@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3406: (2016-05-19 )
MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG
Atome Classification :
(54 SA)
.........10........20........30........40........50.-.......60......-.-.70....--.....80........--90-.-..--..---------...100.......110.......120.......130.......140.......150....---...160-.---.-----.....170........180.......190......-.200-.-......210.......220.......230.......240.......250..-..-...-260.......270.......280.......290...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTD
L
I
T
V
K
K
L
G
S
R
IGAQID
G
V
R
LGGDL
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
FRGQHQ-L
D
D
A
E
Q
L
A
F
A
G
LLGT-P-IG-HP
A
A
--
I
A
LADDA
P
I
I
TPINS--EF-G-KA--N
R
---------
W
H
T
D
V
T
F
AANY
P
A
A
S
V
L
R
A
VSLPSYGGS
T
L
WAN
T
A
A
A
Y
AEL
P
E
P
L
K
C
L
T
E
N
L
W
A
LHTNRY---
D
Y
VTTK-P---
L
-----
T
A
A
Q
R
A
-
F
R
Q
V
FEKPDFRTEH
P
V
V
R
VHPETG
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
VGLDSH
E
S
R
V
L
F
E
V
L
Q
R
RITMPEN
T
I
R
W
NWAPG
D
V
A
I
WDNRATQHRA-ID-DY
D
-
D
Q
H
R
L
M
H
R
V
TLMGDVPVDVYG
Q
A
S
RVISGAPMEIAG
1
PsiBlast_PDB
97.37
100%
-100
- C4 -
4CVY
2
ATSK_MYCTU
A:
[5-293]
----
I
T
V
K
K
L
G
S
R
I
G
A
Q
I
D
G
V
R
L
G
G
D
L
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
F
R
G
Q
H
Q
-
L
D
D
A
E
Q
L
A
F
A
G
L
L
G
T
-
P
-
I
----------------------------------
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
V
L
R
A
V
S
L
P
S
Y
G
G
S
T
L
W
A
N
T
A
A
A
Y
A
E
L
P
E
P
L
K
C
L
T
E
N
L
W
A
L
H
T
N
-------------------------------------
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
V
G
L
D
S
H
E
S
R
V
L
F
E
V
L
Q
R
R
I
T
M
P
E
N
T
I
R
W
N
W
A
P
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
M
H
R
V
T
L
M
G
D
V
P
V
D
V
Y
G
Q
A
S
R
V
I
S
G
A
P
M
E
I
--
69
HHSearch
97.19
100%
-101
- C4 -
4CVY
2
ATSK_MYCTU
A:
[5-293]
----
I
T
V
K
K
L
G
S
R
I
G
A
Q
I
D
G
V
R
L
G
G
D
L
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
F
R
G
Q
-
H
Q
L
D
D
A
E
Q
L
A
F
A
G
L
L
G
T
-
P
-
I
----------------------------------
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
V
L
R
A
V
S
L
P
S
Y
G
G
S
T
L
W
A
N
T
A
A
A
Y
A
E
L
P
E
P
L
K
C
L
T
E
N
L
W
A
L
H
T
N
-------------------------------------
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
V
G
L
D
S
H
E
S
R
V
L
F
E
V
L
Q
R
R
I
T
M
P
E
N
T
I
R
W
N
W
A
P
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
M
H
R
V
T
L
M
G
D
V
P
V
D
V
Y
G
Q
A
S
R
V
I
S
G
A
P
M
E
I
--
2
PsiBlast_PDB
97.12
100%
-100
- C4 -
4FFA
1
ATSK_MYCTU
A:
[8-296]
----
I
T
V
K
K
L
G
S
R
I
G
A
Q
I
D
G
V
R
L
G
G
D
L
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
F
R
G
Q
H
Q
-
L
D
D
A
E
Q
L
A
F
A
G
L
L
G
T
-
P
-
I
----------------------------------
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
V
L
R
A
V
S
L
P
S
Y
G
G
S
T
L
W
A
N
T
A
A
A
Y
A
E
L
P
E
P
L
K
C
L
T
E
N
L
W
A
L
H
T
N
R
-----------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
V
G
L
D
S
H
E
S
R
V
L
F
E
V
L
Q
R
R
I
T
M
P
E
N
T
I
R
W
N
W
A
P
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
M
H
R
V
T
L
M
G
D
V
P
V
D
V
Y
G
Q
A
S
R
V
I
S
G
A
P
M
E
I
--
23
PsiBlast_CBE
96.63
100%
-98
- C4 -
4CVY
1
ATSK_MYCTU
B:
[5-290]
----
I
T
V
K
K
L
G
S
R
I
G
A
Q
I
