@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA1531: (2016-01-30 )
MLAQFTPSALADLANCVLRIPLALQQPSSVAMTLPSLTSFMPHFGAPALLLLQLLAALPATAAETDATPLRFSVMESWSMPLVRLQRGQPIDGIVYDITRSLARQVGRKALYHPYPRGRIEQAMNAGEIDVRCYISPAWLSHDFPGYRWSVALLVQRDILVAREGFAPIPEALPAQRIGTVLGYSYPRLQALFDIGRLRRDDARTQDLVLEKLRAGRYRYAVSHQLSLHWSNRQAPGQPPLQEAAQLEETAVSCMVRDSAEVPVEAILKTFEEMKRSGEIEEILQRYR
Atome Classification :
(20 SA)
-------.........10........20.-.......30........-40........50--........60........70....--....80------......-..90.....---...100....-------.--..110.-...-..-----.120.......130.....---..140...--....150......----.160.....---.--.---170--...--.....180-----.-....--.-.190....--..--..200.......210....------...220.......230.....-..---------.------240--.--..------.-----..-----.-.250.----......260.......270....--...280......-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MLAQF
T
P
S
A
L
A
D
L
A
N
C
V
L
RIPL-ALQQPS
S
V
A
M
T
L
P
S
L
T
S
-
F
M
PHFG
A
P
A
L
L
L
--
L
Q
L
L
A
ALPATAAETDATP
L
R
F
S
V
M
--
E
SWSM
P
------
L
V
R
LQR-GQPI
D
G
I
V
Y
---
D
I
T
R
S
L
A
R
Q
V
-------
G
--
R
K
ALYH-PYP-R
G
-----
R
I
E
Q
AMNAG
E
I
D
V
R
C
Y
I
S
P
---
A
W
LSHDFP--GY
R
W
S
V
A
L
L
V
QR
D
----
I
L
V
AREGFA---P--I---
P
E
---
A
L
P
--
A
Q
R
I
G
T
V
L-----G-YS
Y
P
--
R
-
L
Q
A
-
L
F
D
I
--
G
R
--LRRDDA
R
T
Q
D
L
V
L
E
K
L
RAG------
R
Y
R
Y
A
V
S
H
Q
L
S
L
H
WS-NRQAP-GQ---------P------
P
L
---
Q
--
E
A
------
A
-----
Q
L
-----
E
-
E
T
A
V
S
----
C
MVRDSAEV
P
V
E
A
I
L
K
T
F
E
E
M
K
R--SG
E
I
E
E
I
L
Q
RYR-------
18
HHSearch
88.63
15%
-85
- C4 -
3VV5
1
?
A:
[31-253]
-------------------------------------------------------------------------
E
I
K
R
S
G
E
I
R
I
G
T
E
---
G
A
F
P
P
------
F
N
Y
F
D
E
-
R
N
Q
L
T
G
F
E
V
---
D
L
G
N
A
I
A
E
R
L
-------
G
--
L
K
P
R
W
I
-
A
Q
S
-
F
D
-----
T
L
L
I
Q
L
N
Q
G
R
F
D
F
V
I
-
A
S
H
---
G
I
T
E
E
R
A
R
--
A
V
D
F
T
N
P
H
Y
C
T
G
G
----
V
I
V
S
R
K
G
G
P
---
R
--
T
---
A
K
---
D
L
Q
--
G
K
V
V
G
V
Q
V
-----
G
-
T
T
Y
M
--
E
A
A
Q
K
-
I
-
P
G
---
I
--
K
E
V
R
T
Y
Q
R
D
P
D
A
L
Q
D
L
L
A
G
------
R
I
D
T
W
I
T
D
R
F
V
A
K
E
A
-
I
K
E
R
K
-
L
E
---------
N
------
T
L
---
Q
--
V
G
------
E
-----
L
V
-----
F
-
Q
E
R
V
A
----
M
A
V
A
K
G
N
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
--
D
G
T
Y
A
R
I
S
Q
K
W
F
-------
31
Fugue
86.34
16%
