@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0032: (2015-12-11 )
MMFHKALITFIVLWFFLNGLGAYDFKHCQAFFKKASLQKGGVALKELPKGVYLYYSKTYPKHAKVIKSDPFIGLYLLQSAPSEYVYTLRDLDKDALIRPMASIGANQATEARLLVGQKGYDRYAQISQKTQKNGVISNICYQMLGLGVGGNGFIETKFIKRFLNQQEPYYGDIGVRLEERHKRLVVAQFDPFFPKNPFLKNDEILAINDYKIHSLAEFEWVVSNLSYQSLAKVKIKRNHQIKEVTLKVNKRYGGFLLKDTFLERYGIALDERFIITKIGAHLPKGLDFLKLGDRILWVNHKSVSFNPKALREALSTPKIELLVWRQGFEFYIKVR
Atome Classification :
(20 SA)
----.........10........20........30........40..----------------------......---.50...---------.....---60........70.....--...80-.---....-....90.--....--------...100..-----..-.----..-110.......-----120-----......---..130........140......------.---150---------------..-..----.----...160...-.....----170...-....------------------180-----------.-------...-----..----------...190----...---.-.-..200---------.........210.--.-..--...--220.....--..230.....--..240------.--.....-.250-.....-...260------.......------------270------....------------.....280......-.290.......300...-..-..310..-.---.---..--.320..-.....330...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
M
F
H
K
A
L
I
T
F
I
V
L
W
F
F
L
NGLGA
Y
D
F
K
H
C
Q
A
F
F
K
K
ASLQKG-
G
V
----------------------
A
L
K
ELP---K
G
V
Y
L
Y
---------
Y
SKTY---PK
H
A
K
VIKSDP
F
I
G
L
Y
L
--
L
QSA--P---
S
E
Y
V
-
Y
T
L
R
DL
D
--
K
D
A
L
--------
I
R
P
M
A
S
IG-----AN-Q----AT-
E
A
R
L
L
VGQKG-----
Y
D
------
R
Y
A
Q
I
S
---
Q
K
T
-QKNG
V
I
S
N
I
C
Y
Q
M
L
GLGV------G---GN----------------G
F
-
I
E
----
T
----
K
F
I
K
-
R
F
L
N-QQEPY----YGDIG
V
-
R
L
E
E
------------------R-------------H-------
K
R
L
-----
V
V
----------
A
QFDPF----FPK---N-P-FLK-----------ND
E
I
L
A
I
N
D
Y
K
IH--
S
-
L
A
--
E
F
E
--
W
V
V
SNL
S
Y
--
Q
S
L
A
K
V
K
I
KR--NH
Q
I
K
------
E
--
V
T
L
K
V
-NK-R-YG
G
F
L
-
L
K
D
T
F
L
------
E
R
YGIAL------------D--------
E
R
F
I
------------
I
T
K
I
GAHLPKG
L
D
F
-
L
KLG
D
R
I
L
W
V
NHKSVSF-
N
P
-
K
A
L
R
E
A
L-S---T---P
K
--
I
E
L
L
V
W
-RQG
F
E
F
Y
I
K
VR-----
5
PsiBlast_PDB
81.83
21%
-50
- C5 -
3OTP
-
DEGP_ECOLI
A:
[124-439]
-------------------------------------------------------------------------------------------------------
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
--
I
Q
I
Q
--
N
---
P
K
N
L
-
T
A
I
K
M
A
D
--
S
D
A
L
RVGD
Y
T
V
A
I
G
N
P
F
G
L
G
-----
E
T
-
V
----
T
S
-
G
I
V
S
A
L
G
R
S
G
LNAEN
Y
E
------
N
F
I
Q
T
D
AAI
N
R
G
-
N
A
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
ILAPD
G
---
G
N
IG
I
-------------
G
F
A
I
P
----
S
----
N
M
V
K
-
N
L
T
S
-
Q
M
V
E
Y
GQVK
R
G
E
L
G
I
-
M
G
T
E
------------------
L
-------------
N
-------
S
E
L
A
K
A
M
K
V
D
----------
A
Q
