@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0132c: (2016-04-19 )
MTGISRRTFGLAAGFGAIGAGGLGGGCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWASDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVAQAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLIRQLWSGERISFTGHYFRTDELKLYDTPAMPPPIFVAASGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAGAQAAGRDPTTLGKRAELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAESNPIEKVLANWAVGTDPGVHIGAVQAVLDAGAVPFLHFPQDDPITAIDFYRTNVLPELR
Atome Classification :
(20 SA)
.........10........20........30........40........50----------------.------------.......60........70........80...-----------.-....90---........100.......110.......120.......130.......140.......150-...--.....--160---..--------------.......170.......180--------------------.----------------------.-......190...-.-..---------..200..--.--....210.-.--.....220.......230-.--..--..-.-..-.--240........250.......260..-.....--270.......280--.-----------...--------.-.---.------------.-------------290---.----.-------.----.-------..--.----..--------300------.--.----....--.-----------..---------310.......320.......330--.....-.-..------340----.------........350.......360----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTGIS
R
R
T
F
G
LAAGFGAIGAGGLGGGCSTRSGPTPTPEPASR
G
V
G
V
V
L
S
H
E
----------------Q------------F
R
T
D
R
L
V
A
H
A
Q
A
A
E
QAG
F
R
Y
V
W
ASDHLQPWQD-----------N-EGHSMF---
P
W
L
T
L
A
L
VGNST
S
S
I
L
FGTGVT
C
P
I
Y
RYH
P
A
T
V
A
Q
A
F
A
S
L
A
ILNP
G
R
V
F
L
GLGTGERL
N
E
--QAA--TDTF
G
--
N
-----
Y
R
--------------
E
R
H
D
R
L
I
E
A
I
V
L
I
R
Q
LWSG---------------------
E
----------------------
R
-
I
S
F
T
G
H
Y
F
-RTD-
E
-
L
K
---------
L
YDTPAM--P--P
P
I
F
V
AAS-G--PQ
S
A
T
L
AGRYGDG
W
I
A
---Q--AR--DI-
N
-
D
A
-
K
--
L
-
L
A
A
F
AAGAQAAGRDPTTLGKR
A
E
L
-
F
A
V
VG--DD
K
A
A
A
R
A
A
D
L
W
---
R
-----------FTA--------G-A---V------------D-------------Q-----P----
N
-------
P
----
V
-------
E
I
--
Q
----RA--------A--------E--S----N
P
I
E
--
K
-----------
V
L
---------
A
NWAVGTDPGV
H
I
G
A
V
Q
A
V
L
D
-A--GAV
P
F
-
L
-HF------P------Q------DDP
I
T
A
I
D
F
Y
R
TNVLPELR------------------------
1
PsiBlast_PDB
97.92
36%
-94
- C6 -
3B4Y
2
FGD_MYCTU
A:
[23-353]
----------------------------------------
E
L
K
L
G
Y
K
A
S
A
E
----------------
Q
------------
F
A
P
R
E
L
V
E
L
A
V
A
A
E
A
H
G
M
D
S
A
T
V
S
D
H
F
Q
P
W
R
H
-----------
Q
-
G
G
H
A
P
F
---
S
L
S
W
M
T
A
V
G
E
R
T
N
R
L
L
L
G
T
S
V
L
T
P
T
F
R
Y
N
P
A
V
I
A
Q
A
F
A
T
M
G
C
L
Y
P
N
R
V
F
L
G
V
G
T
G
E
A
L
N
E
--
I
A
T
GY
E
G
A
W
P
--
E
-----
F
K
--------------
E
R
F
A
R
L
R
E
S
V
G
L
M
R
Q
L
W
S
G
---------------------
D
----------------------
R
-
V
D
F
D
G
D
Y
Y
-
R
L
K
-
G
-
A
S
---------
I
Y
D
V
P
D
G
--
G
--
V
P
V
Y
I
A
A
G
-
G
--
P
A
V
A
K
Y
A
G
R
A
G
D
G
F
I
C
T
SG
K
--
G
E
--
E
L
-
Y
-
T
E
-
K
--
L
-
M
P
A
V
R
E
G
A
A
A
A
D
R
S
V
D
G
I
D
K
M
I
E
I
K
I
S
Y
D
P
--
D
P
E
L
A
M
N
N
T
R
F
W
---
A
-----------
P
L
S
--------
L
-
T
---
A
------------
E
-------------
Q
-----
K
H
SID
D
-------
P
----
I
-------
E
M
--
E
----
K
A
--------
A
--------
D
--
A
----
L
P
I
E
--
Q
-----------
I
A
---------
K
R
W
I
V
A
S
D
P
D
E
A
V
E
K
V
G
Q
Y
V
T
-
W
--
G
L
N
H
L
-
V
F
H
A
------
P
------
G
------
H
D
Q
R
R
F
L
E
L
F
Q
S
D
L
A
P
R
L
R
------------------------
2
PsiBlast_PDB
92.00
31%
-96
- C6 -
1RHC
5
?
