@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4389: (2016-02-26 )
MQLKDKVIIITGGCQGLGRAMGEYLAGKGARLALVDLNRERLDEAVAACKAAGGDARAYVCNVADEEQVTHMVAQVASDFGAINGLVNNAGILRDGLTIKVKDGQLSKMSLAQWQSVIDVNLTGVFLCTREVAAKMIELKNEGAIVNISSISRAGNMGQANYSAAKAGVAADTVVWAKELARYGIRVAGVAPGFIETEMTAGMKPEALEKMTAGIPLKRMGKPVEIAHSVAYIFENDYYTGRVLELDGGLRL
Atome Classification :
(38 SA)
.........10........20........30.-..-.....40.......--.50..---......60.........70........80-........90........100....-...110.......120.......130.......140.......150.-..--.....160.......170.......180.......190.......200...--....210.......220.......230..----.--.--.---..240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQLK
D
K
V
I
I
I
TGG
C
Q
G
L
G
R
A
M
G
E
Y
L
AGKG
A
R
L
-
A
L
-
V
DL
N
R
E
R
L
D
E
A
V
A
A
--
C
K
AAG---GD
A
R
A
Y
V
-CNVA
D
E
E
Q
V
T
H
M
V
A
Q
V
A
S
D
F
G
-
A
I
N
G
LVNNAGILRDG
L
T
I
K
VKDGQL-
S
K
M
S
L
A
Q
W
Q
S
V
I
D
V
N
L
T
G
V
F
L
C
T
R
E
V
A
A
K
M
I
E
LKNE
G
A
I
V
N
I
S
S
I
-S-RA--GNMGQAN
Y
S
A
AKAGVA
A
D
T
V
V
W
A
K
E
L
A
RY
G
I
R
V
AGVAP
G
F
I
E
T
E
MTAGM
K
P
--
E
A
L
E
K
M
TAGI
P
L
K
RMGK
P
V
E
I
A
H
S
V
A
Y
I
F----E--N--D---YYT
G
R
V
L
ELDGGLRL
25
PsiBlast_CBE
89.11
45%
-93
- C1 -
4NBW
1
?
C:
[5-253]
----
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
-
V
A
-
W
D
L
A
E
E
A
G
A
A
L
I
A
E
--
I
A
D
A
G
---
G
S
A
D
F
A
R
-
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
-
R
V
D
V
L
V
N
N
A
G
I
L
H
D
G
Q
L
V
K
V
K
G
G
E
V
V
K
K
M
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
K
Y
-
G
R
I
L
N
A
S
S
V
V
G
-
L
Y
--
G
N
F
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
G
F
I
A
T
E
M
V
Q
Q
M
P
E
--
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
--
A
Y
L
F
LASE
E
--
S
--
G
---
F
I
S
G
T
T
L
S
V
D
G
G
M
--
26
PsiBlast_CBE
88.72
45%
-97
- C1 -
4NBW
1
?
B:
[5-253]
----
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
-
V
A
-
W
D
L
A
E
E
A
G
A
A
L
I
A
E
--
I
A
D
A
G
---
G
S
A
D
F
A
R
-
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
-
R
V
D
V
L
V
N
N
A
G
I
L
H
D
G
Q
L
V
K
V
K
G
G
E
V
V
K
K
M
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
K
Y
-
G
R
I
L
N
A
S
S
V
V
G
-
L
Y
--
G
N
F
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
G
F
I
A
T
E
M
V
Q
Q
M
P
E
--
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
--
A
Y
L
F
LASE
E
--
S
--
G
---
F
I
S
G
T
T
L
S
V
D
G
G
M
--
22
PsiBlast_CBE
88.58
45%
-98
- C1 -
4NBU
1
?
C:
[10-250]
-
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
-
V
I
-
A
D
F
N
E
A
A
G
K
E
A
V
E
A
--
N
P
G
V
--------
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
-
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
--------
L
-
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
-
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
--
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
--
A
Y
L
F
LASH
E
--
S
--
D
---
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
21
PsiBlast_CBE
88.50
45%
-96
- C1 -
4NBU
2
?
D:
[10-250]
-
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
-
V
I
-
A
D
F
N
E
A
A
G
K
E
A
V
E
A
--
N
P
G
V
--------
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
-
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
--------
L
-
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
-
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
--
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
--
A
Y
L
F
LASH
E
--
S
--
D
---
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
1
PsiBlast_PDB
88.20
45%
-97
- C1 -
4NBU
1
?
