@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3583c: (2016-05-21 )
MIFKVGDTVVYPHHGAALVEAIETRTIKGEQKEYLVLKVAQGDLTVRVPAENAEYVGVRDVVGQEGLDKVFQVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRRDQERGLSAGEKRMLAKARQILVGELALAESTDDAKAETILDEVLAAAS
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60........70......-..-80.--...-.....90........100....-...--110....-...120.......130.......140.......150.......160-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
F
KVG
D
T
V
V
YPHH
G
A
A
L
V
E
A
I
E
TRTIKGEQK
E
Y
L
V
L
K
V
AQG
D
L
T
V
R
VPAENA
E
Y
V
G
V
R
D
VVG
Q
E
G
L
D
K
V
F
Q
V
L
RAP-HT-E-E--PT
N
-
W
S
R
R
Y
K
A
N
L
E
K
LASG
D
V
N
K
V
A
E
-
V
V
R
--
D
L
W
R
R
D
Q
-
E
RGLSA
G
E
K
R
M
L
A
K
A
R
Q
I
L
V
G
E
L
ALAESTDD
A
K
A
E
T
I
L
D
E
V
L
AAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
96.29
100%
-115
- C4 -
4KBM
-
CARD_MYCTU
B:
[2-160]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
K
V
G
D
T
V
V
Y
P
H
H
G
A
A
L
V
E
A
I
E
T
R
----
E
Q
K
E
Y
L
V
L
K
V
A
Q
G
D
L
T
V
R
V
P
A
E
N
A
E
Y
V
G
V
R
D
V
V
G
Q
E
G
L
D
K
V
F
Q
V
L
R
A
P
-------------
W
S
R
R
Y
K
A
N
L
E
K
L
A
S
G
D
V
N
K
V
A
E
-
V
V
R
--
D
L
W
R
R
D
Q
-
E
R
G
L
S
A
G
E
K
R
M
L
A
K
A
R
Q
I
L
V
G
E
L
A
L
A
E
S
T
D
D
A
K
A
E
T
I
L
D
E
V
L
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.29
100%
-115
- C4 -
4KBM
-
CARD_MYCTU
B:
[2-160]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
K
V
G
D
T
V
V
Y
P
H
H
G
A
A
L
V
E
A
I
E
T
R
----
E
Q
K
E
Y
L
V
L
K
V
A
Q
G
D
L
T
V
R
V
P
A
E
N
A
E
Y
V
G
V
R
D
V
V
G
Q
E
G
L
D
K
V
F
Q
V
L
R
A
P
-------------
W
S
R
R
Y
K
A
N
L
E
K
L
A
S
G
D
V
N
K
V
A
E
-
V
V
R
--
D
L
W
R
R
D
Q
-
E
R
G
L
S
A
G
E
K
R
M
L
A
K
A
R
Q
I
L
V
G
E
L
A
L
A
E
S
T
D
D
A
K
A
E
T
I
L
D
E
V
L
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.89
99%
-96
- C4 -
4MFR
22
CARD_MYCTU
A:
[2-162]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
K
V
G
D
T
V
V
Y
P
H
H
G
A
A
L
V
E
A
I
E
T
R
T
I
K
G
E
Q
K
E
Y
L
V
L
K
V
A
Q
G
D
L
T
V
R
V
P
A
E
N
A
E
Y
V
G
V
R
D
V
V
G
Q
E
G
L
D
K
V
F
Q
V
L
R
A
P
-
H
T
-
E
-
E
--
P
T
N
-
W
S
R
R
Y
K
A
N
L
E
K
L
A
S
G
D
V
N
K
V
A
E
-
V
V
R
--
D
L
W
R
R
D
Q
-
E
R
G
L
S
A
G
E
K
R
M
L
A
K
A
R
Q
I
L
V
G
E
L
A
L
A
-----
A
K
A
E
T
I
L
D
E
V
L
A
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
75.71
32%
-78
- C4 -
2LWJ
-
?