A:
[5-329]
-------------------------------------------
I
G
Y
F
A
S
L
E
----------------
Q
------------
Y
R
P
M
D
A
L
E
Q
A
I
R
A
E
K
V
G
F
D
S
V
W
V
D
D
H
F
H
P
W
Y
H
-----------
D
-
N
A
Q
S
A
Q
---
A
W
A
W
M
G
A
A
L
Q
A
T
K
K
V
F
I
S
T
C
I
T
C
P
I
M
R
Y
N
P
A
I
V
A
Q
T
F
A
T
L
R
Q
M
Y
P
G
R
V
G
V
A
V
G
A
G
E
A
M
N
E
--
V
P
V
--
T
G
E
W
P
--
S
-----
V
P
--------------
V
R
Q
D
M
T
V
E
A
V
K
V
M
R
M
L
W
E
S
---------------------
D
----------------------
K
P
V
T
F
K
G
D
Y
F
-
T
L
D
-
K
-
A
F
---------
L
Y
T
K
P
D
D
--
E
--
V
P
L
Y
F
S
G
M
-
G
--
P
K
G
A
K
L
A
G
M
Y
G
D
H
L
M
T
---
V
--
A
A
--
A
P
-
S
-
T
L
-
K
N
V
T
-
I
P
K
F
E
E
G
A
R
E
A
G
K
D
P
S
K
M
E
H
A
M
L
I
-
W
Y
S
V
D
--
P
D
--
Y
D
K
A
V
E
A
L
---
R
-----------
F
W
A
--------
G
-
C
---
L
V
P
S
M
F
K
Y-----
K
-------------
V
-----
Y
----
D
-------
P
----
K
-------
E
V
--
Q
----
L
H
--------
A
--------
N
--
L
----
V
H
C
D
--
T
-----------
I
K
---------
E
N
Y
M
C
A
T
D
A
E
E
M
I
K
E
I
E
R
F
K
E
-
A
--
G
I
N
H
F
C
L
-
G
N
------
S
------
S
------
P
D
V
N
F
G
I
D
I
F
K
-
E
V
I
P
A
V
R
------------------------
23
HHSearch
91.37
31%
-82
- C6 -
1RHC
5
?
A:
[2-329]
----------------------------------------
K
T
Q
I
G
Y
F
A
S
L
E
----------------
Q
------------
Y
R
P
M
D
A
L
E
Q
A
I
R
A
E
K
V
G
F
D
S
V
W
V
D
D
H
F
H
P
W
Y
H
-----------
D
-
N
A
Q
S
A
Q
---
A
W
A
W
M
G
A
A
L
Q
A
T
K
K
V
F
I
S
T
C
I
T
C
P
I
M
R
Y
N
P
A
I
V
A
Q
T
F
A
T
L
R
Q
M
Y
P
G
R
V
G
V
A
V
G
A
G
E
A
M
N
E
--
V
P
V
--
T
G
E
W
P
--
S
-----
V
P
--------------
V
R
Q
D
M
T
V
E
A
V
K
V
M
R
M
L
W
E
S
---------------------
D
K
---------------------
P
-
V
T
F
K
G
D
Y
F
-
T
L
D
-
K
-
A
F
---------
L
Y
T
K
P
D
D
--
E
--
V
P
L
Y
F
S
G
M
-
G
--
P
K
G
A
K
L
A
G
M
Y
G
D
H
L
M
T
---
V
--
A
A
--
A
P
-
S
T
L
K
N
V
--
T
-
I
P
K
F
E
E
G
A
R
E
A
G
K
D
P
S
K
M
E
H
A
M
L
I
-
W
Y
S
V
D
--
P
D
Y
D
K
A
V
E
A
L
R
F
---
W
-----------
A
G
C
--------
L
-
V
P
S
M
F
------------
K
-------------
Y
-----
K
VY--
D
-------
P
----
K
-------
E
V
--
Q
----
L
H
--------
A
--------
N
--
L
----
V
H
C
D
--
T
-----------
I
K
---------
E
N
Y
M
C
A
T
D
A
E
E
M
I
K
E
I
E
R
F
K
E
-
A
--
G
I
N
H
F
-
C
-
L
G
------
N
S-----
S
------
P
D
V
N
F
G
I
D
I
F
-
K
E
V
I
P
A
V
R
------------------------
45
Fugue
88.47
29%
-80
- C6 -
1RHC
5
?
