@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1424: (2016-03-25 )
MKFAVIGNPISHSLSPVMHRANFNSLGLDDTYEALNIPIEDFHLIKEIISKKELDGFNITIPHKERIIPYLDYVDEQAINAGAVNTVLIKDGKWIGYNTDGIGYVKGLHSVYPDLENAYILILGAGGASKGIAYELAKFVKPKLTVANRTMARFESWNLNINQISLADAEKYLAEFDIVINTTPAGMAGNNESIINLKHLSPNTLMSDIVYIPYKTPILEEAERKGNHIYNGLDMFVYQGAESFKIWTNKDADINSMKTAVLQQLKGE
Atome Classification :
(58 SA)
---.......---..10........20..----.....----.30.......-----.-----40...-......50........60........70........80.......-.-90-.........100......-.110.-........120.......-130.......140.......150--.-------...------....160---------..---------.---------..---...--170----..---------.......180........-190.-.-.-..-.----..-.200.......210--..-......220....-.-.-.-230.......240.......250.......260......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
K
F
A
V
IG---N
P
I
S
H
S
L
S
P
V
M
H
RANF----NSLGL----DDT
Y
E
A
LNI
P
-----
I
-----
E
-
D
F
H
-
L
I
K
E
I
I
S
K
KELDG
F
N
I
T
IPHKERI
I
P
Y
L
D
Y
V
D
E
QAINAGA
V
N
T
V
L
-I-K--DG
K
W
I
G
YNTD
G
I
G
Y
V
K
G
L
-
H
S
--V-YPDLEN
A
Y
I
L
I
L
GAGGAS-K
G
I
A
Y
E
L
A
K
FVKPK
L
T
VAN
R
T
M
---
A
-------
R
FE------SWN
L
N
-
I
---------
N
Q
---------
I
---------
S
L
---
A
D
A
--
E
------
K
Y
---------
L
A
E
F
D
I
V
I
-NTTPAGMAG-N--N-
E
-
S
-
I
I
-
N
----
L
K-HLSP
N
T
L
M
S
D
I
V
Y---IP-YKT
P
I
L
E
E
A
E
RKG-N-H-I-YN
G
L
D
M
F
V
YQGA
E
S
F
K
I
W
TNKDA
D
I
N
S
M
K
T
A
V
L
Q
Q
LKGE
2
PsiBlast_PDB
98.70
71%
-114
- C4 -
3DOO
1
AROE_STAEQ
A:
[1-267]
---
M
K
F
A
V
I
G
---
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
-----
V
-----
N
-
Q
F
Q
-
D
I
K
K
I
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
-
V
-
K
--
D
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
-
K
Q
--
I
-
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
-
K
G
I
A
N
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
T
M
---
S
-------
R
F
N
------
N
W
S
L
N
-
I
---------
N
K
---------
I
---------
N
L
---
S
H
A
--
E
------
S
H
---------
L
D
E
F
D
I
I
I
-
N
T
T
P
---------------
V
I
-
S
----
L
N
-
R
L
A
S
H
T
L
V
S
D
I
V
Y
---
N
P
-
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
-
P
-
I
-
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
-
81
HHSearch
98.50
72%
-111
- C4 -
3DON
1
AROE_STAEQ
A:
[1-268]
---
M
K
F
A
V
I
G
---
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
-----
V
-----
N
-
Q
F
Q
-
D
I
K
K
I
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
-
V
-
K
--
D
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
-
K
Q
--
I
-
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
-
K
G
I
A
N
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
T
M
---
S
-------
R
F
N
------
N
W
S
L
N
-
I
---------
N
K
---------
I
---------
N
L
---
S
H
A
--
E
------
S
H
---------
L
D
E
F
D
I
I
I
-
N
T
T
P
-----------
D
-
S
-
V
I
-
S
----
L
N
-
R
L
A
S
H
T
L
V
S
D
I
V
Y
---
N
P
-
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
-
P
-
I
-
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
E
1
PsiBlast_PDB
98.18
71%
-111
- C4 -
3DON
1
AROE_STAEQ
A:
[1-268]
---
M
K
F
A
V
I
G
---
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
-----
V
-----
N
-
Q
F
Q
-
D
I
K
K
I
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
-
V
-
K
--
D
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
-
K
Q
--
I
-
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
-
K
G
I
A
N
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
T
M
---
S
-------
R
F
N
------
N
W
S
L
N
-
I
---------
N
K
---------
I
---------
N
L
---
S
H
A
--
E
------
S
H
---------
L
D
E
F
D
I
I
I
-
N
T
T
P
-----------
D
-
S
-
V
I
-
S
----
L
N
-
R
L
A
S
H
T
L
V
S
D
I
V
Y
---
N
P
-
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
-
P
-
I
-
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
E
93
HHSearch
83.93
40%
-101
- C4 -
2EGG
2
AROE_GEOKA
A:
[24-295]
---
K
V
Y
G
L
I
G
---
F
P
V
E
H
S
L
S
P
L
M
H
N
D
A
F
----
A
R
L
G
I
----
P
A
R
Y
H
L
F
S
V
E
-----
P
-----
G
-
Q
V
G
-
A
A
I
A
G
V
R
A
L
G
I
A
G
V
N
V
T
I
P
H
K
L
A
V
I
P
F
L
D
E
V
D
E
H
A
R
R
I
G
A
V
N
T
I
I
-
N
-
N
--
D
G
R
L
V
G
Y
N
T
D
G
L
G
Y
V
Q
A
L
-
E
E
E
-
M
-
N
I
T
L
D
G
K
R
I
L
V
I
G
A
G
G
G
A
-
R
G
I
Y
F
S
L
L
S
T
A
A
E
R
I
D
M
A
N
R
T
V
---
E
-------
K
A
E
------
R
L
V
R
E
-
G
---------
D
E
RR
S
A
Y
----
F
---------
S
L
---
A
E
A
--
E
------
T
R
---------
L
A
E
Y
D
I
I
I
-
N
T
T
S
V
G
M
H
P
-
R
--
V
E
V
-
Q
-
P
L
-
S
----
L
E
-
R
L
R
P
G
V
I
V
S
D
I
I
Y
---
N
P
-
L
E
T
K
W
L
K
E
A
K
A
R
G
-
A
-
R
-
V
-
Q
N
G
V
G
M
L
V
Y
Q
G
A
L
A
F
E
K
W
T
G
Q
W
P
D
V
N
R
M
K
Q
L
V
I
E
A
L
---
3
PsiBlast_PDB
82.86
39%
-102
- C4 -
2EGG
2
AROE_GEOKA
A:
[26-296]
-----
Y
G
L
I
G
---
F
P
V
