@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0973: (2016-03-20 )
MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKNSKKEGTFSLEERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYELRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPYVEKALKKKFK
Atome Classification :
(68 SA)
.........10........20........30........40...-..--...50........60.......-.70........80........90........100.......110.......120.......130.......140......----.150.......160
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
H
T
I
A
VIPGSFDPITYG
H
L
D
I
I
ERSTDRF
D
E
I
H
V
C
V
L
KNSKKE-GT--F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
HLPN
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
QV
G
A
K
T
I
I
R
G
L
R
A
VSD
F
E
Y
E
L
R
L
TSM
N
K
K
LNNEI
E
T
L
Y
M
MSSTN
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
EFV
P
----
P
Y
V
E
K
A
L
K
K
KFK
22
PsiBlast_CBE
95.73
100%
-137
- C2 -
4NAU
2
COAD_STAAW
B:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
4
PsiBlast_PDB
94.76
100%
-134
- C2 -
3F3M
1
COAD_STAAW
A:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
------
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
28
PsiBlast_CBE
94.53
100%
-129
- C2 -
4NAH
3
COAD_STAAW
C:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
29
PsiBlast_CBE
93.92
100%
-131
- C2 -
4NAH
3
COAD_STAAW
B:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
27
PsiBlast_CBE
93.61
100%
-129
- C2 -
4NAH
3
COAD_STAAW
D:
[2-160]
-
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
25
PsiBlast_CBE
93.49
100%
-126
- C2 -
4NAH
3
COAD_STAAW
F:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
1
PsiBlast_PDB
93.47
100%
-129
- C2 -
4NAH
3
COAD_STAAW
A:
[2-160]
-
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
26
PsiBlast_CBE
93.12
100%
-128
- C2 -
4NAH
3
COAD_STAAW
E:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
21
PsiBlast_CBE
92.85
100%
-129
- C2 -
4NAU
1
COAD_STAAW
C:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
3
PsiBlast_PDB
92.59
100%
-128
- C2 -
4NAU
3
COAD_STAAW
A:
[2-160]
-
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
N
S
K
K
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
24
PsiBlast_CBE
92.14
100%
-133
- C2 -
4NAT
5
COAD_STAAW
B:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
----
E
-
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
23
PsiBlast_CBE
92.13
100%
-133
- C2 -
4NAT
3
COAD_STAAW
C:
[1-160]
M
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
K
------
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
2
PsiBlast_PDB
91.64
100%
-135
- C2 -
4NAT
4
COAD_STAAW
A:
[2-160]
-
E
H
T
I
A
V
I
P
G
S
F
D
P
I
T
Y
G
H
L
D
I
I
E
R
S
T
D
R
F
D
E
I
H
V
C
V
L
-------
G
T
--
F
S
L
E
E
R
M
D
L
I
E
Q
S
V
K
H
L
P
N
V
K
V
-
H
Q
F
S
G
L
L
V
D
Y
C
E
Q
V
G
A
K
T
I
I
R
G
L
R
A
V
S
D
F
E
Y
E
L
R
L
T
S
M
N
K
K
L
N
N
E
I
E
T
L
Y
M
M
S
S
T
N
Y
S
F
I
S
S
S
I
V
K
E
V
A
A
Y
R
A