A:
[1-330]
---------------------------------------
M
K
T
Q
I
G
Y
F
A
S
L
E
----------------
Q
------------
Y
R
P
M
D
A
L
E
Q
A
I
R
A
E
K
V
G
F
D
S
V
W
V
D
D
H
F
H
P
W
Y
H
-----------
D
-
N
A
Q
S
A
Q
---
A
W
A
W
M
G
A
A
L
Q
A
T
K
K
V
F
I
S
T
C
I
T
C
P
I
M
R
Y
N
P
A
I
V
A
Q
T
F
A
T
L
R
Q
M
Y
P
G
R
V
G
V
A
V
G
A
G
E
A
M
N
E
--
V
P
V
--
T
G
E
W
P
--
S
-----
V
P
--------------
V
R
Q
D
M
T
V
E
A
V
K
V
M
R
M
L
W
E
S
---------------------
D
----------------------
K
P
V
T
F
K
G
D
Y
F
-
T
L
D
-
K
-
A
F
---------
L
Y
T
K
P
D
D
--
E
--
V
P
L
Y
F
S
G
M
-
G
--
P
K
G
A
K
L
A
G
M
Y
G
D
H
L
M
T
---
V
--
A
A
--
A
P
-
S
-
T
L
-
K
N
V
T
-
I
P
K
F
E
E
G
A
R
E
A
G
K
D
P
S
K
M
E
H
A
M
L
I
-
W
Y
S
V
D
--
P
D
Y
D
K
A
V
E
A
L
R
F
---
W
-----------
A
G
C
--------
L
-
V
---
P
------------
S
-------------
M
F
K
YKV
Y
----
D
-------
P
----
K
-------
E
V
--
Q
----
L
H
--------
A
--------
N
--
L
----
V
H
C
D
--
T
-----------
I
K
---------
E
N
Y
M
C
A
T
D
A
E
E
M
I
K
E
I
E
R
F
K
E
-
A
--
G
I
N
H
F
-
C
-
L
G
------
N
------
S
------
S
P
D
V
N
F
G
I
D
I
F
K
E
V
I
P
A
V
R
D-----------------------
27
HHSearch
83.81
23%
-92
- C6 -
1EZW
2
MER_METKA
A:
[3-348]
----------------------------------------
E
V
S
F
G
I
E
L
L
P
D
-----------------------------
D
K
P
T
K
I
A
H
L
I
K
V
A
E
D
N
G
F
E
Y
A
W
I
C
D
H
Y
N
--------------------
N
Y
S
---
Y
M
G
V
L
T
L
A
A
V
I
T
S
K
I
K
L
G
P
G
I
T
N
P
Y
T
-
R
H
P
L
I
T
A
S
N
I
A
T
L
D
W
I
S
G
G
R
A
I
I
G
M
G
P
G
D
-
K
A
T
--
F
D
-----
K
M
G
--
L
P----
F
P
CKIPIWNPEAE
D
E
V
G
P
A
T
A
I
R
E
V
K
E
V
I
Y
Q
Y
L
E
G
---------------------
G
----------------------
P
-
V
E
Y
E
G
K
Y
V
-
K
T
G
-
T
-
A
D
---------
V
K
A
R
S
I
Q
GS
D
--
I
P
F
Y
M
G
A
Q
-
G
--
P
I
M
L
K
T
A
G
E
I
A
N
G
V
L
V
---
N
--
A
S
--
N
P
K
D
-
F
E
-
V
--
A
-
V
P
K
I
E
E
G
A
K
E
A
G
R
S
L
D
E
I
D
V
A
A
Y
T
-
C
F
S
I
D
--
K
D
E
D
K
A
I
E
A
T
K
I
---------------
V
V
A
--------
F
-
I
---
V
------------
M
G
SP
D
V
V
L
E
R
H
GID
T
-----
E
----
K
-------
A
----
E
-------
Q
I
--
A
----
E
A
I
G
KGD
F
G
T
A
--------
I
--
G
----
L
V
D
E
--
D
-----------
M
I
---------
E
A
F
S
I
A
G
D
P
D
T
V
V
D
K
I
E
E
L
L
K
-
A
--
G
V
T
Q
V
-
V
-
V
G
------
S
------
P
IG----
P
D
K
E
K
A
I
E
L
V
G
Q
E
V
I
P
H
F
K
------------------------
25
HHSearch
83.00
25%
-92
- C6 -