E
H
S
L
S
P
L
M
H
N
D
A
F
----
A
R
L
G
I
----
P
A
R
Y
H
L
F
S
V
E
-----
P
-----
G
-
Q
V
G
-
A
A
I
A
G
V
R
A
L
G
I
A
G
V
N
V
T
I
P
H
K
L
A
V
I
P
F
L
D
E
V
D
E
H
A
R
R
I
G
A
V
N
T
I
I
-
N
-
N
--
D
G
R
L
V
G
Y
N
T
D
G
L
G
Y
V
Q
A
L
E
E
E
--
M
-
N
I
T
L
D
G
K
R
I
L
V
I
G
A
G
G
G
A
-
R
G
I
Y
F
S
L
L
S
T
A
A
E
R
I
D
M
A
N
R
T
V
---
E
-------
K
A
E
------
R
L
V
R
E
-
G
---------
D
E
RR
S
A
Y
----
F
---------
S
L
---
A
E
A
--
E
------
T
R
---------
L
A
E
Y
D
I
I
I
-
N
T
T
S
V
G
M
H
P
-
R
--
V
-
E
V
Q
-
P
L
-
S
----
L
E
-
R
L
R
P
G
V
I
V
S
D
I
I
Y
---
N
P
-
L
E
T
K
W
L
K
E
A
K
A
R
G
-
A
-
R
-
V
-
Q
N
G
V
G
M
L
V
Y
Q
G
A
L
A
F
E
K
W
T
G
Q
W
P
D
V
N
R
M
K
Q
L
V
I
E
A
L
R
--
84
HHSearch
80.33
39%
-97
- C4 -
1NVT
2
AROE_METJA
A:
[12-284]
---
K
V
I
G
L
I
G
---
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
-----
P
-----
E
-
N
L
K
-
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
-
I
-
E
--
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
-
E
E
--
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
-
R
A
V
A
F
E
L
A
K
D
N
--
N
I
I
I
A
N
R
T
V
---
E
-------
K
A
E
------
A
L
A
K
E
-
I
---------
A
E
K
L
NKKFGEE
V
---------
K
F
---
S
G
L
--
D
------
V
D
---------
L
D
G
V
D
I
I
I
-
N
A
T
P
I
G
M
Y
P
-
N
--
I
D
V
-
E
-
P
I
V
K
----
A
E
-
K
L
R
E
D
M
V
V
M
D
L
I
Y
---
N
P
-
L
E
T
V
L
L
K
E
A
K
K
V
N
-
A
-
K
-
T
-
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
D
K
----
4
PsiBlast_PDB
79.87
37%
-99
- C4 -
1NVT
2
AROE_METJA
A:
[14-285]
-----
I
G
L
I
G
---
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
-----
P
-----
E
-
N
L
K
-
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
-
I
-
E
--
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
-
E
E
--
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
-
R
A
V
A
F
E
L
A
K
--
D
N
N
I
I
I
A
N
R
T
V
---
E
-------
K
A
E
------
A
L
A
K
E
-
I
A
E
K
L
NKKFG
E
E
---------
V
---------
K
F
---
S
G
L
--
D
------
V
D
---------
L
D
G
V
D
I
I
I
-
N
A
T
P
I
G
M
Y
P
-
N
ID
V
-
E
-
P
-
I
V
-
K
----
A
E
-
K
L
R
E
D
M
V
V
M
D
L
I
Y
---
N
P
-
L
E
T
V
L
L
K
E
A
K
K
V
N
-
A
-
K
-
T
-
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
D
K
I
---
21
PsiBlast_CBE
79.47
37%
-97
- C4 -
1NVT
2
AROE_METJA
B:
[14-285]
-----
I
G
L
I
G
---
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
-----
P
-----
E
-
N
L
K
-
Y
V
I
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
-
I
-
E
--
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
-
E
E
--
E
-
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
-
R
A
V
A
F
E
L
A
K
--
D
N
N
I
I
I
A
N
R
T
V
---
E
-------
K
A
E
------
A
L
A
K
E
-
I
AEKLNKKFG
E
E
---------
V
---------
K
F
---
S
G
L
--
D
------
V
D
---------
L
D
G
V
D
I
I
I
-
N
A
T
P
I
G
M
Y
P
-
N
ID
V
-
E
-
P
-
I
V
-
K
----
A
E
-
K
L
R
E
D
M
V
V
M
D
L
I
Y
---
N
P
-
L
E
T
V
L
L
K
E
A
K
K
V
N
-
A
-
K
-
T
-
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
D
K
I
---
5
PsiBlast_PDB
79.19
35%
-99
- C4 -
2HK7
2
AROE_AQUAE
A:
[9-269]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
L
R
G
-
24
PsiBlast_CBE
78.35
35%
-96
- C4 -
2HK9
2
AROE_AQUAE
B:
[15-273]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
L
---
25
PsiBlast_CBE
77.72
35%
-101
- C4 -
2HK7
2
AROE_AQUAE
B:
[9-268]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
L
R
--
7
PsiBlast_PDB
77.34
35%
-97
- C4 -
2HK9
3
AROE_AQUAE
A:
[15-275]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
L
R
G
-
6
PsiBlast_PDB
77.05
35%
-94
- C4 -
2HK8
-
AROE_AQUAE
A:
[9-266]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
----
23
PsiBlast_CBE
76.92
35%
-94
- C4 -
2HK9
2
AROE_AQUAE
C:
[15-272]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
----
92
HHSearch
76.26
36%
-96
- C4 -
2HK9
3
AROE_AQUAE
A:
[13-270]
---
Q
L
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
---
K
---
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-------
22
PsiBlast_CBE
76.09
35%
-91
- C4 -
2HK9
2
AROE_AQUAE
D:
[15-272]
-----
Y
G
V
I
G
---
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
-----
P
-----
E
-
E
L
K
-
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
-
F
-
E
--
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
S
--
L
-
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
-
R
A
V
I
Y
A
L
V
K
-
E
G
A
K
V
F
L
W
N
R
T
K
---
E
-------
K
A
I
------
K
L
A
Q
K
-
F
---------
P
L
---------
E
---------
V
V
---
N
S
P
--
E
------
E
V
---------
I
D
K
V
Q
V
I
V
-
N
T
T
S
V
G
L
K
D
-
E
--
D
-
P
-
E
-
I
F
-
N
----
Y
D
-
L
I
K
K
D
H
V
V
V
D
I
I
Y
------
K
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
-
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
-
R
D
----
79
HHSearch
