@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0111: (2016-03-12 )
MGLMKFQLFIQPKLDVLQGNIVEYEILLRDDSAVPRFPLSELEAVLADEELYLAFSEWFSEAFLDVLKKYPNDRFAINIAPQQLFYIETLHWLDKLKSESHRITVEMTEDIFDVPGHKRHLNANDKNAFILNKIKVIHGLGYHIAIDDVSCGLNSLERVMSYLPYIIEIKFSLIHFKNIPLEDLLLFIKAWANFAQKNKLDFVVEGIETKETMTLLESHGVSIFQGYLVNKPFPV
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------.........10........20.........-30.-.-.--.-.-...40....-----....50........-60......---.---.----------70--..----...-------...80..-.----.--.-.------..-90..-.----.....100--.----.---.......-110.......120--........130.-......140.......150.......160...-....170...-....180-.......190.......200.......210.......220.......230...------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------MG
L
M
K
F
Q
L
F
I
QP
K
L
D
V
LQGN-
I
V
E
Y
E
I
L
L
R-DDS-A-V--P-R-F
P
L
S
E
L
E
A
V
-----LAD
E
E
L
Y
L
A
F
S
E
W
F
-
S
E
A
F
L
D
V
L
---
K
---K----------YP--ND----
R
F
A
-------
I
N
IAPQ
Q
-
L
----
F
--
Y
-
I
------
E
T
-
L
H
W
L
-
D
----
K
L
KSES----
H
----
R
---
I
T
V
E
M
T
E
-
D
I
FDVPGHKRHL---NANDK
N
A
F
I
L
N
K
-
I
K
V
I
HGLG
Y
H
I
A
I
D
D
V
S
C
G
L
N
S
L
E
R
V
M
S
YLP
Y
-
I
I
E
I
K
F
S
L
I
H
-FKNI
P
L
E
-
D
L
L
L
F
I
K
A
W
A
N
F
A
QKNK
L
D
F
V
V
EGIE
T
K
E
T
M
T
L
L
E
SH
G
V
S
I
F
Q
G
Y
LVNKPFPV------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.00
98%
-141
- C3 -
3KZP
6
?
A:
[5-235]
-------------------------------------------------------------------------------------------------------------------------------
K
F
Q
L
F
I
Q
P
K
L
D
V
L
Q
G
N
-
I
V
E
Y
E
I
L
L
R
-
D
D
S
-
A
-
V
--
P
-
R
-
F
P
L
S
E
L
E
A
V
-----
L
A
D
E
E
L
Y
L
A
F
S
E
W
F
-
S
E
A
F
L
D
V
L
---
K
---
K
----------
Y
P
--
N
D
----
R
F
A
-------
I
N
I
A
P
Q
Q
-
L
----
F
--
Y
-
I
------
E
T
-
L
H
W
L
-
D
----
K
L
K
S
E
S
----
H
----
R
---
I
T
V
E
M
T
E
-
D
I
F
D
V
P
G
H
K
R
H
L
---
N
A
N
D
K
N
A
F
I
L
N
K
-
I
K
V
I
H
G
L
G
Y
H
I
A
I
D
D
V
S
C
G
L
N
S
L
E
R
V
M
S
Y
L
P
Y
-
I
I
E
I
K
F
S
L
I
H
-
F
K
N
I
P
L
E
-
D
L
L
L
F
I
K
A
W
A
N
F
A
Q
K
N
K
L
D
F
V
V
E
G
I
E
T
K
E
T
M
T
L
L
E
S
H
G
V
S
I
F
Q
G
Y
L
V
N
K
P
F
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
87.27
85%
-133
- C3 -
3KZP
6
?