A:
[7-165]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
K
T
G
D
K
A
V
Y
P
G
Q
G
V
G
E
V
M
G
I
E
H
T
E
V
A
G
Q
R
Q
S
F
Y
V
L
R
I
L
E
N
G
M
R
I
M
I
P
I
N
K
V
G
S
V
G
L
R
E
I
I
S
E
E
D
V
K
Q
V
Y
S
I
L
K
E
K
-
D
--
I
-
S
VD
S
T
T
-
W
N
R
R
Y
R
E
Y
M
E
K
I
K
T
G
S
V
F
E
I
A
E
-
V
L
R
--
D
L
Y
L
L
K
G
-
D
K
D
L
S
F
G
E
R
K
M
L
D
T
A
R
S
L
L
I
K
E
L
S
L
A
K
D
C
S
E
D
E
I
E
S
D
L
K
K
I
F
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.46
32%
-74
- C4 -
2LWJ
-
?
A:
[8-167]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
T
G
D
K
A
V
Y
P
G
Q
G
V
G
E
V
M
G
I
E
H
T
E
V
A
G
Q
R
Q
S
F
Y
V
L
R
I
L
E
N
G
M
R
I
M
I
P
I
N
K
V
G
S
V
G
L
R
E
I
I
S
E
E
D
V
K
Q
V
Y
S
I
L
K
E
K
-
D
I
-
S
V
D
--
S
T
T
-
W
N
R
R
Y
R
E
Y
M
E
K
I
K
T
G
S
V
F
E
I
A
E
-
V
L
R
--
D
L
Y
L
L
K
G
-
D
K
D
L
S
F
G
E
R
K
M
L
D
T
A
R
S
L
L
I
K
E
L
S
L
A
K
D
C
S
E
D
E
I
E
S
D
L
K
K
I
F
N
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.14
25%
-78
- C4 -
4XLS
1
?
M:
[4-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
V
P
V
I
L
D
L
L
K
N
G
-
R
M
-
P
-
L
--
P
K
Q
-
W
A
A
R
H
R
K
T
S
E
I
L
A
D
G
N
P
Y
R
I
A
Q
-
M
A
G
--
Q
L
R
A
W
E
V
-
E
R
G
L
P
D
L
D
R
Q
A
L
R
R
A
I
H
L
L
A
E
E
V
A
Q
S
L
E
I
T
V
Q
E
A
K
R
L
F
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.90
25%
-87
- C4 -
4XAX
5
?
B:
[2-155]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
V
P
V
I
L
D
L
L
K
N
G
-
R
M
-
P
-
L
--
P
K
Q
-
W
A
A
R
H
R
K
T
S
E
I
L
A
D
G
N
P
Y
R
I
A
Q
-
M
A
G
--
Q
L
R
A
W
E
V
-
E
R
G
L
P
D
L
D
R
Q
A
L
R
R
A
I
H
L
L
A
E
E
V
A
Q
S
L
E
I
T
V
Q
E
A
K
R
L
F
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.34
25%
-67
- C4 -
4XLR
-
?
M:
[4-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
V
P
V
I
L
D
L
L
K
N
G
-
R
M
-
P
-
L
--
P
K
Q
-
W
A
A
R
H
R
K
T
S
E
I
L
A
D
G
N
P
Y
R
I
A
Q
-
M
A
G
--
Q
L
R
A
W
E
V
-
E
R
G
L
P
D
L
D
R
Q
A
L
R
R
A
I
H
L
L
A
E
E
V
A
Q
S
L
E
I
T
V
Q
E
A
K
R
L
F
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.25
34%
-63
- C4 -
2LT3
-
?
A:
[7-113]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
L
R
E
I
I
S
E
E
D
V
K
Q
V
Y
S
I
L
K
E
K
-
D
I
-
S
V
D
--
S
T
T
-
W
N
R
R
Y
R
E
Y
M
E
K
I
K
T
G
S
V
F
E
I
A
E
-
V
L
R
--
D
L
Y
L
L
K
G
-
D
K
D
L
S
F
G
E
R
K
M
L
D
T
A
R
S
L
L
I
K
E
L
S
L
A
K
D
C
S
E
D
E
I
E
S
D
L
K
K
I
F
N
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.89
100%
-54
- C4 -
4KMC
-
CARD_MYCTU
A:
[83-161]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
-
W
S
R
R
Y
K
A
N
L
E
K
L
A
S
G
D
V
N
K
V
A
E
-
V
V
R
--
D
L
W
R
R
D
Q
-
E
R
G
L
S
A
G
E
K
R
M
L
A
K
A
R
Q
I
L
V
G
E
L
A
L
A
E
S
T
D
D
A
K
A
E
T
I
L
D
E
V
L
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
63.64
33%
-59
- C4 -
2LT3
-
?
