L
ALT
E
L
N
A
V
P
T
-----
S
A
Y
P
T
P
A
S
R
P
G
N
S
R
-
L
N
T
E
K
F
Q
R
N
F
D
L
-
I
L
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
------------
26
PsiBlast_CBE
65.92
32%
-93
- C1 -
2GGS
1
?
B:
[2-238]
------
R
T
L
I
T
G
A
S
G
Q
L
G
I
E
L
S
R
L
L
S
E
R
H
------
E
V
I
-
K
---
V
Y
-------
N
S
S
----
E
IQGGYK
L
--
D
L
T
D
F
P
R
L
E
D
F
I
I
--
K
--
K
--
R
P-
D
--
V
I
I
N
A
A
A
M
T
D
V
D
K
C
E
I
-
E
-
K
E
K
A
Y
K
I
N
A
E
A
V
R
H
I
V
R
A
G
K
V
I
D
S
Y
I
V
H
I
S
T
D
Y
V
F
--
D
G
E
K
G
N
-------
Y
K
E
E
D
I
P
N
P
I
N
Y
Y
G
L
S
K
L
L
G
E
T
F
A
L
Q
--
D
D
S
L
I
I
R
T
S
G
I
F
-----
R
N
K
G
---
F
P
I
Y
V
Y
-
K
T
L
K
--
E
G
K
T
V
F
A
----
F
K
G
Y
Y
S
P
I
S
A
R
K
L
A
S
A
I
-----
L
E
L
L
-----
E
L
R
K
----
T
G
-----
I
I
H
V
A
G
E
--
R
---
I
S
R
F
E
L
A
L
K
I
K
E
K
-----
F
N
L
------
P
G
E
V
-----
K
E
V
D
E
-----
V
R
----------------------------------------------------------
8
PsiBlast_PDB
61.89
32%
-84
- C1 -
2GGS
1
?
A:
[2-238]
------
R
T
L
I
T
G
A
S
G
Q
L
G
I
E
L
S
R
L
L
S
E
R
H
------
E
V
I
-
K
---
V
Y
-------
N
S
S
----
E
IQG
G
Y
K
L
--
D
L
T
D
F
P
R
L
E
D
F
I
I
--
K
--
K
--
R
P-
D
--
V
I
I
N
A
A
A
M
T
D
V
D
K
C
E
I
-
E
-
K
E
K
A
Y
K
I
N
A
E
A
V
R
H
I
V
R
A
G
K
V
I
D
S
Y
I
V
H
I
S
T
D
Y
V
F
--
D
G
E
K
G
N
-------
Y
K
E
E
D
I
P
N
P
I
N
Y
Y
G
L
S
K
L
L
G
E
T
F
A
L
Q
--
D
D
S
L
I
I
R
T
S
G
I
F
-----
R
N
K
G
---
F
P
I
Y
V
Y
-
K
T
L
K
--
E
G
K
T
V
F
A
----
F
K
G
Y
Y
S
P
I
S
A
R
K
L
A
S
A
I
-----
L
E
L
L
-----
E
L
R
K
----
T
G
-----
I
I
H
V
A
G
E
--
R
---
I
S
R
F
E
L
A
L
K
I
K
E
K
-----
F
N
L
------
P
G
E
V
-----
K
E
V
D
E
-----
V
R
----------------------------------------------------------
48
Fugue
54.52
30%
-59
- C1 -
2GGS
1
?
A:
[1-273]
-----
M
R
T
L
I
T
G
A
S
G
Q
L
G
I
E
L
S
R
L
L
S
E
R
H
E
V
I
K
V
Y
N
S
S
-
E
---
I
Q
-------
G
G
Y
----
K
------
L
--
D
L
T
D
-
F
P
R
L
E
D
F
I
--
I
--
K
--
K
RP
D
--
V
I
I
N
A
A
A
M
T
D
V
D
K
C
E
I
-
E
-
K
E
K
A
Y
K
I
N
A
E
A
V
R
H
I
V
R
A
G
K
V
I
D
S
Y
I
V
H
I
S
T
D
Y
V
F
--
D
G
E
-----
K
--
G
N
Y
K
E
E
D
I
P
N
P
I
N
Y
Y
G
L
S
K
L
L
G
E
T
F
A
L
Q
--
D
D
S
L
I
I
R
T
S
G
I
F
--
R
N
---
K
G
---
F
-
P
I
Y
V
-
Y
K
T
L
K
E
G
K
T
V
F
A
F
----
K
-
G
Y
Y
S
P
I
S
A
R
K
L
A
S
A
I
-----
L
E
L
L
-----
E
L
R
K
----
T
G
-----
I
I
H
V
A
G
E
--
R
---
I
S
R
F
E
L
A
L
K
I
K
E
K
-----
F
N
------
L
P
G
E
V
-----
K
E
V
D
E
------
V
R
G
W
I
A
K
R
P
Y
D
S
S
-
L
D
S
S
R
A
R
K
I
L
S
T
-
D
F
Y
T
L
D
L
D
G
M
V
V
--------------------