@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0390: (2015-12-15 )
MSNQASHLDNFMNAKNPKSFFDNKGNTKFIAITSGKGGVGKSNISANLAYSLYKKGYKVGVFDADIGLANLDVIFGVKTHKNILHALKGEAKLQEIICEIEPGLCLIPGDSGEEILKYISGAEALDRFVDEEGVLSSLDYIVIDTGAGIGATTQAFLNASDCVVIVTTPDPSAITDAYACIKINSKNKDELFLIANMVAQPKEGRATYERLFKVAKNNIASLELHYLGAIENSSLLKRYVRERKILRKIAPNDLFSQSIDQIASLLVSKLETGTLEIPKEGLKSFFKRLLKYLG
Atome Classification :
(20 SA)
.........10........20........30........40........50...------.-....60........70.-.....--.-----.--------80-.--------..------..-...---.90------......--------------------..-----100--.......-.110.....---.--.-.--------120------.---..---...-...130.....---..----.140.......150........160.......170.......180---.-.------...--------------------.--------.-.-----190-.......200.......210--.........-220.-...-...230..-..-...240------.........250----------..---.....260.......270.......280.......290..-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSN
Q
A
S
H
L
D
N
F
MNAK
N
P
K
S
F
FDNKG
N
T
K
F
I
A
I
TSGKGGVGKSN
I
S
A
N
L
A
Y
S
L
Y
K------K-G
Y
K
V
G
V
F
DADIGL
A
N
L
D
-
V
I
F
GV--
K
-----
T
--------
H
--
K
--------
N
I
------
L
H
-
A
LK---G
E
A
------
K
L
Q
E
I
I
--------------------
C
E-----I-E--P
G
L
C
L
I
P-GD-
S
G
E
E
I
L
---
K
--
Y
-I--------S--------
G
---
A
E
---
A
L
D
-
R
F
VDE-E
G
V
LS---SL----
D
Y
I
V
I
DTGAGI
G
A
-
T
T
Q
A
FLNAS
D
C
V
V
I
V
TTPDPSAIT
D
A
Y
A
C
I
----
K
-I------NSK--------------------N--------K-
D
-----
E
L
F
-
L
I
A
N
M
VAQPKEG
R
A
T
Y
E
R
----
L
F
K
V
A
KNNI-
A
S
L
E
-
L
H
Y
-
L
GAIE
N
S
S
-
L
L
-
K
R
Y
V
--------
R
E
R
K
I
L
R
K
IA
P
N
----------
D
L
---
F
S
Q
S
I
D
Q
I
A
S
L
L
V
S
K
LETGTLEI
P
K
E
G
L
K
S
F
F
K
R
L
L
K
YLG-----
1
PsiBlast_PDB
94.05
31%
-109
* C2 *
4RZ3
2
?
A:
[29-272]
-------------------------
S
P
R
T
I
A
V
T
S
G
K
G
G
V
G
K
S
N
V
S
L
N
F
S
L
S
L
S
K
------
L
-
G
F
R
V
L
L
L
D
M
A
I
G
M
G
N
I
D
-
I
L
L
G
E
--
S
-----
S
--------
S
--
L
--------
A
L
------
A
D
-
W
F
S
---
A
R
L
------
P
L
S
E
L
V
--------------------
K
S
-----
G
-
P
--
E
H
L
S
Y
I
A
-
G
G
-
T
G
A
A
Q
W
---
Q
--
G
-
L
--------
D
--------
T
---
A
----
S
I
D
-
R
F
L
T
E
L
Q
A
V
A
S
---
Q
Y
----
D
Y
L
I
F
D
M
G
A
G
A
S
G
-
E
R
L
Y
F
L
K
S
V
D
D
V
F
V
V
T
T
P
E
P
T
A
M
T
D
A
Y
A
M
M
----
K
Y
M
------
H
A
A
--------------------
G
--------
S
-
E
-----
A
P
F
S
V
I
V
N
R
A
G
K
E
R
E
G
Y
E
V
F
E
R
----
L
-
K
H
V
T
G
R
F
-
L
N
K
D
-
I
A
L
-
L
G
I
I
P
E
D
R
-
T
V
-
A
R
A
V
--------
V
S
Q
T
P
F
V
L
L
D
P
A
----------
A
K
---
A
S
K
A
V
R
Q
M
A
F
R
Y
A
P
-------------------------------
21
PsiBlast_CBE
93.45
31%
-109
- C2 -
4RZ3
2
?