73.19
30%
-87
- C4 -
3JYO
1
AROE_CORGL
A:
[5-282]
---
I
L
L
G
L
I
G
---
Q
G
L
D
L
S
R
T
P
A
M
H
E
A
E
G
----
L
A
Q
G
R
----
A
T
V
Y
R
R
I
D
T
L
GSRAS
G
-----
Q
-
D
L
K
-
T
L
L
D
A
A
L
Y
L
G
F
N
G
L
N
I
T
H
P
Y
K
Q
A
V
L
P
L
L
D
E
V
S
E
Q
A
T
Q
L
G
A
V
N
T
V
V
-
I
-
D
A-
T
G
H
T
T
G
H
N
T
D
V
S
G
F
G
R
G
M
-
E
E
--
G
-
L
P
N
A
K
L
D
S
V
V
Q
V
G
A
G
G
V
G
-
N
A
V
A
Y
A
L
V
T
H
G
V
Q
K
L
Q
V
A
D
L
D
T
---
S
-------
R
A
Q
------
A
L
A
D
V
-
I
---------
N
N
A
V
GREA
V
V
G
V
---------
D
A
---
R
G
I
--
E
------
D
V
---------
I
A
A
A
D
G
V
V
-
N
A
T
P
M
G
M
P
A
-
H
--
P
-
G
-
T
-
A
F
-
D
----
V
S
-
C
L
T
K
D
H
W
V
G
D
V
V
Y
---
M
P
-
I
E
T
E
L
L
K
A
A
R
A
L
G
-
C
-
E
-
T
-
L
D
G
T
R
M
A
I
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
D
V
S
R
M
R
E
T
F
L
S
-----
67
Fugue
72.41
29%
-86
- C4 -
3JYO
1
AROE_CORGL
A:
[2-283]
ND
S
I
L
L
G
L
I
G
---
Q
G
L
D
L
S
R
T
P
A
M
H
E
A
E
G
----
L
A
Q
G
R
----
A
T
V
Y
R
R
I
D
T
L
-----
G
SRASG
Q
-
D
L
K
-
T
L
L
D
A
A
L
Y
L
G
F
N
G
L
N
I
T
H
P
Y
K
Q
A
V
L
P
L
L
D
E
V
S
E
Q
A
T
Q
L
G
A
V
N
T
V
V
-
I
D
A
--
T
G
H
T
T
G
H
N
T
D
V
S
G
F
G
R
G
M
-
E
E
--
G
-
L
P
N
A
K
L
D
S
V
V
Q
V
G
A
G
G
V
G
-
N
A
V
A
Y
A
L
V
T
H
G
V
Q
K
L
Q
V
A
D
L
D
T
---
S
-------
R
A
Q
------
A
L
A
D
V
-
I
---------
N
N
---------
A
V
GREA
V
V
G
V
D
A
---
R
G
I
--
E
------
D
V
---------
I
A
A
A
D
G
V
V
-
N
A
T
P
M
G
M
P
A
-
H
--
P
-
G
-
T
-
A
F
-
D
----
V
S
-
C
L
T
K
D
H
W
V
G
D
V
V
Y
---
M
P
-
I
E
T
E
L
L
K
A
A
R
A
L
G
-
C
-
E
-
T
-
L
D
G
T
R
M
A
I
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
D
V
S
R
M
R
E
T
F
L
S
L
----
27
PsiBlast_CBE
72.31
34%
-76
- C4 -
3TOZ
2
AROE_LISMO
G:
[41-311]
------
G
L
I
A
---
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
-----
D
-----
K
-
E
L
K
-
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
-
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
E
--
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
-
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
-------
F
Y
A
------
N
A
E
K
T
-
V
---------
E
K
---------
I
NSKTDCKA-
Q
L
---
F
D
I
--
E
DHEQLR
K
E
---------
I
A
E
S
V
I
F
T
-
N
A
T
G
V
G
M
K
P
F
E
--
G
-
E
-
T
-
L
L
P
S
----
A
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
---
K
P
-
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
-
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
----------
78
HHSearch
72.20
35%
-79
* C4 *
3TNL
3
AROE_LISMO
A:
[38-313]
---
E
L
I
G
L
I
A
---
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
-----
D
-----
K
-
E
L
K
-
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
-
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
E
--
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
-
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
DF
Y
A
-------
N
A
E
------
K
T
V
E
K
-
I
---------
N
S
KTD
C
K
A
Q
L
-
F
---------
D
I
ED
H
E
Q
L
--
R
------
K
E
---------
I
A
E
S
V
I
F
T
-
N
A
T
G
V
G
M
K
P
-
F
--
E
-
G
-
E
T
L
L
-
P
S---
A
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
---
K
P
-
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
-
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
E
I
--------
35
PsiBlast_CBE
72.12
34%
-73
- C4 -
3TNL
2
AROE_LISMO
B:
[41-311]
------
G
L
I
A
---
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
-----
D
-----
K
-
E
L
K
-
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
-
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
E
--
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
-
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
-------
F
Y
A
------
N
A
E
K
T
-
V
---------
E
K
---------
I
N
S
KTD
C
K
A
-
Q
L
---
F
D
I
--
E
D
H
E
Q
L
R
K
E
---------
I
A
E
S
V
I
F
T
-
N
A
T
G
V
G
M
K
P
F
E
--
G
-
E
-
T
-
L
L
P
S
----
A
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
---
K
P
-
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
-
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
----------
33
PsiBlast_CBE
72.10
34%
-75
- C4 -
3TNL
2
AROE_LISMO
D:
[41-311]
------
G
L
I
A
---
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
-----
D
-----
K
-
E
L
K
-
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
-
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
E
--
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
-
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
-------
F
Y
A
------
N
A
E
K
T
-
V
---------
E
K
---------
I
NSKTDCKA-
Q
L
---
F
D
I
--
E
DHEQLR
K
E
---------
I
A
E
S
V
I
F
T
-
N
A
T
G
V
G
M
K
P
F
E
--
G
-
E
-
T
-
L
L
P
S
----
A
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
---
K
P
-
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
-