A:
[10-250]
-
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
-
V
I
-
A
D
F
N
E
A
A
G
K
E
A
V
E
A
--
N
P
G
V
--------
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
-
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
--------
L
-
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
-
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
--
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
--
A
Y
L
F
L
A
SH
E
--
S
--
D
---
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
24
PsiBlast_CBE
87.33
45%
-92
- C1 -
4NBW
1
?
D:
[5-253]
----
K
R
V
A
I
I
T
G
A
A
N
G
I
G
R
A
T
A
L
E
F
A
Q
A
G
Y
H
V
-
V
A
-
W
D
L
A
E
E
A
G
A
A
L
I
A
E
--
I
A
D
A
G
---
G
S
A
D
F
A
R
-
V
D
V
S
A
A
E
S
V
E
A
A
V
A
E
I
I
A
E
H
G
-
R
V
D
V
L
V
N
N
A
G
I
L
H
D
G
Q
L
V
K
V
K
G
G
E
V
V
K
K
M
A
E
A
Q
F
D
A
V
I
S
V
N
L
K
G
V
F
L
C
T
Q
A
V
A
P
H
M
I
A
A
K
Y
-
G
R
I
L
N
A
S
S
V
V
G
-
L
Y
--
G
N
F
G
Q
T
N
Y
V
A
A
K
S
G
V
I
G
M
T
K
V
W
A
R
E
L
G
R
Y
G
I
T
V
N
A
I
A
P
G
F
I
A
T
E
M
V
Q
Q
M
P
E
--
R
V
L
E
A
M
V
A
R
T
P
V
G
R
I
G
D
P
V
D
I
A
R
--
A
Y
L
F
LASE
E
--
S
--
G
---
F
I
S
G
T
T
L
S
V
D
G
G
M
--
23
PsiBlast_CBE
87.27
45%
-96
- C1 -
4NBU
2
?
B:
[10-250]
-
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
-
V
I
-
A
D
F
N
E
A
A
G
K
E
A
V
E
A
--
N
P
G
V
--------
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
-
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
M
--------
L
-
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
-
Q
G
K
G
K
I
I
N
T
S
S
V
-
T
G
T
Y
--
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
A
E
V
P
E
--
K
V
I
E
K
M
K
A
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
--
A
Y
L
F
L
A
SH
E
--
S
--
D
---
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
M
105
PsiBlast_CBE
86.16
36%
-100
- C1 -
2PD6
1
DHB8_HUMAN
B:
[5-255]
--
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
-
A
A
-
C
D
L
D
R
A
A
A
Q
E
T
V
R
L
--
L
G
-------
N
H
A
A
F
Q
-
A
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
V
V
S
C
A
G
I
T
Q
D
E
F
--------
L
-
L
H
M
S
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
I
V
G
-
K
V
--
G
N
V
G
Q
T
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
M
T
Q
K
V
P
Q
--
K
V
V
D
K
I
T
E
M
I
P
M
G
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
----
S
--
E
--
D
SG-
Y
I
T
G
T
S
V
E
V
T
G
G
L
--
71
PsiBlast_CBE
86.06
37%
-89
- C1 -
4N5M
6
PHBB_CUPNH
B:
[25-269]
--
M
T
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
101
PsiBlast_CBE
84.96
36%
-98
* C1 *
4CQL
1
DHB8_HUMAN
D:
[8-259]
-
R
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
-
A
A
-
C
D
L
D
R
A
A
A
Q
E
T
V
R
L
--
L
G
G
P
-----
N
H
A
A
F
Q
-
A
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
V
V
S
C
A
G
I
T
Q
D
E
F
--------
L
-
L
H
M
S
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
I
V
G
-
K
V
--
G
N
V
G
Q
T
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
M
T
Q
K
V
P
Q
--
K
V
V
D
K
I
T
E
M
I
P
M
G
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
----
S
--
E
--
D
SG-
Y
I
T
G
T
S
V
E
V
T
G
G
L
--
94
PsiBlast_CBE
84.77
36%
-97
- C1 -
4CQM
2
DHB8_HUMAN
A:
[8-259]
-
R
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
-
A
A
-
C
D
L
D
R
A
A
A
Q
E
T
V
R
L
--
L
----PPR
G
N
H
A
A
F
Q
-
A
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
V
V
S
C
A
G
I
T
Q
D
E
F
--------
L
-
L
H
M
S
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
I
V
G
-
K
V
--
G
N
V
G
Q
T
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
M
T
Q
K
V
P
Q
--
K
V
V
D
K
I
T
E
M
I
P
M
G
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
----
S
--
E
--
D
SG-
Y
I
T
G
T
S
V
E
V
T
G
G
L
--
76
PsiBlast_CBE
83.97
38%
-92
- C1 -
3VZS
3
PHBB_CUPNH
A:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
92
PsiBlast_CBE
83.66
36%
-96
- C1 -
4CQM
1
DHB8_HUMAN
H:
[8-259]
-
R
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
-
A
A
-
C
D
L
D
R
A
A
A
Q
E
T
V
R
L
--
L
G
-------
N
H
A
A
F
Q
-
A
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
V
V
S
C
A
G
I
T
Q
D
E
F
--------
L
-
L
H
M
S
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
I
V
G
-
K
V
--
G
N
V
G
Q
T
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
M
T
Q
K
V
P
Q
--
K
V
V
D
K
I
T
E
M
I
P
M
G
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
----
S
--
E
--
D
SG-
Y
I
T
G
T
S
V
E
V
T
G
G
L
--
124
HHSearch
83.60
35%
-95
- C1 -
3AWD
-
?