D
G
V
R
L
G
G
D
L
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
F
R
G
Q
H
Q
-
L
D
D
A
E
Q
L
A
F
A
G
L
L
G
T
-
P
-
I
-------------------------------
A
--
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
V
L
R
A
V
S
L
P
S
Y
G
G
S
T
L
W
A
N
T
A
A
A
Y
A
E
L
P
E
P
L
K
C
L
T
E
N
L
W
A
L
H
T
N
R
-----------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
V
G
L
D
S
H
E
S
R
V
L
F
E
V
L
Q
R
R
I
T
M
P
E
N
T
I
R
W
N
W
A
P
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
M
H
R
V
T
L
M
G
D
V
P
V
D
V
Y
G
Q
A
S
R
V
I
S
G
A
P
-----
21
PsiBlast_CBE
95.69
100%
-100
- C4 -
4CVY
1
ATSK_MYCTU
D:
[4-287]
---
L
I
T
V
K
K
L
G
S
R
I
G
A
Q
I
D
G
V
R
L
G
G
D
L
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
F
R
G
Q
H
Q
-
L
D
D
A
E
Q
L
A
F
A
G
L
L
G
T
-
P
-
I
----------------------------------
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
V
L
R
A
V
S
L
P
S
Y
G
G
S
T
L
W
A
N
T
A
A
A
Y
A
E
L
P
E
P
L
K
C
L
T
E
N
L
W
A
L
H
T
N
-------------------------------------
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
V
G
L
D
S
H
E
S
R
V
L
F
E
V
L
Q
R
R
I
T
M
P
E
N
T
I
R
W
N
W
A
P
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
M
H
R
V
T
L
M
G
D
V
P
V
D
V
Y
G
Q
A
S
R
V
I
S
--------
22
PsiBlast_CBE
95.15
100%
-101
- C4 -
4CVY
1
ATSK_MYCTU
C:
[4-286]
---
L
I
T
V
K
K
L
G
S
R
I
G
A
Q
I
D
G
V
R
L
G
G
D
L
D
P
A
A
V
N
E
I
R
A
A
L
L
A
H
K
V
V
F
F
R
G
Q
H
Q
-
L
D
D
A
E
Q
L
A
F
A
G
L
L
G
T
-
P
-
I
-------------------------------
A
--
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
V
L
R
A
V
S
L
P
S
Y
G
G
S
T
L
W
A
N
T
A
A
A
Y
A
E
L
P
E
P
L
K
C
L
T
E
N
L
W
A
L
H
T
N
------------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
S
F
V
G
L
D
S
H
E
S
R
V
L
F
E
V
L
Q
R
R
I
T
M
P
E
N
T
I
R
W
N
W
A
P
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
M
H
R
V
T
L
M
G
D
V
P
V
D
V
Y
G
Q
A
S
R
V
I
---------
24
PsiBlast_CBE
94.50
83%
-98
- C4 -
3SWT
2
?
B:
[8-301]
---
L
I
T
V
K
K
L
G
S
R
I
G
A
Q
V
D
G
V
S
L
G
A
D
L
D
A
A
A
V
D
Q
I
R
A
A
L
L
E
H
K
V
I
F
F
R
N
Q
H
H
-
L
D
D
Q
Q
Q
L
Q
F
A
G
L
L
G
T
-
P
-
I
G
-
H
-------------------------------
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
I
L
R
A
V
T
L
P
N
Y
G
G
S
T
L
W
A
N
T
A
T
A
Y
A
E
L
P
E
P
L
K
C
L
V
E
N
L
W
A
L
H
T
N
R
-----------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
G
F
V
G
L
D
S
Q
E
S
S
A
L
F
E
L
L
Q
R
R
I
T
S
P
E
N
T
I
R
W
N
W
E
S
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
L
H
R
V
T
L
M
G
D
V
P
V
D
V
H
G
Q
R
S
R
V
I
S
G
A
P
L
A
L
A
-
3
PsiBlast_PDB
94.04
83%
-100
- C4 -
3SWT
2
?
A:
[8-300]
---
L
I
T
V
K
K
L
G
S
R
I
G
A
Q
V
D
G
V
S
L
G
A
D
L
D
A
A
A
V
D
Q
I
R
A
A
L
L
E
H
K
V
I
F
F
R
N
Q
H
H
-
L
D
D
Q
Q
Q
L
Q
F
A
G
L
L
G
T
-
P
-
I
-------------------------------
A
--
N
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
I
L
R
A
V
T
L
P
N
Y
G
G
S
T
L
W
A
N
T
A
T
A
Y
A
E
L
P
E
P
L
K
C
L
V
E
N
L
W
A
L
H
T
N
R
-----------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
T
L
-
L
A
G
D
-
F
-
V
R
G
F
V
G
L
D
S
Q
E
S
S
A
L
F
E
L
L
Q
R
R
I
T
S
P
E
N
T
I
R
W
N
W
E
S
G
D
V
A
I
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
H
R
L
L
H
R
V
T
L
M
G
D
V
P
V
D
V
H
G
Q
R
S
R
V
I
S
G
A
P
L
A
L
--
4
PsiBlast_PDB
93.60
79%
-100
- C4 -
3R1J
4
?
