@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1469: (2015-12-24 )
MLVTRFKKAFISYSLGVLVVSLLLNVCNASAQEVKVKDYFGEQTIKLPVSKIAYIGSYVEVPAMLNVWDRVVGVSDYAFKDDIVKATLKGEDLKRVKHMSTDHTAALNVELLKKLSPDLVVTFVGNPKAVEHAKKFGISFLSFQETTIAEAMQAMQAQATVLEIDASKKFAKMQETLDFIAERLKGVKKKKGVELFHKANKISGHQAISSDILEKGGIDNFGLKYVKFGRADISVEKIVKENPEIIFIWWVSPLTPEDVLNNPKFSTIKAIKNKQVYKLPTMDIGGPRAPLISLFIALKAHPEAFKGVDINAIVKDYYKVVFDLNDAEIEPFLWH
Atome Classification :
(20 SA)
.........10........20........30........40--..-......50....-.-.-..60........70.....-..--.80........90........100.......110.......120-.--...----.-..130....----.--..140--...--.---..--------------------..150.......160--...--....170.......180.......190...-..--.-.---.--.--200-.---..--......210.......220....-.--------...230-----.........240........--250.-------.---..-----...260.......270.......280.--.--.--.--....-.-290...---.....300.......310.......320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
V
T
R
F
K
K
A
F
I
S
Y
S
L
G
V
L
V
V
S
L
L
L
N
V
CNASA
Q
E
V
K
V
KDYFG--E
Q
-
T
I
KL
P
V
S
K
I
A
Y
I-G-
S
-
Y
VEV
P
A
M
L
N
V
W
D
R
V
VGVSD-YA--FK
D
D
I
V
K
A
TLK
G
E
D
L
K
R
V
K
HMSTDHTAAL
N
V
E
L
L
K
KLSP
D
L
V
V
T
-F--VGN----
P
-
K
A
V
E
H
A
K
K
F----G--
I
S
F
L---
S
F
Q
--
E
---
T
T
--------------------
I
A
E
A
M
Q
A
M
Q
AQ
A
T
V
L
--
E
ID--AS
K
K
F
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K--K
G
V
-
E
L
--
F
-
H
---
K
--A--N---K---IS--G
H
Q
A
I
S
S
D
I
L
E
KGGIDN-FG
L
K
Y
-
V
--------KFGR-------AD
I
S
V
E
K
I
V
K-ENP
E
I
I
F
I
W
--WVSP-------L---
T
P
-----
E
D
VLNNPK
F
S
T
I
K
A
I
KNKQ
V
Y
KLP--T--M--D--I--GGPR-
A
-
P
-
L
I
S
L
---
F
I
A
LKAHPEAFKGV
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
DLNDAEIEPFLWH
49
Fugue
99.85
89%
-113
- C1 -
4INO
-
?
A:
[1-302]
-------------------------------
Q
E
V
K
V
K
D
Y
F
G
--
E
Q
-
T
I
K
L
P
V
S
K
I
I
Y
L
-
G
-
S
-
F
A
E
V
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
-
Y
A
--
F
K
S
D
I
V
K
A
T
L
K
--
D
P
E
R
I
K
P
M
S
S
D
H
A
A
A
L
N
V
E
L
L
K
K
L
S
P
D
L
V
V
T
-
F
--
V
G
N
----
P
-
K
A
V
E
H
A
K
K
F
----
G
--
I
S
F
L
---
S
F
Q
--
E
---
K
T
--------------------
I
A
E
V
M
E
D
I
D
T
Q
A
K
A
L
--
E
V
D
--
A
S
K
K
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
--
K
G
V
-
E
L
--
F
-
H
---
K
--
A
--
N
---
K
---
I
S
--
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
-
F
G
L
K
Y
-
V
--------
K
F
G
R
-------
A
D
I
S
V
E
K
I
V
K
-
E
N
P
E
I
I
F
I
W
--
W
I
S
P
-------
L
---
S
P
-----
E
D
V
L
N
N
P
K
F
A
T
I
K
A
I
K
N
K
Q
V
Y
K
L
P
--
T
--
M
--
D
--
I
--
G
G
P
R
-
A
-
P
-
L
I
S
L
---
F
I
A
L
K
A
H
P
E
A
F
K
G
V
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
D
L
N
D
A
E
V
E
P
F
L
W
H
1
PsiBlast_PDB
99.57
88%
-113
- C1 -
4INO
-
?