D
I
S
E
F
V
P
----
P
Y
V
E
K
A
L
K
K
K
F
K
34
PsiBlast_CBE
83.37
53%
-125
- C2 -
1VLH
3
COAD_THEMA
B:
[15-169]
-----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
31
PsiBlast_CBE
82.90
53%
-128
- C2 -
1VLH
2
COAD_THEMA
E:
[15-169]
-----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
109
HHSearch
82.57
53%
-126
- C2 -
1VLH
2
COAD_THEMA
A:
[13-169]
---
M
K
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
7
PsiBlast_PDB
82.14
53%
-127
- C2 -
1VLH
2
COAD_THEMA
A:
[15-169]
-----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
30
PsiBlast_CBE
82.08
53%
-126
- C2 -
1VLH
2
COAD_THEMA
F:
[15-169]
-----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
32
PsiBlast_CBE
81.55
53%
-126
- C2 -
1VLH
2
COAD_THEMA
D:
[15-169]
-----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
8
PsiBlast_PDB
80.55
46%
-122
- C2 -
1B6T
2
COAD_ECOLI
A:
[5-158]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
33
PsiBlast_CBE
80.31
53%
-128
- C2 -
1VLH
2
COAD_THEMA
C:
[15-169]
-----
A
V
Y
P
G
S
F
D
P
I
T
L
G
H
V
D
I
I
K
R
A
L
S
I
F
D
E
L
V
V
L
V
T
E
N
P
R
K
K
-
C
M
--
F
T
L
E
E
R
K
K
L
I
E
E
V
L
S
D
L
D
G
V
K
V
-
D
V
H
H
G
L
L
V
D
Y
L
K
K
H
G
I
K
V
L
V
R
G
L
R
A
V
T
D
Y
E
Y
E
L
Q
M
A
L
A
N
K
K
L
Y
S
D
L
E
T
V
F
L
I
A
S
E
K
F
S
F
I
S
S
S
L
V
K
E
V
A
L
Y
G
G
D
V
T
E
W
V
P
----
P
E
V
A
R
A
L
N
E
K
L
K
10
PsiBlast_PDB
80.20
46%
-116
- C2 -
1H1T
3
COAD_ECOLI
A:
[5-158]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
6
PsiBlast_PDB
79.36
50%
-139
- C2 -
1OD6
4
COAD_THET8
A:
[4-158]
------
V
Y
P
G
S
F
D
P
L
T
N
G
H
L
D
V
I
Q
R
A
S
R
L
F
E
K
V
T
V
A
V
L
E
N
------
Q
YL
F
S
A
E
E
R
L
A
I
I
R
E
A
T
A
H
L
A
N
V
E
A
-
A
T
F
S
G
L
L
V
D
F
V
R
R
V
G
A
Q
A
I
V
K
G
L
R
A
V
S
D
Y
E
Y
E
L
Q
M
A
H
L
N
R
Q
L
Y
P
G
L
E
T
L
F
I
L
A
A
T
R
Y
S
F
V
S
S
T
M
V
K
E
I
A
R
Y
G
G
D
V
S
K
L
V
P
----
P
A
T
L
R
A
L
K
A
K
L
-
41
PsiBlast_CBE
79.22
43%
-124
- C2 -
3PNB
1
COAD_MYCTU
B:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
9
PsiBlast_PDB
79.02
46%
-114
- C2 -
1GN8
3
COAD_ECOLI
A:
[5-158]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
108
HHSearch
78.94
49%
-131
- C2 -
1OD6
4
COAD_THET8
A:
[1-159]
---
M
H
V
V
Y
P
G
S
F
D
P
L
T
N
G
H
L
D
V
I
Q
R
A
S
R
L
F
E
K
V
T
V
A
V
L
E
N
----Q
Y
L
--
F
S
A
E
E
R
L
A
I
I
R
E
A
T
A
H
L
A
N
V
E
A
-
A
T
F
S
G
L
L
V
D
F
V
R
R
V
G
A
Q
A
I
V
K
G
L
R
A
V
S
D
Y
E
Y
E
L
Q
M
A
H
L
N
R
Q
L
Y
P
G
L
E
T
L
F
I
L
A
A
T
R
Y
S
F
V
S
S
T
M
V
K
E
I
A
R
Y
G
G
D
V
S
K
L
V
P
----
P
A
T
L
R
A
L
K
A
K
L
G
35
PsiBlast_CBE
78.93
46%
-122
- C2 -
1H1T
5
COAD_ECOLI
B:
[5-158]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
5
PsiBlast_PDB
78.63
56%
-126
- C2 -
1O6B
4
COAD_BACSU
A:
[3-159]
---
S
I
A
V
C
P
G
S
F
D
P
V
T
Y
G
H
L
D
I
I
K
R
G
A
H
I
F
E
Q
V
Y
V
C
V
L
N
N
S
S
K
K
-
P
L
--
F
S
V
E
E
R
C
E
L
L
R
E
V
T
K
D
I
P
N
I
T
V
-
E
T
S
Q
G
L
L
I
D
Y
A
R
R
K
N
A
K
A
I
L
R
G
L
R
A
V
S
D
F
E
Y
E
M
Q
G
T
S
V
N
R
V
L
D