A:
[9-298]
----
I
T
V
T
K
L
G
S
R
I
G
A
R
V
D
G
V
R
L
G
G
D
L
D
D
A
T
V
E
Q
I
R
R
A
L
L
T
H
K
V
I
F
F
R
H
Q
H
H
-
L
D
D
S
R
Q
L
E
F
A
R
L
L
G
T
-
P
-
I
G
------------------------------
A
--
T
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
I
L
R
A
V
T
L
P
S
Y
G
G
S
T
L
W
A
S
T
V
A
A
Y
Q
Q
L
P
E
P
L
R
H
L
T
E
N
L
W
A
L
H
T
N
R
-----------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
A
L
-
L
A
G
D
-
F
-
V
R
G
F
V
G
L
D
G
H
E
S
S
V
L
L
E
L
L
Q
R
R
I
T
M
P
E
N
T
V
R
W
S
W
A
P
G
D
V
A
M
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
P
R
L
M
H
R
I
T
L
M
G
D
V
P
V
N
V
H
G
E
R
S
R
V
I
S
G
A
P
L
E
V
--
25
PsiBlast_CBE
92.71
79%
-99
- C4 -
3R1J
4
?
B:
[9-296]
----
I
T
V
T
K
L
G
S
R
I
G
A
R
V
D
G
V
R
L
G
G
D
L
D
D
A
T
V
E
Q
I
R
R
A
L
L
T
H
K
V
I
F
F
R
H
Q
H
H
-
L
D
D
S
R
Q
L
E
F
A
R
L
L
G
T
-
P
-
I
-------------------------------
A
--
T
R
---------
W
H
T
D
V
T
F
A
A
N
Y
P
A
A
S
I
L
R
A
V
T
L
P
S
Y
G
G
S
T
L
W
A
S
T
V
A
A
Y
Q
Q
L
P
E
P
L
R
H
L
T
E
N
L
W
A
L
H
T
N
R
-----------------------------------
P
D
F
R
T
E
H
P
V
V
R
V
H
P
E
T
G
E
R
A
L
-
L
A
G
D
-
F
-
V
R
G
F
V
G
L
D
G
H
E
S
S
V
L
L
E
L
L
Q
R
R
I
T
M
P
E
N
T
V
R
W
S
W
A
P
G
D
V
A
M
W
D
N
R
A
T
Q
H
R
A
-
I
D
-
D
Y
D
-
D
Q
P
R
L
M
H
R
I
T
L
M
G
D
V
P
V
N
V
H
G
E
R
S
R
V
I
S
G
A
P
L
----
31
PsiBlast_CBE
92.01
63%
-91
- C4 -
4J5I
1
?
B:
[8-288]
----
V
T
V
T
K
L
G
A
H
I
G
A
R
I
D
G
V
R
V
G
G
D
L
S
P
A
T
V
S
A
I
N
A
A
L
L
E
H
K
V
I
F
F
S
G
Q
D
H
-
L
D
D
A
G
Q
L
E
F
A
E
L
L
G
T
-
P
T
V
A
-
H
P
T
-----
L
A
E
G
A
E
Q
L
L
P
I
D
S
--
R
Y
-
D
-
K
A
--
N
S
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
L
L
R
A
V
T
L
P
S
Y
G
G
T
T
A
W
A
S
T
E
A
A
Y
Q
Q
L
P
A
P
L
R
T
L
A
D
N
L
W
A
V
H
T
N
R
---------------
I
-----
S
A
E
Q
R
G
-
Y
R
Q
R
F
E
S
D
Y
Y
E
V
E
H
P
V
V
R
V
H
P
E
T
G
E
R
V
L
-
L
L
G
H
-
F
-
V
K
S
F
V
G
L
K
D
T
E
S
A
A
L
F
R
L
F
Q
D
R
I
T
R
L
E
N
T
V
R
W
S
W
K
P
G
D
L
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
A
-
D
Y
D
-
D
Q
Y
R
R
L
N
R
V
T
L
A
G
D
I
P
V
D
V
Y
G
E
R
S
R
V
I
A
G
-------
30
PsiBlast_CBE
89.63
63%
-91
- C4 -
4J5I
1
?
C:
[8-288]
----
V
T
V
T
K
L
G
A
H
I
G
A
R
I
D
G
V
R
V
G
G
D
L
S
P
A
T
V
S
A
I
N
A
A
L
L
E
H
K
V
I
F
F
S
G
Q
D
H
-
L
D
D
A
G
Q
L
E
F
A
E
L
L
G
T
-
P
T
V
A
-
H
P
T
-----
L
A
E
G
A
E
Q
L
L
P
I
D
S
--
R
Y
-
D
-
K
A
--
N
S
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
L
L
R
A
V
T
L
P
S
Y
G
G
T
T
A
W
A
S
T
E
A
A
Y
Q
Q
L
P
A
P
L
R
T
L
A
D
N
L
W
A
V
H
T
N
R
-----------------------------------
D
Y
Y
E
V
E
H
P
V
V
R
V
H
P
E
T
G
E
R
V
L
-
L
L
G
H
-
F
-
V
K
S
F
V
G
L
K
D
T
E
S
A
A
L
F
R
L
F
Q
D
R
I
T
R
L
E
N
T
V
R
W
S
W
K
P
G
D
L
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
A
-
D
Y
D
-
D
Q
Y
R
R
L
N
R
V
T
L
A
G
D
I
P
V
D
V
Y
G
E
R
S
R
V
I
A
G
-------
27
PsiBlast_CBE
89.51
63%
-95
- C4 -
4J5I
1
?
