@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1170: (2015-12-21 )
MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESRIKNEFLHLGLSGANVTLPFKERAFQICDKIKGIALECASVNTLVLENDELVGYNTDALGFYLSLKHQNYQNDQNALILGAGGSAKALACGLQKQGLKVSVLNRSARGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKESKLAYDLAYGFLTPFLSLAKELKIPFQDGKDMLIYQASLSFEKFSDSQIPYSKAFEVMRSVF
Atome Classification :
(33 SA)
.........10........20........30....----....40......---.---.50--........60........70........80........90.-.-..-....100.......110-.....-.-.-120.......130...-....140.......150.-------.-..-..---.160---...-..-------.-.170.--......180.......190..--.-......200........210.-.-.-.-...220.......-230........240.......250.......260....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKLKSFGVFGNPIKHSKSPLI
H
N
A
C
F
L
T
F
Q
K
E
LGF----LGHYHP
I
L
L
P
L
E
---
S
---
R
I
K
--
N
E
F
L
HLGLSGA
N
V
T
L
P
F
K
E
R
A
F
Q
I
C
D
K
IKG
I
A
L
E
C
AS
V
N
T
L
-
V
-
L
E-ND
E
L
VGYNTD
A
L
G
F
Y
L
S
-
L
KHQN-Y-Q-NDQ
N
A
L
I
L
GAGGS
A
K
A
-
L
A
CGLQKQG
L
K
V
S
V
LNRS-------A-R
G
-
L
D
---
F
F
Q
R
---LGC-
D
C
-------F-MEPPK--
S
A
F
D
L
I
I
NATSASLHNE--LP--L-
N
K
E
V
L
K
G
Y
-
F
K
E
S
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
ELKIP-FQ-DG
K
D
M
L
I
Y
QASLSFEKFSDSQI
P
Y
S
K
A
F
E
V
M
R
S
VF
22
PsiBlast_CBE
93.19
92%
-126
- C4 -
3PHI
2
AROE_HELPY
B:
[1-262]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
-
9
PsiBlast_PDB
93.14
92%
-123
- C4 -
4FQ8
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
Q
K
N
-
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
A
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
1
PsiBlast_PDB
93.03
94%
-124
- C4 -
4FSH
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
K
L
G
F
----
L
G
H
Y
R
P
I
L
L
P
L
E
---
S
---
H
I
K
--
N
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
A
S
I
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
H
Q
N
-
Y
-
Q
-
N
---
A
L
I
L
G
S
G
G
S
A
K
A
-
L
A
C
G
L
K
K
Q
G
L
K
V
S
V
L
N
R
S
-------
P
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
N
-----
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
A
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
A
L
A
K
E
L
K
I
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
S
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
6
PsiBlast_PDB
92.96
92%
-125
- C4 -
4FOO
-
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
--
N
-
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
K
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
23
PsiBlast_CBE
92.71
92%
-124
- C4 -
4FQ8
1
AROE_HELPY
B:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
Q
K
N
-
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
A
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
10
PsiBlast_PDB
92.55
92%
-120
- C4 -
4FR5
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
Q
K
N
-
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
S
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
8
PsiBlast_PDB
92.54
92%
-128
- C4 -
4FPX
-
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
N
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
7
PsiBlast_PDB
92.47
92%
-122
- C4 -
4FOS
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
Q
K
N
-
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
A
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
2
PsiBlast_PDB
92.46
92%
-126
- C4 -
3PHG
-
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-----
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
24
PsiBlast_CBE
92.43
92%
-124
- C4 -
4FR5
1
AROE_HELPY
B:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
Q
K
N
-
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
S
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
3
PsiBlast_PDB
92.17
92%
-124
- C4 -
3PHH
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
4
PsiBlast_PDB
91.83
92%
-123
- C4 -
3PHI
2
AROE_HELPY
A:
[1-262]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
-
5
PsiBlast_PDB
91.57
92%
-125
- C4 -
3PHJ
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
-----
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
21