E
S
I
E
T
F
F
M
M
A
N
N
Q
Y
S
F
L
S
S
S
I
V
K
E
V
A
R
Y
D
G
S
V
S
E
F
V
P
----
P
E
V
E
L
A
L
Q
Q
K
F
R
112
HHSearch
78.59
44%
-121
- C2 -
3NBK
2
COAD_MYCTU
A:
[20-176]
-
H
M
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
-
G
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
-
40
PsiBlast_CBE
78.59
43%
-122
- C2 -
3PNB
1
COAD_MYCTU
C:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
15
PsiBlast_PDB
78.56
43%
-123
- C2 -
3NBK
2
COAD_MYCTU
A:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
115
HHSearch
78.47
57%
-125
- C2 -
1O6B
4
COAD_BACSU
A:
[2-158]
--
A
S
I
A
V
C
P
G
S
F
D
P
V
T
Y
G
H
L
D
I
I
K
R
G
A
H
I
F
E
Q
V
Y
V
C
V
L
N
N
S
S
K
K
-
P
L
--
F
S
V
E
E
R
C
E
L
L
R
E
V
T
K
D
I
P
N
I
T
V
-
E
T
S
Q
G
L
L
I
D
Y
A
R
R
K
N
A
K
A
I
L
R
G
L
R
A
V
S
D
F
E
Y
E
M
Q
G
T
S
V
N
R
V
L
D
E
S
I
E
T
F
F
M
M
A
N
N
Q
Y
S
F
L
S
S
S
I
V
K
E
V
A
R
Y
D
G
S
V
S
E
F
V
P
----
P
E
V
E
L
A
L
Q
Q
K
F
-
16
PsiBlast_PDB
78.42
43%
-121
- C2 -
3PNB
1
COAD_MYCTU
A:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
38
PsiBlast_CBE
78.30
46%
-118
- C2 -
1QJC
5
COAD_ECOLI
B:
[4-157]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
36
PsiBlast_CBE
78.15
46%
-121
- C2 -
1GN8
5
COAD_ECOLI
B:
[5-158]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
37
PsiBlast_CBE
78.01
46%
-115
- C2 -
1B6T
4
COAD_ECOLI
B:
[5-158]
-----
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
I
D
I
V
T
R
A
T
Q
M
F
D
H
V
I
L
A
I
A
A
S
P
S
K
K
-
P
M
--
F
T
L
E
E
R
V
A
L
A
Q
Q
A
T
A
H
L
G
N
V
E
V
-
V
G
F
S
D
L
M
A
N
F
A
R
N
Q
H
A
T
V
L
I
R
G
L
R
A
V
A
D
F
E
Y
E
M
Q
L
A
H
M
N
R
H
L
M
P
E
L
E
S
V
F
L
M
P
S
K
E
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
Q
G
D
V
T
H
F
L
P
----
E
N
V
H
Q
A
L
M
A
K
L
-
17
PsiBlast_PDB
77.89
43%
-126
- C2 -
3LCJ
1
COAD_MYCTU
A:
[2-157]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
18
PsiBlast_PDB
77.68
43%
-120
- C2 -
4E1A
1
COAD_MYCTU
A:
[2-157]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
39
PsiBlast_CBE
77.51
43%
-120
- C2 -
3PNB
1
COAD_MYCTU
D:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
43
PsiBlast_CBE
77.41
43%
-121
- C2 -
3NBK
2
COAD_MYCTU
C:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
114
HHSearch
77.10
46%
-123
- C2 -
3K9W
5
COAD_BURP1
A:
[21-178]
-
S
M
V
V
A
V
Y
P
G
T
F
D
P
L
T
R
G
H
E
D
L
V
R
R
A
S
S
I
F
D
T
L
V
V
G
V
A
D
S
R
A
K
K
-
P
F
--
F
S
L
E
E
R
L
K
I
A
N
E
V
L
G
H
Y
P
N
V
K
V
-
M
G
F
T
G
L
L
K
D
F
V
R
A
N
D
A
R
V
I
V
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
M
A
G
M
N
R
Y
L
L
P
D
V
E
T
M
F
M
T
P
S
D
Q
Y
Q
F
I
S
G
T
I
V
R
E
I
A
Q
L
G
G
D
V
S
K
F
V
F
----
P
S
V
E
K
W
L
T
E
K
V
-
44
PsiBlast_CBE
77.09
43%
-122
- C2 -
3NBK
2
COAD_MYCTU
B:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
42
PsiBlast_CBE
77.01
43%
-123
- C2 -
3NBK
2
COAD_MYCTU
D:
[22-177]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
49
PsiBlast_CBE
76.28
43%
-120
- C2 -