G:
[8-288]
----
V
T
V
T
K
L
G
A
H
I
G
A
R
I
D
G
V
R
V
G
G
D
L
S
P
A
T
V
S
A
I
N
A
A
L
L
E
H
K
V
I
F
F
S
G
Q
D
H
-
L
D
D
A
G
Q
L
E
F
A
E
L
L
G
T
-
P
T
V
A
-
H
P
T
-----
L
A
E
G
A
E
Q
L
L
P
I
D
---------
A
--
N
S
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
L
L
R
A
V
T
L
P
S
Y
G
G
T
T
A
W
A
S
T
E
A
A
Y
Q
Q
L
P
A
P
L
R
T
L
A
D
N
L
W
A
V
H
T
N
R
-----------------------------------
D
Y
Y
E
V
E
H
P
V
V
R
V
H
P
E
T
G
E
R
V
L
-
L
L
G
H
-
F
-
V
K
S
F
V
G
L
K
D
T
E
S
A
A
L
F
R
L
F
Q
D
R
I
T
R
L
E
N
T
V
R
W
S
W
K
P
G
D
L
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
A
-
D
Y
D
-
D
Q
Y
R
R
L
N
R
V
T
L
A
G
D
I
P
V
D
V
Y
G
E
R
S
R
V
I
A
G
-------
38
PsiBlast_CBE
88.05
53%
-77
- C4 -
4Y0E
3
?
C:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
Y
---
D
-------SGG
V
-----
S
A
E
R
R
A
A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
33
PsiBlast_CBE
87.85
53%
-76
- C4 -
4Y0E
6
?
H:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
Y
---
D
------
A
SGG
V
-----
S
A
E
R
R
A
A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
35
PsiBlast_CBE
87.50
53%
-76
- C4 -
4Y0E
3
?
F:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
Y
---
D
------
A
SGG
V
-----
S
A
E
R
R
A
A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
7
PsiBlast_PDB
87.12
53%
-79
- C4 -
4Y0E
3
?
A:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
Y
---
D
------------------
E
R
R
A
A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
39
PsiBlast_CBE
87.07
53%
-81
- C4 -
4Y0E
3
?
B:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
Y
-------------------------
A
A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
37
PsiBlast_CBE
86.93
53%
-78
- C4 -
4Y0E
3
?
D:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
Y
--------------------------A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
36
PsiBlast_CBE
86.55
53%
-78
- C4 -
4Y0E
3
?
E:
[37-326]
----
I
T
V
E
K
L
G
E
H
I
G
A
R
V
N
G
I
E
L
R
G
D
L
S
A
D
R
V
E
A
I
R
L
A
L
A
I
N
K
V
L
V
F
T
E
Q
H
H
-
L
D
D
A
G
Q
Y
A
F
A
R
L
L
G
E
-
P
T
L
P
-
H
P
T
V
--
R
S
H
G
T
E
L
-----
L
N
L
--
E
--
G
-
A
A
--
N
G
---------
W
H
T
D
V
T
F
V
D
R
I
P
K
A
S
V
L
R
P
V
T
L
P
S
Y
G
G
A
T
T
W
A
S
T
V
A
A
Y
E
Q
L
P
K
P
L
R
S
L
V
D
D
L
W
A
T
H
T
N
L
--------------------------
A
A
Y
Y
T
E
F
T
S
S
R
Y
E
T
V
H
P
V
V
R
V
H
P
E
T
G
E
R
S
L
-
L
L
G
Q
-
F
-
V
K
S
F
Q
D
L
P
S
A
E
F
A
S
L
F
Q
L
L
Q
A
R
I
T
K
L
E
N
T
F
R
W
N
W
R
L
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
G
-
I
A
-
D
F
G
-
E
Q
Q
R
E
L
H
R
V
T
L
A
G
D
V
P
V
D
V
H
G
R
R
S
Q
I
L
L
G
D
A
S
H
Y
S
G
43
PsiBlast_CBE
84.87
53%
-90
- C4 -
1VZ4
2
ATSK_PSEPU
D:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
-
H
P
------
V
V
D
G
T
R
Y
L
L
Q
L
D
G
-------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
Y
---
D
Y
A
------------------------------
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
32
PsiBlast_CBE
84.75
54%
-90
- C4 -
1OIK
3
ATSK_PSEPU
D:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
-
H
P
------
V
V
D
G
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
R
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
9
PsiBlast_PDB
84.56
53%
-92
- C4 -
1OII
2
ATSK_PSEPU
A:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
----------
V
P
V
V
D
G
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
44
PsiBlast_CBE
84.38
53%
-90
- C4 -
1OIJ
2
ATSK_PSEPU
B:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
--------
P
V
V
D
G
T
R
Y
L
L
Q
L
D
G
-------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
5
PsiBlast_PDB
83.82
54%
-90
- C4 -
1OIJ
2