PsiBlast_CBE
91.46
92%
-127
- C4 -
3PHJ
1
AROE_HELPY
B:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
--
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
----
Y
-
Q
-
N
---
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
-
L
D
---
F
F
Q
R
---
L
G
C
-
D
C
-------
F
-
M
E
P
P
K
--
S
A
F
D
L
I
I
N
A
T
S
-----
E
--
L
P
--
L
-
N
K
E
V
L
K
G
Y
-
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
94
HHSearch
78.92
82%
-96
- C4 -
3PHH
1
AROE_HELPY
A:
[1-263]
M
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
----
C
F
L
T
F
Q
K
ELR
F
L
G
H
Y
H
P
I
L
L
P
L
E
---
S
---
H
I
K
S
-
E
F
L
-
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
-
L
K
---------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
-------
S
-
R
G
L
D
F
F
Q
-
R
L
G
----
C
D
C
-
F
M
---------
E
P
P
-
K
--
S
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
--
L
---
P
-
L
N
K
E
V
L
K
G
Y
F
K
E
G
K
L
A
Y
D
L
A
Y
-
G
-
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
P
-
F
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
45
PsiBlast_CBE
63.79
35%
-103
- C4 -
1WXD
3
AROE_THET8
B:
[4-244]
-----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
---
A
LPG
R
L
K
--
E
--
V
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
-
L
K
A
G
G
-
I
-
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
-
V
A
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
T
-------
P
Q
R
A
-
L
A
---
L
A
E
E
---
F
G
L
-
R
A
-------
V
P
L
E
K
A
R
--
E
A
-
R
L
L
V
N
A
T
R
V
G
L
E
D
P
SA
S
P
--
L
-
P
A
E
L
-----
F
P
E
E
G
A
A
V
D
L
V
Y
-
R
-
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
44
PsiBlast_CBE
63.75
35%
-100
- C4 -
2CY0
2
AROE_THET8
A:
[4-244]
-----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
---
A
L
P
G
R
L
K
--
E
--
V
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
-
L
K
A
G
G
-
I
-
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
-
V
A
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
T
-------
P
Q
R
A
-
L
A
---
L
A
E
E
---
F
G
L
-
R
A
-------
V
P
L
E
K
A
R
--
E
A
-
R
L
L
V
N
A
T
R
V
G
L
E
D
P
SA
S
P
--
L
-
P
A
E
L
-----
F
P
E
E
G
A
A
V
D
L
V
Y
-
R
-
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
41
PsiBlast_CBE
63.47
35%
-101
- C4 -
2D5C
3
AROE_THET8
B:
[4-244]
-----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
---
A
L
P
G
R
L
K
--
E
--
V
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
-
L
K
A
G
G
-
I
-
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
-
V
A
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
T
-------
P
Q
R
A
-
L
A
---
L
A
E
E
---
F
G
L
-
R
A
-------
V
P
L
E
K
A
R
--
E
A
-
R
L
L
V
N
A
T
R
V
G
L
---A-
S
P
--
L
-
P
A
E
L
-----
F
P
E
E
G
A
A
V
D
L
V
Y
-
R
-
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
40
PsiBlast_CBE
63.24
35%
-99
- C4 -
2EV9
3
AROE_THET8
A:
[4-244]
-----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
---
A
L
P
G
R
L
K
--
E
--
V
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
-
L
K
A
G
G
-
I
-
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
-
V
A
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
T
-------
P
Q
R
A
-
L
A
---
L
A
E
E
---
F
G
L
-
R
A
-------
V
P
L
E
K
A
R
--
E
A
-
R
L
L
V
N
A
T
R
V
G
L
E
D
P
SA
S
P
--
L
-
P
A
E
L
-----
F
P
E
E
G
A
A
V
D
L
V
Y
-
R
-
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
42
PsiBlast_CBE
63.17
35%
-97
- C4 -
2D5C
4
AROE_THET8
A:
[4-244]
-----
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
---
A
L
P
G
R
L
K
--
E
--
V
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
-
L
K
A
G
G
-
I
-
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
-
V
A
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
T
-------
P
Q
R
A
-
L
A
---
L
A
E
E
---
F
G
L
-
R
A
-------
V
P
L
E
K
A
R
--
E
A
-
R
L
L
V
N
A
T
R
V
G
L
E
D
P
SA
S
P
--
L
-
P
A
E
L
-----
F
P
E
E
G
A
A
V
D
L
V
Y
-
R
-
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
88
HHSearch
62.44
31%
-83
- C4 -
1NYT
7
AROE_ECOLI
A:
[1-269]
--
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
F
I
N
---
T
L
N
--
A
F
F
S
-
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
-