B:
[29-272]
-------------------------
S
P
R
T
I
A
V
T
S
G
K
G
G
V
G
K
S
N
V
S
L
N
F
S
L
S
L
S
K
------
L
-
G
F
R
V
L
L
L
D
M
A
I
G
M
G
N
I
D
-
I
L
L
G
E
--
S
-----
S
--------
S
--
L
--------
A
L
------
A
D
-
W
F
S
---
A
R
L
------
P
L
S
E
L
V
--------------------
K
S
-----
G
-
P
--
E
H
L
S
Y
I
A
-
G
G
-
T
G
A
A
Q
W
---
Q
--
G
-
L
--------
D
--------
T
---
A
----
S
I
D
-
R
F
L
T
E
L
Q
A
V
A
S
---
Q
Y
----
D
Y
L
I
F
D
M
G
A
G
A
S
G
-
E
R
L
Y
F
L
K
S
V
D
D
V
F
V
V
T
T
P
E
P
T
A
M
T
D
A
Y
A
M
M
----
K
Y
M
------
H
A
A
--------------------
G
--------
S
-
E
-----
A
P
F
S
V
I
V
N
R
A
G
K
E
R
E
G
Y
E
V
F
E
R
----
L
-
K
H
V
T
G
R
F
-
L
N
K
D
-
I
A
L
-
L
G
I
I
P
E
D
R
-
T
V
-
A
R
A
V
--------
V
S
Q
T
P
F
V
L
L
D
P
A
----------
A
K
---
A
S
K
A
V
R
Q
M
A
F
R
Y
A
P
-------------------------------
58
HHSearch
85.31
24%
-97
- C2 -
1G3Q
2
?
A:
[1-236]
-------------------------
M
G
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
D
------
R
-
G
R
K
V
L
A
V
D
G
D
L
T
M
A
N
L
S
-
L
V
L
G
V
--
D
-----
D
--------
P
D-
V
--------
T
L
------
H
D
-
V
L
A
---
G
E
A
------
N
V
E
D
A
I
--------------------
Y
M
-----
T
Q
F
--
D
N
V
Y
V
L
P
-
G
A
-
V
D
W
E
H
V
---
L
--
K
-
A
--------
D
--------
P
----
R
---
K
L
P
-
E
V
I
K
S
-
L
K
--
D
---
K
F
----
D
F
I
L
I
D
C
P
A
G
L
Q
L
-
D
A
M
S
A
M
L
S
G
E
E
A
L
L
V
T
N
P
E
I
S
C
L
T
D
T
M
K
V
G
----
I
-
V
------
L
K
K
A
-------------------
G
--------
L
-
A
-----
I
L
G
-
F
V
L
N
R
Y
G
R
S
D
R
D
--
I
P
-------
P
E
A
A
E
D
V
----
M
E
-
V
P
L
-
L
A
V
I
P
E
D
P
-
A
I
-
R
E
G
T
--------
L
E
G
I
P
A
V
K
Y
K
P
E
----------
S
K
---
G
A
K
A
F
V
K
L
A
E
E
I
E
K
L
A
-----------------------------
4
PsiBlast_PDB
84.48
27%
-100
- C2 -
1HYQ
-
?