ATSK_PSEPU
A:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
--------
P
V
V
D
G
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
R
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
47
PsiBlast_CBE
83.77
53%
-89
- C4 -
1OII
2
ATSK_PSEPU
B:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
----------
V
P
V
V
D
G
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
40
PsiBlast_CBE
83.57
53%
-95
- C4 -
1VZ5
1
ATSK_PSEPU
D:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
--------------
T
R
Y
L
L
Q
L
D
---------
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
--------------------------------------
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
45
PsiBlast_CBE
83.42
53%
-95
- C4 -
1OII
2
ATSK_PSEPU
D:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
--------------
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
--------------------------------------
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
10
PsiBlast_PDB
83.17
53%
-92
- C4 -
1VZ4
2
ATSK_PSEPU
A:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
-
H
--------------
L
L
Q
L
D
-------Q
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
Y
---
D
Y
A
------------------------------
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
41
PsiBlast_CBE
83.05
53%
-90
- C4 -
1VZ5
1
ATSK_PSEPU
C:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
---------------
R
Y
L
L
Q
L
---------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
Y
-------------------------------------
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
6
PsiBlast_PDB
83.04
54%
-89
- C4 -
1OIK
3
ATSK_PSEPU
A:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
-
H
---------------------------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
R
-------------------------------------
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
11
PsiBlast_PDB
83.00
53%
-92
- C4 -
1VZ5
1
ATSK_PSEPU
A:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
--------
P
V
V
D
G
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
42
PsiBlast_CBE
82.90
53%
-92
- C4 -
1VZ5
1
ATSK_PSEPU
B:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
A
--------
P
V
V
D
G
T
R
Y
L
L
Q
L
D
--------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
------------------------------------
V
Y
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
46
PsiBlast_CBE
82.22
53%
-91
- C4 -
1OII
2
ATSK_PSEPU
C:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
------------------------------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
Y
-------------------------------------
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Q
L
S
R
-----------
51
PsiBlast_CBE
81.52
53%
-87
- C4 -
1OIJ
2
ATSK_PSEPU
C:
[15-296]
----
L
D
V
H
P
V
A
G
R
I
G
A
E
I
R
G
V
K
L
S
P
D
L
D
A
A
T
V
E
A
I
Q
A
A
L
V
R
H
K
V
I
F
F
R
G
Q
T
H
-
L
D
D
Q
S
Q
E
G
F
A
K
L
L
G
E
-
P
-
V
------------------------------
R
A
--
N
S
---------
W
H
T
D
V
T
F
V
E
A
Y
P
K
A
S
I
L
R
S
V
V
A
P
A
S
G
G
D
T
V
W
A
N
T
A
A
A
Y
Q
E
L
P
E
P
L
R
E
L
A
D
K
L
W
A
V
H
S
N
E
Y
-------------------------------------
E
T
E
H
P
V
V
R
V
H
P
I
S
G
E
R
A
L
-
Q
L
G
H
-
F
-
V
K
R
I
K
G
Y
S
L
A
D
S
Q
H
L
F
A
V
L
Q
G
H
V
T
R
L
E
N
T
V
R
W
R
W
E
A
G
D
V
A
I
W
D
N
R
A
T
Q
H
Y
A
-
V
D
-
D
Y
G
-
T
Q
P
R
I
V
R
R
V
T
L
A
G
E
V
P
V
G
V
D
G
Y
L
S
R
-----------
14
PsiBlast_PDB
80.31
38%
-76
- C4 -
1GY9
4
TAUD_ECOLI
A:
[4-278]
---
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
S
F
P
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
52
PsiBlast_CBE
80.14
43%
-83
- C4 -
5HSX
12
?