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
-
L
E
R
L
S
-
F
I
R
-
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
-
V
L
L
P
L
L
S
L
D
C
A
V
T
I
T
N
R
T
-------
V
-
S
R
A
E
E
L
A
K
L
F
A
H
TG
S
I
Q
A
-
L
S
-------
M
-
D
E
L
E
G
--
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
--
I
P
--
A
-
I
P
S
S
L
----
I
H
P
G
I
Y
C
Y
D
M
F
Y
-
Q
-
K
G
K
-
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
N
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
L
25
PsiBlast_CBE
62.03
32%
-94
- C4 -
2HK9
2
AROE_AQUAE
D:
[15-272]
-----
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
---
E
---
L
K
K
AF
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
-
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
-
L
K
S
L
I
-
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
-
V
I
Y
A
L
V
K
E
G
A
K
V
F
L
W
N
R
T
K------
E
-
K
A
-
I
K
---
L
A
Q
K
---
F
P
L
-
E
V
-------
V
-
N
S
P
E
E
VI
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
--
D
P
EI
F
-
N
Y
D
L
I
-----
K
K
D
H
V
V
V
D
I
I
Y
-
K
---
E
-
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
--
20
PsiBlast_PDB
61.70
32%
-93
- C4 -
1NYT
7
AROE_ECOLI
A:
[1-249]
--
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
----
Q
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
---
D
---
F
I
N
T
L
N
A
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
-
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
-
L
E
R
L
S
-
F
I
R
-
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
-
V
L
L
P
L
L
S
L
D
C
A
V
T
I
T
N
R
T
-------
V
-
S
R
-
A
E
---
E
L
A
K
---
L
F
A
-
H
T
G
S
I
Q
A
L
S
M
-
D
E
L
E
G
--
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
--
I
P
------
A
I
P
S
S
L
-
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
K
-
G
-
K
-
T
P
F
L
A
W
C
E
Q
R
G
S
K
-
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
L
13
PsiBlast_PDB
61.15
32%
-98
- C4 -
2HK9
3
AROE_AQUAE
A:
[15-273]
-----
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
---
E
---
L
K
K
A
F
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
-
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
-
L
K
S
L
I
-
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
-
V
I
Y
A
L
V
K
E
G
A
K
V
F
L
W
N
R
T
K
------
E
-
K
A
-
I
K
---
L
A
Q
K
---
F
P
L
-
E
V
-------
V
-
N
S
P
E
E
VI
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
--
D
P
EI
F
-
N
Y
D
L
I
-----
K
K
D
H
V
V
V
D
I
I
Y
-
K
---
E
-
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
R
27
PsiBlast_CBE
60.80
32%
-96
- C4 -
2HK9
2
AROE_AQUAE
B:
[15-273]
-----
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
---
E
---
L
K
K
AF
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
-
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
-
L
K
S
L
I
-
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
-
V
I
Y
A
L
V
K
E
G
A
K
V
F
L
W
N
R
T
K------
E
-
K
A
-
I
K
---
L
A
Q
K
---
F
P
L
-
E
V
-------
V
-
N
S
P
E
E
VI
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
--
D
P
EI
F
-
N
Y
D
L
I
-----
K
K
D
H
V
V
V
D
I
I
Y
-
K
---
E
-
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
-
26
PsiBlast_CBE
60.39
32%
-94
- C4 -
2HK9
2
AROE_AQUAE
C:
[15-272]
-----
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
---
E
---
L
K
K
AF
E
G
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
-
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
-
L
K
S
L
I
-
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
-
V
I
Y
A
L
V
K
E
G
A
K
V
F
L
W
N
R
T
K------
E
-
K
A
-
I
K
---
L
A
Q
K
---
F
P
L
-
E
V
-------
V
-
N
S
P
E
E
VI
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
--
D
P
EI
F
-
N
Y
D
L
I
-----
K
K
D
H
V
V
V
D
I
I
Y
-
K
---
E
-
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
--
85
HHSearch
59.41
35%
-76
* C4 *
2D5C
4
AROE_THET8
A:
[1-260]
--
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
L
P
G
---
R
L
K
--
E
V
R
--
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
-
L
K
A
G
G
-
I
-
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
-
V
A
F
A
L
R
E
A
G
L
E
V
W
V
W
N
R
T
-------
P
-
Q
R
A
L
A
L
A
E
E
F
G
----
L
R
A
-
V
P
-------
L
-
E
K
--
A
--
R