R
G
A
F
VSQV
L
P
N
---
S
-
S
-
A
A
K
A
GIKA------
G
D
V
I
T
S
L
N
G
K
P
I
S
--
S
-
F
A
--
A
L
R
--
A
Q
V
G
T
M
P
V
--
G
S
K
L
T
L
G
L
L
R
--
D
G
K
Q
V
------
N
--
V
N
L
E
L
-
Q
Q
-
S
------------
F
NGIEG
A
E
M
S
N
K
G
K
------------
D
--------
Q
G
V
V
------------
V
N
N
V
K
T
G
T
P
A
A
Q
I
G
-
L
K
K
G
D
V
I
I
G
A
N
Q
Q
A
V
K
--
N
I
-
A
E
L
R
K
V
L
D
S
---
K
---
P
S
--
V
L
A
L
N
I
-
Q
R
G
D
S
T
I
Y
L
L
M
-----
3
PsiBlast_PDB
77.80
21%
-45
- C5 -
3MH6
1
DEGP_ECOLI
A:
[124-439]
-------------------------------------------------------------------------------------------------------
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
--
I
Q
I
Q
--
N
---
P
K
N
L
-
T
A
I
K
M
A
D
--
S
D
A
L
RVG
D
Y
T
V
A
I
G
N
P
F
G
L
G
-----
E
T
-
V
----
T
S
-
G
I
V
S
A
L
G
R
S
G
LNAEN
Y
E
------
N
F
I
Q
T
D
AAI
N
R
G
-
N
S
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
I
L
A
PD
G
---
G
N
IG
I
-------------
G
F
A
I
P
----
S
----
N
M
V
K
-
N
L
T
S
-
Q
M
V
E
Y
GQVK
R
G
E
L
G
I
-
M
G
T
E
------------------
L
-------------
N
-------
S
E
L
A
K
A
M
K
V
D
----------
A
Q
R
G
A
F
V
S
Q
V
L
P
N
---
S
-
S
-
A
A
K
A
GIKA------
G
D
V
I
T
S
L
N
G
K
P
I
S
--
S
-
F
A
--
A
L
R
--
A
Q
V
G
T
M
P
V
--
G
S
K
L
T
L
G
L
L
R
--
D
G
K
Q
V
------
N
--
V
N
L
E
L
-
Q
Q
-
S
-
S
Q
N
Q
V
-
D
S
S
S
I
F
NGIE
G
A
E
M
S
N
K
G
K
------------
D
--------
Q
G
V
V
------------
V
N
N
V
K
T
G
T
P
A
A
Q
I
G
-
L
K
K
G
D
V
I
I
G
A
N
Q
Q
A
V
K
--
N
I
-
A
E
L
R
K
V
L
D
S
---
K
---
P
S
--
V
L
A
L
N
I
-
Q
R
G
D
S
T
I
Y
L
L
M
-----
36
Fugue
73.86
19%
-77
- C5 -
3PV2
-
?
A:
[6-439]
MPSM
A
P
V
L
K
N
I
M
P
A
I
V
N
V
A
V
Q
G
Y
L
P
N
R
K
F
E
S
I
G
S
G
V
I
I
D
P
N
N
G
V
-
I
I
----------------------
T
N
D
H
V
I
---
R
N
A
S
L
I
---------
T
V
T
L
Q
DG
R
R
L
K
A
R
L
I
G
G
D
S
E
T
D
L
A
V
--
L
K
I
D
--
A
---
K
N
L
K
S
L
V
I
G
D
S
D
--
K
L
E
V
--------
G
D
F
V
V
A
I
G
N
PFGL
S
Q
-
S
----
A
T
-
F
G
I
V
S
A
L
K
N
F
-----
I
Q
------
T
D
A
A
I
N
---
P
G
N
-
S
-
G
G
A
L
V
N
A
K
G
E
L
I
G
I
N
T
------
A
I
LV
G
I
----------------
G
F
A
I
P
----
I
----
N
M
V
K
-
D
V
A
Q
-
Q
I
I
K
F
G
S
I
H
R
G
L
M
G
I
-
F
V
Q
H
------------------
L
-------------
T
-------
P
E
L
-----
A
Q
A
M
GYPED
F
Q
G
A
L
V
S
Q
V
----
N
P
N
---
S
-
P
-
A
E
L
A
GLKA------
G
D
I
I
T
Q
I
N
D
T
K
I
T
--
Q
-
A
T
--
Q
V
K
--
T
T
I
S
L
L
R
V
--
G
S
T
V
K
I
I
V
E
R
--
D
N
K
P
L
------
T
--
L
S
A
V
V
T
D
I
-
K
-
S
H
E
Q
K
-
L
Q
S
N
N
P
------
F
L
Y
G
L
A
L
------------
R
--------
A
F
E
Q
ESPPH
G
N
V
I
G
V
Q
V
V
G
A
S
E
N
S
A
G
W
R
A
G
-
I
R
P
G
D
I
I
I
S
A
N
K
K
P
V
T
--
D
V
-
K
S
L
Q
T
I
A
-
Q
---
E
---
K
K
K
E
L
L
V
Q
V
L
-
R
G
P
G
S
M
Y
L
L
V
I
-----
16
HHSearch
73.24
20%
-66
- C5 -
3PV2
-
?