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
----------
9
PsiBlast_PDB
71.63
34%
-74
- C4 -
3TNL
3
AROE_LISMO
A:
[41-311]
------
G
L
I
A
---
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
-----
D
-----
K
-
E
L
K
-
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
-
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
E
--
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
-
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
-------
F
Y
A
------
N
A
E
K
T
-
V
---------
E
K
---------
I
N
S
KTD
C
K
A
-
Q
L
---
F
D
I
--
E
D
H
E
Q
L
R
K
E
---------
I
A
E
S
V
I
F
T
-
N
A
T
G
V
G
M
K
P
F
E
--
G
-
E
-
T
-
L
L
P
S
----
A
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
---
K
P
-
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
-
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
----------
41
PsiBlast_CBE
71.36
33%
-81
- C4 -
1NYT
6
AROE_ECOLI
C:
[4-269]
-----
Y
A
V
F
G
---
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
-----
I
-----
N
-
D
F
I
-
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
-
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
-
E
R
--
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
-
R
G
V
L
L
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
T
V
---
S
-------
R
A
E
ELAKLF
A
H
T
G
S
-
I
---------
Q
A
---------
L
---------
S
M
---
D
E
L
--
E
------
G
H
-----------
E
F
D
L
I
I
-
N
A
T
S
S
G
I
S
G
-
D
--
I
-
P
-
A
-
I
P
-
S
-----
S
-
L
I
H
P
G
I
Y
C
Y
D
M
F
Y
---
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
-
K
-
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
----
V
I
K
Q
L
Q
E
E
34
PsiBlast_CBE
71.27
34%
-76
- C4 -
3TNL
3
AROE_LISMO
C:
[41-311]
------
G
L
I
A
---
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
E
V
G
-----
D
-----
K
-
E
L
K
-
D
V
V
Q
G
F
R
A
M
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
V
-
N
-
D
--
D
G
V
L
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
-
K
E
--
A
-
G
H
D
I
I
G
K
K
M
T
I
C
G
A
G
G
A
A
-
T
A
I
C
I
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
K
D
---
D
-------
F
Y
A
------
N
A
E
K
T
-
V
---------
E
K
---------
I
NSKTDCKA-
Q
L
---
F
D
I
--
E
DHEQLR
K
E
---------
I
A
E
S
V
I
F
T
-
N
A
T
G
V
G
M
K
P
F
E
--
G
-
E
-
T
-
L
L
P
S
----
A
D
-
M
L
R
P
E
L
I
V
S
D
V
V
Y
---
K
P
-
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
-
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
H
K
E
M
P
V
D
Y
I
K
----------
40
PsiBlast_CBE
71.09
33%
-79
- C4 -
1NYT
5
AROE_ECOLI
D:
[4-269]
-----
Y
A
V
F
G
---
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
-----
I
-----
N
-
D
F
I
-
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
-
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
-
E
R
--
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
-
R
G
V
L
L
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
T
V
---
S
-------
R
A
E
ELAKLF
A
H
T
G
S
-
I
---------
Q
A
---------
L
---------
S
M
---
D
E
L
--
E
------
G
H
-----------
E
F
D
L
I
I
-
N
A
T
S
S
G
I
S
G
-
D
--
I
-
P
-
A
-
I
P
-
S
-----
S
-
L
I
H
P
G
I
Y
C
Y
D
M
F
Y
---
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
-
K
-
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
----
V
I
K
Q
L
Q
E
E
64
PsiBlast_CBE
70.20
32%
-81
- C4 -
3T4E
2
YDIB_SALTY
A:
[30-297]
----
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
----
E
K
A
G
L
----
P
Y
T
Y
M
A
F
E
V
D
-----
N
-----
T
-
T
F
A
-
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
-
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
-
K
E
--
S
-
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
-
T
A
I
G
A
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
---
D
-------
F
F
E
K
A
V
---
A
F
A
K
R
-
V
---------
N
E
N
TD
C
V
V
T
V
-
T
---------
D
L
---
A
D
Q
--
H
------
A
F
T
E
A
------
L
A
S
A
D
I
L
T
-
N
G
T
K
V
G
M
K
P
L
E
--
N
-
E
-
S
-
L
I
G
D
----
V
S
-
L
L
R
P
E
L
L
V
T
E
C
V
Y
---
N
P
-
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
-
C
-
K
-
T
-
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
------------------
42
PsiBlast_CBE
70.07
33%
-77
- C4 -
1NYT
5
AROE_ECOLI
B:
[4-269]
-----
Y
A
V
F
G
---
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
-----
I
-----
N
-
D
F
I
-
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
-
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
-
E
R
--
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
-
R
G
V
L
L
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
T
V
---
S
-------
R
A
E
ELAKLF
A
H
T
G
S
-
I
---------
Q
A
---------
L
---------
S
M
---
D
E
L
--
E
------
G
H
-----------
E
F
D
L
I
I
-
N
A
T
S
S
G
I
S
G
-
D
--
I
-
P
-
A
-
I
P
-
S
-----
S
-
L
I
H