A:
[1-302]
-------------------------------
Q
E
V
K
V
K
D
Y
F
G
--
E
Q
-
T
I
K
L
P
V
S
K
I
I
Y
L
-
G
-
S
-
F
A
E
V
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
-
Y
A
--
F
K
S
D
I
V
K
A
T
L
K
--
D
P
E
R
I
K
P
M
S
S
D
H
A
A
A
L
N
V
E
L
L
K
K
L
S
P
D
L
V
V
T
-
F
--
V
G
N
----
P
-
K
A
V
E
H
A
K
K
F
----
G
--
I
S
F
L
---
S
F
Q
--
E
---
K
T
--------------------
I
A
E
V
M
E
D
I
D
T
Q
A
K
A
L
--
E
V
D
--
A
S
K
K
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
--
K
G
V
-
E
L
--
F
-
H
---
K
--
A
--
N
---
K
---
I
S
--
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
-
F
G
L
K
Y
-
V
--------
K
F
G
R
-------
A
D
I
S
V
E
K
I
V
K
-
E
N
P
E
I
I
F
I
W
--
W
I
S
P
-------
L
---
S
P
-----
E
D
V
L
N
N
P
K
F
A
T
I
K
A
I
K
N
K
Q
V
Y
K
L
P
--
T
--
M
--
D
--
I
--
G
G
P
R
-
A
-
P
-
L
I
S
L
---
F
I
A
L
K
A
H
P
E
A
F
K
G
V
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
D
L
N
D
A
E
V
E
P
F
L
W
H
22
PsiBlast_CBE
98.84
88%
-111
- C1 -
4LS3
3
?
B:
[1-301]
-------------------------------
Q
E
V
K
V
K
D
Y
F
G
--
E
Q
-
T
I
K
L
P
V
S
K
I
I
Y
L
-
G
-
S
-
F
A
E
V
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
-
Y
A
--
F
K
S
D
I
V
K
A
T
L
K
--
D
P
E
R
I
K
P
M
S
S
D
H
V
A
A
L
N
V
E
L
L
K
K
L
S
P
D
L
V
V
T
-
F
--
V
G
N
----
P
-
K
A
V
E
H
A
K
K
F
----
G
--
I
S
F
L
---
S
F
Q
--
E
---
K
T
--------------------
I
A
E
V
M
E
D
I
D
T
Q
A
K
A
L
--
E
V
D
--
A
S
K
K
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
--
K
G
V
-
E
L
--
F
-
H
---
K
--
A
--
N
---
K
---
I
S
--
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
-
F
G
L
K
Y
-
V
--------
K
F
G
R
-------
A
D
I
S
V
E
K
I
V
K
-
E
N
P
E
I
I
F
I
W
--
W
I
S
P
-------
L
---
S
P
-----
E
D
V
L
N
N
P
K
F
A
T
I
K
A
I
K
N
K
Q
V
Y
K
L
P
--
T
--
M
--
D
--
I
--
G
G
P
R
-
A
-
P
-
L
I
S
L
---
F
I
A
L
K
A
H
P
E
A
F
K
G
V
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
D
L
N
D
A
E
V
E
P
F
L
W
K
3
PsiBlast_PDB
98.54
88%
-111
- C1 -
4LS3
3
?
A:
[1-301]
-------------------------------
Q
E
V
K
V
K
D
Y
F
G
--
E
Q
-
T
I
K
L
P
V
S
K
I
I
Y
L
-
G
-
S
-
F
A
E
V
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
-
Y
A
--
F
K
S
D
I
V
K
A
T
L
K
--
D
P
E
R
I
K
P
M
S
S
D
H
V
A
A
L
N
V
E
L
L
K
K
L
S
P
D
L
V
V
T
-
F
--
V
G
N
----
P
-
K
A
V
E
H
A
K
K
F
----
G
--
I
S
F
L
---
S
F
Q
--
E
---
K
T
--------------------
I
A
E
V
M
E
D
I
D
T
Q
A
K
A
L
--
E
V
D
--
A
S
K
K
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
--
K
G
V
-
E
L
--
F
-
H
---
K
--
A
--
N
---
K
---
I
S
--
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
-
F
G
L
K
Y
-
V
--------
K
F
G
R
-------
A
D
I
S
V
E
K
I
V
K
-
E
N
P
E
I
I
F
I
W
--
W
I
S
P
-------
L
---
S
P
-----
E
D
V
L
N
N
P
K
F
A
T
I
K
A
I
K
N
K
Q
V
Y
K
L
P
--
T
--
M
--
D
--
I
--
G
G
P
R
-
A
-
P
-
L
I
S
L
---
F
I
A
L
K
A
H
P
E
A
F
K
G
V
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
D
L
N
D
A
E
V
E
P
F
L
W
K
2
PsiBlast_PDB
97.40
88%
-110
- C1 -
4INP
4
?