A:
[96-438]
---------------------------------------------------------------------------------------------
L
Q
D
G
R
---
R
L
K
A
R
L
I
G
G
D
S
E
T
D
L
A
V
--
L
K
I
D
A
-
K
---
N
L
K
S
-
L
V
I
G
D
S
D
--
K
L
E
V
--------
G
D
F
V
V
A
I
G
-----
N
P
F
G
LS
Q
S
A
T
-
F
G
I
V
S
A
L
K
------------------
N
F
I
Q
T
D
A
A
I
N
P
G
N
S
--
G
G
A
L
V
N
A
K
G
E
L
I
------
G
---
I
N
T
A
I
LVG
I
---------
G
F
A
I
P
----
I
N
M
V
K
D
V
A
Q
-
Q
I
I
K
-
F
G
S
I
H
----
R
G
L
M
G
I
-
F
V
Q
H
------------------
L
T
P
E
L
A
Q
A
M
GYPED
F
-------
Q
G
A
-----
L
V
----------
S
Q
V
N
P
N
----
S
P
A
E
L
-
A
-
G
-
L
K
A
-----------
G
D
I
I
T
Q
I
N
D
T
K
I
T
--
Q
-
A
T
--
Q
V
K
--
T
T
I
S
L
L
R
V
--
G
S
T
V
K
I
I
V
E
R
--
D
N
K
P
L
------
T
--
L
S
A
V
V
-
T
D
-
I
-
K
S
H
E
Q
K
L
Q
S
N
N
P
------
F
L
Y
G
L
A
L
R
A
F
E
Q
ESPPH
G
N
V
--------
I
G
V
Q
------------
V
V
G
A
S
E
N
S
A
G
W
R
A
G
-
I
R
P
G
D
I
I
I
S
A
N
K
K
P
V
T
D
-
V
--
K
S
L
Q
T
I
A
-
Q
EK-
K
---
K
E
--
L
L
V
Q
V
L
-
R
G
P
G
S
M
Y
L
L
V
I
-----
2
PsiBlast_PDB
71.37
21%
-38
- C5 -
2ZLE
-
DEGP_ECOLI
A:
[87-389]
-------------------------------------------------------------------------------------------------------
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
--
I
Q
I
Q
--
N
---
P
K
N
L
-
T
A
I
K
M
A
D
--
S
D
A
L
RVG
D
Y
T
V
A
I
G
N
P
F
G
L
G
-----
E
T
-
V
----
T
S
-
G
I
V
S
A
L
G
R
--------
E
------
N
F
I
Q
T
D
AAI
N
R
G
-
N
S
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
ILAP
D
G
---
G
N
IG
I
-------------
G
F
A
I
P
----
S
----
N
M
V
K
-
N
L
T
S
-
Q
M
V
E
Y
GQVK
R
G
E
L
G
I
-
M
G
T
E
------------------
L
-------------
N
-------
S
E
L
A
K
A
M
K
V
D
----------
A
Q
R
G
A
F
V
S
Q
V
L
P
N
---
S
-
S
-
A
A
K
A
G
I
K
A
------
G
D
V
I
T
S
L
N
G
K
P
I
S
--
S
-
F
A
--
A
L
R
--
A
Q
V
G
T
M
P
V
--
G
S
K
L
T
L
G
L
L
R
--
D
G
K
Q
V
------
N
--
V
N
L
E
L
-
Q
Q
-
S
-
S
Q
N
Q
V