P
G
I
Y
C
Y
D
M
F
Y
---
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
-
K
-
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
----
V
I
K
Q
L
Q
E
E
80
HHSearch
70.04
33%
-83
- C4 -
2D5C
4
AROE_THET8
A:
[2-261]
---
L
R
F
A
V
L
G
---
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
-----
L
-----
E
-
A
L
P
-
G
R
L
K
E
V
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
-
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
-
K
A
--
G
-
G
I
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
-
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
W
N
R
T
P
---
Q
-------
R
A
L
------
A
L
A
E
E
-
F
---------
G
L
---------
R
----------
A
---
V
P
L
---------
E
K
---------
A
R
E
A
R
L
L
V
-
N
A
T
R
V
G
L
E
D
-
P
--
S
-
A
-
S
-
P
L
-
P
----
A
E
-
L
F
P
E
E
G
A
A
V
D
L
V
Y
---
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
-
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
63
PsiBlast_CBE
69.70
32%
-81
- C4 -
3T4E
2
YDIB_SALTY
B:
[30-297]
----
K
Y
E
L
I
G
L
M
A
Y
P
I
R
H
S
L
S
P
E
M
Q
N
K
A
L
----
E
K
A
G
L
----
P
Y
T
Y
M
A
F
E
V
D
-----
N
-----
T
-
T
F
A
-
S
A
I
E
G
L
K
A
L
K
M
R
G
T
G
V
S
M
P
N
K
Q
L
A
C
E
Y
V
D
E
L
T
P
A
A
K
L
V
G
A
I
N
T
I
V
-
N
-
D
--
D
G
Y
L
R
G
Y
N
T
D
G
T
G
H
I
R
A
I
-
K
E
--
S
-
G
F
D
M
R
G
K
T
M
V
L
L
G
A
G
G
A
A
-
T
A
I
G
A
Q
A
A
I
E
G
I
K
E
I
K
L
F
N
R
K
D
---
D
-------
F
F
E
K
A
V
---
A
F
A
K
R
-
V
---------
N
E
N
TD
C
V
V
T
V
-
T
---------
D
L
---
A
D
Q
--
H
------
A
F
T
E
A
------
L
A
S
A
D
I
L
T
-
N
G
T
K
V
G
M
K
P
L
E
--
N
-
E
-
S
-
L
I
G
D
----
V
S
-
L
L
R
P
E
L
L
V
T
E
C
V
Y
---
N
P
-
H
M
T
K
L
L
Q
Q
A
Q
Q
A
G
-
C
-
K
-
T
-
I
D
G
Y
G
M
L
L
W
Q
G
A
E
Q
F
E
L
W
T
G
K
------------------
89
HHSearch
69.41
36%
-84
- C4 -
2O7S
2
DHQSD_ARATH
A:
[235-512]
---
K
V
Y
G
I
I
G
---
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
----
K
S
V
D
F
----
N
G
V
Y
V
H
L
L
V
D
-------------
N
L
V
-
S
F
L
Q
A
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
-
R
-
R
KS
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
-
E
D
--
G
L
-------
T
V
V
V
I
G
A
G
G
A
G
-
K
A
L
A
Y
G
A
K
E
K
G
A
--
V
V
I
A
N
R
T
Y
---
E
-------
R
A
L
------
E
L
A
E
A
-
I
---------
G
G
A--------
L
---------
S
L
---
T
D
L
--
D
------
N
Y
----------
E
D
G
M
V
L
A
-
N
T
T
S
M
G
M
Q
P
-
N
--
V
-
E
-
E
T
P
I
-
S
----
K
D
-
A
L
K
H
Y
A
L
V
F
D
A
V
Y
---
T
P
-
R
I
T
R
L
L
R
E
A
E
E
S
G
-
A
-
I
-
T
-
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
A
P
K
E
L
Y
W
Q
I
M
S
------
14
PsiBlast_PDB
69.03
33%
-78
- C4 -
1NYT
7
AROE_ECOLI
A:
[4-269]
-----
Y
A
V
F
G
---
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
-----
I
-----
N
-
D
F
I
-
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
-
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
-
E
R
--
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
-
R
G
V
L
L
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
T
V
---
S
-------
R
A
E
E
L
A
K
L
F
A
H
T
G
S
-
I
---------
Q
A
---------
L
---------
S
M
---
D
E
L
--
E
------
G
H
-----------
E
F
D
L
I
I
-
N
A
T
S
S
G
I
S
G
-
D
--
I
-
P
-
A
-
I
P
-
S
-----
S
-
L
I
H
P
G
I
Y
C
Y
D
M
F
Y
---
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
-
K
-
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
----
V
I
K
Q
L
Q
E
E
66
PsiBlast_CBE
68.94
32%
-86
- C4 -
1P77
1
AROE_HAEIN
A:
[4-268]
-----
Y
A
V
W
G
---
N
P
I
A
Q
S
K
S
P
L
I
Q
N
K
L
A
----
A
Q
T
H
Q
----
T
M
E
Y
I
A
K
L
G
D
-----
L
-----
D
-
A
F
E
-
Q
Q
L
L
A
F
F
E
E
G
A
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
K
L
-
D
--
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
-
Q
R
--
L
-
N
W
L
R
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
-
K
G
V
L
L
P
L
L
Q
-
A
Q
Q
N
I
V
L
A
N
R
T
F
---
S
K
T
K
E
L
A
E
R
F
Q
------
P
Y
G
-
N
-
I
---------
Q
A
---------
V
---------
S
M
---
D
S
I
--
P
-----------------
L
Q
T
Y
D
L
V
I
-
N
A
T
S
A
------------
S
--
V
-
D
----
A
E
-
I
L
K
L
G
S
A
F
Y
D
M
Q
Y
---
A
K
G
T
D
T
P
F
I
A
L
C
K
S
L
G
L
T
-
N
-
V
-
S
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
D
F
V
S
----
V
Y
E
Q
L
K
--
87
HHSearch
65.40
33%
-78
- C4 -
1NYT
7
AROE_ECOLI
A:
[2-268]
---
E
T
Y
A
V
F
G
---
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
-----
I
-----
N
-
D
F
I
-
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
-
R
L
E
--
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
-
E
R
--
L
-
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
-
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
T
N
R
T
V
---
S
-------
R
A
E
------
E
L
A
K
L
-
F
---------
A
H
TG
S
------
I
---------
Q
A
---
L
S
M
--
D
------
E
L
E--------
G
H
E
F
D
L
I
I
-
N
A
T
S
S
G
I