A:
[5-235]
-------------------------------------------------------------------------------------------------------------------------------
K
F
Q
L
F
I
Q
P
K
L
D
V
L
Q
G
N
-
I
V
E
Y
E
I
L
L
R
-
D
D
--
S
-
A
VP
R
-
F
-
P
L
S
E
L
E
A
V
L
-----
A
D
----
E
E
L
Y
L
A
F
S
-
E
W
F
S
E
A
F
L
---
D
V
L
K
K
----------
Y
P
--
N
D
----
R
F
A
-------
I
N
I
A
P
Q
Q
-
L
----
F
--
Y
-
I
------
E
T
-
L
H
W
L
-
D
----
K
L
K
S
E
S
----
H
----
R
---
I
T
V
E
M
T
E
-
D
I
F
D
V
P
G
H
K
R
H
L
N
A
N
D
K
N
---
A
F
I
L
N
K
-
I
K
V
I
H
G
L
G
Y
H
I
A
I
D
D
V
S
C
G
L
N
S
L
E
R
V
M
S
Y
L
P
Y
-
I
I
E
I
K
F
S
L
I
H
-
F
K
N
I
P
L
E
-
D
L
L
L
F
I
K
A
W
A
N
F
A
Q
K
N
K
L
D
F
V
V
E
G
I
E
T
K
E
T
M
T
L
L
E
S
H
G
V
S
I
F
Q
G
Y
L
V
N
K
P
F
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.79
24%
-117
- C3 -
3N3T
4
?
A:
[42-266]
----------------------------------------------------------------------------------------------------------------------------------
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
-
E
-
R
--
G
-
L
-
V
M
P
S
A
F
I
P
A
-----
A
E
D
T
G
L
I
V
A
L
S
D
W
V
-
L
E
A
C
C
T
Q
L
---
R
---
A
----------
W
Q
--
Q
Q
----
G
R
A
ADD
L
T
L
S
V
N
I
S
T
R
Q
-
F
----
E
--
G
-
E
------
H
L
-
T
R
A
V
-
D
----
R
A
L
A
R
S
----
G
LRPD
C
---
L
E
L
E
I
T
E
-
N
V
M
--------
L
---
V
M
T
D
E
V
R
T
C
L
D
A
-
L
R
A
---
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
-
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
---
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.60
21%
-113
- C3 -
4LJ3
5
YAHA_ECOLI
A:
[38-265]
-------------------------------------------------------------------------------------------------------------------------------
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
-
L
T
G
C
E
V
L
V
R
W
E
H
P
-
Q
-
T
--
G
-
I
-
I
P
P
D
Q
F
I
P
L
-----
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
-
M
K
Q
T
A
D
I
L
M
PV
K
---
H
----------
L
L
--
P
D
----
N
F
H
-------
I
G
I
N
V
S
A
-
G
----
C
--
F
-
L
AAG
F
E
K
E
C
-
L
N
L
V
-
N
----
K
L
G
N
D
K
----
I
----
K
---
L
V
L
E
L
T
E
---------
R
N
P
I
---
P
V
T
P
E
A
R
A
I
F
D
S
-
L
---
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
-
F
I
K
I
D
K
S
F
V
Q
-
M
A
S
V
D
-
E
-
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.27
21%
-108
- C3 -
4LYK
4
YAHA_ECOLI
A:
[38-265]
-------------------------------------------------------------------------------------------------------------------------------
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
-
L
T
G
C
E
V
L
V
R
W
E
H
P
-
Q
-
T
--
G
-
I
-
I
P
P
D
Q
F
I
P
L
-----
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
-
M
K
Q
T
A
D
I
L
M
PV
K
---
H
----------
L
L
--
P
D
----
N
F
H
-------
I
G
I
N
V
S
A
-
G
----
C
--
F
-
L
AAG
F
E
K
E
C
-
L
N
L
V
-
N
----
K
L
G
N
D
K
----
I
----
K
---
L
V
L
E
L
T
E
---------
R
N
P
I
---
P
V
T
P
E
A
R
A
I
F
D
S
-
L
---
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
-
F
I
K
I
D
K
S
F
V
Q
-
M
A
S
V
D
-
E
-
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.09
24%
-119
- C3 -
2R6O
4
?