B:
[20-314]
----
I
E
V
T
P
L
S
A
H
I
G
A
E
I
H
G
V
D
L
T
Q
K
L
E
A
R
Q
I
A
E
I
R
A
A
L
L
K
W
R
V
V
F
F
R
E
Q
F
--
L
T
H
E
Q
H
V
A
F
S
A
Q
F
G
E
L
T
-
L
G
-
H
P
V
---
F
G
H
V
E
G
H
P
E
V
Y
S
I
-
S
-------------QTLQRPWTG
W
H
T
D
V
T
A
A
V
N
P
P
W
A
S
I
L
R
G
V
T
I
P
P
Y
G
G
D
T
Q
W
T
N
L
V
A
A
Y
Q
K
L
S
A
P
L
R
S
F
V
D
G
L
R
G
I
H
--
R
F
-------
T
P
-
P
------------------------
I
L
V
T
E
H
P
L
V
R
V
H
P
E
T
G
E
R
A
L
Y
V
S
P
S
-
F
-
L
K
S
I
V
G
V
S
P
R
E
S
Q
V
L
L
E
L
L
W
E
H
V
T
R
P
E
F
T
V
R
F
K
W
Q
A
G
S
V
A
F
W
D
N
R
A
T
A
H
L
A
P
T
D
-
I
F
D
L
D
F
D
R
Q
L
Y
R
T
T
L
V
G
D
V
P
V
G
P
D
G
T
Q
S
V
A
I
E
G
S
P
V
----
15
PsiBlast_PDB
79.89
38%
-74
- C4 -
1OS7
3
TAUD_ECOLI
A:
[2-278]
-
S
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
S
F
P
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
56
PsiBlast_CBE
79.53
38%
-74
- C4 -
1OS7
2
TAUD_ECOLI
D:
[3-278]
--
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
PH
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
SFP
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
57
PsiBlast_CBE
79.27
38%
-74
- C4 -
1OS7
3
TAUD_ECOLI
C:
[3-278]
--
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
PH
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
SFP
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
55
PsiBlast_CBE
79.21
38%
-73
- C4 -
1OTJ
2
TAUD_ECOLI
B:
[4-278]
---
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
SFP
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
16
PsiBlast_PDB
79.03
38%
-76
- C4 -
1OTJ
2
TAUD_ECOLI
A:
[2-278]
-
S
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
SFP
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
59
PsiBlast_CBE
78.42
38%
-74
- C4 -
1GY9
3
TAUD_ECOLI
B:
[3-278]
--
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
S
F
P
E
Y
K
Y
--------------
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
12
PsiBlast_PDB
78.29
43%
-82
- C4 -
5HSX
12
?
A:
[20-314]
----
I
E
V
T
P
L
S
A
H
I
G
A
E
I
H
G
V
D
L
T
Q
K
L
E
A
R
Q
I
A
E
I
R
A
A
L
L
K
W
R
V
V
F
F
R
E
Q
F
--
L
T
H
E
Q
H
V
A
F
S
A
Q
F
G
E
L
T
-
L
G
---
V
---
F
G
H
V
E
G
H
P
E
V
Y
S
I
-
S
--
K
Y
---------QTLQRPWTG
W
H
T
D
V
T
A
A
V
N
P
P
W
A
S
I
L
R
G
V
T
I
P
P
Y
G
G
D
T
Q
W
T
N
L
V
A
A
Y
Q
K
L
S
A
P
L
R
S
F
V
D
G
L
R
G
I
H
--
R
F
-------
T
P
-------------------------
R
I
L
V
T
E
H
P
L
V
R
V
H
P
E
T
G
E
R
A
L
Y
V
S
P
S
-
F
-
L
K
S
I
V
G
V
S
P
R
E
S
Q
V
L
L
E
L
L
W
E
H
V
T
R
P
E
F
T
V
R
F
K
W
Q
A
G
S
V
A
F
W
D
N
R
A
T
A
H
L
A
P
T
D
-
I
F
D
L
D
F
D
R
Q
L
Y
R
T
T
L
V
G
D
V
P
V
G
P
D
G
T
Q
S
V
A
I
E
G
S
P
V
----
58
PsiBlast_CBE
77.54
38%
-67
- C4 -
1OS7
3
TAUD_ECOLI
B:
[3-278]
--
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
PH
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
SFP
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
13
PsiBlast_PDB
76.98
38%
-70
- C4 -
1GQW
3
TAUD_ECOLI
A:
[4-278]
---
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
--
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
S
F
P
E
Y
K
Y
R
K
-
T
---
E
-----
E
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
72
HHSearch
76.96
43%
-75
- C4 -
5HSX
12
?
A:
[19-314]
---
S
I
E
V
T
P
L
S
A
H
I
G
A
E
I
H
G
V
D
L
T
Q
K
L
E
A
R
Q
I
A
E
I
R
A
A
L
L
K
W
R
V
V
F
F
R
E
Q
-
F
-
L
T
H
E
Q
H
V
A
F
S
A
Q
F
G
E
-
L
-
T
L
G--
V
F
---
G
H
V
E
G
H
P
E
V
Y
S
I
S
K
YQ
T
L
Q
R
-
P
W
--
T
G
---------
W
H
T
D
V
T
A
A
V
N
P
P
W
A
S
I
L
R
G
V
T
I
P
P
Y
G
G
D
T
Q
W
T
N
L
V
A
A
Y
Q
K
L
S
A
P
L
R
S
F
V
D
G
L
R
G
I
H
R
F
T
P
----------------------------------
R
I
L
V
T
E
H
P
L
V
R
V
H
P
E
T
G
E
R
A
L
-
Y
V
S
P
-
S
F
L
K
S
I
V
G
V
S
P
R
E
S
Q
V
L
L
E
L
L
W
E
H
V
T
R
P
E
F
T
V
R
F
K
W
Q
A
G
S
V
A
F
W
D
N
R
A
T
A
H
L
A
-
P
T
D
I
F
D
L
D
F
D
R
Q
L
Y
R
T
T
L
V
G
D
V
P
V
G
P
D
G
T
Q
S
V
A
I
E
G
S
P
V
----
19
PsiBlast_PDB
76.76
36%
-81
- C4 -
3V17
1
?