-90
- C4 -
1HSL
6
HISJ_ECOLI
A:
[1-238]
---------------------------------------------------------------------------
A
I
P
Q
K
I
R
I
G
T
D
--
P
T
Y
A
-
P
------
F
E
S
K
N
A
-
Q
G
E
L
V
G
F
D
I
---
D
L
A
K
E
L
C
K
R
I
-------
N
--
T
Q
C
T
F
V
-
E
N
P
-
L
D
-----
A
L
I
P
S
L
K
A
K
K
I
D
A
I
M
S
-
S
L
---
S
I
T
E
K
R
Q
Q
--
E
I
A
F
T
D
K
L
Y
A
A
D
S
----
R
L
V
V
A
K
N
S
----
D
--
I
QPT
V
A
---
S
L
K
--
G
K
R
V
G
V
L
Q
-----
G
T
T
Q
E
T
--
F
-
G
N
E
-
H
W
A
P
--
K
G
--
I
E
I
V
S
Y
Q
G
Q
D
N
I
Y
S
D
L
T
A
G
------
R
I
D
A
A
F
Q
D
E
V
A
A
S
E
G
-
F
L
K
Q
P
-
V
G
---------
K
------
D
Y
---
K
--
F
G
G
P
A
V
K
D
E
-----
K
L
-----
F
-
G
V
G
T
G
----
M
G
L
R
K
E
D
N
E
L
R
E
A
L
N
K
A
F
A
E
M
R
A
--
D
G
T
Y
E
K
L
A
K
K
Y
F
DFDVYGG
12
HHSearch
85.53
16%
-86
- C4 -
1LST
1
ARGT_SALTY
A:
[2-231]
----------------------------------------------------------------------------
L
P
Q
T
V
R
I
G
T
D
---
T
T
Y
A
P
------
F
S
S
K
D
A
-
K
G
E
F
I
G
F
D
I
---
D
L
G
N
E
M
C
K
R
M
-------
Q
--
V
K
C
T
W
V
-
A
S
D
-
F
D
-----
A
L
I
P
S
L
K
A
K
K
I
D
A
I
I
-
S
S
L
---
S
I
T
D
K
R
Q
Q
--
E
I
A
F
S
D
K
L
Y
A
A
D
S
----
R
L
I
A
A
K
G
S
P
IQ-
P
--
T
---
L
E
---
S
L
K
--
G
K
H
V
G
V
L
Q
-----
G
-
S
T
Q
E
--
A
Y
A
N
D
-
N
W
R
T
--
K
G
--
V
D
V
V
A
Y
A
N
Q
D
L
I
Y
S
D
L
T
A
G
------
R
L
D
A
A
L
Q
D
E
V
A
A
S
E
G
F
L
K
Q
P
A
-
G
K
---------
E
------
Y
A
---
F
--
A
G
------
P
SVKDK
K
Y
-----
F
-
G
D
G
T
G
----
V
G
L
R
K
D
D
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
--
D
G
T
Y
D
K
M
A
K
K
Y
F
-------
21
HHSearch
82.61
16%
-71
- C4 -
2Q88
3
?
A:
[8-239]
-------------------------------------------------------------------------
E
L
K
E
Q
G
F
A
R
I
A
I
----
A
N
E
P
P
------
F
T
A
V
G
A
-
D
G
K
V
S
G
A
A
P
---
D
V
A
R
E
I
F
K
R
L
-------
G
--
V
A
D
V
V
A
S
I
S
E
-
Y
G
-----
A
M
I
P
G
L
Q
A
G
R
H
D
A
I
T
-
A
G
L
---
F
M
K
P
E
R
C
A
--
A
V
A
Y
S
Q
P
I
L
C
D
A
E
----
A
F
A
L
K
K
G
N
P
LGL
K
--
S
---
Y
K
D
I
A
D
N
P
--
D
A
K
I
G
A
P
G
-----
G
-
G
T
E
E
--
K
L
A
L
E
A
G
V
P
----
R
--
D
R
V
I
V
V
P
D
G
Q
S
G
L
K
M
L
Q
D
G
------
R
I
D
V
Y
S
L
P
V
L
S
I
N
D
L
-
V
S
K
A
N
-
D
P
---------
N
------
V
E
---
V
--
L
A
------
P
-----
V
E
G
A
---
P
-
V
Y
C
D
G
----
A
A
F
R
K
G
D
E
A
L
R
D
A
F
D
V
E
L
A
K
L
K
E
--
S
G
E
F
A
K
I
I
E
P
Y
G
-------
28
HHSearch
79.89
13%
-95
* C4 *
3K4U
1
?