A:
[2-301]
--------------------------------
E
V
K
V
K
D
Y
F
G
--
E
Q
-
T
I
K
L
P
V
S
K
I
I
Y
L
-
G
-
S
-
F
A
E
V
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
-
Y
A
--
F
K
S
D
I
V
K
A
T
L
K
--
D
P
E
R
I
K
P
M
S
S
D
H
A
A
A
L
N
V
E
L
L
K
K
L
S
P
D
L
V
V
T
-
F
--
V
G
N
----
P
-
K
A
V
E
H
A
K
K
F
----
G
--
I
S
F
L
---
S
F
Q
--
E
---
K
T
--------------------
I
A
E
V
M
E
D
I
D
T
Q
A
K
A
L
--
E
V
D
--
A
S
K
K
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
--
K
G
V
-
E
L
--
F
-
H
---
K
--
A
--
N
---
K
---
I
S
--
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
-
F
G
L
K
Y
-
V
--------
K
F
G
R
-------
A
D
I
S
V
E
K
I
V
K
-
E
N
P
E
I
I
F
I
W
--
W
I
S
P
-------
L
---
S
P
-----
E
D
V
L
N
N
P
K
F
A
T
I
K
A
I
K
N
K
Q
V
Y
K
L
P
--
T
--
M
--
D
--
I
--
G
G
P
R
-
A
-
P
-
L
I
S
L
---
F
I
A
L
K
A
H
P
E
A
F
K
G
V
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
D
L
N
D
A
E
V
E
P
F
L
W
-
21
PsiBlast_CBE
97.14
88%
-111
- C1 -
4INP
6
?
B:
[2-301]
--------------------------------
E
V
K
V
K
D
Y
F
G
--
E
Q
-
T
I
K
L
P
V
S
K
I
I
Y
L
-
G
-
S
-
F
A
E
V
P
A
M
F
H
T
W
D
R
V
V
G
I
S
D
-
Y
A
--
F
K
S
D
I
V
K
A
T
L
K
--
D
P
E
R
I
K
P
M
S
S
D
H
A
A
A
L
N
V
E
L
L
K
K
L
S
P
D
L
V
V
T
-
F
--
V
G
N
----
P
-
K
A
V
E
H
A
K
K
F
----
G
--
I
S
F
L
---
S
F
Q
--
E
---
K
T
--------------------
I
A
E
V
M
E
D
I
D
T
Q
A
K
A
L
--
E
V
D
--
A
S
K
K
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
--
K
G
V
-
E
L
--
F
-
H
---
K
--
A
--
N
---
K
---
I
S
--
G
H
Q
A
L
D
S
D
I
L
E
K
G
G
I
D
N
-
F
G
L
K
Y
-
V
--------
K
F
G
R
-------
A
D
I
S
V
E
K
I
V
K
-
E
N
P
E
I
I
F
I
W
--
W
I
S
P
-------
L
---
S
P
-----
E
D
V
L
N
N
P
K
F
A
T
I
K
A
I
K
N
K
Q
V
Y
K
L
P
--
T
--
M
--
D
--
I
--
G
G
P
R
-
A
-
P
-
L
I
S
L
---
F
I
A
L
K
A
H
P
E
A
F
K
G
V
D
I
N
A
I
V
K
D
Y
Y
K
V
V
F
D
L
N
D
A
E
V
E
P
F
L
W
-
25
HHSearch
60.88
20%
-86
- C1 -
3PSH
1
Y1472_HAEIN
A:
[2-322]
---------------------------------
R
I
I
T
D
Q
L
D
--
R
K
V
T
I
P
D
H
I
N
R
A
V
V
L
-
Q
H
Q
-
T
L
N
I
A
V
Q
L
D
A
T
K
Q
I
V
G
V
L
S
-
N
W
--
K
K
Q
L
G
K
N
Y
V
R
L
A
P
E
L
E
N
M
A
M
P
G
D
--
L
N
S
V
N
I
E
S
L
L
A
L
K
P
D
V
V
F
V
-
T
--
N
Y
A
P---
S
-
E
M
I
K
Q
I
S
D
V
----
N
--
I
P
V
V
---
A
I
S
--
L
---
R
T
G
E
VGEKGKL
N
P
T
L
TD
E
D
K
A
Y
N
D
G
L
K
Q
G
I
E
L
I
A
E
V
F
--
E
K
K
Q
Q
G
D
E
L
V
K
A
A
F
A
N
R
K
L
L
A
D
R
L
G
D
V
S
A
D
KR
V
R
T
-
Y
M
--
A
-
N
---
P
--
D
--
L
---
G
---
T
Y
--
G
S
G
K
Y
T
G
L
M
M
E
H
A
G
A
Y
N
-
V
A
A
A
T
----------
I
K
G
F
-------
K
Q
V
S
L
E
N
V
L
E
-
W
N
P
A
V
I
L
V
Q
--
D
R
Y
P
-------
D
---
V
V
-----
P
Q
I
L
N
D
Q
G
W
A
N
I
Q
A
L
K
D
K
K
V
F
L
M
P
--
E
--
Y
A-
K
A-
W
GY
P
M
P
E
-
A
L
A
-
L
G
E
V
---
W
L
A
K
A
L
Y
P
Q
R
F
Q
D
V
D
L
D
K
M
V
N
D
Y
Y
Q
K
F
Y
R
T
S
Y
K
P
D
------
58
Fugue
58.45
18%
-70
- C1 -
3R5T
4
?