A:
[9-259]
L
R
L
D
N
R
V
A
I
V
T
G
G
A
Q
N
I
G
L
A
C
V
T
A
L
A
E
A
G
A
R
V
-
I
I
-
A
D
L
D
E
A
M
A
T
K
A
V
E
D
--
L
R
M
E
G
---
H
D
V
S
S
V
V
-
M
D
V
T
N
T
E
S
V
Q
N
A
V
R
S
V
H
E
Q
E
G
-
R
V
D
I
L
V
A
C
A
G
I
C
I
S
E
V
-------
K
A
-
E
D
M
T
D
G
Q
W
L
K
Q
V
D
I
N
L
N
G
M
F
R
S
C
Q
A
V
G
R
I
M
L
E
Q
K
-
Q
G
V
I
V
A
I
G
S
M
-
S
G
L
I
V
N
R
P
Q
Q
Q
A
A
Y
N
A
S
K
A
G
V
H
Q
Y
I
R
S
L
A
A
E
W
A
P
H
G
I
R
A
N
A
V
A
P
T
Y
I
E
T
T
L
T
R
F
G
M
E
K
P
E
L
Y
D
A
W
I
A
G
T
P
M
G
R
V
G
Q
P
D
E
V
A
S
V
V
Q
F
L
A
----
S
DA
A
--
S
---
L
M
T
G
A
I
V
N
V
D
A
G
F
T
V
72
PsiBlast_CBE
83.51
37%
-90
- C1 -
4N5M
4
PHBB_CUPNH
A:
[25-269]
--
M
T
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
103
PsiBlast_CBE
83.46
36%
-94
- C1 -
2PD6
1
DHB8_HUMAN
D:
[4-255]
-
R
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
-
A
A
-
C
D
L
D
R
A
A
A
Q
E
T
V
R
L
--
L
--------
N
H
A
A
F
Q
-
A
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
V
V
S
C
A
G
I
T
Q
D
E
F
--------
L
-
L
H
M
S
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
I
V
G
-
K
V
--
G
N
V
G
Q
T
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
M
T
Q
K
V
P
Q
--
K
V
V
D
K
I
T
E
M
I
P
M
G
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
----
S
--
E
--
D
SG-
Y
I
T
G
T
S
V
E
V
T
G
G
L
--
96
PsiBlast_CBE
83.41
36%
-98
- C1 -
4CQL
1
DHB8_HUMAN
M:
[8-259]
-
R
L
R
S
A
L
A
L
V
T
G
A
G
S
G
I
G
R
A
V
S
V
R
L
A
G
E
G
A
T
V
-
A
A
-
C
D
L
D
R
A
A
A
Q
E
T
V
R
L
--
L
--------
N
H
A
A
F
Q
-
A
D
V
S
E
A
R
A
A
R
C
L
L
E
Q
V
Q
A
C
F
S
R
P
P
S
V
V
V
S
C
A
G
I
T
Q
D
E
F
--------
L
-
L
H
M
S
E
D
D
W
D
K
V
I
A
V
N
L
K
G
T
F
L
V
T
Q
A
A
A
Q
A
L
V
S
N
G
C
R
G
S
I
I
N
I
S
S
I
V
G
-
K
V
--
G
N
V
G
Q
T
N
Y
A
A
S
K
A
G
V
I
G
L
T
Q
T
A
A
R
E
L
G
R
H
G
I
R
C
N
S
V
L
P
G
F
I
A
T
P
M
T
Q
K
V
P
Q
--
K
V
V
D
K
I
T
E
M
I
P
M
G
H
L
G
D
P
E
D
V
A
D
V
V
A
F
L
A
----
S
--
E
--
D
SG-
Y
I
T
G
T
S
V
E
V
T
G
G
L
--
74
PsiBlast_CBE
83.41
38%
-92
- C1 -
3VZS
3
PHBB_CUPNH
C:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
79
PsiBlast_CBE
83.10
38%
-89
- C1 -
3VZP
5
PHBB_CUPNH
B:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
78
PsiBlast_CBE
83.06
38%
-92
- C1 -
3VZP
4
PHBB_CUPNH
C:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
80
PsiBlast_CBE
82.95
38%
-89
- C1 -
3VZP
5
PHBB_CUPNH
A:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
77
PsiBlast_CBE
82.78
38%
-92
- C1 -
3VZP
4
PHBB_CUPNH
D:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
75
PsiBlast_CBE
82.53
38%
-88
- C1 -
3VZS
3
PHBB_CUPNH
B:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
70
PsiBlast_CBE
81.94
37%
-91
- C1 -
4N5N
1
PHBB_CUPNH
A:
[27-269]
----
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
73
PsiBlast_CBE
81.35
38%
-88
- C1 -
3VZS
3
PHBB_CUPNH
D:
[15-256]
-----
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