3RHS
1
COAD_MYCTU
A:
[2-157]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
13
PsiBlast_PDB
76.11
47%
-127
- C2 -
3PXU
5
COAD_BURP1
A:
[7-160]
----
V
A
V
Y
P
G
T
F
D
P
L
T
R
G
H
E
D
L
V
R
R
A
S
S
I
F
D
T
L
V
V
G
V
A
D
S
R
A
K
K
-
P
F
--
F
S
L
E
E
R
L
K
I
A
N
E
V
L
G
H
Y
P
N
V
K
V
-
M
G
F
T
G
L
L
K
D
F
V
R
A
N
D
A
R
V
I
V
R
G
L
R
A
---
F
E
Y
E
F
Q
M
A
G
M
N
R
Y
L
L
P
D
V
E
T
M
F
M
T
P
S
D
Q
Y
Q
F
I
S
G
T
I
V
R
E
I
A
Q
L
G
G
D
V
S
K
F
V
F
----
P
S
V
E
K
W
L
T
E
K
--
12
PsiBlast_PDB
75.49
47%
-124
- C2 -
3K9W
5
COAD_BURP1
A:
[24-177]
----
V
A
V
Y
P
G
T
F
D
P
L
T
R
G
H
E
D
L
V
R
R
A
S
S
I
F
D
T
L
V
V
G
V
A
D
S
R
A
K
K
-
P
F
--
F
S
L
E
E
R
L
K
I
A
N
E
V
L
G
H
Y
P
N
V
K
V
-
M
G
F
T
G
L
L
K
D
F
V
R
A
N
D
A
R
V
I
V
R
G
L
R
A
V
S
D
F
E
Y
E
F
Q
M
A
G
M
N
R
Y
L
L
P
D
V
E
T
M
F
M
T
P
S
D
Q
Y
Q
F
I
S
G
T
I
V
R
E
I
A
Q
L
G
G
D
V
S
K
F
V
F
----
P
S
V
E
K
W
L
T
E
K
--
47
PsiBlast_CBE
75.36
43%
-114
- C2 -
3NBA
1
COAD_MYCTU
B:
[22-176]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
-
74
PsiBlast_CBE
75.16
45%
-128
- C2 -
3OTW
4
COAD_HELPY
B:
[10-162]
----
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEIY
P
L
I
S
K
-------
46
PsiBlast_CBE
75.12
43%
-116
- C2 -
3NBA
1
COAD_MYCTU
C:
[22-176]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
-
14
PsiBlast_PDB
75.00
43%
-118
- C2 -
3NBA
1
COAD_MYCTU
A:
[22-176]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
-
48
PsiBlast_CBE
74.59
43%
-119
- C2 -
3UC5
1
COAD_MYCTU
A:
[2-157]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
20
PsiBlast_PDB
74.18
43%
-116
- C2 -
3RBA
1
COAD_MYCTU
A:
[2-157]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
N
71
PsiBlast_CBE
74.09
45%
-124
- C2 -
3OTW
4
COAD_HELPY
E:
[10-162]
----
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEIY
P
L
I
S
K
-------
75
PsiBlast_CBE
73.36
45%
-125
- C2 -
3OTW
3
COAD_HELPY
A:
[10-163]
----
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEI
Y
P
L
I
S
K
A
------
69
PsiBlast_CBE
73.33
42%
-119
- C2 -
3L92
1
COAD_YERPE
A:
[6-161]
---
T
K
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
L
D
L
V
T
R
A
S
A
M
F
S
H
V
I
L
A
I
A
D
S
S
S
K
K
-
P
M
--
F
T
L
D
E
R
V
A
L
A
K
K
V
T
A
P
L
K
N
V
E
V
-
L
G
F
S
E
L
M
A
E
F
A
K
K
H
N
A
N
I
L
V
R
G
L
R
S
V
S
D
F
E
Y
E
W
Q
L
A
N
M
N
R
H
L
M
P
K
L
E
S
V
F
L
I
P
S
E
K
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
G
G
D
I
T
P
F
L
P
----
K
P
V
T
K
A
L
L
A
K
L
-
70
PsiBlast_CBE
73.19
45%
-123
- C2 -
3OTW
2
COAD_HELPY
F:
[10-162]
----
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEIY
P
L
I
S
K
-------
72
PsiBlast_CBE
73.17
45%
-126
- C2 -
3OTW
3
COAD_HELPY
D:
[10-162]
----
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEIY
P
L
I
S
K
-------
68
PsiBlast_CBE
72.97
42%
-120
* C2 *
3L93
1
COAD_YERPE
A:
[6-161]
---
T
K
A
I
Y
P
G
T
F
D
P
I
T
N
G
H
L
D
L
V
T
R
A
S
A
M
F
S
H
V
I
L
A
I
A
D
S
S
S
K
K
-
P
M
--
F
T
L
D
E
R
V
A
L
A
K
K