-
D
S
S
S
I
F
N-----
E
M
S
N
K
G
K
------------
D
--------
Q
G
V
V
------------
V
N
N
V
K
T
G
T
P
A
A
Q
I
G
-
L
K
K
G
D
V
I
I
G
A
N
Q
Q
A
V
K
--
N
I
-
A
E
L
R
K
V
L
D
S
---
K
---
P
S
--
V
L
A
L
N
I
-
Q
R
G
D
S
T
I
Y
L
L
------
6
PsiBlast_PDB
63.19
21%
-21
- C5 -
3MH4
-
DEGP_ECOLI
A:
[124-353]
-------------------------------------------------------------------------------------------------------
D
A
K
M
V
G
K
D
P
R
S
D
I
A
L
--
I
Q
I
Q
--
N
---
P
K
N
L
-
T
A
I
K
M
A
D
--
S
D
A
L
RVG
D
Y
T
V
A
I
G
N
P
F
G
L
G
-----
E
T
-
V
----
T
S
-
G
I
V
S
A
L
G
R
S
--------------
N
F
I
Q
T
D
AAI
N
R
G
-
N
A
G
G
A
L
V
N
L
N
G
E
L
I
G
I
N
T
A
ILAPD
G
---
G
N
IG
I
-------------
G
F
A
I
P
----
S
----
N
M
V
K
-
N
L
T
S
-
Q
M
V
E
Y
G
Q
V
K
R
G
E
L
G
I
-
M
G
T
E
------------------
L
-------------
N
-------
S
E
L
AKAMK
V
D
----------
A
Q
R
G
A
F
V
S
Q
V
L
P
N
---
S
-
S
-
A
A
K
AGIKA------
G
D
V
I
T
S
L
N
G
K
P
I
S
--
S
-
F
A
--
A
L
R
--
A
Q
V
G
T
M
P
V
--
G
S
K
L
T
L
G
L
L
R
--
D
G
K
Q
V
------
N
--
V
N
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
61.55
19%
-33
- C5 -
3STJ
2
DEGQ_ECOLI
A:
[93-334]
-----------------------------------------------------------------------------------
Q
---------
L
N
D
G
R
---
E
F
D
A
K
L
I
G
S
D
D
Q
S
D
I
A
L
--
L
Q
I
Q
NP
S
---
K
L
T
Q
-
I
A
I
A
D
S
D
--
K
L
R
V
--------
G
D
F
A
V
A
V
G
-----
N
P
F
G
L
G
Q
T
A
T
-
S
G
I
V
S
A
L
G
R
S
-----
G
L
NLE---
G
L
E
N
F
I
Q
T
D
A
S
I
N
R
G
N
S
--
G
G
A
L
L
N
L
N
G
E
L
I
------
G
---
I
N
TAILAPGGGSVG
I
---
G
F
A
I
P
S
N
M
A
R
----
T
L
A
Q
-
Q
L
I
D
-
F
G
E
I
K
----
R
G
L
L
G
I
-
K
G
T
E
------------------
M
S
A
D
I
A
K
A
F
NLDV-
Q
-------
R
G
A
-----
F
V
----------
S
E
V
L
P
G
----
S
G
S
A
K
-
A
-
G
-
V
K
A
-----------
G
D
I
I
T
S
L
N
G
K
P
L
N
--
S
-
F
A
--
E
L
R
--
S
R
I
A
T
T
E
P
--
G
T
K
V
K
L
G
L
L
R
--
N
G
K
P
L
------
E
--
V
E
V
T
L
-
D
T
-
S