S
G
-
D
--
I
---
P
-
A
I
-
P
----
S
S
-
L
I
H
P
G
I
Y
C
Y
D
M
F
Y
---
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
-
K
R
N
-
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
-----
49
PsiBlast_CBE
65.21
32%
-81
- C4 -
3PGJ
1
AROE_VIBCH
C:
[31-280]
----
Q
Y
A
V
F
G
---
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-----
V
-----
D
-
G
F
T
-
E
A
A
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
-
D
--
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
A
--
Q
-
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
-
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
---
A
-------
K
A
E
------
Q
L
A
E
L
-
V
AAY------
G
E
---------
V
---------
K
A
---
Q
A
F
--
E
------
Q
L
---------
K
Q
S
Y
D
V
I
I
-
N
S
T
S
-----------
P
-
A
--
I
-
D
----
P
V
-
I
F
S
S
R
S
V
C
Y
D
M
M
Y
---
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
-
C
A
Q
-
A
-
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
---------------------
86
HHSearch
64.95
30%
-81
- C4 -
1P77
1
AROE_HAEIN
A:
[2-271]
---
D
L
Y
A
V
W
G
---
N
P
I
A
Q
S
K
S
P
L
I
Q
N
K
L
A
----
A
Q
T
H
Q
----
T
M
E
Y
I
A
K
L
G
D
-----
L
-----
D
-
A
F
E
-
Q
Q
L
L
A
F
F
E
E
G
A
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
-
K
-
L
D-
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
-
Q
R
--
L
-
N
W
L
R
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
-
K
G
V
L
L
P
L
L
Q
A
Q
-
Q
N
I
V
L
A
N
R
T
F
---
S
-------
K
T
K
------
E
L
A
E
R
-
F
---------
Q
P
Y
G
N
------
I
---------
Q
A
---
V
S
M
D-
S
------
I
P
---------
L
Q
T
Y
D
L
V
I
-
N
A
T
S
A
--------------
S
V
-
D
----
A
E
-
I
L
K
L
G
S
A
F
Y
D
M
Q
Y
---
A
K
G
T
D
T
P
F
I
A
L
C
K
S
L
G
-
L
-
T
N
V
-
S
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
D
F
V
S
V
Y
E
Q
L
K
K
A
M
---
48
PsiBlast_CBE
64.49
32%
-71
- C4 -
3PGJ
1
AROE_VIBCH
D:
[31-280]
----
Q
Y
A
V
F
G
---
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-----
V
-----
D
-
G
F
T
-
E
A
A
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
-
D
--
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
A
--
Q
-
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
-
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
---
A
-------
K
A
E
------
Q
L
A
E
L
-
V
AAY------
G
E
---------
V
---------
K
A
---
Q
A
F
--
E
------
Q
L
---------
K
Q
S
Y
D
V
I
I
-
N
S
T
S
A
S
L
D
G
-
E
--
L
-
P
-
A
--
I
-
D
----
P
V
-
I
F
S
S
R
S
V
C
Y
D
M
M
Y
---
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
-
C
A
Q
-
A
-
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
---------------------
37
PsiBlast_CBE
64.30
32%
-68
- C4 -
2D5C
3
AROE_THET8
B:
[2-261]
---
L
R
F
A
V
L
G
---
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
-----
L
-----
E
-
A
L
P
G
R
L
K
E
V
--
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
-
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
-
K
------------------
A
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
---
A
-------
G
L
E
------
V
W
V
W
N
R
T
---------
P
Q
---------
R
---------
A
L
---
A
L
A
--
E
------
E
F
G
L
R
A
V
P
LEK
A
R
E
A
R
L
L
V
-
N
A
T
R
V
G
L
--------
A
-
S
-
P
L
-
P
----
A
E
-
L
F
P
E
E
G
A
A
V
D
L
V
Y
---
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
-
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
36
PsiBlast_CBE
64.04
32%
-65
- C4 -
2EV9
2
AROE_THET8
B:
[2-261]
---
L
R
F
A
V
L
G
---
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
-----
L
-----
E
-
A
L
P
G
R
L
K
E
V
--
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
-
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
-
K
------------------
A
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
---
A
-------
G
L
E
------
V
W
V
W
N
R
T
---------
P
Q
---------
R
---------
A
L
---
A
L
A
--
E
------
E
F
GLRAVPLEK
A
R
E
A
R
L
L
V
-
N
A
T
R
V
G
L
E
D
-
P
--
S
-
A
-
S
-
P
L
-
P
----
A
E
-
L
F
P
E
E
G
A
A
V
D
L
V
Y
---
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
-
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
13
PsiBlast_PDB
63.90
32%
-65
- C4 -
2EV9
3
AROE_THET8
A:
[2-261]
---
L
R
F
A
V
L
G
---
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
-----
L
-----
E
-
A
L
P
G
R
L
K
E
V
--
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
-
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
-
K
------------------
A
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
---
A
-------
G
L
E
------
V
W
V
W
N
R
T
---------
P
Q
---------
R
---------
A
L
---
A
L
A
--
E
------
E
F
G
L
R
A
V
P
LEK
A
R
E
A
R
L
L
V
-
N
A
T
R
V
G
L
E
D
-
P
--
S
-
A
-
S
-
P
L
-
P
----
A
E
-
L
F
P
E
E
G
A
A
V
D
L
V
Y
---
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