A:
[1-113]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
G
S
V
G
L
R
E
I
I
S
E
E
D
V
K
Q
V
Y
S
I
L
K
E
K
-
D
I
-
S
V
D
--
S
T
T
-
W
N
R
R
Y
R
E
Y
M
E
K
I
K
T
G
S
V
F
E
I
A
E
-
V
L
R
--
D
L
Y
L
L
K
G
-
D
K
D
L
S
F
G
E
R
K
M
L
D
T
A
R
S
L
L
I
K
E
L
S
L
A
K
D
C
S
E
D
E
I
E
S
D
L
K
K
I
F
N
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
63.23
33%
-57
- C4 -
2LT3
-
?
A:
[3-112]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
G
S
V
G
L
R
E
I
I
S
E
E
D
V
K
Q
V
Y
S
I
L
K
E
K
-
D
--
I
-
S
VD
S
T
T
-
W
N
R
R
Y
R
E
Y
M
E
K
I
K
T
G
S
V
F
E
I
A
E
-
V
L
R
--
D
L
Y
L
L
K
G
-
D
K
D
L
S
F
G
E
R
K
M
L
D
T
A
R
S
L
L
I
K
E
L
S
L
A
K
D
C
S
E
D
E
I
E
S
D
L
K
K
I
F
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
62.65
25%
-33
- C4 -
4L5G
-
?
A:
[3-161]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
V
P
V
I
L
D
L
L
K
N
G
-
R
M
-
P
-
L
--
P
K
Q
-
W
A
A
R
H
R
K
T
S
E
I
L
A
D
G
N
P
Y
R
I
A
Q
-
M
A
G
--
Q
L
R
A
W
E
V
-
E
R
G
L
P
D
L
D
R
Q
A
L
R
R
A
I
H
L
L
A
E
E
V
A
Q
S
L
E
I
T
V
Q
E
A
K
R
L
F
E
E
A
W
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
61.68
25%
-35
- C4 -
4L5G
-
?
A:
[3-164]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
V
P
V
I
L
D
L
L
K
N
G
--
R
M
P
-
L
--
P
K
Q
-
W
A
A
R
H
R
K
T
S
E
I
L
A
D
G
N
P
Y
R
I
A
Q
M
A
G
Q
---
L
R
A
W
E
V
-
E
R
G
L
P
D
L
D
R
Q
A
L
R
R
A
I
H
L
L
A
E
E
V
A
Q
S
L
E
I
T
V
Q
E
A
K
R
L
F
E
E
A
W
G
E
E
L
N----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.34
25%
-39
- C4 -
4L5G
-
?
A:
[4-157]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
V
P
V
I
L
D
L
L
K
N
G
-
R
M
-
P
-
L
--
P
K
Q
-
W
A
A
R
H
R
K
T
S
E
I
L
A
D
G
N
P
Y
R
I
A
Q
-
M
A
G
--
Q
L
R
A
W
E
V
-
E
R
G
L
P
D
L
D
R
Q
A
L
R
R
A
I
H
L
L
A
E
E
V
A
Q
S
L
E
I
T
V
Q
E
A
K
R
L
F
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
56.89
23%
-41
- C4 -
2EYQ
5
MFD_ECOLI
A:
[5-1150]
PEQYR
Y
T
L
P
V
K
AG
E
Q
R
L
L
GELTGA
A
C
A
T
L
V
A
E
I
A
E
R
HA
G
P
V
V
L
I
A
PD
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
N
LADWETLPYDSFSPH
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
LPTMQ
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
KGQRLS
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
DQVMEHG
E
Y
A
T
R
GA
L
L
D
L
FPMGSE
L
P
Y
R
L
D
F
F
DDEID
S
L
R
V
F
D
VDSQRTLEEVE
A
I
N
L
L
P
AHEFPTD
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
RDPEH
I
Y
Q
Q
V
S
K
GTLPAGIEYW
Q
P
L
F
F
SEPLPPLFSYFPAN
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
GVDPM
R
P
L
L
P
PQSLWLR
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
TEHLPTKAA
N
A
N
L
GFQKLPDLAVQAQQKAPL
D
A
L
R
K
F
L
E
T
FD
G
P
V
V
F
S
V
ES
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
MRLDEASDR
G
R
Y
L
M
I
GAAE
H
G
F
V
D
TVRN
L
A
L
I
C
ESDLLG
E
R
V
A
R
R
RQDSRRTIN
P