V
T
A
P
L
K
N
V
E
V
-
L
G
F
S
E
L
M
A
E
F
A
K
K
H
N
A
N
I
L
V
R
G
L
R
S
V
S
D
F
E
Y
E
W
Q
L
A
N
M
N
R
H
L
M
P
K
L
E
S
V
F
L
I
P
S
E
K
W
S
F
I
S
S
S
L
V
K
E
V
A
R
H
G
G
D
I
T
P
F
L
P
----
K
P
V
T
K
A
L
L
A
K
L
-
45
PsiBlast_CBE
72.92
43%
-121
- C2 -
3NBA
1
COAD_MYCTU
D:
[22-176]
---
T
G
A
V
C
P
G
S
F
D
P
V
T
L
G
H
V
D
I
F
E
R
A
A
A
Q
F
D
E
V
V
V
A
I
L
V
N
P
A
K
T
-
G
M
--
F
D
L
D
E
R
I
A
M
V
K
E
S
T
T
H
L
P
N
L
R
V
-
Q
V
G
H
G
L
V
V
D
F
V
R
S
C
G
M
T
A
I
V
K
G
L
R
T
G
T
D
F
E
Y
E
L
Q
M
A
Q
M
N
K
H
I
A
G
-
V
D
T
F
F
V
A
T
A
P
R
Y
S
F
V
S
S
S
L
A
K
E
V
A
M
L
G
G
D
V
S
E
L
L
P
----
E
P
V
N
R
R
L
R
D
R
L
-
73
PsiBlast_CBE
72.05
45%
-123
- C2 -
3OTW
3
COAD_HELPY
C:
[10-162]
----
I
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
N
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEIY
P
L
I
S
K
-------
67
PsiBlast_CBE
71.28
44%
-121
- C2 -
3ND6
1
COAD_ENTFA
A:
[4-158]
----
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
--
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
----
P
N
I
Y
H
A
L
K
Q
K
--
61
PsiBlast_CBE
70.58
44%
-120
- C2 -
3ND7
2
COAD_ENTFA
A:
[4-158]
----
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
--
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
----
P
N
I
Y
H
A
L
K
Q
K
--
56
PsiBlast_CBE
70.48
44%
-122
- C2 -
3ND7
2
COAD_ENTFA
F:
[4-158]
----
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
--
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
----
P
N
I
Y
H
A
L
K
Q
K
--
57
PsiBlast_CBE
70.39
44%
-124
- C2 -
3ND7
2
COAD_ENTFA
E:
[4-158]
----
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
--
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
----
P
N
I
Y
H
A
L
K
Q
K
--
62
PsiBlast_CBE
69.68
44%
-123
- C2 -
3ND6
1
COAD_ENTFA
F:
[4-158]
----
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
--
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
----
P
N
I
Y
H
A
L
K
Q
K
--
59
PsiBlast_CBE
69.65
44%
-116
- C2 -
3ND7
2
COAD_ENTFA
C:
[4-158]
----
I
A
L
F
P
G
S
F
D
P
M
T
N
G
H
L
N
L
I
E
R
S
A
K
L
F
D
E
V
I
I
G
V
F
I
-------
L
--
F
T
P
E
E
K
K
Y
L
I
E
E
A
T
K
E
M
P
N
V
R
V
I
M
Q
E
T
Q
L
T
V
E
S
A
K
S
L
G
A
N
F
L
I
R
G
I
R
N
V
K
D
Y
E
Y
E
K
D
I
A
K
M
N
Q
H
L
A
P
E
I
E
T
V
F
L
L
A
E
E
P
Y
A
H
V
S
S
S
L
L
K
E
V
L
R
F
G
G
D
V
S
D
Y
L
P
----
P
N
I
Y
H
A
L
K
Q
K
--
113
HHSearch
61.95
43%
-133
- C2 -
3NV7
5
COAD_HELPY
A:
[3-157]
---
K
V
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
Y
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
----
K
E
I
Y
P
L
I
S
K
A
--
76
PsiBlast_CBE
61.63
44%
-137
- C2 -
3NV7
5
COAD_HELPY
A:
[4-157]
----
V
G
I
Y
P
G
T
F
D
P
V
T
N
G
H
I
D
I
I
H
R
S
S
E
L
F
E
K
L
I
V
A
V
A
H
S
S
A
K
N
-
P
M
--
F
S
L
D
E
R
L
K
M
I
Q
L
A
T
K
S
F
K
N
V
E
C
-
V
A
F
E
G
L
L
A
Y
L
A
K
E
Y
H
C
K
V
L
V
R
G
L
R
V
V
S
D
F
E
Y
E
L
Q
M
G
Y
A
N
K
S
L
N
H
E
L
E
T
L
Y
F
M
P
T
L
Q
N
A
F
I
S
S
S
I
V
R
S
I
I
A
H
K
G
D
A
S
H
L
V
P
KEIY
P
L
I
S
K
A
------