A:
[3-227]
----------------------------------------------------------------------------
L
R
G
E
L
R
V
G
L
E
---
P
G
Y
L
P
------
F
E
M
K
D
K
-
K
G
N
V
I
G
F
D
V
---
D
L
A
R
E
M
A
K
A
M
-------
G
--
V
K
L
K
L
V
-
P
T
S
-
W
D
-----
G
L
I
P
G
L
V
T
E
K
F
D
I
I
I
-
S
G
M
---
T
I
S
Q
E
R
N
L
--
R
V
N
F
V
E
P
Y
I
V
V
G
Q
----
S
L
L
V
K
K
G
L
E
KGV
K
--
S
---
Y
K
---
D
L
D
--
K
P
E
L
T
L
V
T
K
F
---
G
-
V
S
A
E
--
Y
A
A
K
R
-
L
F
K
----
N
--
A
K
L
K
T
Y
D
T
E
A
E
A
V
Q
E
V
L
N
G
------
K
A
D
M
F
I
F
D
L
P
F
N
V
A
F
-
M
A
Q
K
G
-
Q
G
---------
Y
------
L
V
---
H
--
L
D
------
T
-----
S
L
-----
T
-
Y
E
P
L
G
----
W
A
I
K
K
G
D
P
D
F
L
N
W
L
N
H
F
L
A
Q
I
K
H
--
D
G
S
Y
D
E
L
Y
E
R
W
F
-------
23
HHSearch
79.22
13%
-84
- C4 -
2YLN
10
?
A:
[53-276]
--------------------------------------------------------------------------
I
N
N
K
G
T
V
T
V
G
T
E
---
G
T
Y
A
P
------
F
T
Y
H
D
K
-
D
G
K
L
T
G
Y
D
V
---
E
V
T
R
A
V
A
E
K
L
-------
G
--
V
K
V
E
F
K
-
E
T
Q
-
W
D
-----
S
M
M
A
G
L
K
A
G
R
F
D
V
V
A
N
Q
V
G
---
L
T
S
P
E
R
Q
A
--
T
F
D
K
S
E
P
Y
S
W
S
G
A
----
V
L
V
A
H
N
D
S
N
I--
K
--
S
---
I
A
---
D
I
K
--
G
V
K
T
A
Q
S
L
-----
T
-
S
N
Y
G
--
E
K
A
K
A
-------
A
G
--
A
Q
L
V
P
V
D
G
L
A
Q
S
L
T
L
I
E
Q
K
------
R
A
D
A
T
L
N
D
E
L
A
V
L
D
Y
-
L
K
K
N
P
-
N
A
---------
G
------
V
K
---
I
VW
S
A
------
P
-----
A
D
-----
E
-
K
V
G
S
G
----
L
I
V
N
K
G
N
D
E
A
V
A
K
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A
I
N
E
L
K
A
--
D
G
T
L
K
K
L
G
E
Q
F
F
-------
20
HHSearch
78.18
16%
-85
- C4 -
2VHA
2
?