A:
[42-266]
----------------------------------------------------------------------------------------------------------------------------------
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
-
E
-
R
--
G
-
L
-
V
M
P
S
A
F
I
P
A
-----
A
E
D
T
G
L
I
V
A
L
S
D
W
V
-
L
E
A
C
C
T
Q
L
---
R
---
A
----------
W
Q
--
Q
Q
----
G
R
A
ADD
L
T
L
S
V
N
I
S
T
R
Q
-
F
----
E
--
G
-
E
------
H
L
-
T
R
A
V
-
D
----
R
A
L
A
R
S
----
G
LRPD
C
---
L
E
L
E
I
T
E
-
N
V
M
--------
L
---
V
M
T
D
E
V
R
T
C
L
D
A
-
L
R
A
---
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
-
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
---
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.71
21%
-114
- C3 -
4KIE
5
YAHA_ECOLI
A:
[27-254]
-------------------------------------------------------------------------------------------------------------------------------
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
-
L
T
G
C
E
V
L
V
R
W
E
H
P
-
Q
-
T
--
G
-
I
-
I
P
P
D
Q
F
I
P
L
-----
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
-
M
K
Q
T
A
D
I
L
M
PV
K
---
H
----------
L
L
--
P
D
----
N
F
H
-------
I
G
I
N
V
S
A
-
G
----
C
--
F
-
L
AAG
F
E
K
E
C
-
L
N
L
V
-
N
----
K
L
G
N
D
K
----
I
----
K
---
L
V
L
E
L
T
E
---------
R
N
P
I
---
P
V
T
P
E
A
R
A
I
F
D
S
-
L
---
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
-
F
I
K
I
D
K
S
F
V
Q
-
M
A
S
V
D
-
E
-
I
S
G
H
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
63.63
24%
-123
- C3 -
3SY8
2
?
D:
[3-398]
D
L
N
V
L
V
LQ
R
L
V
A
V
T
A
L
K
K
V
VPGSILEAAD
G
K
E
A
V
A
ILED
I
A
I
C
D
LQMSG
M
D
G
L
A
F
L
R
H
A
S
L
S
GKVH
S
V
I
L
SSEVDPIL
R
Q
A
T
I
S
M
I
E
C
L
GLNFLGDE
R
I
T
A
L
L
T
R
Y
NAREVAELPS
V
A
D
V
V
R
G
L
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
-
W
N
H
-
P
-
H
--
L
G
V
-
L
P
P
S
H
F
L
Y
V
-----
M
E
T
Y
N
L
V
D
K
L
F
W
Q
L
-
F
S
Q
G
L
A
T
R
---
R
---
K
----------
L
A
--
Q
L
GQP
I
N
L
A
-------
F
N
V
H
P
S
Q
-
L
G
SRA
L
--
A
-
E
------
N
I
-
S
A
L
L
-
T
----
E
F
H
L
P
P
----
S
----
S
---
V
M
F
E
I
T
E
-
T
G
L
I
--------------
S
A
P
A
S
S
L
E
N
-
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
-
Q
I
K
L
D
R
T
F
V
Q
--
K
M
K
T
Q
P
-
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
E
Q
H
F
L
D
Y
C
S
G
S
L
E
H
H
H
H--------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.29
24%
-97
- C3 -
3GFX
2
?
A:
[178-394]
---------------------------------------------------------------------------------------------------------------------------------
Q
F
A
L
Q
A
I
V
E
P
A
K
K
R
-
V
S
S
F
E
A
L
I
R
---
S
-
P
-
T
--
G
-
G
-
S
P
V
-
E
M
F
A
A
-----
I
A
A
E
D
R
Y
R
F
D
L
E
S
K
-
A
Y
A
F
A
-
L
A
---
G
---
Q
----------
L
P
LG
K
H
----
Q
L
A
-------
I
N
L
L
P
G
S
-
L
----
Y
--
H
H
P
------
D
A
-
V
G
W
L
M
D
----
S
L
L
A
A
G
----
L
----
R
PDQ
V
L
I
E
V
T
E
---------
T
E
V
I
---
T
C
F
D
Q
F
R
K
V
L
K
A
-
L
R
V
A
---
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
-
K
I
K
V
D
A
E
L
V
R
-
D
I
H
I
S
G
T
-
K
Q
A
I
-
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.15
25%
-115
- C3 -
3SY8
1
?
A:
[155-381]
-------------------------------------------------------------------------------------------------------------------------------
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
W
N
H
P
-
H
-
L
--
G
-
V
-
L
P
P
S
H
F
L
Y
V
M
E
T
Y
N
L
V
D
K
L
F
W
Q
L
F
S
Q
G
L
A
T
R
R
K
L
A
Q
L
---
G
---
Q
----------
P
I
--
N
------
L
A
-------
F
N
V
H
P
S
Q
-
L
----
G
--
S
-
R
------
A
L
-
A
E
N
I
-
S
----
A
L
L
T
E
F
----
H
LPPS
S
---
V
M
F
E
I
T
E
T
G
L
I
S
A
P
---------------
A
S
S
L
E
N
-
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
-
Q
I
K
L
D
R
T
F
V
Q
K
M
K
T
Q
P
R
S
---
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.45
24%
-99
- C3 -
3GG0
3
?