-
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
46
PsiBlast_CBE
63.87
32%
-74
- C4 -
3SEF
2
AROE_VIBCH
B:
[31-280]
----
Q
Y
A
V
F
G
------
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-----
V
-----
D
-
G
F
T
-
E
A
A
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
-
D
--
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
A
--
Q
-
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
-
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
---
A
-------
K
A
E
------
Q
L
A
E
L
-
V
AAY------
G
E
---------
V
---------
K
A
---
Q
A
F
--
E
------
Q
L
---------
K
Q
S
Y
D
V
I
I
-
N
S
T
S
A
S
L
D
G
-
E
--
L
-
P
-
A
--
I
-
D
----
P
V
-
I
F
S
S
R
S
V
C
Y
D
M
M
Y
---
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
-
C
A
Q
-
A
-
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
---------------------
12
PsiBlast_PDB
63.80
32%
-71
- C4 -
2D5C
4
AROE_THET8
A:
[2-261]
---
L
R
F
A
V
L
G
---
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
-----
L
-----
E
-
A
L
P
G
R
L
K
E
V
--
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
-
Q
-
V
--
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
-
K
------------------
A
G
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
---
A
-------
G
L
E
------
V
W
V
W
N
R
T
---------
P
Q
---------
R
---------
A
L
---
A
L
A
--
E
------
E
F
G
L
R
A
V
P
LEK
A
R
E
A
R
L
L
V
-
N
A
T
R
V
G
L
E
D
-
P
--
S
-
A
-
S
-
P
L
-
P
----
A
E
-
L
F
P
E
E
G
A
A
V
D
L
V
Y
---
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
-
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
20
PsiBlast_PDB
63.75
32%
-76
- C4 -
3PGJ
1
AROE_VIBCH
A:
[31-280]
----
Q
Y
A
V
F
G
---
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-----
V
-----
D
-
G
F
T
-
E
A
A
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
-
D
--
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
A
--
Q
-
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
-
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
---
A
-------
K
A
E
------
Q
L
A
E
L
-
V
AAY------
G
E
---------
V
---------
K
A
---
Q
A
F
--
E
------
Q
L
---------
K
Q
S
Y
D
V
I
I
-
N
S
T
S
A
S
L
D
G
-
E
--
L
-
P
-
A
--
I
-
D
----
P
V
-
I
F
S
S
R
S
V
C
Y
D
M
M
Y
---
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
-
C
A
Q
-
A
-
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
---------------------
50
PsiBlast_CBE
63.70
32%
-75
- C4 -
3PGJ
1
AROE_VIBCH
B:
[31-280]
----
Q
Y
A
V
F
G
------
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-----
V
-----
D
-
G
F
T
-
E
A
A
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
-
D
--
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
A
--
Q
-
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
-
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
---
A
-------
K
A
E
------
Q
L
A
E
L
-
V
AAY------
G
E
---------
V
---------
K
A
---
Q
A
F
--
E
------
Q
L
---------
K
Q
S
Y
D
V
I
I
-
N
S
T
S
A
S
L
D
G
-
E
--
L
-
P
-
A
--
I
-
D
----
P
V
-
I
F
S
S
R
S
V
C
Y
D
M
M
Y
---
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
-
C
A
Q
-
A
-
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
---------------------
45
PsiBlast_CBE
61.58
32%
-84
- C4 -
3SEF
1
AROE_VIBCH
C:
[31-280]
----
Q
Y
A
V
F
G
---
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-----
V
-----
D
-
G
F
T
-
E
A
A
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K--
D
--
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
A
--
Q
-
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
-
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
---
A
-------
K
A
E
------
Q
L
A
E
L
-
V
AAY------
G
E
---------
V
---------
K
A
---
Q
A
F
--
E
------
Q
L
---------
K
Q
S
Y
D
V
I
I
-
N
S
T
S
A
---------------
I
-
D
----
P
V
-
I
F
S
S
R
S
V
C
Y
D
M
M
Y
---
G
----------------------
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
---------------------
58
PsiBlast_CBE
60.90
33%
-76
- C4 -
4FQ8
1
AROE_HELPY
B:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
Q
-----
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
----
K
E
-
V
L
K
G
Y
F
K
E
G
K
L
A
Y
DLA
A
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
57
PsiBlast_CBE
59.69
34%
-71
- C4 -
4FOS
1
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
Q
-----
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
F
M
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
K
E
V
-
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
A
A
A
L
S
F
E
K
F
S
--------------------
62
PsiBlast_CBE
59.61
32%
-71
- C4 -
2GPT
2
DHQSD_ARATH
A:
[237-498]
-----
Y
G
I
I
G
---
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
----
K
S
V
D
F