A:
[11-247]
------------------------------------------------------------------------
D
K
I
A
K
N
G
V
I
V
V
G
H
R
---
E
S
S
V
P
------
F
S
Y
Y
D
N
-
Q
Q
K
V
V
G
Y
S
Q
---
D
Y
S
N
A
I
V
E
A
V
K
K
K
L
NKP
D
--
L
Q
V
K
L
I
-
P
I
T
-
S
Q
-----
N
R
I
P
L
L
Q
N
G
T
F
D
F
E
C
-
G
S
T
---
T
N
N
V
E
R
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K
--
Q
A
A
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S
D
T
I
F
V
V
G
T
----
R
L
L
T
K
K
G
G
D
I--
K
--
D
---
F
A
---
D
L
K
--
G
K
A
V
V
V
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S
-----
G
-
T
T
S
E
--
V
L
L
N
K
-
L
N
E
E
Q
K
M
N
--
M
R
I
I
S
A
K
D
H
G
D
S
F
R
T
L
E
S
G
------
R
A
V
A
F
M
M
D
D
A
L
L
A
G
E
-
R
A
K
A
K
K
P
D
---------
N
------
W
D
---
I
--
V
G
------
K
-----
P
Q
-----
S
-
Q
E
A
Y
G
----
C
M
L
R
K
D
D
P
Q
F
K
K
L
M
D
D
T
I
A
Q
V
Q
T
--
S
G
E
A
E
K
W
F
D
K
W
F
-------
16
HHSearch
77.80
11%
-83
- C4 -
1WDN
1
GLNH_ECOLI
A:
[4-221]
-------------------------------------------------------------------------------
K
L
V
V
A
T
D
---
T
A
F
V
P
------
F
E
F
K
Q
--
G
D
L
Y
V
G
F
D
V
---
D
L
W
A
A
I
A
K
E
L
-------
K
--
L
D
Y
E
L
K
-
P
M
D
-
F
S
-----
G
I
I
P
A
L
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N
V
D
L
A
L
-
A
G
I
---
T
I
T
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E
R
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--
A
I
D
F
S
D
G
Y
Y
K
S
G
L
----
L
V
M
V
K
A
N
N
N
DV-
K
--
S
---
V
K
---
D
L
D
--
G
K
V
V
A
V
K
S
-----
G
-
T
G
S
V
--
D
Y
A
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A
-
N
I
K
----
T
--
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D
L
R
Q
F
P
N
I
D
N
A
Y
M
E
L
G
T
N
------
R
A
D
A
V
L
H
D
T
P
N
I
L
Y
F
-
I
K
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A
G
-
N
G
---------
Q
------
F
K
---
A
--
V
G
------
D
-----
S
L
-----
E
-
A
Q
Q
Y
G
----
I
A
F
P
K
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S
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E
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N
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A
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T
L
R
E
--
N
G
T
Y
N
E
I
Y
K
K
W
F
-------
27
HHSearch
75.67
14%
-95
- C4 -
3MPK
4
A:
[26-251]
------------------------------------------------------------------------
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
---
N
L
F
A
P
------
F
T
L
F
R
T
-
D
E
Q
F
G
G
I
S
A
---
A
V
L
Q
L
L
Q
L
R
T
-------
G
--
L
D
F
E
I
I
-
G
V
D
T
V
E
-----
E
L
I
A
K
L
R
S
G
E
A
D
M
A
G
--
A
L
---
F
V
N
S
A
R
E
S
--
F
L
S
F
S
R
P
Y
V
R
N
G
M
----
V
I
V
T
R
Q
D
P
D
AP-
V
--
D
---
A
D
---
H
L
D
--
G
R
T
V
A
L
V
R
-----
N
-
S
A
A
I
--
P
L
L
Q
R
-
R
Y
P
----
Q
--
A
K
V
V
T
A
D
N
P
S
E
A
M
L
M
V
A
N
G
------
Q
A
D
A
V
V
Q
T
Q
I
S
A
S
Y
Y
-
V
N
R
Y
F
-
A
G
---------
K
------
L
R
---
I
--
A
S
------
A
L----
D
L
-----
P
-
P
A
E
I
A
----
L
A
T
T
R
G
Q
T
E
L
M
S
I
L
N
K
A
L
Y
S
I
S
N
---
D
E
L
A
S
I
I
S
R
W
R
-------
17
HHSearch
75.47
15%
-98
- C4 -
3TQL
2
?