A:
[3-230]
---------------------------
R
T
I
T
V
A
S
G
K
G
G
T
G
K
T
T
I
T
A
N
L
G
V
A
L
A
Q
------
L
-
G
H
D
V
T
I
V
D
A
D
I
T
M
A
N
L
E
-
L
I
L
G
M
--
E
GLPV-
T
--------
L
--
Q
--------
N
V
------
L
A
-------
G
E
A
------
R
I
D
E
A
I
--------------------
Y
V
-----
G
-
P
--
G
G
V
K
V
V
P
-
A
G
-
V
S
L
E
G
L
---
R
--
K
----------
A
--------
N
---
P
E
---
K
L
E
-
D
V
L
T
Q
---
I
M
E
---
S
T
----
D
I
L
L
L
D
A
P
A
G
L
E
R
-
S
A
V
I
A
I
A
A
A
Q
E
L
L
L
V
V
N
P
E
I
S
S
I
T
D
G
L
K
T
K
----
I
-
V
------
A
E
R
L
-------------------
G
--------
T
-
K
-----
V
L
G
-
V
V
V
N
R
I
T
T
L
G
-------------
I
E
M
A
K
N
E
I
E
A
I
L
E
-
A
K
V
-
I
G
L
I
P
E
D
P
-
E
V
-
R
R
A
A
--------
A
Y
G
K
P
V
V
L
R
S
P
N
----------
S
P
---
A
A
R
A
I
V
E
L
A
N
Y
I
A
--------------------------------
76
Fugue
82.57
25%
-79
- C2 -
3Q9L
3
MIND_ECOLI
A:
[2-258]
--------------------------
A
R
I
I
V
V
T
S
G
K
G
G
V
G
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
------
K
-
G
K
K
T
V
V
I
D
F
A
I
G
L
R
N
L
D
-
L
I
M
G
C
--
E
-----
R
--------
R
--
V
VY------
D
F
------
V
N
-
V
I
Q
---
G
D
A
------
T
L
N
Q
A
L
--------------------
I
K
-----
D
-
K
RT
E
N
L
Y
I
L
P
-
A
S
-
Q
T
R
D
-----
K
--
D
-
A
--------
L
--------
T
---
R
E
---
G
V
A
-
K
V
L
D
D
-
L
K
A
M
D
----
F
----
E
F
I
V
C
D
S
P
A
G
I
E
T
-
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
N
P
E
V
S
S
V
R
D
S
D
R
I
L
----
G
-
I
L
A
SKS
R
R
A
E
--------------------
N
--------
G
-
E
-----
E
P
I
-
K
E
H
L
L
L
T
R
Y
N
P
G
R
V
S
R
G
D
----
M
L
S
-
M
E
D
V
L
-
E
I
L
R
-
I
K
L
-
V
G
V
I
P
E
D
Q
-
S
V
-
L
R
A
S
--------
N
Q
G
E
P
V
I
L
D
I
N
A
----------
D
A
---
G
K
A
Y
A
D
T
V
E
R
L
L
G
E
-------
E
R
P
F
R
F
I
E
E
---------------
53
HHSearch
81.38
24%
-92
- C2 -
1HYQ
-
?
A:
[2-233]
--------------------------
V
R
T
I
T
V
A
S
G
K
G
G
T
G
K
T
T
I
T
A
N
L
G
V
A
L
A
Q
------
L
-
G
H
D
V
T
I
V
D
A
D
I
T
M
A
N
L
E
-
L
I
L
G
M
--
E
-----
G
L-------
P
--
V
--------
T
L
------
Q
N
-
V
L
A
---
G
E
A
------
R
I
D
E
A
I
--------------------
Y
V
-----
G
-
P
--
G
G
V
K
V
V
P
-
A
G
-
V
S
L
E
G
L
---
R
--
K
-
A
--------
N
--------
P
----
E
---
K
L
E
-
D
V
L
T
Q
-
I
M
--
E
---
S
T
----
D
I
L
L
L
D
A
P
A
G
L
E
R
-
S
A
V
I
A
I
A
A
A
Q
E
L
L
L
V
V
N
P
E
I
S
S
I
T
D
G
L
K
T
K
----
I
-
V
------
A
E
R
L
-------------------
G
--------
T
-
K
-----
V
L
G
-
V
V
V
N
R
I
T
T
L
G
I
E
-
M
A
--------
K
N
E
I
E
A
I
----
L
E
-
A
K
V
-
I
G
L
I
P
E
D
P
-
E
V
-
R
R
A
A
--------
A
Y
G
K
P
V
V
L
R
S
P
N
----------
S
P
---
A
A
R
A
I
V
E
L
A
N
Y
I
A
--------------------------------
55
HHSearch
80.08
23%
-98
- C2 -
3EA0
3
?