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
--
S
A
S-
P
-
L
P
A
E
L
----
F
P
E
E
G
A
A
V
D
L
V
Y
-
R
-
P
L
W
-
T
R
F
L
R
E
A
K
A
K
G
L
K
-
V
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
98
HHSearch
57.16
34%
-84
- C4 -
2HK9
3
AROE_AQUAE
A:
[11-271]
-
Q
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
----
L
I
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
L
K
K
---
A
F
E
--
G
F
K
A
-
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
-
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
-
L
K
S
L
I
P
E
-
V
-
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
-
V
I
Y
A
L
V
K
E
G
A
K
V
F
L
W
N
R
T
-------
K
-
E
K
A
I
K
L
A
Q
K
F
P
----
L
E
V
V
N
S
-------
P
-
E
E
V
-
I
--
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
--
D
P
--
E
I
F
N
Y
D
L
----
I
K
K
D
H
V
V
V
D
I
I
Y
-
K
---
E
-
T
K
L
L
K
K
A
K
E
K
G
A
K
-
L
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
R
30
PsiBlast_CBE
56.77
33%
-75
- C4 -
3PGJ
1
AROE_VIBCH
D:
[29-277]
--
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
R
Q
T
Q
Q
S
M
I
Y
----
T
A
Q
C
V
P
V
D
G
F
T
E
---
A
-----
A
--
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
-
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
-
L
-
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
FAKAEQL
A
-
E
L
-
V
A
---
A
Y
G
E
---
V
K
A
-
Q
A
-------
F
--
E
Q
L
K
--
Q
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
--
L
P
--
A
-
I
D
P
V
I
----
F
S
S
R
S
V
C
Y
D
M
M
Y
-
G
K
G
-
Y
-
T
V
F
N
Q
W
A
R
Q
H
G
C
A
-
Q
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
16
PsiBlast_PDB
56.19
33%
-77
- C4 -
3PGJ
1
AROE_VIBCH
A:
[29-277]
--
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
R
Q
T
Q
Q
S
M
I
Y
----
T
A
Q
C
V
P
V
D
G
F
T
E
---
A
-----
A
--
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
-
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
-
L
-
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
-
V
A
---
A
Y
G
E
---
V
K
A
-
Q
A
-------
F
--
E
Q
L
K
--
Q
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
--
L
P
--
A
-
I
D
P
V
I
----
F
S
S
R
S
V
C
Y
D
M
M
Y
-
G
K
G
-
Y
-
T
V
F
N
Q
W
A
R
Q
H
G
C
A
-
Q
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
31
PsiBlast_CBE
55.80
33%
-77
- C4 -
3PGJ
1
AROE_VIBCH
C:
[29-277]
--
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
R
Q
T
Q
Q
S
M
I
Y
----
T
A
Q
C
V
P
V
D
G
F
T
E
---
A
-----
A
--
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
-
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
-
L
-
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
-
V
A
---
A
Y
G
E
---
V
K
A
-
Q
A
-------
F
--
E
Q
L
K
--
Q
S
Y
D
V
I
I
N
S
T
S
---------
P
--
A
-
I
D
P
V
I
----
F
S
S
R
S
V
C
Y
D
M
M
Y
-
G
K
G
-
Y
-
T
V
F
N
Q
W
A
R
Q
H
G
C
A
-
Q
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
29
PsiBlast_CBE
55.62
33%
-72
- C4 -
3SEF
2
AROE_VIBCH
B:
[29-277]
--
I
D
Q
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
L
F
A
R
Q
T
Q
Q
S
M
I
Y
----
T
A
Q
C
V
P
V
D
G
F
T
E
---
A
-----
A
--
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
-
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
-
L
-
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
-
V
A
---
A
Y
G
E
---
V
K
A
-
Q
A
-------
F
--
E
Q
L
K
--
Q
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
--
L
P
--
A
-
I
D
P
V
I
----
F
S
S
R
S
V
C
Y
D
M
M
Y
-
G
K
G
-
Y
-
T
V
F
N
Q
W
A
R
Q
H
G
C
A
-
Q
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
32
PsiBlast_CBE
54.80
33%
-74
- C4 -
3PGJ
1
AROE_VIBCH
B:
[29-277]
--
I
D
Q
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
L
F
A
R
Q
T
Q
Q
S
M
I
Y
----
T
A
Q
C
V
P
V
D
G
F
T
E
---
A
-----
A
--
K
H
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
-
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
Q
Q
V
-
L
-
L
-
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
-
V
A
---
A
Y
G
E
---
V
K
A
-
Q
A
-------
F
--
E
Q
L
K
--
Q
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
--
L
P
--
A
-
I
D
P
V
I
----
F
S
S
R
S
V
C
Y
D
M
M
Y
-
G
K
G
-
Y
-
T
V
F
N
Q
W
A
R
Q
H
G
C
A
-
Q
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L