A:
[2-227]
------------------------------------------------------------------------------
D
T
I
K
F
A
T
E
---
A
T
Y
P
P
------
Y
V
Y
M
G
---
G
Q
V
E
G
F
G
A
---
D
I
V
K
A
V
C
K
Q
M
-------
Q
--
A
V
C
T
I
S
-
N
Q
P
-
W
D
-----
S
L
I
P
S
L
K
L
G
K
F
D
A
L
F
-
G
G
M
---
N
I
T
T
A
R
Q
K
--
E
V
D
F
T
D
P
Y
Y
T
N
S
V
----
S
F
I
A
D
K
N
T
P
LT-
L
--
S
---
K
Q
---
G
L
K
--
G
K
I
I
G
V
Q
G
-----
G
-
T
T
F
D
--
S
Y
L
Q
D
-
S
F
G
---
N
S
--
I
T
I
Q
R
Y
P
S
E
E
D
A
L
M
D
L
T
S
G
------
R
V
D
A
V
V
G
D
T
P
L
I
K
Q
W
-
L
K
Q
N
G
-
R
R
---------
E
------
Y
V
---
L
--
I
G
------
K
-----
P
V
NDPNY
F
-
G
K
G
V
G
----
I
A
V
K
K
G
N
Q
A
L
L
L
K
L
N
K
A
L
A
A
I
K
A
--
N
G
V
Y
A
A
I
V
Q
K
Y
F
-------
24
HHSearch
74.50
13%
-90
- C4 -
1II5
1
?
A:
[2-225]
----------------------------------------------------------------------------
S
A
M
A
L
K
V
G
V
V
----
G
N
P
P
------
F
V
F
Y
G
----
A
F
T
G
I
S
L
---
D
V
W
R
A
V
A
E
S
Q
-------
K
--
W
N
S
E
Y
V
-
R
Q
N
S
I
S
-----
A
G
I
T
A
V
A
E
G
E
L
D
I
L
I
-
G
P
I
---
S
V
T
P
E
R
A
A
IE
G
I
T
F
T
Q
P
Y
F
S
S
G
I
----
G
L
L
I
P
G
T
A
T
PLF
R
--
S
---
V
G
---
D
L
K
--
N
K
E
V
A
V
V
R
-----
D
-
T
T
A
V
--
D
-
W
A
N
-
F
-----
Y
Q
--
A
D
V
R
E
T
N
N
L
T
A
A
I
T
L
L
Q
K
K
------
Q
V
E
A
V
M
F
D
R
P
A
L
I
Y
Y
-
T
R
Q
N
P
-
N
L
---------
N
------
L
E
---
V
--
T
E
------
I
-----
R
V
-----
S
-
L
E
P
Y
G
----
F
V
L
K
E
N
-
S
P
L
Q
K
T
I
N
V
E
M
L
N
L
L
Y
--
S
R
V
I
A
E
F
T
E
R
W
L
-------
29
HHSearch
74.44
11%
-87
- C4 -
2PVU
3
?
A:
[38-261]
--------------------------------------------------------------------------
G
A
T
K
K
K
V
V
V
G
T
D
---
A
A
F
A
P
------
F
E
Y
M
Q
--
K
G
K
I
V
G
F
D
V
---
D
L
L
D
A
V
M
K
A
A
-------
G
--
L
D
Y
E
L
K
-
N
I
G
-
W
D
-----
P
L
F
A
S
L
Q
S
K
E
V
D
M
G
I
-
S
G
I
---
T
I
T
D
E
R
K
Q
--
S
Y
D
F
S
D
P
Y
F
E
A
T
Q
----
V
I
L
V
K
Q
G
S
P
V--
K
--
N
---
A
L
---
D
L
K
--
G
K
T
I
G
V
Q
N
-----
A
-
T
T
G
Q
--
E
A
A
E
K
-
L
F
G
K
---
G
--
P
H
I
K
K
F
E
T
T
V
V
A
I
M
E
L
L
N
G
------
G
V
D
A
V
I
T
D
N
A
V
A
N
E
Y
-
V
K
N
N
P
-
N
K
---------
K
------
L
Q
---
V
--
I
E
D
P----
K
-----
N
F
-----
A
-
S
E
Y
Y
G
----
M
I
F
P
-
K
N
S
E
L
K
A
K
V
D
E
A
L
K
N
V
I
N
--
S
G
K
Y
T
E
I
Y
K
K
W
F
-------
22
HHSearch
74.31
12%
-92
- C4 -
2Y7I
7
?