69
PsiBlast_CBE
80.89
37%
-89
- C1 -
4N5N
1
PHBB_CUPNH
B:
[27-269]
----
Q
R
I
A
Y
V
T
G
G
M
G
G
I
G
T
A
I
C
Q
R
L
A
K
D
G
F
R
V
V
A
G
-
C
G
P
N
S
P
R
R
E
K
W
L
E
Q
--
Q
K
A
L
G
---
F
D
F
I
A
S
E
-
G
N
V
A
D
W
D
S
T
K
T
A
F
D
K
V
K
S
E
V
G
-
E
V
D
V
L
I
N
N
A
G
I
T
R
D
V
V
--------
F
-
R
K
M
T
R
A
D
W
D
A
V
I
D
T
N
L
T
S
L
F
N
V
T
K
Q
V
I
D
G
M
A
D
-
R
G
W
G
R
I
V
N
I
S
S
V
-
N
G
Q
K
--
G
Q
F
G
Q
T
N
Y
S
T
A
K
A
G
L
H
G
F
T
M
A
L
A
Q
E
V
A
T
K
G
V
T
V
N
T
V
S
P
G
Y
I
A
T
D
M
V
K
A
I
R
Q
--
D
V
L
D
K
I
V
A
T
I
P
V
K
R
L
G
L
P
E
E
I
A
S
I
C
A
W
L
S
SE--
E
--
S
--
G
---
F
S
T
G
A
D
F
S
L
N
G
G
L
H
M
36
PsiBlast_CBE
79.08
40%
-85
- C1 -
2PNF
3
FABG_AQUAE
B:
[3-247]
I
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
-
I
I
-
T
G
T
S
G
E
R
-
A
K
A
V
A
E
EI
A
N
K
Y
G
---
V
K
A
H
G
V
E
-
M
N
L
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
-
G
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
---------
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
-
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
-
F
T
--
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
--
E
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
----
S
--
E
LA
S
---
Y
I
T
G
E
V
I
H
V
N
G
G
M
--
50
PsiBlast_CBE
78.00
36%
-89
- C1 -
3RRO
13
FABG_VIBCH
B:
[8-250]
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
-
T
A
T
S
E
---
S
G
A
Q
A
I
--
S
D
Y
L
G
---
D
N
G
K
G
M
A
-
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
-
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
---------
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
-
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
-
T
M
--
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
--
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
SP--
E
--
A
--
A
---
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
12
PsiBlast_PDB
77.51
40%
-83
- C1 -
2PNF
3
FABG_AQUAE
A:
[3-247]
I
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
-
I
I
-
T
G
T
S
G
E
R
-
A
K
A
V
A
E
E
I
A
N
K
Y
G
---
V
K
A
H
G
V
E
-
M
N
L
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
-
G
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
---------
M
S
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
V
T
Q
N
S
L
R
K
M
I
K
-
Q
R
W
G
R
I
V
N
I
S
S
V
V
G
-
F
T
--
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
E
T
D
M
T
A
V
L
S
E
--
E
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
----
S
--
E
LA
S
---
Y
I
T
G
E
V
I
H
V
N
G
G
M
--
11
PsiBlast_PDB
77.47
39%
-90
- C1 -
3OSU
15
FABG_STAAM
A:
[5-243]
-----
K
S
A
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
Q
L
A
E
E
G
Y
N
V
-
A
V
N
Y
A
G
S
K
E
K
A
E
A
V
V
E
E
--
I
K
A
K
G
---
V
D
S
F
A
I
Q
-
A
N
V
A
D
A
D
E
V
K
A
M
I
K
E
V
V
S
Q
F
G
-
S
L
D
V
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