A:
[3-298]
-----------------------------
N
V
W
P
R
T
F
Q
N
A
D
G
S
-
I
T
-
T
I
P
S
Q
P
K
R
I
L
S
T
-----
A
V
T
V
T
G
T
L
L
A
I
D
A
P
V
I
A
S
A
-
A
T
--
T
Q
S
T
F
F
E
Q
W
R
K
L
A
E
L
R
Q
V
K
K
L
W
P
A
G
--
S
V
D
L
E
S
V
Y
V
E
Q
P
D
L
I
V
V
S
M
--
I
G
A
----
D
-
S
A
R
D
Q
I
P
L
L
Q
A
I
A
P
--
T
I
L
V
---
D
Y
S
--
D
---
Q
T
--------------------
W
Q
S
L
A
Q
Q
L
-
G
L
A
T
G
L
--
E
E
Q
--
A
E
R
T
I
H
N
F
E
Q
W
T
K
Q
V
R
D
V
L
D
L
P
K
G
R
--
A
N
I
-
V
S
--
Y
-
H
GPG
V
--
V
--
N
---
A
---
V
A
--
K
A
Q
S
A
H
A
Q
L
L
Q
S
V
G
V
V
L
-
E
E
P
D
P
-
A
--------
W
Q
A
G
SIVHRD
F
L
R
I
H
Y
E
H
L
T
Q
-
L
Q
A
E
T
T
F
L
I
--
T
M
T
D
-------
Q
---
Q
A
-----
Q
A
F
L
H
D
P
I
L
K
N
L
P
S
I
Q
R
K
Q
V
Y
G
L
G
--
E
-----------
N
S
F
R
-
I
-
D
-
L
F
S
A
---
R
E
I
I
N
S
L
L
R
R
F
A
G
E
Q
A
Q
S
L
V
M
P
L
------------------
31
HHSearch
55.08
17%
-79
- C1 -
2R7A
1
?
A:
[2-256]
---------------------------------------------------
A
E
R
I
V
V
A
-
G
G
S
-
L
T
E
L
I
Y
A
M
G
A
G
E
R
V
V
G
V
D
E
-
T
T
--
S
Y
P
P
---------
E
T
A
K
L
P
H
I
G
Y
--
W
K
Q
L
S
S
E
G
I
L
S
L
R
P
D
S
V
I
T
-
W
--
Q
D
A
GP--
Q
-
I
V
L
D
Q
L
R
A
Q
----
K
--
V
N
V
V
---
T
L
P
RV
P
---
A
T
--------------------
L
E
Q
M
Y
A
N
I
R
Q
L
A
K
T
L
--
Q
V
P
E
Q
G
D
A
L
V
T
Q
I
N
Q
R
L
E
R
V
Q
Q
N
V
A
A
K
K
A
P
--
V
K
A
-
M
F
--
I
L
S
A--
G
GS
A
--
P
---
Q
---
V
A
--
G
K
G
S
V
A
D
A
I
L
S
L
A
G
A
E
N
-
V
A
T
H
------------
Q
Q
Y
-------
K
S
Y
S
A
E
S
L
I
A
-
A
N
P
E
V
I
V
V
T
--
S
Q
M
V
D------
G
---
D
I
-----
N
R
L
R
S
I
A
G
I
T
H
T
A
A
W
K
N
Q
R
I
I
T
V
D
--
Q
N
L
I
--
L
--
G
--
M
G
P
R
-
I
-
A
-
D
V
V
E
---
S
L
H
Q
Q
L
W
P
Q
--------------------------------
34
HHSearch
54.70
19%
-76
* C1 *
3LHS
4
?