A:
[178-394]
---------------------------------------------------------------------------------------------------------------------------------
Q
F
A
L
Q
A
I
V
E
P
A
K
K
R
-
V
S
S
F
E
A
L
I
R
---
S
-
P
-
T
--
G
-
G
-
S
P
V
-
E
M
F
A
A
-----
I
A
A
E
D
R
Y
R
F
D
L
E
S
K
-
A
Y
A
F
A
-
L
A
---
G
---
Q
----------
L
P
LG
K
H
----
Q
L
A
-------
I
N
L
L
P
G
S
-
L
----
Y
--
H
H
P
------
D
A
-
V
G
W
L
M
D
----
S
L
L
A
A
G
----
L
----
R
PDQ
V
L
I
E
V
T
E
---------
T
E
V
I
---
T
C
F
D
Q
F
R
K
V
L
K
A
-
L
R
V
A
---
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
-
K
I
K
V
D
A
E
L
V
R
-
D
I
H
I
S
G
T
-
K
Q
A
I
-
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.36
24%
-94
- C3 -
3GFZ
3
?
A:
[178-394]
---------------------------------------------------------------------------------------------------------------------------------
Q
F
A
L
Q
A
I
V
E
P
A
K
K
R
-
V
S
S
F
E
A
L
I
R
---
S
-
P
-
T
--
G
-
G
-
S
P
V
-
E
M
F
A
A
-----
I
A
A
E
D
R
Y
R
F
D
L
E
S
K
-
A
Y
A
F
A
-
L
A
---
G
---
Q
----------
L
P
LG
K
H
----
Q
L
A
-------
I
N
L
L
P
G
S
-
L
----
Y
--
H
H
P
------
D
A
-
V
G
W
L
M
D
----
S
L
L
A
A
G
----
L
----
R
PDQ
V
L
I
E
V
T
E
---------
T
E
V
I
---
T
C
F
D
Q
F
R
K
V
L
K
A
-
L
R
V
A
---
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
-
K
I
K
V
D
A
E
L
V
R
-
D
I
H
I
S
G
T
-
K
Q
A
I
-
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.34
24%
-101
- C3 -
3GG1
3
?
A:
[178-394]
---------------------------------------------------------------------------------------------------------------------------------
Q
F
A
L
Q
A
I
V
E
P
A
K
K
R
-
V
S
S
F
E
A
L
I
R
---
S
-
P
-
T
--
G
-
G
-
S
P
V
-
E
M
F
A
A
-----
I
A
A
E
D
R
Y
R
F
D
L
E
S
K
-
A
Y
A
F
A
-
L
A
---
G
---
Q
----------
L
P
LG
K
H
----
Q
L
A
-------
I
N
L
L
P
G
S
-
L
----
Y
--
H
H
P
------
D
A
-
V
G
W
L
M
D
----
S
L
L
A
A
G
----
L
----
R
PDQ
V
L
I
E
V
T
E
---------
T
E
V
I
---
T
C
F
D
Q
F
R
K
V
L
K
A
-
L
R
V
A
---
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
-
K
I
K
V
D
A
E
L
V
R
-
D
I
H
I
S
G
T
-
K
Q
A
I
-
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
62.23
24%
-106
- C3 -
3SY8
1
?