----------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
59.19
23%
-93
- C5 -
3WKM
-
Y1964_AQUAE
A:
[10-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
V
-----
V
V
----------
G
Y
V
Q
R
D
----
S
I
A
Q
K
-
I
-
G
-
I
K
P
-----------
G
D
K
I
I
K
I
N
G
Y
E
V
R
--
T
-
W
E
--
D
L
R
--
D
A
L
I
R
L
S
L
D
G
V
K
E
T
T
L
F
L
E
R
--
N
G
E
V
L
------
H
--
L
T
I
K
V
-
P
N
-
V
-
Q
---------
K
G
------
E
E
L
G
I
A
P
------------
L
--------
V
K
P
V
------------
V
G
G
V
K
K
G
S
P
A
D
Q
V
G
-
I
K
P
G
D
L
I
L
E
V
N
G
K
K
I
N
T
-
W
--
Y
E
L
V
E
E
V
-
R
K
SQ
G
---
K
A
--
I
K
L
K
I
L
-
R
N
G
K
M
I
E
K
E
L
I
-----
27
HHSearch
56.92
20%
-88
- C5 -
3GSL
-
DLG4_RAT
A:
[92-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
-----
F
I
----------
T
K
I
I
P
G
----
G
A
A
A
Q
-
D
-
G
R
L
R
V
-----------
N
D
S
I
L
F
V
N
E
V
D
V
R
--
E
-
V
T
--
H
S
A
--
A
V
E
A
L
K
E
A
--
G
S
I
V
R
L
Y
V
M
R
--
R
K
P
P
A
E
K
----
V
--
M
E
I
K
L
-
I
K
-
G
-
P
-----------------
K
G
L
G
F
S
I
A
G
G
VGNQHIPG-
D
--------
N
S
I
Y
------------
V
T
K
I
I
E
G
G
A
A
H
K
D
G
R
L
Q
I
G
D
K
I
L
A
V
N
S
V
G
L
E
D
-
V
M
H
E
D
A
V
A
A
L
-
K
NT-
Y
---
D
V
--
V
Y
L
K
V
A
-
K
P
S
N
A
E
T
M
A
-------
29
HHSearch
55.84
18%
-82
- C5 -
3R0H
5
INAD_DROME
A:
[28-200]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
P
M
G
V
-
I
V
C
G
------------------
G
-------------
K
NNHVT--
T
G
C
-----
V
I
----------
T
H
V
Y
P
E
----
G
Q
V
A
A
D
K
-
R
-
L
K
I
-----------
F
D
H
I
C
D
I
N
G
T
P
I
H
VG
S
-
M
T
--
T
L
K
V
H
Q
L
F
H
-
T
T
Y
--
E
K
A
V
T
L
T
V
F
R
--
A
D
P
P
E
------
L
E
K
F
N
V
D
L
-
M
K
------------
K
A
G
------
K
E
L
G
L
S
L
S
P
N
---------
E
--------
I
G
C
T
------------
I
A
D
L
I
Q
G
Q
Y
P
E
I
D
S
K
L
Q
R
G
D
I
I
T
K
F
N
G
D
A
L
E
G
-
L
P
F
Q
V
C
Y
A
L
F
-
K
G
A-
N
---
G
K
--
V
S
M
E
V
T
-
R
P
K
P
T
L
R
T
E
A
P
-----
1
PsiBlast_PDB
55.37
40%
-30
* C4 *
4YO1
2
?