A:
[3-227]
---------------------------------------------------------------------------
V
S
A
R
T
L
H
F
G
T
S
---
A
T
Y
A
P
------
Y
E
F
V
D
A
-
D
N
K
I
V
G
F
D
I
---
D
V
A
N
A
V
C
K
E
M
-------
Q
--
A
E
C
S
F
T
-
N
Q
S
-
F
D
-----
S
L
I
P
S
L
R
F
K
K
F
D
A
V
I
-
A
G
M
---
D
M
T
P
K
R
E
Q
--
Q
V
S
F
S
Q
P
Y
Y
E
G
L
S
----
A
V
V
V
T
R
K
G
A
Y--
H
--
T
---
F
A
---
D
L
K
--
G
K
K
V
G
L
E
N
-----
G
-
T
T
H
Q
--
R
Y
L
Q
D
-
K
Q
Q
----
A
--
I
T
P
V
A
Y
D
S
Y
L
N
A
F
T
D
L
K
N
N
------
R
L
E
G
V
F
G
D
V
A
A
I
G
K
W
-
L
K
N
N
P
-
D
Y
---------
A
------
I
M
D
E
R
A
--
S
D
------
P
-----
D
Y
-----
Y
-
G
K
G
L
G
----
I
A
V
R
K
D
N
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
K
A
--
S
P
E
Y
A
Q
M
Q
E
K
W
F
-------
11
HHSearch
73.99
14%
-73
- C4 -
3H7M
1
?
A:
[7-229]
--------------------------------------------------------------------------
R
D
R
H
R
T
I
V
V
G
G
D
---
R
D
Y
P
P
------
Y
E
F
I
D
Q
-
N
G
K
P
A
G
Y
N
V
---
E
L
T
R
A
I
A
E
V
M
-------
G
--
M
T
V
E
F
R
-
L
G
A
-
W
S
-----
E
M
F
S
A
L
K
S
G
R
V
D
V
L
Q
--
G
I
---
S
W
S
E
K
R
A
R
--
Q
I
D
F
T
P
P
H
T
I
V
Y
H
----
A
I
F
A
R
R
D
S
P
PA-
A
--
G
---
L
E
---
D
L
R
--
G
R
K
V
A
L
H
R
-----
D
-
G
I
M
H
--
E
Y
L
A
E
-
R
G
Y
----
G
--
K
D
L
V
L
T
P
T
P
A
D
A
L
R
L
L
A
A
G
------
G
C
D
Y
A
V
V
A
M
V
P
G
M
Y
I
-
I
R
E
N
R
-
L
T
---------
N
------
L
V
---
P
--
V
A
------
R
-----
S
I
-----
A
-
A
Q
R
Y
G
----
Y
A
V
R
Q
G
D
A
E
L
L
A
R
F
S
E
G
L
A
I
L
R
K
--
T
G
Q
Y
E
A
I
R
A
K
W
L
-------
13
HHSearch
68.28
12%
-100
- C4 -
2V25
3
PEB1A_CAMJE
A:
[33-258]
-------------------------------------------------------------------------
S
I
K
S
K
G
Q
L
I
V
G
V
K
---
N
D
V
P
H
------
Y
A
L
L
D
Q
A
T
G
E
I
K
G
F
E
V
---
D
V
A
K
L
L
A
K
S
I
L------
G
DD
K
K
I
K
L
V
-
A
V
N
-
A
K
-----
T
R
G
P
L
L
D
N
G
S
V
D
A
V
I
-
A
T
F
---
T
I
T
P
E
R
K
R
--
I
Y
N
F
S
E
P
Y
Y
Q
D
A
I
----
G
L
L
V
L
K
E
K
K
Y--
K
--
S
---
L
A
---
D
M
K
--
G
A
N
I
G
V
A
Q
-----
A
-
A
T
T
K
--
K
A
I
G
E
-
A
A
K
K
--
I
G
I
D
V
K
F
S
E
F
P
D
Y
P
S
I
K
A
A
L
D
A
K
------
R
V
D
A
F
S
V
D
K
S
I
L
L
G
Y
-
V
D
D
K
--------------------
S
E
---
I
--
L
P
------
D
-----
S
F
-----
E
-
P
Q
S
Y
G
----
I
V
T
K
K
D
D
P
A
F
A
K
Y
V
D
D
F
V
K
E
H
K
N
----
E
I
D
A
L
A
K
K
W
G
-------
25
HHSearch
68.17
10%
-89
- C4 -
3KBR
10
PHEC_PSEAE
A:
[9-236]
