@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4992: (2016-03-03 )
MIRDTLHDLHRPLGDTGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYGRSEERLGPLLRGQREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKRLETDRIELVLVHSDGNDLDILENSEVYPTLAALKREGLIGAYGLSGKTVEGGLRALREGDCAMVTYNLNERAERPVIEYAAAHAKGILVKKALASGHACLGAGQDPVRASFELVFDQPGVAAAIVGTINPLHLAHNVAMAAQALKKA
Atome Classification :
(20 SA)
.........10........20........30..-......40........50........60........70.--.---------......80..-------.-.....90........100----.......110.......120.......130.......140----------------.......150.......160.......170.......180------..--.......190....--....200.......210.......220--------------------.-----------------------------------------.--------------------------------------------.....230.......240.......250.......260..-.--....270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
R
D
T
L
H
D
L
H
RPLGDTG
L
A
VSPLG
L
G
T
V
K
FGRD-QGVKYPSGFTIPDD
R
E
A
A
D
L
L
A
L
A
R
D
LG
I
N
L
IDTAPAYG--R---------
S
E
E
R
L
G
P
L
LR-------G-QRE
H
W
V
I
V
S
K
V
G
E
E
FVDG----Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
LETD
R
I
E
L
V
L
V
HSDGN
D
L
D
----------------ILENSEV
Y
P
T
L
A
A
L
K
REGL
I
G
AYGLSG
K
T
V
E
G
G
L
R
A
LR--------EG--
D
C
A
M
V
T
YN-LNERA--ER
P
V
I
E
Y
A
A
A
HAKG
I
L
V
K
K
A
L
ASGHAC--------------------L-----------------------------------------G--------------------------------------------AGQD
P
V
R
A
S
F
E
L
V
FDQPG
V
A
A
A
I
VGTI
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
KKA
21
PsiBlast_CBE
99.10
100%
-112
- C7 -
4EXA
1
?
F:
[23-290]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
D
-
Q
G
V
K
Y
P
S
--
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
---
G
----
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
S
----------------------------------------------------------------------------------------------------------------
G
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
23
PsiBlast_CBE
97.60
100%
-112
- C7 -
4EXA
2
?
D:
[23-290]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
D
----------
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
F
V
D
G
----
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
S
----------------------------------------------------------------------------------------------------------------
G
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
25
PsiBlast_CBE
97.29
100%
-115
- C7 -
4EXA
2
?
B:
[23-290]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
-----------
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
F
V
D
G
----
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
S
----------------------------------------------------------------------------------------------------------------
G
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
22
PsiBlast_CBE
97.29
100%
-115
- C7 -
4EXA
1
?
E:
[23-290]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
D
----------
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
F
V
D
G
----
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
S
----------------------------------------------------------------------------------------------------------------
G
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
2
PsiBlast_PDB
97.17
100%
-110
- C7 -
4EXB
-
?
A:
[1-268]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
D
----------
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
--
D
G
----
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
S
----------------------------------------------------------------------------------------------------------------
G
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
1
PsiBlast_PDB
97.01
100%
-116
- C7 -
4EXA
1
?
A:
[23-290]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
D
----------
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
F
V
D
G
----
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
------------------------------------------------------------------------------------------------------------------
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
24
PsiBlast_CBE
96.85
100%
-115
- C7 -
4EXA
2
?