A:
[301-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
V
Q
I
N
D
T
K
I
T
--
Q
-
A
T
--
Q
V
K
--
T
T
I
S
L
L
R
A
--
G
S
T
A
K
I
K
I
L
R
--
D
N
--
K
------
P
--
L
T
L
D
V
-
E
V
-
T
-
D
--------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
54.95
11%
-44
- C5 -
3QO6
2
DEGP1_ARATH
A:
[12-334]
---------------------
L
Q
T
D
E
L
A
T
V
R
L
F
Q
E
N
T
P
S
V
V
Y
I
T
-
N
L
A
V
R
Q
DAFTL
D
V
L
E
V
P
Q
G
S
G
S
G
F
V
W
D
K
Q
G
H
I
V
T
N
Y
H
V
I
RGAS
D
L
R
V
T
L
A
D
Q
T
---
T
F
D
A
K
V
V
G
F
D
Q
D
K
D
V
A
V
--
L
R
I
D
--
A
P
KN
K
L
R
P
-
I
P
V
G
V
S
A
--
D
L
L
V
--------
G
Q
K
V
F
A
I
G
-----
N
P
F
G
LDH
T
L
T
-
T
G
V
I
S
G
L
R
R
E
-----
I
S
SAAT
G
R
P
I
Q
D
V
I
Q
T
D
A
A
I
N
P
G
N
S
--
G
G
P
L
L
D
S
S
G
T
L
I
------
G
---
I
N
TAIYSPSGASSG
V
---
G
F
S
I
P
V
D
T
V
G
----
G
I
V
D
-
Q
L
V
R
-
F
G
K
V
T
----
R
P
I
L
G
I
-
K
F
A
P
------------------
D
-------------
Q
S
V
E
QLGV
S
G
V
-----
L
V
----------
L
D
A
P
P
S
----
G
P
A
G
K
-
A
-
G
-
L
Q
S
T
KRDGYGRLVL
G
D
I
I
T
S
V
N
G
T
K
V
S
--
N
-
G
S
--
D
L
Y
--
R
I
L
D
Q
C
K
V
--
G
D
E
V
T
V
E
V
L
R
--
G
D
H
K
E
------
K
--
I
S
V
T
L
-
E
P
-
K
-
P
--------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
53.62
17%
-31
- C5 -
1TE0
-
DEGS_ECOLI
A:
[106-352]
----------------------------------------------------------------------------------
V
A
---------
L
Q
D
G
R
---
V
F
E
A
L
L
V
G
S
D
S
L
T
D
L
A
V
--
L
I
I
K
--
A
T
G-
G
L
P
T
-
I
P
I
N
A
R
R
--
V
P
H
I
--------
G
D
V
V
L
A
I
G
-----
N
P
Y
N
L
G
Q
T
I
T
-
Q
G
I
I
S
A
T
G
R
I
-----
G
L
NPT---
G
R
Q
N
F
L
Q
T
D
A
S
I
N
H
G
N
S
--
G
G
A
L
V
N
S
L
G
E
L
M
------
G
---
I
N
T
LSFDKSNDGETPEG
I
G
F
A
I
P
----
F
Q
L
A
T
K
I
M
D
-
K
L
I
R
-
D
G
R
V
I
----
R
G
Y
I
G
I
-
G
G
R
E
------------------
I
A
PLHAQGGGID
Q
-
L
-------
Q
G
I
-----
V
V
----------
N
E
V
S
P
D
----
G
P
A
A
N
-
A
-
G
-
I
Q
V
-----------
N
D
L
I
I
S
V
D
N
K
P
A
I
--
S
-
A
L
--
E
T
M
--
D
Q
V
A
E
I
R
P
--
G
S
V
I
P
V
V
V
M
R
--
D
D
K
Q
L
------
T
--
L
Q
V
T
I
-
Q
E
-
Y
-
P
A
T
------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
52.15
16%
-88
- C5 -
1P1D
-
A:
[36-212]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
G
I
-
Q
L
Q
G
------------------
S