------------------------------------------------------------------------
D
R
I
L
E
S
G
V
L
R
V
A
T
T
---
G
D
Y
K
P
------
F
S
Y
R
T
E
-
E
G
G
Y
A
G
F
D
V
---
D
M
A
Q
R
L
A
E
S
L
-------
G
--
A
K
L
V
V
V
-
P
T
S
-
W
P
-----
N
L
M
R
D
F
A
D
D
R
F
D
I
A
M
-
S
G
I
---
S
I
N
L
E
R
Q
R
--
Q
A
Y
F
S
I
P
Y
L
R
D
G
K
----
T
P
I
T
L
C
S
E
E
ARF
Q
--
T
---
L
E
---
Q
I
D
QP
G
V
T
A
I
V
N
P
-----
G
-
G
T
N
E
--
K
F
A
R
A
-
N
L
K
----
K
--
A
R
I
L
V
H
P
D
N
V
T
I
F
Q
Q
I
V
D
G
------
K
A
D
L
M
M
T
D
A
I
E
A
R
L
Q
-
S
R
L
H
P
-
E
L
---------
C
------
A
V
---
H
--
P
-------
Q
-----
P
F
-----
D
-
F
A
E
K
A
----
Y
L
L
P
R
-
D
E
A
F
K
R
Y
V
D
Q
W
L
H
I
A
E
Q
--
S
G
L
L
R
Q
R
M
E
H
W
L
-------
15
HHSearch
67.28
10%
-83
- C4 -
2YJP
10
?
A:
[51-275]
--------------------------------------------------------------------------
I
K
E
K
G
V
I
R
I
G
V
F
---
G
D
K
P
P
------
F
G
Y
V
D
A
-
N
G
K
N
Q
G
F
D
V
---
E
I
A
K
D
L
A
K
D
L
LGS----
P
--
D
K
V
E
F
V
-
L
T
E
-
A
A
-----
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
-
A
N
F
---
T
Q
T
P
E
R
A
E
--
A
V
D
F
A
D
P
Y
M
K
V
A
L
----
G
V
V
S
P
K
N
K
P
I--
T
--
D
---
M
A
---
Q
L
K
--
D
Q
T
L
L
V
N
K
-----
G
-
T
T
A
D
--
A
F
F
T
K
-
S
H
P
----
E
--
V
K
L
L
K
F
D
Q
N
T
E
T
F
D
A
L
K
D
G
------
R
G
V
A
L
A
H
D
N
A
L
L
W
A
W
-
A
K
E
N
P
-
N
F
---------
E
------
V
A
---
I
---
G
------
N
-----
L
G
-----
P
-
A
E
F
I
A
----
P
A
V
Q
K
G
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
--
D
G
R
L
K
A
A
Y
E
K
T
L
-------
40
Fugue
66.43
16%
-72
* C1 *
4QCC
-
DGOA_ECOLI
A:
[5-274]
TKLP
L
I
A
I
L
R
G
I
T
P
D
E
A
L
A
H
V
G
A
V
I
D
A
G
F
D
A
V
E
I
P
L
N
S
P
Q
W
E
Q
S
I
P
A
-
I
V
D
A
Y
G
D
K
A
L
I
G
--
A
G
T
V
L
K
-
P
E
Q
V
D
A
L
A
R
M
G
C
Q
L
I
V
T
--
P
N
I
H
S
E
------
V
I
R
R
A
V
-
G
-------
Y
---
G
M
T
V
C
P
G
C
A
--------------------
T
-
A
T
-----
E
A
F
T
A
L
E
A
G
A
Q
A
L
K
I
F
P
S
S
---
A
F
G
P
Q
Y
I
K
--
A
L
K
---
A
V
L
P
S
D
I
----
A
V
F
A
V
G
G
V
T
---
P
EN
L
---
A
Q
---
W
I
D
--
A
G
C
A
G
A
G
L
-----
G
----------
S
D
-
L
Y
R
A
--
G
Q
--
S
V
E
R
T
A
Q
Q
A
A
A
F
V
K
A
Y
R
E
A
------
Q
K
Q
K
E
Q
R
Q
D
Q
K
S
A
Y
A
-
L
G
A
S
L
-
G
R
---------
Y
------
M
E
---
N
--
S
L
------
K
-----
E
Q
-----
E
-
K
L
G
I
--------
K
L
D
K
D
Q
L
I
A
G
V
Q
D
A
F
A
D
K
S
K
LS
D
Q
E
I
E
Q
T
L
Q
A
F
E
A------
14
HHSearch
62.13
13%
-32
- C4 -
3KZG
-
?