C:
[23-290]
M
I
R
D
T
L
H
D
L
H
R
P
L
G
D
T
G
L
A
V
S
P
L
G
L
G
T
V
K
F
G
R
D
----------
T
I
P
D
D
R
E
A
A
D
L
L
A
L
A
R
D
L
G
I
N
L
I
D
T
A
P
A
Y
G
--
R
---------
S
E
E
R
L
G
P
L
L
R
-------
G
-
Q
R
E
H
W
V
I
V
S
K
V
G
E
E
--------
Q
S
V
F
D
F
S
A
A
H
T
R
R
S
V
E
R
S
L
K
R
L
E
T
D
R
I
E
L
V
L
V
H
S
D
G
N
D
L
D
----------------
I
L
E
N
S
E
V
Y
P
T
L
A
A
L
K
R
E
G
L
I
G
A
Y
G
L
S
G
K
T
V
E
G
G
L
R
A
L
R
--------
E
G
--
D
C
A
M
V
T
Y
N
-
L
N
E
R
A
--
E
R
P
V
I
E
Y
A
A
A
H
A
K
G
I
L
V
K
K
A
L
A
S
----------------------------------------------------------------------------------------------------------------
G
Q
D
P
V
R
A
S
F
E
L
V
F
D
Q
P
G
V
A
A
A
I
V
G
T
I
N
P
L
H
L
A
H
N
V
A
M
A
A
-
Q
--
A
L
K
--
45
HHSearch
72.34
29%
-81
* C7 *
1PYF
2
IOLS_BACSU
A:
[2-300]
-------
K
K
-
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
H
-
N
L
------
Y
P
N
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
--
I
G
R
-------
S
E
E
L
I
G
E
V
L
R
E
------
F
-
N
R
E
D
V
V
I
A
T
K
A
A
H
R
K
Q
G
N
----
D
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-------------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
E
Q
L
K
E
A
N
K
DG------
L
V
--
D
V
L
Q
G
E
Y
N
-
L
L
N
R
E
A-
E
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
--------------------
G
-----------------------------------------
K
YTED
T
T
F
P
EGDLRNEQEHFKG
E
R
F
K
E
N
I
R
K
V
N
K
L
A
P
I
A
E
K
----
H
N
V
D
I
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
L
S
Q
E
43
HHSearch
72.10
30%
-76
- C7 -
1PZ1
1
GS69_BACSU
A:
[1-301]
------
M
E
Y
-
T
S
I
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
A
I
G
G
T
M
W
G
--------
G
T
D
E
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
--
F
G
Q
-------
S
E
E
I
V
G
K
A
I
K
E
Y
-----
M
-
K
R
D
Q
V
I
L
A
T
K
T
A
L
D
W
K
N
N
----
Q
L
F
R
H
A
N
R
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
V
-------------------
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
I
E
Q
M
D
T
F
R
A
V
A
------
P
L
--
H
T
I
Q
P
P
Y
N
-
L
F
E
R
E
M-
E
E
S
V
L
P
Y
A
K
D
N
K
I
T
T
L
L
Y
G
S
L
C
R
G
L
L
T
--------------------
G
KMTEE
Y
T
F
E
G
DDLRNHDPKFQKPR
F
K
E
Y
L
S
A
V
N
Q
L
D
K
L
A
K
T
R
--------------------------------------------
Y
G
K
S
V
I
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
L
N
S
E
46
HHSearch
69.74
29%
-71
- C7 -
1LQA
1
TAS_ECOLI
A:
[1-329]
------
M
Q
Y
-
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
M
T
F
G
E
Q
------------
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
--
V
PPRPETQG
L
T
E
T
Y
V
G
N
W
L
A
K
H
-----
G
-
S
R
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
DKGI
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
N
CFGKL
G
Y
S
W
T
DSAP--
A
V
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
DLP
R
I
--
V
T
I
Q
N
P
Y
S
-
L
L
N
R
S
F-
E
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
--------------------
G
-----------------------------------------
K
YLNGAKPAGA
R
N
T
L
F
SRFTRYSG
E
Q
T
Q
K
A
V
A
A
Y
V
D
I
A
R
R
-----
H
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
44
HHSearch
68.93
27%
-94
- C7 -
1YNP
11
?