A:
[152-381]
----------------------------------------------------------------------------------------------------------------------------
D
N
G
E
F
E
A
Y
Y
Q
P
K
V
A
L
D
G
G
G
-
L
I
G
A
E
V
L
A
R
-
W
N
H
P
H
-
L
G-
V
-
L
-
P
P
S
H
F
L
Y
V
M
-----
E
T
----
Y
N
L
V
D
K
L
F
-
W
Q
L
F
S
Q
G
L
---
A
---
T
R
R
K
L
A
Q
L
---
G
Q
--
P
I
----
N
L
A
-------
F
N
V
H
P
S
Q
-
L
----
G
--
S
-
R
------
A
L
-
A
E
N
I
-
S
A
L
L
T
E
F
H
L
P
P
----
S
----
S
---
V
M
F
E
I
T
E
-
T
G
L
I
-----------
S
A
P
---
A
S
S
L
E
N
-
L
V
R
L
W
I
M
G
C
G
L
A
M
D
D
F
G
A
G
Y
S
S
L
D
R
L
C
E
F
P
F
S
-
Q
I
K
L
D
R
T
F
V
Q
-
K
M
K
T
Q
-
P
-
R
S
C
A
V
I
S
S
V
V
A
L
A
Q
A
L
G
I
S
L
V
V
E
G
V
E
S
D
E
Q
R
V
R
L
I
E
L
G
C
S
I
A
Q
G
Y
L
F
A
R
P
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
61.89
19%
-114
- C3 -
2BAS
-
YKUI_BACSU
A:
[34-262]
----------------------------------------------------------------------------------------------------------------------------
N
I
D
D
V
L
P
Y
Y
Q
A
I
F
S
A
E
E
Q
K
-
V
V
G
Y
E
V
L
G
R
-
I
L
--
A
-
D
S
E
I
-
Q
S
L
G
P
F
F
L
D
A
G
-----
I
P
----
E
E
Y
K
L
E
V
D
-
N
R
I
I
R
Q
A
L
---
D
---
R
F
L
E
A
------
D
S
--
D
L
----
L
I
F
-------
M
N
Q
D
A
N
L
-
L
----
M
LD
H
-
G
------
E
S
F
L
E
L
L
-
K
E
Y
E
-
A
K
G
I
E
L
----
H
----
R
---
F
V
L
E
I
T
E
-
H
N
F
E
-----------
G
D
I
---
E
Q
L
Y
H
M
-
L
A
Y
Y
R
T
Y
G
I
K
I
A
V
D
N
I
G
K
E
S
S
N
L
D
R
I
A
L
L
S
P
D
-
L
L
K
I
D
L
Q
A
L
K
-----
S
-
P
-
S
Y
E
H
V
L
Y
S
I
S
L
L
A
R
K
I
G
A
A
L
L
Y
E
D
I
E
A
N
F
Q
L
Q
Y
A
W
R
N
G
G
R
Y
F
Q
G
Y
Y
L
V
S
P
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
61.55
19%
-111
- C3 -
3PJX
6
?
A:
[203-429]
---------------------------------------------------------------------------------------------------------------------------
L
N
Q
R
R
F
E
L
F
F
Q
P
V
V
A
A
Q
D
T
Q
L
V
L
H
Y
K
V
L
S
R
-
L
L
D
E
Q
G
Q
--
T
-
I
-
P
A
G
R
F
L
P
W
L
-----
E
R
----
F
G
W
T
A
R
L
D
-
R
L
M
L
E
R
V
L
---
E
Q
M
-
A
----------
G
H
--
E
E
----
S
L
A
-------
L
N
L
S
S
A
T
-
L
----
A
--
D
-
P
------
Q
A
-
L
N
K
V
-
F
E
I
L
R
A
H
S
N
L
G
----
A
----
R
---
L
T
L
E
I
G
E
-
E
Q
L
P
-----------
E
-
Q
---
A
V
L
E
Q
L
-
T
R
R
L
R
E
L
G
F
S
L
S
L
Q
R
F
G
G
R
F
S
M
I
G
N
L
A
R
L
G
L
A
-
Y
L
K
I
D
G
S
Y
I
R
-
A
I
D
Q
E
-
S
-
D
K
R
L
F
I
E
A
I
Q
R
A
A
H
S
I
D
L
P
L
I
A
E
R
V
E
T
E
G
E
L
S
V
I
R
E
M
G
L
Y
G
V
Q
G
Q
L
F
G
E
P
K
P
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Fugue
61.15
19%
-109
- C3 -
2BAS
1
YKUI_BACSU
A:
[26-431]
--------------------------------------------------------------------------------------------------------------------LD
P
L
D
I
L
T
N
I
D
D
V
L
P
Y
Y
Q
A
I
F
S
A
E
E
Q
K
-
V
V
G
Y
E
V
L
G
R
I
L
A
D
-
S
-
E
--
I
-
Q
-
S
L
G
P
F
F
L
D
A
-----
G
I
P
E
E
Y
K
L
E
V
D
N
R
I
-
I
R
Q
A
L
D
R
F
---
L
---
E
----------
A
D