A:
[20-245]
-------------------------------------------------------------------------------
N
L
T
I
G
T
S
---
K
F
N
P
P
------
F
E
V
W
S
G
N
N
S
S
L
Y
G
F
D
I
---
D
L
M
Q
E
I
C
R
R
L
-------
H
--
A
T
C
T
F
E
-
A
Y
I
-
F
D
-----
D
L
F
P
A
L
K
N
R
E
V
D
L
V
I
-
A
S
M
---
I
I
T
D
E
R
K
K
--
H
F
I
F
S
L
P
Y
M
E
S
N
S
----
Q
Y
I
T
T
V
D
S
K
I--
S
--
T
---
F
D
---
D
L
H
--
G
K
K
I
G
V
R
K
-----
G
-
T
P
Y
A
--
R
Q
V
L
S
-
E
N
R
N
------
N
Q
V
I
F
Y
E
L
I
Q
D
M
L
L
G
L
S
N
N
------
Q
V
D
A
S
L
M
D
Y
E
A
A
K
Y
W
-
M
A
S
E
P
-
Y
A
---------
Y
KLIGKK
Y
K
---
L
--
I
G
------
K
-----
K
I
-----
S
I
G
E
G
Y
S
----
I
M
A
N
P
D
Q
F
V
L
I
K
K
I
N
K
I
L
L
E
M
E
A
--
D
G
T
Y
L
R
L
Y
S
E
Y
F
-------
34
Fugue
60.30
13%
-56
- C1 -
1S4P
9
KRE2_YEAST
A:
[10-348]
-------
K
T
T
M
D
Y
I
T
P
S
F
G
K
P
K
A
C
Y
V
T
L
V
-
R
N
K
E
L
K
G
L
L
S
S
I
K
Y
V
E
N
K
I
N
K
K
F
P
Y
P
W
V
F
L
N
D
E
P
F
T
E
E
F
K
E
A
V
T
K
A
V
S
S
E
V
K
F
G
I
L
P
K
E
H
W
S
Y
P
EWIN
Q
T
K
A
A
E
I
R
-
A
D
A
A
T
K
Y
I
Y
GGS
E
S
Y
R
H
M
C
R
Y
Q
-------
S
--
G
F
F
W
R
H
-
E
L
L
-
E
E
YD
W
Y
W
R
V
E
P
-----
D
I
K
L
Y
C
D
I
N
Y
D
V
F
K
W
M
Q
E
N
E
K
--
V
Y
G
F
T
V
S
I
H
E
Y
E
V
TIPT
L
W
Q
T
S
M
D
F
I
---
K
--
K
---
N
P
---
E
Y
L
--
D
E
N
N
L
M
S
F
L
S
NDN
G
-
K
T
Y
N
LC
H
-
F
W
S
-
N
F
E
I
--
A
N
--
L
N
L
W
R
S
P
A
Y
R
E
Y
F
D
T
L
D
H
Q
GGFFYE
R
W
G
D
A
P
V
H
S
I
A
A
A
L
F
-
L
P
K
D
K
-
I
H
YFSD
I
G
Y
H
H
P
------
P
Y
---
D
--
N
C
------
P
-----
L
D
-----
K
-
E
V
Y
N
S
N
NCE
C
D
Q
G
N
D
F
T
F
Q
G
Y
S
C
G
K
E
Y
Y
D
A
Q
G
--
L
-
V
K
P
K
N
W
K
K
F
R
E------