A:
[20-298]
-----
H
M
K
K
-
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
T
--------------
D
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
--
Q
GL-------
N
E
Q
F
V
G
K
A
L
K
-------
G
-
R
R
Q
D
I
I
L
A
T
K
V
-----------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
D
-------------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
N
V
I
K
E
Y
L
K
R
S------
N
I
--
V
S
I
M
M
Q
Y
S
-
I
L
D
R
R
--
P
E
E
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
--------------------
R
-----------------------------------------
R
PLPEGEGYLNYR
Y
D
E
L
K
L
L
R
E
S
LP--------------------
T
D
R
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
--
P
L
T
A
E
47
HHSearch
66.99
23%
-79
- C7 -
3N6Q
1
GPR_ECOLI
A:
[10-323]
---
Y
G
Q
M
Q
Y
-
R
Y
C
G
K
S
G
L
R
L
P
A
L
S
L
G
L
W
H
N
F
G
H
-----------
V
N
A
L
E
S
Q
R
A
I
L
R
K
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
G
--
P
PPG
S
-----
A
E
E
N
F
G
R
L
L
R
E
DFA---
A
-
Y
R
D
E
L
I
I
S
T
K
A
G
Y
D
M
W
P
G
----
P
Y
G
S
G
G
S
R
K
Y
L
L
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
S
H
R
V
D
E
N
T
-------------------
P
M
E
E
T
A
S
A
L
A
H
A
V
Q
S
G
K
A
L
Y
V
G
I
S
S
Y
S
P
E
R
T
Q
K
M
V
E
L
L
R
E
W
KI-
P
L
--
L
I
H
Q
P
S
Y
N
-
L
L
N
R
W
V
D
K
S
G
L
L
D
T
L
Q
N
N
G
V
G
C
I
A
F
T
P
L
A
Q
G
L
L
T
--------------------
G
KYLLT
E
A
N
L
N
S
L
R
L
L
N
E
M
A
Q
---------------------
Q
--------------------------------------------
R
G
Q
S
M
A
Q
M
A
L
S
W
L
L
K
D
D
R
V
T
S
V
L
I
G
A
S
R
A
E
Q
L
E
E
N
V
Q
A
L
N
N
L
--
T
F
S
T
K
51
HHSearch
66.90
24%
-83
- C7 -
3ERP
16
?
A:
[30-340]
--
R
Y
H
T
M
E
Y
-
R
R
C
G
R
S
G
V
K
L
P
A
I
S
L
G
L
W
H
N
F
G
D
-----------
T
T
R
V
E
N
S
R
A
L
L
Q
R
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
G
--
P
PPG
S
-----
A
E
C
N
F
G
R
I
L
Q
E
DFL---
P
-
W
R
D
E
L
I
I
S
T
K
A
G
Y
T
M
W
D
G
----
P
Y
G
D
W
G
S
R
K
Y
L
I
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
H
H
R
P
D
P
E
T
-------------------
P
L
K
E
T
M
K
A
L
D
H
L
V
R
H
G
K
A
L
Y
V
G
I
S
N
Y
P
A
D
L
A
R
Q
A
I
D
I
L
E
D
L
GT-
P
C
--
L
I
H
Q
P
K
Y
S
-
L
F
E
R
W
V-
E
D
G
L
L
A
L
L
Q
E
K
G
V
G
S
I
A
F
S
P
L
A
G
G
Q
L
T
--------------------
D
RYLNIT
A
D
K
L
E
K
V
R
R
L
N
E
L
A
A
--------------------
R
--------------------------------------------
R
G
Q
K
L
S
Q
M
A
L
A
W
V
L
R
N
D
N
V
T
S
V
L
I
G
A
S
K
P
S
Q
I
E
D
A
V
G
M
L
A
N
R
--
R
F
S
A
A
59
HHSearch
65.37
20%
-72
- C7 -
1AFS
2
DIDH_RAT
A:
[2-291]
----
D
S
I
S
L
-
R
V
A
L
N
D
G
N
F
I
P
V
L
G
F
G
T
T
V
P
E
K
-------------
V
A
K
D
E
V
I
K
A
T
K
I
A
I
D
N
G
F
R
H
F
D
S
A
Y
L
Y
E
------------
V
E
E
E
V
G
Q
A
I
R
S
K
I
E
D
GT
V
-
K
R
E
D
I
F
Y
T
S
K
L
W
S
T
F
------------
H
R
P
E
L
V
R
T
C
L
E
K
T
L
K
S
T
Q
L
D
Y
V
D
L
Y
I
I
H
F
P
M
A
L
Q
P
GDIF
F
P
R
D
EHGKLLFE
T
V
D
I
C
D
T
W
E
A
M
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
C
R
Q
L
E
R
I
L
N
KPGLKY--
K
P
--
V
C
N
Q
V
E
C
H
-
L
Y
L
N
Q
---
S
K
M
L
D
Y
C
K
S
K
D
I
I
L
V
S
Y
C
T
L
G
S
S
R
D
K
TWVDQKSPVLLDD
P
V
L
C
A
I
A
K
-----------------------------------------
K
--------------------------------------------
Y
K
Q
T
P
A
L
V
A
L
R
Y
Q
L
Q
R
G
V
--
V
P
L
I
R
S
F
N
A
K
R
I
K
E
L
T
Q
V
F
E
-
F
--
Q
L
A
S
E
57
HHSearch
65.18
20%
-81
- C7 -
1US0
4
ALDR_HUMAN
A:
[1-284]
------
M
A
S
-
R
I
L
L
N
N
G
A
K
M
P
I
L
G
L
G
T
W
K
S
P
----------------
P
G
Q
V
T
E
A
V
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
V
Y
Q
------------
N
E
N
E
V
G
V
A
I
Q
E
K
L
R
E
QV
V
-
K
R
E
E
L
F
I
V
S
K
L
W
C
T
Y
------------
H
E
K
G
L
V
K
G
A
C
Q
K
T
L
S
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
T
G
F
K
P
GKEF
F
P
L
D
ESGNVVPS
D
T
N
I
L
D
T
W
A