--
S
D
L
---
L
I
F
M
------
N
Q
D
A
N
L
L
M
L
----
D
--
H
-
G
------
E
S
-
F
L
E
L
-
L
----
K
E
Y
E
A
K
GIEL
H
----
R
---
F
V
L
E
I
T
E
-
H
N
F
E
---------------
G
D
I
E
Q
L
Y
H
M
L
A
Y
Y
R
T
Y
G
I
K
I
A
V
D
N
I
G
K
E
S
S
N
L
D
R
I
A
L
L
S
P
D
-
L
L
K
I
D
L
Q
A
L
K
-
S
P
------
S
Y
E
H
V
L
Y
S
I
S
L
L
A
R
K
I
G
A
A
L
L
Y
E
D
I
E
A
N
F
Q
L
Q
Y
A
W
R
N
G
G
R
Y
F
Q
G
Y
Y
L
V
S
P
S
E
T
FLERDVL
K
Q
R
L
K
T
E
F
H
Q
F
I
T
H
E
K
K
K
L
E
T
V
Y
E
H
S
E
Q
F
Y
K
R
V
H
Q
A
V
T
S
L
R
KNNLSS
D
D
D
F
I
K
K
L
A
E
E
L
TDCSF
R
I
Y
M
C
D
EEGDQL
T
G
N
V
F
K
Q
DG
E
W
I
Y
Q
PEYAEKNWSWRPY
F
L
E
N
I
M
R
M
R
N
L
R
K
G
F
F
S
D
LYSDLETG
E
M
I
R
T
F
S
Y
P
M
D
DQ
M
Y
L
F
I
D
L
P
Y
S
Y
L
Y
E
QDGLI
6
PsiBlast_PDB
59.92
24%
-114
- C3 -
3GFY
1
?
A:
[178-394]
---------------------------------------------------------------------------------------------------------------------------------
Q
F
A
L
Q
A
I
V
E
P
A
K
K
R
-
V
S
S
F
E
A
L
I
R
---
S
-
P
-
T
--
G
-
G
-
S
P
V
-
E
M
F
A
A
-----
I
A
A
E
D
R
Y
R
F
D
L
E
S
K
-
A
Y
A
F
A
-
L
A
---
G
---
Q
----------
L
P
LG
K
H
----
Q
L
A
-------
I
N
L
L
P
G
S
-
L
----
Y
--
H
H
P
------
D
A
-
V
G
W
L
M
D
----
S
L
L
A
A
G
----
L
----
R
PDQ
V
L
I
E
----------------------
D
Q
F
R
K
V
L
K
A
-
L
R
V
A
---
G
M
K
L
A
I
D
-----------
L
T
R
F
Q
P
D
-
K
I
K
V
D
A
E
L
V
R
-
D
I
H
I
S
G
T
-
K
Q
A
I
-
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
59.46
17%
-112
- C3 -
3S83
2
?
A:
[11-244]
---------------------------------------------------------------------------------------------------------------------------
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
-
W
I
H
P
R
-
R
G-
M
-
L
-
P
P
D
E
F
L
P
L
I
-----
E
E
----
M
G
L
M
S
E
L
G
-
A
H
M
M
H
A
A
A
---
Q
---
Q
L
S
T
W
R
A
A
H
PA
M
G
--
N
L
----
T
V
S
-------
V
N
L
S
T
G
E
-
I
----
D
--
R
-
P
------
G
L
-
V
A
D
V
-
A
E
T
L
R
V
N
R
L
P
R
----
G
----
A
---
L
K
L
E
V
T
E
-
S
D
I
M
-----------
R
D
P
---
E
R
A
A
V
I
-
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
-
T
L
K
I
D
R
Y
F
V
R
-
T
M
G
N
N
-
A
-
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
59.32
18%
-104
- C3 -
2R6O
4
?
A:
[35-268]
---------------------------------------------------------------------------------------------------------------------------
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
-
W
E
D
P
E
-
R
G-
L
-
V
-
M
P
S
A
F
I
P
A
A
-----
E
D
----
T
G
L
I
V
A
L
S
-
D
W
V
L
E
A
C
C
---
T
---
Q
L
R
A
W
Q
Q
Q
GRA
A
D
--
D
L
----
T
L
S
-------
V
N
I
S
T
R
Q
-
F
----
E
--
G
-
E
------
H
L
-
T
R
A
V
-
D
R
A
L
A
R
S
G
L
R
P
----
D
----
C
---
L
E
L
E
I
T
E
-
N
V
M
L
-----------
V
M
T
---
D
E
V
R
T
C
-
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
-
G
L
K
I
D
Q
S
F
V
R
-
K
I
P
A
H
-
P
-
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------