1Z69
2
MER_METBF
A:
[1-327]
-----------------------------------------
M
K
F
G
I
E
F
V
P
S
----------------
D
-------------
P
A
L
K
I
A
Y
Y
A
K
L
S
E
Q
Q
G
F
D
H
V
W
I
T
D
H
Y
N
--------------------
N
R
D
---
V
Y
S
T
L
T
V
L
A
L
N
T
N
S
I
K
I
G
P
G
V
T
N
S
Y
T
-
R
N
P
A
I
T
A
S
S
I
A
S
I
A
E
I
S
G
G
R
A
V
L
G
L
G
P
G
D
-
K
A
T
--
F
D
-----
A
M
G
--
I
A----
W
K
--------------
K
P
L
A
T
T
K
E
A
I
Q
A
I
R
D
F
I
S
G
---------------------
K
----------------------
K
-
V
S
M
D
G
E
M
I
-
K
F
A
-
G
-
A
K
---------
L
A
F
K
A
-
G
--
N
--
I
P
I
Y
M
G
A
Q
-
G
--
P
K
M
L
E
L
A
G
E
I
A
D
G
V
L
I
---
N
--
A
S
--
H
P
K
D
-
F
E
-
V
--
A
-
V
E
Q
I
K
K
G
A
E
K
A
G
R
D
P
S
E
V
D
V
T
A
Y
A
-
C
F
S
I
D
--
K
D
P
V
K
A
V
N
A
A
K
V
---
V
------------
V
A
--------
F
-
I
---
V
------------
A
G
SP
D
L
V
L
E
R
H
G--
I
-----
P
V
---
E
A
------
K
----
S
-------
Q
I
--
G
A
A
I
A
K
G
D
F
G
A
L
---
M
--------
G
--
G
----
L
V
T
P
--
Q
-----------
M
I
---------
E
A
F
S
I
C
G
T
P
D
D
C
M
K
R
I
K
D
L
E
A
-
I
--
G
V
T
Q
I
-
V
-
A
G
------
S
P-----
I
G-----
P
A
K
E
K
A
I
K
L
I
G
K
E
I
I
A
K
--------------------------
26
HHSearch
78.11
18%
-87
- C6 -
1LUC
6
LUXA_VIBHA
A:
[1-352]
-----------------------------------------
M
K
F
G
N
F
L
L
T
Y
----------------
Q
PPELS
Q
T
-----
E
V
M
K
R
L
V
N
L
G
K
A
S
E
G
C
G
F
D
T
V
W
L
L
E
H
H
F
T
E
F
---------------
G
L
L
G
N
---
P
Y
V
A
A
A
H
L
L
G
A
T
E
T
L
N
V
G
T
A
A
I
V
L
P
T
-
A
H
P
V
R
Q
A
E
D
V
N
L
L
D
Q
M
S
K
G
R
F
R
F
G
I
C
R
G
L
Y
D
K
D
--
F
R
-----
V
F
G
--
T
D----
M
D
--------------
N
S
R
A
L
M
D
C
W
Y
D
L
M
K
E
G
F
N
E
---------------------
G
----------------------
Y
-
I
A
A
D
N
E
H
I
-
K
F
P
-
K
-
I
Q
---------
L
N
P
S
A
Y
T
QG
G
--
A
P
V
Y
V
V
A
E
-
S
--
A
S
T
T
E
W
A
A
E
R
G
L
P
M
I
L
---
S
--
W
I
I-
N
T
H
E
-
K
K
-
A
--
Q
-
L
D
L
Y
N
E
V
A
T
E
H
G
Y
D
V
T
K
I
D
H
C
L
S
Y
-
I
T
S
V
D
--
H
D
S
N
R
A
K
D
I
C
R
N
---
F
-----------
L
G
H
--------
W
-
Y
---
D
S
Y
V
---------
N
-------------
A
T
----
K
----
I
-------
F
----------------------------------------------------RI
D
-----------
Y
S
---------
Y
E
I
N
P
V
G
T
P
E
E
C
I
A
I
I
Q
Q
D
I
D
A
T
--
G
I
D
N
I
-
C
-
C
G
------
F
------
E
ANGS
E
-
E
E
I
I
A
S
M
K
L
F
Q
S
D
V
M
P
Y
L
K
------------------------
35
HHSearch
77.79
24%
-87
- C6 -