A:
[3-276]
----
L
T
I
T
P
L
S
P
A
L
G
A
Q
I
S
G
V
D
I
S
R
D
I
S
A
E
E
R
D
A
I
E
Q
A
L
L
Q
H
Q
V
L
F
L
R
D
Q
-
P
-
I
N
P
E
Q
Q
A
R
F
A
A
R
F
G
D
-
L
-
H
I
-
H
P
I
Y
--
P
N
V
P
D
-
T
P
Q
V
L
V
L
D
T
--
A
V
-
T
-
D
V
--
R
D
NAV------
W
H
T
D
V
T
F
L
P
T
P
A
L
G
A
V
L
S
A
K
Q
L
P
A
Y
G
G
D
T
L
W
A
S
G
I
A
A
F
E
A
L
S
A
P
L
R
E
M
L
D
G
L
T
A
T
H
-------
D
F
T
K
S
F
-
P
---
L
ERFGT
T
P
Q
D
L
A
-
R
W
E
A
T
R
R
N
N
P
P
L
S
H
P
V
V
R
T
H
P
V
S
G
R
K
A
L
-
F
V
N
E
G
F
-
T
T
R
I
N
E
L
S
E
L
E
S
D
A
L
L
R
L
L
F
A
H
A
T
R
P
E
F
S
I
R
W
R
W
Q
E
N
D
V
A
F
W
D
N
R
V
T
Q
H
F
A
-
V
D
-
D
Y
R
-
P
N
R
R
V
M
H
R
A
T
I
L
G
D
A
P
--------------------
61
PsiBlast_CBE
76.58
36%
-82
- C4 -
3V17
1
?
D:
[3-276]
----
L
T
I
T
P
L
S
P
A
L
G
A
Q
I
S
G
V
D
I
S
R
D
I
S
A
E
E
R
D
A
I
E
Q
A
L
L
Q
H
Q
V
L
F
L
R
D
Q
-
P
-
I
N
P
E
Q
Q
A
R
F
A
A
R
F
G
D
-
L
-
H
I
-
H
P
I
Y
--
P
N
V
P
D
-
T
P
Q
V
L
V
L
D
T
--
A
V
-
T
-
D
V
--
R
D
NAV------
W
H
T
D
V
T
F
L
P
T
P
A
L
G
A
V
L
S
A
K
Q
L
P
A
Y
G
G
D
T
L
W
A
S
G
I
A
A
F
E
A
L
S
A
P
L
R
E
M
L
D
G
L
T
A
T
H
-------
D
F
T
K
S
F
-
P
---
L
ERFGT
T
P
Q
D
L
A
-
R
W
E
A
T
R
R
N
N
P
P
L
S
H
P
V
V
R
T
H
P
V
S
G
R
K
A
L
-
F
V
N
E
G
F
-
T
T
R
I
N
E
L
S
E
L
E
S
D
A
L
L
R
L
L
F
A
H
A
T
R
P
E
F
S
I
R
W
R
W
Q
E
N
D
V
A
F
W
D
N
R
V
T
Q
H
F
A
-
V
D
-
D
Y
R
-
P
N
R
R
V
M
H
R
A
T
I
L
G
D
A
P
--------------------
62
PsiBlast_CBE
76.21
36%
-77
- C4 -
3V17
1
?