VFATETL------
S
-------
S
P
P
-----
L
I
----------
S
Y
I
E
A
D
----
S
P
A
ER-
C
-
G
V
L
Q
I
-----------
G
D
R
V
M
A
I
N
G
I
P
T
E
--
D
-
S
T
F
E
E
A
N
--
Q
L
L
R
D
S
S
I
--
T
S
K
V
T
L
E
I
E
F
--
D
V
A
E
S
V
I
P
S
S
G
T
--
F
H
V
K
L
-
P
K
------------
K
H
S
------
V
E
L
G
I
T
I
------------
S
S
PSSRKPG
D
P
L
V
------------
I
S
D
I
K
K
G
S
V
A
H
R
T
G
T
L
E
L
G
D
K
L
L
A
I
D
N
I
R
L
D
S
-
C
S
M
E
D
A
V
Q
I
L
-
Q
Q
C
-
E
---
D
L
--
V
K
L
K
I
R
-
K
D
E
D
------------
43
Fugue
51.26
17%
-35
- C1 -
3ZX7
12
TXL_EISFE
A:
[5-300]
-----
A
E
G
Y
E
Q
I
E
V
D
V
V
A
V
W
K
E
G
-
Y
V
Y
E
N
R
G
S
T
S
V
D
Q
K
I
T
I
T
K
G
M
K
N
----------------------
V
N
S
E
---------------------
T
R
T
V
---
T
A
T
H
S
I
G
S
T
I
S
T
G
D
A
F
E
--
I
G
S
V
--
E
---
V
S
Y
S
-
H
S
H
E
------------------------------
E
S
-
Q
----
V
S
M
T
E
T
E
V
Y
E
S
K
V
-----
I
E
------
H
T
I
T
I
P
---
P
T
--------
S
K
F
T
R
W
Q
L
N
A
D
V
------
G
---
G
--------------------------
A
----
D
I
E
Y
M
Y
L
I
D
-
E
V
T
P
I
----
G
G
T
Q
S
I
P
Q
V
I
T
------------------
S
-------------
R
-------
A
K
I
-----
I
V
----------
G
-----------
R
---
Q
-
I
-
I
L
G
-----------
K
T
E
I
R
I
K
H
A
E
R
K
E
--
Y
M
T
V
--
V
S
R
KS
W
P
A
A
T
L
G
H
--
S
K
L
F
K
F
V
L
Y
E
--
D
W
--
G
------
G
--
F
R
I
K
T
-
L
N
-
T
M
Y
S
G
Y
E
-
Y
A
Y
S
-
S
------
D
Q
G
G
I
Y
F
------------
D
--------
Q
G
T
D
------------
N
P
K
Q
R
W
A
I
N
K
S
L
P
--
L
R
H
G
D
--------
V
V
T
F
M
N
K
-
Y
F
T
R
S
G
L
-
C
---
Y
D
DG
P
A
--
T
N
V
Y
C
L
D
K
R
E
D
K
W
I
L
E
V
V
G
L
VPR
30
HHSearch
51.22
14%
-64
- C5 -
2QT5
4
GRIP1_RAT
A:
[18-197]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
T
L
G
L
-
T
V
S
G
------------------
G
IDK----------
D
-------
G
K
P
-----
R
V
----------
S
N
L
R
Q
G
----
G
I
A
AR-
S
D
Q
-
L
D
V
-----------
G
D
Y
I
K
A
V
N
G
I
N
L
A
--
K
-
F
R
--
H
D
E
--
I
I
S
L
L
K
N
V
--
G
E
R
V
V
L
E
V
E
Y
--
E
L
P
P
V
------
S
--
I
Q
G
S
S
-
V
M
F
R
-
T
V
E
V
T
-
L
-
H
K
E
G
------
N
T
F
G
F
V
I
R
G
GAHDDRNK--
S
--------
R
P
V
V
------------
I
T
C
V
R
P
G
G
P
A
D
R
E
G
T
I
K
P
G
D
R
L
L
S
V
D
G
I
R
L
L
G
-
T
T
H
A
E
A
M
S
I
L
-
K
Q
C-
G
---
Q
E
--
A
T
L
L
I
E
-
Y
D
V
S
V
-----------
4
PsiBlast_PDB
50.27
40%
-53
- C4 -
4YNN
-
?