---------
Q
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
T
P
Q
M
L
R
Q
R
S
-
G
A
I
I
N
L
S
S
V
-
V
-
G
A
V
-
G
N
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
R
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
V
S
D
M
T
D
A
L
S
D
--
E
L
K
E
Q
M
L
T
Q
I
P
L
A
R
F
G
Q
D
T
D
I
A
N
T
V
A
F
L
A
----
S
--
D
KA
K
---
Y
I
T
G
Q
T
I
H
V
N
G
G
---
18
PsiBlast_PDB
75.81
36%
-89
- C1 -
3RRO
11
FABG_VIBCH
A:
[8-250]
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
-
I
G
-
T
A
T
S
E
---
S
G
A
Q
A
I
--
S
D
Y
L
G
---
D
N
G
K
G
M
A
-
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
-
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
---------
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
-
K
R
Q
G
R
I
I
N
V
G
S
V
V
G
-
T
M
--
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
--
E
Q
R
T
A
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
SP--
E
--
A
--
A
---
Y
I
T
G
E
T
L
H
V
N
G
G
M
Y
M
46
PsiBlast_CBE
74.67
38%
-87
- C1 -
4JRO
1
?
C:
[25-269]
M
T
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
-
F
F
N
Y
N
G
S
P
E
A
A
E
E
T
A
K
L
--
V
A
E
H
G
---
V
E
V
E
A
M
K
-
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
-
R
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
D
E
---------
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
-
Q
R
A
G
K
I
I
N
M
A
S
V
V
G
-
L
I
--
G
N
A
G
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
M
T
D
K
L
D
E
--
K
T
K
E
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
----
S
--
D
AS
K
---
Y
I
T
G
Q
T
L
S
V
D
G
G
M
--
57
PsiBlast_CBE
74.63
42%
-94
- C1 -
4DMM
1
?
B:
[24-266]
L
P
L
T
D
R
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
-
A
V
-
N
Y
A
S
S
A
G
A
A
D
E
V
V
A
--
A
I
A
A
A
---
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
-
R
L
D
V
L
V
N
N
A
G
I
T
R
D
T
L
L
L
R
M
K
R
D
D
---------
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
-
A
A
A
K
I
M
L
K
Q
R
S
G
R
I
I
N
I
A
S
V
V
G
-
E
M
--
G
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
A
T
D
M
T
S
-----------
L
L
E
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
----
A
--
D
--
P
AAA
Y
I
T
G
Q
V
I
N
I
D
G
G
L
--
56
PsiBlast_CBE
74.29
42%
-92
- C1 -
4DMM
1
?
C:
[24-266]
L
P
L
T
D
R
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
-
A
V
-
N
Y
A
S
S
A
G
A
A
D
E
V
V
A
--
A
I
A
A
A
---
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
-
R
L
D
V
L
V
N
N
A
G
I
T
R
D
T
L
L
L
R
M
K
R
D
D
---------
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
-
A
A
A
K
I
M
L
K
Q
R
S
G
R
I
I
N
I
A
S
V
V
G
-
E
M
--
G
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
A
T
D
M
-----------
E
K
L
L
E
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
----
A
--
D
--
P
AAA
Y
I
T
G
Q
V
I
N
I
D
G
G
L
--
27
PsiBlast_CBE
74.09
40%
-87
- C1 -
3SJ7
2
?