C:
[3-276]
----
L
T
I
T
P
L
S
P
A
L
G
A
Q
I
S
G
V
D
I
S
R
D
I
S
A
E
E
R
D
A
I
E
Q
A
L
L
Q
H
Q
V
L
F
L
R
D
Q
-
P
-
I
N
P
E
Q
Q
A
R
F
A
A
R
F
G
D
-
L
-
H
I
-
H
P
I
Y
--
P
N
V
P
D
-
T
P
Q
V
L
V
L
D
T
--
A
V
-
T
-
D
V
--
R
D
NAV------
W
H
T
D
V
T
F
L
P
T
P
A
L
G
A
V
L
S
A
K
Q
L
P
A
Y
G
G
D
T
L
W
A
S
G
I
A
A
F
E
A
L
S
A
P
L
R
E
M
L
D
G
L
T
A
T
H
-------
D
F
T
K
S
F
-
P
---
L
ERFGT
T
P
Q
D
L
A
-
R
W
E
A
T
R
R
N
N
P
P
L
S
H
P
V
V
R
T
H
P
V
S
G
R
K
A
L
-
F
V
N
E
G
F
-
T
T
R
I
N
E
L
S
E
L
E
S
D
A
L
L
R
L
L
F
A
H
A
T
R
P
E
F
S
I
R
W
R
W
Q
E
N
D
V
A
F
W
D
N
R
V
T
Q
H
F
A
-
V
D
-
D
Y
R
-
P
N
R
R
V
M
H
R
A
T
I
L
G
D
A
P
--------------------
91
Fugue
76.16
37%
-75
- C4 -
1GY9
4
TAUD_ECOLI
A:
[4-282]
---
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
L
T
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
A
--
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
--
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
--
N
D
-
N
-
P
P
DN
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
---
S
F
P
E
Y
K
Y
R
---
K
-----
T
E
E
E
H
Q
-
R
W
R
E
A
V
A
K
N
P
P
L
L
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
F
V
N
E
G
-
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
---
F
Y
R
A
-------------
60
PsiBlast_CBE
75.83
38%
-70
- C4 -
1GQW
3
TAUD_ECOLI
B:
[3-278]
--
E
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
--
R
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
-
A
-
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
N
D
--
N
P
-
P
-
D
N
--
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
S
F
P
E
Y
K
Y
--------------
E
H
Q
R
W
-
R
E
A
V
A
K
N
P
P
L
L
--
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
-
F
V
N
E
G
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
--------------------
63
PsiBlast_CBE
75.35
36%
-78
- C4 -
3V17
1
?
B:
[3-276]
----
L
T
I
T
P
L
S
P
A
L
G
A
Q
I
S
G
V
D
I
S
R
D
I
S
A
E
E
R
D
A
I
E
Q
A
L
L
Q
H
Q
V
L
F
L
R
D
Q
-
P
-
I
N
P
E
Q
Q
A
R
F
A
A
R
F
G
D
-
L
-
H
I
-
H
P
I
Y
--
P
N
V
P
D
-
T
P
Q
V
L
V
L
D
T
--
A
V
-
T
-
D
V
--
R
D
NAV------
W
H
T
D
V
T
F
L
P
T
P
A
L
G
A
V
L
S
A
K
Q
L
P
A
Y
G
G
D
T
L
W
A
S
G
I
A
A
F
E
A
L
S
A
P
L
R
E
M
L
D
G
L
T
A
T
H
-------
D
F
T
K
S
F
-
P
---
L
ERFGT
T
P
Q
D
L
A
-
R
W
E
A
T
R
R
N
N
P
P
L
S
H
P
V
V
R
T
H
P
V
S
G
R
K
A
L
-
F
V
N
E
G
F
-
T
T
R
I
N
E
L
S
E
L
E
S
D
A
L
L
R
L
L
F
A
H
A
T
R
P
E
F
S
I
R
W
R
W
Q
E
N
D
V
A
F
W
D
N
R
V
T
Q
H
F
A
-
V
D
-
D
Y
R
-
P
N
R
R
V
M
H
R
A
T
I
L
G
D
A
P
--------------------
92
Fugue
72.65
37%
-66
- C4 -
1GQW
3
TAUD_ECOLI
A:
[4-282]
---
R
L
S
I
T
P
L
G
P
Y
I
G
A
Q
I
S
G
A
D
R
--
P
L
S
D
N
Q
F
E
Q
L
Y
H
A
V
L
R
H
Q
V
V
F
L
R
D
Q
A
--
I
T
P
Q
Q
Q
R
A
L
A
Q
R
F
G
E
-
L
-
H
I
-
H
P
V
Y
--
P
H
A
E
G
V
D
E
I
I
V
L
D
T
H
--
N
D
-
N
-
P
P
DN
D
N
---------
W
H
T
D
V
T
F
I
E
T
P
P
A
G
A
I
L
A
A
K
E
L
P
S
T
G
G
D
T
L
W
T
S
G
I
A
A
Y
E
A
L
S
V
P
F
R
Q
L
L
S
G
L
R
A
E
H
D
F
R
K
---
S
F
P
E
Y
K
Y
R
---
K
-----
T
E
E
E
H
Q
-
R
W
R
E
A
V
A
K
N
P
P
L
L
H
P
V
V
R
T
H
P
V
S
G
K
Q
A
L
F
V
N
E
G
-
F
-
T
T
R
I
V
D
V
S
E
K
E
S
E
A
L
L
S
F
L
F
A
H
I
T
K
P
E
F
Q
V
R
W
R
W
Q
P
N
D
I
A
I
W
D
N
R
V
T
Q
H
Y
A
-
N
A
-
D
Y
L
-
P
Q
R
R
I
M
H
R
A
T
I
L
G
D
K
P
---
F
Y
R
A
-------------