A:
[3-242]
-------------------------
A
K
R
V
F
G
F
V
S
A
K
G
G
D
G
G
S
C
I
A
A
N
F
A
F
A
L
S
Q
E-----
P
-
D
I
H
V
L
A
V
D
I
S
L
P
F
G
D
L
D
-
M
Y
L
S
G
--
N
-----
T
H-------
S
--
Q
--------
D
L
------
A
D
-
I
S
N
---
A
S
D
RLD
K
S
-
L
L
D
T
M
V
--------------------
Q
H
-----
I
-
S
--
P
S
L
D
L
I
P
-
S
P
-
A
T
F
E
K
I
---
V
--
N
-
I
--------
E
--------
P
----
E
---
R
V
S
-
D
L
I
H
I
-
A
A
--
S
---
F
Y
----
D
Y
I
I
V
D
F
G
A
S
I
D
H
-
V
G
V
W
V
L
E
H
L
D
E
L
C
I
V
T
T
P
S
L
Q
S
L
R
R
A
G
Q
L
L
----
K
-
L
------
C
K
E
F-------------------
E
KP------
I
-
S
-----
R
I
E
-
I
I
L
N
R
A
D
T
N
S
R
I
T
----------
S
D
E
I
E
K
V
----
I
G
-
R
P
I
-
S
K
R
I
P
Q
D
E
D
A
M
-
Q
E
S
L
--------
L
S
G
Q
S
V
L
K
V
A
P
K
----------
S
Q
---
L
S
K
T
I
V
D
W
A
L
H
L
---------------------------------
57
HHSearch
79.64
24%
-95
- C2 -
3Q9L
3
MIND_ECOLI
A:
[2-251]
--------------------------
A
R
I
I
V
V
T
S
G
K
G
G
V
G
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
------
K
-
G
K
K
T
V
V
I
D
F
A
I
G
L
R
N
L
D
-
L
I
M
G
C
--
E
-----
R
--------
R
VV
Y
--------
D
F
------
V
N
-
V
I
Q
---
G
D
A
------
T
L
N
Q
A
L
--------------------
I
K
DK---
R
-
T
--
E
N
L
Y
I
L
P
-
A
S
-
Q
T
R
D
K
----
D
--
A
-
L
--------
T
--------
R
----
E
---
G
V
A
-
K
V
L
D
D
-
L
K
--
A
M
--
D
F
----
E
F
I
V
C
D
S
P
A
G
I
E
T
-
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
N
P
E
V
S
S
V
R
D
S
D
R
I
L
----
G
-
I
------
L
A
S
K-------------------
S
R
R
A
E
N
GEE
P
-
I
-----
K
E
H
-
L
L
L
T
R
Y
N
P
G
R
V
S
R
G
D
M
L
S
----
M
E
D
V
L
E
I
-----
L
R
-
I
K
L
-
V
G
V
I
P
E
D
Q
-
S
V
-
L
R
A
S
--------
N
Q
G
E
P
V
I
L
D
-
I
N
----------
A
D
---
A
G
K
A
Y
A
D
T
V
E
R
L
L
G
E
E
R
P
F
R
F
I
E
E
---------------------
59
HHSearch
77.96
25%
-97
- C2 -
3K9G
12
?
A:
[26-266]
-------------------------
K
P
K
I
I
T
I
A
S
I
K
G
G
V
G
K
S
T
S
A
I
I
L
A
T
L
L
S
K
--------
N
N
K
V
L
L
I
D
M
D
T
Q
A
-
S
I
T
-
S
Y
F
Y
E
--
K
-----
I
E
K
L
GINFT
K
--
F
--------
N
I
------
Y
E
-
I
L
K
---
E
N
V
------
D
I
D
S
T
I
--------------------
I
N
-----
V
-
D
--
N
N
L
D
L
I
P
-
S
Y
-
L
T
L
H
N
F
---
S
--
E
-
D
--------
K
--------
I
E
HK
D
F
---
L
L
K
-
T
S
L
G
T
-
L
Y
--
Y
---
K
Y
----
D
Y
I
V
I
D
T
N
P
S
L
D
V
-
T
L
K
N
A
L
L
C
S
D
Y
V
I
I
P
M
T
A
E
K
W
A
V
E
S
L
D
L
F
N
----
F
-
F
------
V
R
K
L
-------------------
N
L-------
F
-
L
-----
P
I
F
-
L
I
I
T
R
F
K
K
N
R
T
H
K
-----------
T
L
F
E
I
L
K
-
T
--
K
-
D
R
F
-
L
G
T
I
S
E
-----------------------------
N
----------
K
D
---
Y
I
K
E
Y
E
N
I
L
E
I
F
L
K
K
I
-----------------------------
75
Fugue
76.44
22%
-103
- C2 -
3EA0
3
?