B:
[11-252]
-----
K
S
A
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
Q
L
A
E
E
G
Y
N
V
-
A
V
N
Y
A
G
S
K
E
K
A
E
A
V
V
E
E
--
I
K
A
K
G
---
V
D
S
F
A
I
Q
-
A
N
V
A
D
A
D
E
V
K
A
M
I
K
E
V
V
S
Q
F
G
-
S
L
D
V
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
---------
Q
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
T
P
Q
M
L
R
Q
R
S
-
G
A
I
I
N
L
S
S
V
-
V
-
G
A
V-
G
N
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
R
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
V
S
D
-
T
D
A
L
S
D
--
E
L
K
E
Q
M
L
T
Q
I
P
L
A
R
F
G
Q
D
T
D
I
A
N
T
V
A
F
L
A
----
S
--
D
KA
K
---
Y
I
T
G
Q
T
I
H
V
N
G
G
M
Y
M
55
PsiBlast_CBE
73.38
42%
-93
- C1 -
4DMM
1
?
D:
[24-266]
L
P
L
T
D
R
I
A
L
V
T
G
A
S
R
G
I
G
R
A
I
A
L
E
L
A
A
A
G
A
K
V
-
A
V
-
N
Y
A
S
S
A
G
A
A
D
E
V
V
A
--
A
I
A
A
A
---
G
G
E
A
F
A
V
K
A
D
V
S
Q
E
S
E
V
E
A
L
F
A
A
V
I
E
R
W
G
-
R
L
D
V
L
V
N
N
A
G
I
T
R
D
T
L
L
L
R
M
K
R
D
D
---------
W
Q
S
V
L
D
L
N
L
G
G
V
F
L
C
S
R
-
A
A
A
K
I
M
L
K
Q
R
S
G
R
I
I
N
I
A
S
V
V
G
-
E
M
--
G
N
P
G
Q
A
N
Y
S
A
A
K
A
G
V
I
G
L
T
K
T
V
A
K
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
A
T
--------------
K
L
L
E
V
I
P
L
G
R
Y
G
E
A
A
E
V
A
G
V
V
R
F
L
A
----
A
--
D
--
P
AAA
Y
I
T
G
Q
V
I
N
I
D
G
G
L
--
2
PsiBlast_PDB
73.01
40%
-88
- C1 -
3SJ7
3
?
A:
[11-252]
-----
K
S
A
L
V
T
G
A
S
R
G
I
G
R
S
I
A
L
Q
L
A
E
E
G
Y
N
V
-
A
V
N
Y
A
G
S
K
E
K
A
E
A
V
V
E
E
--
I
K
A
K
G
---
V
D
S
F
A
I
Q
-
A
N
V
A
D
A
D
E
V
K
A
M
I
K
E
V
V
S
Q
F
G
-
S
L
D
V
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
---------
Q
E
W
D
D
V
I
D
T
N
L
K
G
V
F
N
C
I
Q
K
A
T
P
Q
M
L
R
Q
R
S
-
G
A
I
I
N
L
S
S
V
-
V
-
G
A
V
-
G
N
P
G
Q
A
N
Y
V
A
T
K
A
G
V
I
G
L
T
K
S
A
A
R
E
L
A
S
R
G
I
T
V
N
A
V
A
P
G
F
I
V
S
D
M
T
----
D
--
E
L
K
E
Q
M
L
T
Q
I
P
L
A
R
F
G
Q
D
T
D
I
A
N
T
V
A
F
L
A
----
S
--
D
KA
K
---
Y
I
T
G
Q
T
I
H
V
N
G
G
M
Y
M
45
PsiBlast_CBE
71.87
38%
-83
- C1 -
4JRO
1
?
D:
[25-269]
M
T
L
Q
G
K
V
A
V
V
T
G
G
S
R
G
I
G
R
D
I
A
I
N
L
A
K
E
G
A
N
I
-
F
F
N
Y
N
G
S
P
E
A
A
E
E
T
A
K
L
--
V
A
E
H
G
---
V
E
V
E
A
M
K
-
A
N
V
A
I
A
E
D
V
D
A
F
F
K
Q
A
I
E
R
F
G
-
R
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
D
E
---------
W
D
D
V
I
N
I
N
L
K
G
T
F
L
C
T
K
A
V
S
R
T
M
M
K
-
Q
R
A
G
K
I
I
N
M
A
S
V
V
G
-
L
I
--
G
N
A
G
Q
A
N
Y
V
A
S
K
A
G
V
I
G
L
T
K
T
T
A
R
E
L
A
P
R
G
I
N
V
N
A
V
A
P
G
F
I
T
T
D
M
T
---
D
E
--
K
T
K
E
A
M
L
A
Q
I
P
L
G
A
Y
G
T
T
E
D
I
A
N
A
V
L
F
L
A
----
S
--
D
AS
K
---
Y
I
T
G
Q
T
L
S
V
D
G
G
M
--