A:
[5-291]
------------------------------
A
S
T
I
S
V
K
D
E
N
G
--
T
V
-
K
V
P
K
D
A
K
R
I
V
V
L
-
E
Y
S
-
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
-
D
G
--
K
K
K
R
I
I
K
-
P
V
-
R
E
K
I
G
D
Y
T
S
V
G
T
--
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
-
D
--
S
S
R
H---
K
-
G
I
N
K
E
L
N
K
I
----
A
---
P
T
L
---
S
L
K
--
S
FD-
G
D
--------------------
Y
K
Q
N
I
N
S
F
K
T
I
A
K
A
L
--
N
K
E
K
E
G
E
K
R
L
A
E
H
D
K
L
I
N
K
Y
K
D
E
I
K
F
D
-
R
N
--
Q
K
V
-
L
P
A
V
V
-
A
K--
A
--
G
--
L
---
L
---
A
H
--
P
N
Y
S
Y
V
G
Q
F
L
N
E
L
G
F
K
N
-
A
L
S
D
D
-
V
T
K
G
L
SKYL
K
G
P
Y
-------
L
Q
L
D
T
E
H
L
A
D
-
L
N
P
E
R
M
I
I
M
--
T
D
H
A
KKDS---
A
---
E
F
-----
K
K
L
Q
E
D
A
T
W
K
K
L
N
A
V
K
N
N
R
V
D
I
V
D
--
R
--
D
--
V
--
W
--
A
R
S
R
-
G
-
L
-
I
S
S
E
---
E
M
A
K
E
L
V
E
L
S
K
K
E
Q
---------------------------
52
Fugue
54.61
19%
-87
- C1 -
1N2Z
17
BTUF_ECOLI
A:
[1-245]
-----
A
A
P
R
V
I
T
L
S
P
A
N
T
E
L
A
F
A
A
G
I
-------------------------------------------------
T
P
V
G
V
S
S
-----
Y
S
D
----
Y
P
P
Q
A
Q
K
I
E
Q
V
S
T
W
Q
G
-----
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
-
W
RG
G
N
A
----
E
-
R
Q
V
D
Q
L
A
S
L
----
G
--
I
K
V
M
W
V
D
A
T
--------
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
PQ
P
D
K
--
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
K
P
K
K
--
R
V
F
-
L
Q
--
F
-
G
---
I
---------
N
P
P
F
T
S
--
G
K
E
S
I
Q
N
Q
V
L
E
V
C
G
G
E
N
I
F
K
D
S
R
-
V
----------
P
W
-------
P
Q
V
S
R
E
Q
V
L
A
-
R
S
P
Q
A
I
V
I
T
G
G
P
D
Q
I
-------
P
---
K
I
-----
K
Q
Y
W
G
----
E
Q
L
----
K
I
P
V
I
P
L
T
--
S
--
D
--
W
--
F
--
E
R
A
------
S
P
R
I
---
I
L
A
A
Q
Q
L
C
N
A
L
S
Q
V
D
--------------------------
33
HHSearch
54.53
18%
-72
- C1 -
3TNY
1
?
A:
[17-292]
-------------------------------
E
V
V
T
V
E
H
A
M
G
--
K
T
-
E
V
P
A
N
P
K
R
V
V
I
L
-
T
N
E
-
G
T
E
A
L
L
E
L
G
V
--
K
P
V
G
A
V
K
S
W
T
--
G
D
P
-
W
Y
P
-
H
I
-
K
D
K
M
K
D
V
K
V
V
G
D
--
E
G
Q
V
N
V
E
T
I
A
S
L
K
P
D
L
I
I
G
-
N
--
K
M
R
H---
E
-
K
V
Y
E
Q
L
K
A
I
----
A
---
P
T
V
---
F
S
E
------
T
L
--------------------
R
G
E
W
K
D
N
F
K
F
Y
A
K
A
L
--
N
K
E
K
E
G
Q
K
V
V
A
D
Y
E
S
R
M
K
D
L
K
G
K
L
G
D
K
V
N
Q
--
E
I
S
-
M
V
R
-
F
-
M
P--
G
--
D
--
V
---
R
---
I
Y
--
H
G
D
T
F
S
G
V
I
L
K
E
L
G
F
K
R
-
P
G
D
Q
N
-
K
D-------
D
F
A
E
-------
R
N
V
S
K
E
R
I
S
A
-
M
D
G
D
V
L
F
Y
F
--
T
F
D
K
GNEK
K
G
S
E
---
L
E
-----
K
E
Y
I
N
D
P
L
F
K
N
L
N
A
V
K
N
G
K
A
Y
K
V
D
--
D
--
V
--
I
--
W
--
N
T
A
G
-
G
-
V
-
I
A
A
N
---
L
L
L
D
D
I
E
K
R
F
V
------------------------------
28
HHSearch
53.71
13%
-72
- C1 -
3R5T
4
?