A:
[3-242]
-------------------------
A
K
R
V
F
G
F
V
S
A
K
G
G
D
G
G
S
C
I
A
A
N
F
A
F
A
L
S
Q
------
E
P
D
I
H
V
L
A
V
D
I
S
L
P
F
G
D
L
D
M
Y
L
S
G
N
--
T
-----
H
--------
S
--
Q
--------
D
L
------
A
D
-
I
S
N
---
A
S
D
------
R
L
D
K
S
L
--------------------
L
D
T
M
VQH
I
-
S
--
P
S
L
D
L
I
P
-
S
P
-
A
T
F
E
K
I
---
V
--
N
-
I
--------
E
------------
P
E
---
R
V
S
-
D
L
I
H
I
---
A
A
S
---
F
Y
----
D
Y
I
I
V
D
F
G
A
S
I
D
H
-
V
G
V
W
V
L
E
H
L
D
E
L
C
I
V
T
T
P
S
L
Q
S
L
R
R
A
G
Q
L
L
----
K
-
L
------
C
K
E
--------------------
F
--------
E
-
K
-----
P
I
S
-
R
I
E
I
I
L
N
R
A
D
T
N
S
R
I
----------
T
S
D
E
I
E
-
K
V
I
G
-
R
P
I
-
S
K
R
I
P
Q
D
E
-
D
A
M
Q
E
S
L
--------
L
S
G
Q
S
V
L
K
V
A
P
K
----------
S
Q
---
L
S
K
T
I
V
D
W
A
L
H
L
---------------------------------
61
HHSearch
75.04
22%
-88
- C2 -
2OZE
3
?
A:
[32-291]
----------------------
N
K
N
E
A
I
V
I
L
N
N
Y
F
K
G
G
V
G
K
S
K
L
S
T
M
F
A
Y
L
T
D
K
------
L
-
N
L
K
V
L
M
I
D
K
D
L
Q
A
-
T
L
T
-
K
D
L
A
K
--
T
F
KVEL
P
--------
R
--
V
--------
N
F
------
Y
E
-
G
L
K
---
N
G
-------
N
L
A
S
S
I
--------------------
V
H
-----
L
-
T
--
D
N
L
D
L
I
P
-
G
T
-
F
D
L
M
L
L
---
P
--
K
-
L
T
R
SWT
F
E
N
E
--------
S
----
R
---
L
L
A
-
T
L
L
A
P
-
L
K
--
S
---
D
Y
----
D
L
I
I
I
D
T
V
P
T
P
S
V
-
Y
T
N
N
A
I
V
A
S
D
Y
V
M
I
P
L
Q
A
E
E
E
S
T
N
N
I
Q
N
Y
I
----
S
-
Y
------
L
I
D
L
Q
E
Q
FNP-------------
G
--------
L
-
D
-----
M
I
G
-
F
V
P
Y
L
V
D
T
D
S
A
T
I
--
K
S
N
----
L
E
E
L
Y
K
Q
H
K
-
E
--
D
N
L
V
F
-
Q
N
I
I
K
R
S
N
-
K
V
-
S
T
W
S
--------
K
N
G
I
T
E
H
K
G
Y
D
-----------
K
K
---
V
L
S
M
Y
K
N
V
F
F
E
M
L
E
R
I
I
Q
L
E
N
E
K
E
---------------------
80
Fugue
74.28
26%
-96
- C2 -
3K9G
12
?
A:
[26-267]
-------------------------
K
P
K
I
I
T
I
A
S
I
K
G
G
V
G
K
S
T
S
A
I
I
L
A
T
L
L
S
K
--------
N
N
K
V
L
L
I
D
M
D
T
Q
-
A
S
I
T
-
S
Y
F
Y
E
--
K
-----
I
--------
E
--
K
L
GINFTKF
N
I
------
Y
E
-
I
L
K
---
E
N
V
------
D
I
D
S
T
I
--------------------
I
N
-----
V
-
D
--
N
N
L
D
L
I
P
----
S
Y
L
T
L
H
---
N
--
F
-
S
--------
E
--------
D
---
K
I
---
E
H
K
-
D
F
L
L
K
-
T
S
L
G
T
LYY
K
Y
----
D
Y
I
V
I
D
T
N
P
S
L
D
V
-
T
L
K
N
A
L
L
C
S
D
Y
V
I
I
P
M
T
A
E
K
W
A
V
E
S
L
D
L
F
N
----
F
-
F
------
V
R
K
--------------------
L
--------
N
-
L
-----
F
L
P
-
I
F
L
I
I
T
R
F
K
K
N
R
T
---------------------------------
H
K
T
-
L
F
-
E
I
L
K
--------
T
K
D
R
F
L
G
T
I
S
E
N
----------
K
D
---
Y
I
K
E
Y
E
N
I
L
E
I
F
L
K
K
I
-----------------------------
82
Fugue
73.47
20%
-65
- C2 -
2XJ9
4
?