----
N
G
V
Y
--
V
H
L
L
-----
V
-----
D
-
N
L
V
-
S
F
L
Q
A
Y
S
S
S
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
L
-
R
-
R
KS
D
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
-
E
D
G
L----------
T
V
V
V
I
G
A
G
G
A
-
G
K
A
L
A
Y
G
A
K
E
K
G
A
K
V
V
I
A
N
R
T
Y
---
E
-------
R
--------
E
L
A
E
A
-
I
G---------
A
---------
L
---------
S
L
---
T
D
L
--
D
------
N
Y
-----------
E
D
G
M
V
L
A
N
T
T
S
M
G
M
Q
P
-
N
V-
E
-
E
-
T
-
P
I
-
S
----
K
D
-
A
L
K
H
Y
A
L
V
F
D
A
V
Y
---
T
P
-
R
I
T
R
L
L
R
E
A
E
E
S
G
-
A
-
I
-
T
-
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
--------------------
55
PsiBlast_CBE
59.60
34%
-76
- C4 -
3PHI
2
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
--------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
F
M
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
K
E
V
-
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
65
PsiBlast_CBE
59.47
33%
-79
- C4 -
4FSH
1
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
K
L
G
F
----
L
G
H
Y
R
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
N
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
A
S
I
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
-----
H
Q
N
Y
Q
N
A
--
L
I
L
G
S
G
G
S
A
-
K
A
L
A
C
G
L
K
K
-
Q
G
L
K
V
S
V
L
N
R
S
---------------------
P
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
N
--------
P
L
-
N
K
E
V
-
L
K
G
Y
F
K
E
A
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
A
L
A
K
E
L
K
-
I
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
S
L
S
F
E
K
F
S
--------------------
54
PsiBlast_CBE
59.19
34%
-75
- C4 -
3PHI
2
AROE_HELPY
B:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
--------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
KEV-
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
60
PsiBlast_CBE
59.10
33%
-71
- C4 -
4FR5
1
AROE_HELPY
B:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
Q
-----
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
----
K
E
-
V
L
K
G
Y
F
K
E
G
K
L
A
Y
DLA
S
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
61
PsiBlast_CBE
58.79
33%
-71
- C4 -
4FR5
1
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
Q
-----
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
----
K
E
-
V
L
K
G
Y
F
K
E
G
K
L
A
Y
D
LA
S
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
56
PsiBlast_CBE
58.60
34%
-72
- C4 -
3PHH
1
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
--------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
F
M
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
K
E
V
-
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
52
PsiBlast_CBE
58.11
34%
-78
- C4 -
3PHJ
1
AROE_HELPY
B:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
LTFQ
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
--------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
-----------
E
-
L
-
P
L
-
N
KEV-
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
53
PsiBlast_CBE
57.99
34%
-78
- C4 -
3PHJ
1
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
--------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
-----------
E
-
L
-
P
L
-
N
K
E
V
-
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
----
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
59
PsiBlast_CBE
57.60
33%
-72
- C4 -
4FQ8
1
AROE_HELPY
A:
[6-246]
-----
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
-
S
-
H
-
I
K
S
E
F
L
H
L
G
-
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
Q
-----
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
-
Q
G
L
Q
V
S
V
L
N
R
S
---------------------
S
R
G
L
D
-
F
---------
F
Q
---------
R
---------
L
G
---
C
D
C
FM
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
---
H
--
N
-
E
-
L
-
P
L
-
N
----
K
E
-
V
L
K
G
Y
F
K
E
G
K
L
A
Y
D
LA
A
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
--------------------
91
HHSearch
56.99
31%
-72
- C4 -
3PHH
1
AROE_HELPY
A:
[4-257]
---
K
S
F
G
V
F
G
---
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
----
L
T
F
Q
K
ELR
F
L
G
H
Y
H
P
I
L
L
P
-----
L
-----
E
S
H
I
K
-
S
E
---
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
-
E
--
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
-
K
A
L
A
C
E
L
K
K
Q
G
L
-
Q
V
S
V
L
N
R
S
S
---
R
-------
G
L
D
------
F
-
F
Q
R
-
L
---------
G
C
---------
D
---------
C
F
---
M
----
E
------
P
P
---------
K
S
A
F
D
L
I
I
-
N
A
T
S
A
S
L
H
N
-
E
--
L
-----
P
L
-
N
K
E
V
L
K
G
-
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
---
G
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
-
T
-
P
-
F
-
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
---------