D
T
L
I
R
NL
A
E
L
H
I
G
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
-
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
-
S
R
Y
A
G
G
A
E
E
--------
N
A
P
L
H
K
-
L
-
G
--
G
D
A
-
W
S
R
A
R
Q
K
A
A
E
K
V
R
----
D
V
A
A
E
-
L
L
D
--
I
Y
A
Q
R
A
A
-
K
E
G
F
A
F
K
H
D
---
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
VGFGKT
E
V
A
M
R
A
A
F
L
A
V
D
N
H
K
Q
V
A
V
L
V
PT
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
NWP
V
R
I
E
M
I
SRFRS
A
K
E
Q
T
Q
I
L
A
E
V
A
E
GKID
I
L
I
G
T
H
K
L
L
Q
S
DVKFKDLG
L
L
I
V
D
EEHRFG
V
R
H
K
E
R
I
K
A
M
R
AN
V
D
I
L
T
L
T
ATPIP
R
T
L
N
M
A
M
SGM
R
D
L
S
I
IATPPARR
L
A
V
K
T
F
V
R
E
YD
S
M
V
V
R
E
A
I
L
R
E
I
L
R
G
G
Q
V
Y
Y
L
Y
NDVEN
I
Q
K
A
A
E
R
L
A
E
L
V
PE
A
R
I
A
I
G
H
G
QMR
E
R
E
L
E
R
V
M
N
D
F
H
H
QRFN
V
L
V
C
TTIIETGIDIPTAN
T
I
I
I
ERADHFG
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
LLTPHPKAMT
T
D
A
Q
K
R
L
E
A
I
A
S
LEDLGA
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
IG
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
GREPSLEDLTSQQ
T
E
V
E
LR
M
P
S
L
L
P
DDFIPD
V
N
T
R
L
S
F
Y
K
R
I
A
S
AKT
E
N
E
L
E
E
I
K
V
E
L
I
D
R
FGLLP
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
GIR
K
L
E
G
N
EK
G
G
V
I
E
F
A
EKNHVN
P
A
W
L
I
G
L
L
Q
KQPQH
Y
R
L
D
G
PT
R
L
K
F
I
Q
DLSE
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
AI
43
Fugue
54.61
28%
-100
- C4 -
2LQK
-
?
A:
[1-70]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGHM
K
E
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
52.86
30%
-93
- C4 -
2LQK
-
?
A:
[7-69]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
P
G
D
K
V
V
L
P
P
Y
G
V
G
V
V
A
G
I
A
Q
R
S
V
S
G
V
S
R
A
Y
Y
Q
V
D
F
P
G
S
R
S
K
A
Y
V
P
V
E
A
P
H
S
V
G
L
R
K
A
L
A
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
51.73
23%
-57
- C4 -
2EYQ
-
MFD_ECOLI
A:
[479-617]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
H
I
G
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
-
D
A
K
L
Y
V
P
V
S
S
L
H
L
--
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
-----------
G
D
A
-
W
S
R
A
R
Q
K
A
A
E
K
-----
V
R
D
V
A
A
-
E
L
L
--
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
---
E
Q
Y
Q
L
F
C
D
S
F
P
F
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
48.06
21%
-59
- C5 -
4C6S
7
WR52C_ARATH
A:
[5-146]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E
E
F
V
C
I
S
C
V
E
E
V
R
Y
S
-
F
V
S
H
L
S
E
A
L
R
R
K
G
I
N
-----
N
V
V
V
D
V
D
I
D
D
L
L
F
K
E
S
Q
A
K
I
E
K
A
G
-------------
V
S
V
M
V
L
P
-
G
N
-
C
-
D
--
P
S
E
V
W
L
D
K
F
A
K
V
L
E
C
Q
R
N
N
K
D
Q
A
V
V
S
-
V
L
Y
GD
S
L
L
R
D
Q
W
-
L
S
E
L
D
F
R
G
L
S
R
I
H
Q
S
R
K
---------
E
C
S
D
S
I
L
V
E
E
I
V
R
D
V
Y
E
T
H
F
YV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------