A:
[3-270]
-------------------------
E
T
R
V
I
V
V
G
N
E
K
G
G
A
G
K
S
T
I
A
V
H
L
V
T
A
L
L
Y
------
G
-
G
A
K
V
A
V
I
D
L
A
----------
L
R
Q
--
R
-----
T
--------
S
--
A
--------
R
F
------
F
E
-
N
R
R
---
A
W
L
------
D
N
K
K
I
E
--------------------
L
P
-----
E
-
P
--
L
A
L
N
L
S
D
-
N
D
-
V
A
L
A
E
R
---
P
--
E
-
E
--------
E
--------
Q
---
V
A
---
G
F
E
-
A
A
F
A
R
---
A
M
A
---
E
C
----
D
F
I
L
I
D
T
P
G
G
D
S
A
-
I
T
R
M
A
H
G
R
A
D
L
V
V
T
P
M
N
D
S
---
F
V
D
F
D
M
L
G
----
T
-
V
------
D
P
L
--------------------
E
--------
L
-
T
-----
K
P
S
-
L
Y
S
L
T
V
W
E
G
R
K
Q
R
A
L
S
G
Q
RQ
A
M
D
W
V
V
L
R
N
R
L
-
A
T
T
A
-
R
N
R
-
K
R
L
E
D
R
L
N
-
A
L
-
A
K
R
V
G
F
R
I
G
P
GL
R
D
R
V
I
Y
R
E
L
F
P
F
----------
G
L
---
T
I
A
D
L
S
P
-------
Q
V
R
P
V
P
V
S
L
Q
H
L
A
A
R
Q
E
L
R
A
L
M
H
S
L
G
LSAYS
77
Fugue
70.74
22%
-84
- C2 -
3KJH
1
?
A:
[1-254]
----------------------------
M
K
L
A
V
A
G
K
G
G
V
G
K
T
T
V
A
A
G
L
I
K
I
M
A
S
------
D
-
Y
D
K
I
Y
A
V
D
G
D
P
D
-
S
C
L
G
-
Q
T
L
G
L
S
I
E
-----
E
--------
A
--
Y
--------
A
I
------
T
P
-
L
I
E
---
M
K
D
------
E
I
R
E
K
T
GDGGLLILNPKVDGDLDKYG
R
Y
-----
I
-
D
--
D
K
I
F
L
I
R
M
G
E
-
I
K
K
G
G
S
---
Q
--
C
-
Y
--------
C
--------
R
---
E
N
---
S
F
L
-
G
S
V
V
S
-
A
L
F
L
D
---
K
K
----
E
A
V
V
M
D
M
G
A
G
I
E
H
-
L
T
R
G
T
A
K
A
V
D
M
M
I
A
V
I
E
P
N
L
N
S
I
K
T
G
L
N
I
E
----
K
-
L
------
A
G
D
--------------------
L
--------
G
I
K
-----
K
V
R
-
Y
V
I
N
K
V
R
N
I
K
E
E
K
L
I
K
K
H
----
L
------------------------------------------
P
E
D
K
I
L
G
I
I
P
Y
N
----------
E
L
---
F
I
E
L
S
L
K
G
E
E
I
W
Q
S
T
------
N
P
A
F
V
N
L
H
D
I
Y
Q
K
L
R
L
E
V
G
-----
64
HHSearch
69.85
16%
-83
- C2 -
3EZ2
4
PARA_ECOLX
A:
[105-393]
-----------------------
Y
S
E
A
Y
V
I
F
I
S
N
L
K
G
G
V
S
K
T
V
S
T
V
S
L
A
H
A
M
R
A
HPHLLM
E
-
D
L
R
I
L
V
I
D
L
D
P
Q
S
-
S
A
T
-
M
F
L
S
H
--
K
-----
H
--------
S
--
I
--------
G
I
VNAT
S
A
Q
A
-
M
L
Q
NVS
R
E
E
------
L
L
E
E
F
I
--------------------
V
P
S
----
V
-
V
--
P
G
V
D
V
M
P
-
A
S
-
I
D
D
A
F
I
---
A
--
S
D
W
--------
R
E
L
C
N
E
HLP
G
---
Q
N
IHA
V
L
K
E
N
V
I
D
K
-
L
K
--
S
---
D
Y
----
D
F
I
L
V
D
S
G
P