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
I
S
N
F
N
H
L
Q
V
E
M
I
L
N
KPGLKY--
K
P
--
A
V
N
Q
I
E
C
H
-
P
Y
L
T
Q
---
E
K
L
I
Q
Y
C
Q
S
K
G
I
V
V
T
A
Y
S
P
L
G
S
P
D
R
P
--------------------
W
AKPEDPSLLED
P
R
I
K
A
I
A
A
----------------------
K
--------------------------------------------
H
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
--
L
V
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
K
V
F
D
-
F
--
E
L
S
S
Q
54
HHSearch
63.73
25%
-76
- C7 -
3LUT
1
KCAB2_RAT
A:
[36-346]
-----
L
Q
F
Y
-
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
G
-----------
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
--
A
G
K
-------
A
E
V
V
L
G
N
I
I
K
K
K
G----
W
-
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-------------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
NLI
P
P
--
I
C
E
Q
A
E
Y
H
-
M
F
Q
R
E
KV
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
--------------------
G
-----------------------------------------
K
YDSGIPPYSRASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
49
HHSearch
63.63
25%
-77
- C7 -
3EAU
3
KCAB2_RAT
A:
[2-312]
-----
L
Q
F
Y
-
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
G
-----------
Q
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
--
A
G
K
-------
A
E
V
V
L
G
N
I
I
K
K
K
G----
W
-
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-------------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
NLI
P
P
--
I
C
E
Q
A
E
Y
H
-
M
F
Q
R
E
KV
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
--------------------
G
-----------------------------------------
K
YDSGIPPYSRASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
R
L
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
61
HHSearch
63.60
21%
-83
- C7 -
1HW6
4
DKGA_CORSC
A:
[2-253]
-----
T
V
P
S
-
I
V
L
-
N
D
G
N
S
I
P
Q
L
G
Y
G
V
F
K
V
----------------
P
P
A
D
T
Q
R
A
V
E
E
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
------------
N
E
E
G
V
G
A
A
I
A
A
SG----
I
-
A
R
D
D
L
F
I
T
T
K
L
W
N
D
-----------------
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
T
P
A
A
------------------
D
N
Y
V
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
TGV----
V
P
--
A
V
N
Q
I
E
L
H
-
P
A
Y
Q
Q
---
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
G
K
Y
D
--------------------
L
FGA
E
P
V
T
A
A
A
A
------------------------------
A
--------------------------------------------
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
--
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
-
F
--
D
L
T
D
T
6
PsiBlast_PDB
63.45
32%
-70
- C7 -
1PYF
1
IOLS_BACSU
A:
[6-209]
------------
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
H
-
N
--
L
Y
P
N
----
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
IG
R
---------
S
E
E
L
I
G
E
V
L
R
-------
E
F
N
R
E
D
V
V
I
A
T
K
A
A
H
R
K
Q
G
N
----
D
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
---
E
----------------
H
T
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
E
Q
L
K
E
A
N
K
--------
D
G
LV
D
V
L
Q
G
E
Y
N
L
L
N
R
E
A
--
E
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.25
32%
-71
- C7 -
1PZ0
1
IOLS_BACSU
A:
[6-209]
------------
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
H
-
N
--
L
Y
P
N
----
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
IG
R
---------
S
E
E
L
I
G
E
V
L
R
-------
E
F
N
R
E
D
V
V
I
A
T
K
A
A
H
R
K
Q
G
N
----
D
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
---
E
----------------
H
T
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
E
Q
L
K
E
A
N
K
--------
D
G
LV
D
V
L
Q
G
E
Y
N
L
L
N
R
E
A
--
E
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------