A:
[3-297]
-----------------------------
N
V
W
P
R
T
F
Q
N
A
D
G
--
S
I
T
T
I
P
S
Q
P
K
R
I
L
S
T
-
A
V
T
-
V
T
G
T
L
L
A
I
D
A
--
P
V
I
A
S
A
A
-
T
T
QS
T
F
F
E
Q
W
R
-
K
L
--
A
E
L
R
Q
V
K
K
L
W
P
--
A
G
S
V
D
L
E
S
V
Y
V
E
Q
P
D
L
I
V
V
-
S
--
M
I
G
ADSA
R
-
D
Q
I
P
L
L
Q
A
-----
I
--
A
P
T
I
---
L
V
D
--
Y
---
S
---------------------
D
Q
T
W
Q
S
L
A
Q
Q
L
G
L
A
T
--
G
L
E
E
Q
A
E
R
T
I
H
N
F
E
Q
W
T
K
Q
V
R
D
V
L
D
L
-
P
-
K
--
G
R
A
-
N
I
V
S
Y
-
H
---
G
--
P
G
V
V
---
N
A
--
V
A
--
K
A
Q
S
A
H
A
Q
L
L
Q
S
V
G
V
V
L
-
E
E
P
D
P
-
A
WQAGSIV-
H
R
D
F
-------
L
R
I
H
Y
E
H
L
T
Q
-
L
Q
A
E
T
T
F
L
I
--
T
M
T
D
-------
Q
---
Q
A
-----
Q
A
F
L
H
D
P
I
L
K
N
L
P
S
I
Q
R
K
Q
V
Y
G
L
G
--
E
N-
S
--
F
--
R
--
I
D
L
F
-
S
-
A
R
E
I
I
N
---
S
L
L
R
R
F
A
G
E
Q
A
Q
S
L
V
M
P
L
-----------------------
42
HHSearch
53.61
19%
-78
- C1 -
1N2Z
15
BTUF_ECOLI
A:
[1-244]
--------------------------------------------------
A
A
P
R
V
I
T
L
-
S
-
P
A
N
T
E
L
A
F
A
A
G
I
--
T
P
V
G
V
S
S
-
Y
S
--
D
Y
P
P
Q
---------
A
Q
K
I
E
Q
V
S
T
--
W
Q
G
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
-
W
--
R
G
G
NA--
E
-
R
Q
V
D
Q
L
A
S
L
----
G
--
I
K
V
M
---
W
V
D
--
A
---
T
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
--
P
Q
P
D
K
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
K
-
P
K
--
K
R
V
-
F
L
--
Q
-
F
GI-
N
--
P
--
P
---
F
---
T
S
--
G
K
E
S
I
Q
N
Q
V
L
E
V
C
G
G
E
N
-
I
F
K
D
S
----------
R
V
P
W
-------
P
Q
V
S
R
E
Q
V
L
A
-
R
S
P
Q
A
I
V
I
T
--
G
G
P
D
-------
Q
----
I
-----
P
K
I
--
K
Q
Y
W
G
E
Q
---
L
K
I
P
V
I
P
L
T
--
S
D
-
W
F
-
E
--
R
--
A
S
P
R
-
I
-
I
-
L
A
A
Q
---
Q
L
C
N
A
L
S
Q
V
D
-------------------------------
35
HHSearch
53.21
16%
-72
- C1 -
3MD9
4
HMUT_YERPE
A:
[2-254]
---------------------------------------------------
A
E
R
I
V
T
I
-
G
G
D
-
V
T
E
I
A
Y
A
L
G
A
G
D
E
I
V
A
R
D
S
-
T
S
--
Q
Q
P
Q
A
---------
A
Q
K
L
P
D
V
G
Y
--
M
R
T
L
N
A
E
G
I
L
A
M
K
P
T
M
L
L
V
-
S
--
E
L
A
Q---
P
S
L
V
L
T
Q
I
A
S
S
----
G
--
V
N
V
V
---
T
V
P
G-
Q
---
T
T
--------------------
P
E
S
V
A
M
K
I
N
A
V
A
T
A
L
--
H
Q
T
E
K
G
Q
K
L
I
E
D
Y
Q