H
L
D
A
-
F
L
K
N
A
L
A
S
A
N
I
L
F
T
P
L
P
P
A
T
V
D
F
H
S
S
L
K
Y
V
----
A
-
R
------
L
P
E
L
V
K
L
I
---------------
S
D
E
------
G
-
C
E
C
QLA
T
N
I
-
G
F
M
S
K
L
S
N
K
A
D
H
K
----
Y
----
C
H
S
L
A
K
E
V
----
F
G
-
G
D
M
L
D
V
F
L
P
R
L
D
-
G
F
-
E
R
C
G
--------
E
S
F
D
T
V
I
S
A
N
P
A
TYVGS
A
D
A
L
-
K
N
---
A
R
I
A
A
E
D
F
A
K
A
V
F
D
R
I
E
F
I
R
S
N
-----------------------
56
HHSearch
69.31
18%
-105
- C2 -
3FWY
3
BCHL_RHOS4
A:
[47-295]
-------------------------
G
A
K
V
F
A
V
-
Y
G
K
G
G
I
G
K
S
T
T
S
S
N
L
S
A
A
F
S
I
------
L
-
G
K
R
V
L
Q
I
G
C
D
P
K
H
D
S
T
--
F
T
L
T
G
--
S
-----
L
--------
V
--
P
--------
T
V
------
I
D
-
V
L
K
---
D
V
D
FHPEEL
R
P
E
D
F
V
--------------------
F
E
-----
G
-
F
--
N
G
V
M
C
V
E
-
A
G
-
G
P
P
A
G
T
---
G
CG
G
-
Y
--------
V
--------
V
----
G
---
Q
T
V
-
K
L
L
K
Q
-
H
H
L
L
D
---
D
T
----
D
V
V
I
F
D
V
L
G
D
V
V
C
G
G
F
A
A
P
L
Q
H
A
D
Q
A
V
V
V
T
A
N
D
F
D
S
I
Y
A
M
N
R
I
I
----
A
-
A
------
V
Q
A
K
S
KNY---------------
K
--------
V
-
R
-----
L
A
G
-
C
V
A
N
R
S
R
A
T
D
E
V
-----------
D
R
F
C
K
E
-----
T
N
-
F
R
R
-
L
A
H
M
P
D
L
D
-
A
I
-
R
R
S
R
--------
L
K
K
K
T
L
F
E
M
D
E
D
----------
Q
D
V
L
A
A
R
A
E
Y
I
R
L
A
E
S
L
W
R
G
L
D
P
I
D
P
H
S
L
P
D
R
D
I
F
E
L
L
G
F
D
---------
2
PsiBlast_PDB
68.75
36%
-101
- C2 -
4V03
2
?
A:
[3-158]
---------------------------
E
V
I
V
I
T
S
G
K
G
G
V
G
K
T
T
L
T
A
N
I
G
T
A
L
A
K
------
L
-
G
K
K
V
L
L
I
D
A
D
---
R
N
L
D
-
M
I
L
G
L
--
E
-----
N
--------
R
IV
Y
--------
D
I
------
L
D
-
V
L
E
---
G
R
V
------
P
Y
E
K
A
L
--------------------
V
K
-----
D
-
K
--
R
G
L
S
L
W
L
-
L
P
---------------
V
--------
I
--------
D
---
I
E
---
K
W
N
-
K
T
V
E
E
-
I
K
N
S
G
---
N
Y
----
D
Y
I
L
V
D
S
P
A
G
I
E
K
-
G
F
Q
I
A
V
S
P
A
D
K
A
L
I
V
V
N
P
E
V
S
S
I
R
D
A
D
R
V
I
----
G
-
L
------
L
E
S
--------------------
M
--------
D
-
K
-----
R
N
Y
-
K
V
I
V
N
R
I
K
W
E
M
V
K
R
G
A
M
L
----
S
V
E
D
I
V
D
I
L
-
K
A
E
I
-
I
G
I
-
I
P
E
E
P
K
L
V
-
D
F
-
T
N
R
G
--------
E
P
I
V
L
D
E
K
F
P
A
S
----------
Q
A
---
I
I
D
T
A
R
R
L
M
G
E
S
I
P
L
K
R
----------------------------
67
HHSearch
68.59
18%
-76
- C2 -
2XJ4
-
?