A:
[301-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
I
V
Q
I
N
D
T
K
I
T
--
Q
-
A
T
--
Q
V
K
--
T
T
I
S
L
L
R
A
--
G
S
T
A
K
I
K
I
L
R
--
D
N
--
K
------
P
--
L
T
L
D
V
-
E
V
-
T
-
D
I
K
K
H
-
E
Q
K
L
Q
S
------
N
N
P
F
L
Y
G
------------
L
--------
A
L
R
N
------------
F
E
Q
E
S
P
P
H
G
N
V
V
G
V
-
Q
V
V
G
A
S
E
T
S
A
G
W
R
A
G
L
R
-
P
G
-
D
I
I
I
S
A
N
-
K
---
T
---
P
V
--
K
D
I
K
S
L
-
Q
A
V
A
H
E
K
G
K
Q
L
-----
22
HHSearch
50.21
17%
-41
- C5 -
1LCY
-
HTRA2_HUMAN
A:
[78-321]
----------------------------------------------------------------------------------------------
L
S
G
D
---
T
Y
E
A
V
V
T
A
V
D
P
V
A
D
I
A
T
--
L
R
I
Q
--
T
KE-
P
L
P
T
-
L
P
L
G
R
S
A
--
D
V
R
Q
--------
G
E
F
V
V
A
M
G
S----
P
F
-
A
LQN
T
I
T
-
S
G
I
V
S
S
A
Q
R
P
--------------
N
V
E
Y
I
Q
T
D
A
A
I
D
F
G
N
A
--
G
G
P
L
V
N
L
D
G
E
V
I
------
G
---
V
N
T
M
K
VTAG
I
--------
S
F
A
I
P
----
S
----
D
R
L
R
-
E
F
L
H
R----------
R
Y
I
G
V
-
M
M
L
T
LS
P
S
I
L
A
E
L
Q
LREPSFPD
V
-------------
Q
-------
H
G
V
-----
L
I
----------
H
K
V
I
L
G
----
S
P
A
H
R
-
A
-
G
-
L
R
P
-----------
G
D
V
I
L
A
I
G
E
Q
M
V
Q
--
N
-
A
E
--
D
V
Y
--
E
A
V
R
---
T
--
Q
S
Q
L
A
V
Q
I
R
R
--
G
R
E
T
L
------
T
--
L
Y
V
T
P
-
E
V
-
T
-
E
--------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
49.68
17%
-82
- C5 -
1W9E
3
SDCB1_HUMAN
A:
[15-164]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
K
I
G
L
-
R
L
K
S
------------------
I
-------------
D
-------
N
G
I
-----
F
V
----------
Q
L
V
Q
A
N
----
S
P
A
S
L
-
V
-
G
-
L
R
F
-----------
G
D
Q
V
L
Q
I
N
G
E
N
C
A
--
G
-
W
S
--
S
D
K
A
H
K
V
L
K
-
Q
A
F
--
G
E
K
I
T
M
T
I
R
D
--
R
P
F
E
R
------
T
--
I
T
M
H
K
---------------
D
S
T
------
G
H
V
G
F
I
F
------------
K
--------
N
G
-
K
------------
I
T
S
I
V
K
D
S
S
A
A
R
N
G
-
L
L
T
E
H
N
I
C
E
I
N
G
Q
N
V
I
G
-
L
K
D
S
Q
I
A
D
I
L
-
S
T
S-
G
---
T
V
--
V
T
I
T
I
M
-
P
A
F
-------------
45
Fugue
48.87
17%
-11
- C2 -
3R6O
4
?
A:
[22-323]
------
M
N
L
R
I
V
S
F
A
W
Q
P
G
V
L
I
D
D
D
T
V
A
P
L
A
P
M
S
A
R
E
L
I
A
L
L
P
Q
-
I
S
----------------------
P
L
I
S
D
E
-------
L
V
---------
P
L
D
S
V
---
A
L
G
A
P
I
P
E
P
G
Q
V
I
A
L
G
F
NY
P
T
H
D
--
P
---
V
V
F
M
-
K
S
P
T
S
I
S
GP
R
D
A
V
--------
I
A
P
R
T
S
H
A
-----
L
D
-
Y
----
E
I
-
E
I
A
V
V
I
G
K
P
G
-----
Y
R
I-----
E
R
S
Q
A
I
---
K
H
V
-
A
G
Y
M
L
A
N
D
I
T
A
R
D
V
A
L
P
F
------
G
---
Q
A
----------------
Q
V
-
V
R
----
G
----
K
------------------------------------------------------------------------------------------
G
Y
P
T
F
----
C
P
T
---
G
-
P
-
W
L
F
-----------
T
T
G
----
S
D
T
T
F
E
--
T
-
F
---
D
F
E
--
L
R
I
N
G
E
L
R
--
Q
S
G
S
T
V
D
M
T
L
G
F
A
E
V
V
E
------
T
--
V
S
A
T
I
-
A
L
-
R
-
A
G
D
I
I
-
L
T
G
T
P
---------
G
G
C
G
F
------------
Q
--------------------------------
F
D
P
P
R
Y
-
L
R
P
G
D
V
I
E
A
H
S
A
K
--------------
L
-
G
---
K
---
M
R
--
L
P
V
H
D
E
-
K
P
--------------