Q
R
L
A
A
V
N
K
T
P
----
L
P
--
V
K
V
-
L
F
--
V
-
M
S
H
-
G
--
G
L
T
P
---
M
---
A
A
--
G
Q
N
T
A
A
D
A
M
I
R
A
A
G
G
S
N
-
A
M
Q
G
-----------
F
S
R
Y
-------
R
P
L
S
Q
E
G
V
I
A
-
S
A
P
D
L
L
L
I
T
--
T
D
G
V
-------
K
A
L
G
S
S
-----
E
N
I
W
K
L
P
G
M
A
L
T
P
A
G
K
H
K
R
L
L
V
V
D
--
D
--
M
AL
L
--
G
--
F
G
L
E
-
T
-
P
-
Q
V
L
A
---
Q
L
R
E
K
M
E
Q
M
--------------------------------
54
Fugue
52.75
17%
-73
- C1 -
1N2Z
17
BTUF_ECOLI
A:
[1-245]
-----
A
A
P
R
V
I
T
L
S
P
A
N
T
E
L
A
F
A
A
G
I
-------------------------------------------------
T
P
V
G
V
S
S
-
Y
-----------
S
D
Y
P
P
Q
A
Q
K
I
E
Q
V
S
T
W
Q
G
--
M
N
L
E
R
I
V
A
L
K
P
D
L
V
I
A
-
W
RG
G
N
A
----
E
-
R
Q
V
D
Q
L
A
S
L
----
G
--
I
K
V
M
---
W
V
D
--
A
---
T
S
--------------------
I
E
Q
I
A
N
A
L
R
Q
L
A
P
W
S
PQ
P
D
K
--
A
E
Q
A
A
Q
S
L
L
D
Q
Y
A
Q
L
K
A
Q
Y
A
D
K
P
K
K
--
R
V
F
L
Q
F
--
G
-
I
---
N
--
P
--
P
---
F
---
T
S
--
G
K
E
S
I
Q
N
Q
V
L
E
V
C
G
G
E
N
-
I
-
F
K
D
-
S
--------
R
V
P
W
-------
P
Q
V
S
R
E
Q
V
L
A
-
R
S
P
Q
A
I
V
I
T
------------------
G
-----
G
P
D
Q
I
P
K
I
K
Q
Y
W
G
E
Q
L
K
I
P
V
I
P
L
T
--
S
--
D
--
W
--
F
--
E
R
A
-------------------------
S
P
R
I
I
L
A
A
Q
Q
L
C
N
A
L
S
Q
V
D
----------
32
HHSearch
52.62
13%
-75
- C1 -
3GFV
1
YCLQ_BACSU
A:
[14-299]
------------------------------
K
E
Q
I
T
V
K
H
Q
L
D
KN
G
T
-
K
V
P
K
N
P
K
K
V
V
V
F
-
D
F
G
-
S
L
D
T
L
D
K
L
G
L
D
D
I
V
A
G
L
P
K
-
Q
V
--
L
-
P
K
Y
L
S
-
K
F
--
K
-
D
D
K
Y
A
D
V
G
S
--
L
K
E
P
D
F
D
K
V
A
E
L
D
P
D
L
I
I
I
-
S
--
A
R
Q
----
S
-
E
S
Y
K
E
F
S
K
I
----
A
---
P
T
I
---
Y
L
G
--
V
DTA
K
Y
--------------------
M
E
S
F
K
S
D
A
E
T
I
G
K
I
F
--
D
K
E
D
K
V
K
D
E
L
A
N
I
D
H
S
I
A
D
V
K
K
T
A
E
K
L
N
K
N
--
G
L
V
-
I
M
--
A
-
N
D--
G
--
K
--
I
---
S
---
A
F
--
G
P
K
S
R
Y
G
L
I
H
D
V
F
G
V
A
P
-
A
D
Q
N
I
K
A
--------
S
T
H
G
-------
Q
S
V
S
Y
E
Y
I
S
K
-
T
N
P
D
Y
L
F
V
I
--
D
R
G
T
A
I
GET--
S
---
S
T
-----
K
Q
V
V
E
N
D
Y
V
K
N
V
N
A
V
K
N
G
H
V
I
Y
L
D
--
S
A
T
W
--
Y
LS
G
--
G
G
L
E
S
M
-
T
-
Q
M
I
K
---
E
V
K
D
G
L
E
K
E
N
-------------------------------
51
Fugue
52.38
19%
-66
- C1 -
2CHU
4
?