A:
[4-269]
--------------------------
T
R
V
I
V
V
G
N
E
K
G
G
A
G
K
S
T
I
A
V
H
L
V
T
A
L
L
Y
------
G
-
G
A
K
V
A
V
I
D
L
D
L
R
Q
R
T
S
A
-
R
F
F
E
N
--
R
-----
R
--------
A
--
W
--------------------
L
D
---
N
K
K
--------------------------------
I
E
-----
L
-
P
--
E
P
L
A
L
N
L
-
S
D
-
N
D
V
A
L
A
E
RP
E
--
E
-
E
--------
Q
--------
V
----
A
---
G
F
E
-
A
A
F
A
R
-
A
M
--
A
---
E
C
----
D
F
I
L
I
D
T
P
G
G
D
S
A
-
I
T
R
M
A
H
G
R
A
D
L
V
V
T
P
M
N
D
S
F
V
D
F
D
M
L
G
T
V
D
PVTL
E
-
L
------
T
K
P
S
L
Y
S
L
T
V
W
E
G
R
K
Q
R
A
L
S
GQR
Q
--------
A
-
M
-----
D
W
V
-
V
L
R
N
R
L
A
T
T
E
A
R
N
--
R
K
R
----
L
E
D
R
L
N
A
L
A
-
K
R
V
G
-
F
R
I
-
G
P
G
L
R
D
R
V
-
I
Y
-
R
E
L
F
--------
P
F
G
L
T
I
A
D
L
S
P
Q
VRPVPVSLQH
L
A
---
A
R
Q
E
L
R
A
L
M
H
S
L
G
L
S
A
Y
S
G
E
T
------------------------
5
PsiBlast_PDB
68.59
33%
-131
- C2 -
1G3Q
2
?
A:
[3-150]
---------------------------
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
D
------
R
-
G
R
K
V
L
A
V
D
G
D
L
T
M
A
N
L
S
-
L
V
L
G
V
--
D
-----
D
--------
P
--
D
--------
V
T
------
L
H
D
V
L
A
---
G
E
A
------
N
V
E
D
A
I
--------------------
Y
M
-----
T
-
Q
F-
D
N
V
Y
V
L
P
-
G
A
V
D
W
E
H
V
L
---
K
-------------------------------
A
D
P
-
R
K
L
P
E
---
V
I
K
---
S
L
KDKF
D
F
I
L
I
D
C
P
A
G
L
Q
L
-
D
A
M
S
A
M
L
S
G
E
E
A
L
L
V
T
N
P
E
I
S
C
L
T
D
T
M
K
V
G
----
I
-
V
------
L
K
K
--------------------
A
--------
G
-
L
-----
A
I
L
-
G
F
V
L
N
R
Y
G
R
S
D
R
D
I
P
P
E
A
----
A
E
D
V
M
E
V
P
L
-
L
A
V
I
-
P
E
D
-
P
A
I
R
E
G
T
L
-
E
G
-
I
P
A
V
--------
K
Y
K
P
E
S
K
G
A
K
A
F
----------
V
K
---
L
A
E
E
I
E
K
L
A
------------------------------------
6
PsiBlast_PDB
68.46
33%
-131
- C2 -
1G3R
2
?
A:
[3-150]
---------------------------
R
I
I
S
I
V
S
G
K
G
G
T
G
K
T
T
V
T
A
N
L
S
V
A
L
G
D
------
R
-
G
R
K
V
L
A
V
D
G
D
L
T
M
A
N
L
S
-
L
V
L
G
V
--
D
-----
D
--------
P
--
D
--------
V
T
------
L
H
D
V
L
A
---
G
E
A
------
N
V
E
D
A
I
--------------------
Y
M
-----
T
-
Q
F-
D
N
V
Y
V
L
P
-
G
A
V
D
W
E
H
V
L
---
K
-------------------------------
A
D
P
-
R
K
L
P
E
---
V
I
K
---
S
L
KDKF
D
F
I
L
I
D
C
P
A
G
L
Q
L
-
D
A
M
S
A
M
L
S
G
E
E
A
L
L
V
T
N
P
E
I
S
C
L
T
D
T
M
K
V
G
----
I
-
V
------
L
K
K
--------------------
A
--------
G
-
L
-----
A
I
L
-
G
F
V
L
N
R
Y
G
R
S
D
R
D
I
P
P
E
A
----
A
E
D
V
M
E
V
P
L
-
L
A
V
I
-
P
E
D
-
P
A
I
R
E
G
T
L
-
E
G
-
I
P
A
V
--------
K
Y
K
P
E
S
K
G
A
K
A
F
----------
V
K
---
L
A
E
E
I
E
K
L
A
------------------------------------