1F07
3
MER_METTM
A:
[1-321]
-----------------------------------------
M
K
F
G
I
E
F
V
P
N
----------------
E
-------------
P
I
E
K
I
V
K
L
V
K
L
A
E
D
V
G
F
E
Y
A
W
I
T
D
H
Y
N
--------------------
N
K
N
---
V
Y
E
T
L
A
L
I
A
E
G
T
E
T
I
K
L
G
P
G
V
T
N
P
Y
V
-
R
S
P
A
I
T
A
S
A
I
A
T
L
D
E
L
S
N
G
R
A
T
L
G
I
G
P
G
D
-
K
A
T
--
F
D
-----
A
L
G
--
I
E----
W
V
--------------
K
P
V
S
T
I
R
D
A
I
A
M
M
R
T
L
L
A
G
---------------------
E
----------------------
K
-
T
E
S
-
G
A
Q
L
------------------
M
G
V
K
A
V
Q
E-
K
--
I
P
I
Y
M
G
A
Q
-
G
--
P
M
M
L
K
T
A
G
E
I
S
D
G
A
L
I
---
N
--
A
S
--
N
P
K
D
-
F
E
-
A
--
A
-
V
P
L
I
K
E
G
A
E
A
A
G
K
S
I
A
D
I
D
V
A
A
Y
T
-
C
C
S
I
D
--
E
D
A
A
A
A
A
N
A
A
K
I
V
V
A
F
-----------
I
A
A
--------
G
S
P
P
P
V
F
------------
E
R
H
GL---------
P
-----
A
----
D
-------
T
G
---
K
-------
K
F
--
G
----
E
L
--------
L
G
K
GD
F
G
G
A
I
--
G
----
A
V
D
D
--
A
-----------
L
M
---------
E
A
F
S
V
V
G
T
P
D
E
F
I
P
K
I
E
A
L
G
E
-
M
--
G
V
T
Q
Y
-
V
-
A
G
------
S
PI----
G
------
P
D
K
E
K
S
I
K
L
L
G
E
V
I
A
S
F
--------------------------
31
HHSearch
77.68
19%
-88
- C6 -
2I7G
2
?
A:
[21-360]
----------------------------------------
G
M
E
L
G
L
Y
T
F
A
D
VNPNPADG
R
G
P
E
G
---
A
------------
R
R
L
R
E
L
L
E
E
I
E
L
A
D
Q
V
G
L
D
V
F
G
L
G
E
H
H
R
P
D
----------------
Y
V
V
S
S
---
P
S
T
V
L
A
A
A
A
V
K
T
K
N
I
R
L
T
S
A
V
S
V
L
S
S
-
D
D
P
V
R
V
F
Q
Q
F
S
T
V
D
L
L
S
N
G
R
A
E
I
M
A
G
R
G
S
F
I
E
S
--
Y
P
-----
L
F
G
--
Y
D----
L
E
--------------
D
Y
D
V
L
F
A
E
K
L
D
L
L
L
A
L
R
E
Q
---------------------
E
----------------------
V
-
V
T
W
S
G
T
K
H
P
A
I
N
-
G
-
R
G
---------
V
Y
P
R
P
L
Q
E-
R
--
L
P
V
W
I
A
V
G
G
T
--
P
Q
S
V
A
R
A
G
A
M
G
L
P
V
A
L
---
A
--
I
I
GG
E
Y
R
R
-
F
A
-
P
--
L
-
F
D
L
Y
H
E
A
A
R
R
A
G
Q
E
K
T
K
L
R
T
S
I
N
V
-
H
G
F
I
A
--
D
T
T
D
K
A
A
D
Q
F
Y
G
---
P
-----------
Q
A
E
--------
V
-
M
---
N
------------
R
-------------
I
-----
G
----
R
-------
E
----
R
-------
G
W
--
G
----
P
T
--------
N
-----------
R
----
A
H
F
D
--
A
A
R
---------
G
P
---------
E
G
N
L
F
L
G
E
P
E
L
V
A
E
K
I
I
K
A
H
G
V
F
--
K
N
D
R
F
-
L
-
L
Q
------
M
AIGLMP
H
------
D
Q
I
M
R
G
I
E
L
Y
G
T
K
V
A
P
L
V
R
------------------------
34
HHSearch
77.18
23%
-86
- C6 -
3SDO
2
?