A:
[10-296]
----------------------
L
P
I
S
M
S
D
E
G
D
S
F
L
V
K
D
S
L
G
--
E
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
-
G
-
I
L
D
T
F
D
A
L
K
L
N
D
K
V
V
G
V
P
A
-
K
N
--
L
P
K
Y
L
Q
Q
F
K
---------
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
-
S
--
G
R
Q
----
S
-
K
F
Y
D
K
L
K
E
I
----
A
PT
L
F
V
G
---
L
D
N
--
A
---
N
F
--------------------
L
S
S
F
E
N
N
V
L
S
V
A
K
L
Y
GL
E
K
E
--
A
L
E
K
I
S
D
I
K
N
E
I
E
K
A
K
S
I
V
D
E
D
K
K
A
--
L
I
I
-
L
T
--
N
-
S
---
N
--
K
--
I
---
S
---
A
F
--
G
P
Q
S
R
F
G
I
I
H
D
V
L
G
I
N
A
-
V
D
E
N
I
------------
K
G
-------
K
S
I
N
S
E
F
I
L
E
-
K
N
P
D
Y
I
F
V
V
--
D
R
N
V
-------
I
---
L
G
NKER
A
Q
G
I
L
D
N
A
L
V
A
K
T
K
A
A
Q
N
K
K
I
I
Y
L
D
--
P
--
E
--
Y
--
W
--
Y
L
A
S
-
G
N
G
-
L
E
S
L
---
K
T
M
I
L
E
I
K
N
A
V
K
-----------------------------
55
Fugue
51.37
13%
-79
- C1 -
1EFD
1
FHUD_ECOLI
N:
[2-263]
---
G
I
D
P
N
R
I
V
A
L
E
W
L
P
V
E
L
L
L
A
L
G
I
-------------------------------------------------
V
P
Y
G
V
A
D
-
T
I
--
N
Y
R
L
W
V
S
E
P
P
L
P
D
S
V
I
D
V
G
L
R
T
E
-----
P
N
L
E
L
L
T
E
M
K
P
S
F
M
V
W
-
S
--
A
G
Y
----
G
-
P
S
P
E
M
L
A
R
I
----
A
--
P
G
R
G
FNF
S
D
G
--
K
---
Q
P
--------------------
L
A
M
A
R
K
S
L
T
E
M
A
D
L
L
NL
Q
S
A
--
A
E
T
H
L
A
Q
Y
E
D
F
I
R
S
M
K
P
R
F
V
K
R
G
A
R
--
P
L
L
-
L
T
--
T
-
L
---
I
--
D
--
P
RHM
L
---
V
F
--
G
P
N
S
L
F
Q
E
I
L
D
E
Y
G
I
P
N
A
W
Q
G
E
T
-
N
--------
F
W
G
S
-------
T
A
V
S
I
D
R
L
A
A
Y
K
D
V
D
V
L
C
F
D
--
H
D
N
S
-------
K
---
D
M
-----
D
A
L
M
A
T
P
L
W
Q
A
M
P
F
V
R
A
G
R
F
Q
R
V
P
--
A
--
V
--
W
--
F
--
Y
G
A
T
-
L
-
S
-
A
M
H
F
---
V
R
V
L
D
N
A
I
G
--------------------------------
6
PsiBlast_PDB
50.50
25%
-83
- C1 -
3PSH
1
Y1472_HAEIN
A:
[170-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
D
R
L
G
D
V
S
A
D
--
K
R
V
-
R
T
--
Y
-
M
---
A
--
N
--
P
---
D
---
L
G
T
Y
G
S
G
K
Y
T
G
L
M
M
E
H
A
G
A
Y
N
-
V
A
A
A
T
-
I
--------
K
-
G
F
-------
K
Q
V
S
L
E
N
V
L
E
-
W
N
P
A
V
I
L
V
Q
--
D
R
Y
P
-------
D
---
V
V
-----
P
Q
I
L
N
D
Q
G
W
A
N
I
Q
A
L
K
D
K
K
V
F
L
M
P
EY
A
--
K
--
A
--
W
--
G
Y
P
M
-
P
-
E
-
A
L
A
L
G
E
V
W
L
A
K
A
L
Y
P
Q
R
F
Q
D
V
D
L
D
K
M
V
N
D
Y
Y
Q
K
F
Y
R
T
S
Y
K
P
D
------