A:
[4-417]
-----------------------------------
S
M
T
R
K
H
I
H
F
G
V
L
I
Q
G
A
GANMNAWKHPSVPPDA
S
------------
V
N
F
D
F
Y
V
D
R
A
R
R
A
E
N
A
G
I
A
F
A
F
I
A
D
S
A
Y
V
T
P
K
SAP--------
H
-
F
L
N
R
F
E
---
P
I
S
L
L
S
A
L
A
V
L
T
S
K
I
G
L
V
-
G
T
M
S
S
S
Y
-
S
E
P
Y
N
V
A
R
Q
F
A
S
L
D
L
I
S
G
G
R
A
G
W
N
V
V
T
S
S
I
E
G
T
--
G
K
-----
N
Y
G
--
R
PHPD-
H
A
--------------
Q
R
Y
A
I
A
A
E
H
L
D
V
V
Q
G
L
W
D
S
---------------------
W
DDDALVRDRATGRFFDPDKLH-
R
-
L
D
H
R
G
R
F
F
-
S
V
E
-
G
P
L
N
---------
I
R
R
S
P
Q
G
--
Q
--
P
V
I
F
Q
A
G
S
-
S
--
D
D
G
I
D
L
A
G
R
S
A
D
A
V
F
S
---
N
--
G
S
--
T
F
D
E
-
A
R
-
V
--
F
-
Y
R
R
V
K
A
A
A
A
A
A
G
R
N
P
D
H
V
K
V
F
P
G
I
-
G
P
I
V
G
--
A
T
Q
Q
E
A
D
D
K
Y
R
Q
---
V
R
D
LLS
P
R
E
A
L
A
Y
L
S
--------
H
-
F
---
F
QQH---------
D
FSVYPLD------
G
-----
P
----
F
PDIGTLG
S
----
D
GF
Q
S
T
T
D
N
I
--
K
----
R
L
--------
A
--------
R
E
R
K
----
L
T
L
R
--
E
V
A
Y
E
V
S
T
R
R
S
N
I
G
---------
T
S
E
A
F
I
G
T
P
E
A
V
A
S
E
M
I
R
W
V
D
-
E
G-
A
A
D
G
F
-
M
-
L
G
------
L
-------------
P
V
T
G
F
G
L
D
D
F
V
D
H
V
L
P
V
L
S
------------------------
49
Fugue
75.55
17%
-84
- C6 -
1TVL
-
MOXC_BACSU
A:
[3-432]
----
R
A
D
F
I
Q
F
G
A
M
I
H
G
V
G
-----------------
G
T
T
D
G
W
R
H
P
D
V
D
P
S
A
----------------
S
------------
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
L
F
I
S
E
K
-----------
S
-
I
P
H
F
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
T
S
F
T
--
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
N
H
S
--
K
S
N
L
P
--
E
-----
H
T
--------------
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
S
WEHDAFIHNKKTGQFFDQAKL
H
----------------------
R
-
L
N
H
K
G
K
Y
F
-
Q
V
E
G
P
-
L
N
---------
I
G
R
S
K
Q
G
--
E
--
P
V
V
F
Q
A
G
S
-
S
--
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
---
H
--
S
N
--
S
L
-
E
-
E
T
-
K
A
-
F
-
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
-
S
P
I
V
A
DT
E
E
E
A
E
K
K
Y
R
E
F
A
---
E
-----------
L
I
P
--------
I
-
E
---
N
------------
A
-------------
V
-----
T
----
E
-------
A
----
K
-------
A
R
--
N
----
L
T
--------
L
--------
R
--
E
----
V
A
Q
E
--
M
-----------
A
F
---------
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
-
A
--
E
A
A
D
G
-
F
-
I
V
------
G
------
S
------
D
I
P
-
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
GLYRQDYRGGT
L
R
E
N
L
G
L
G
I
P
Q
36
HHSearch
74.53
18%
-85
- C6 -
1TVL
-
MOXC_BACSU
A:
[34-408]
--------------------------------------------------------------------------------
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
L
F
I
S
E
K
SIP--------
H
-
F
L
N
R
F
E
---
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
-
S
T
S
F
-
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
--
A
R
N
--
H
S
K
S
N
LP
E
-----
H
T
--------------
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
S
---------------------
W
EHDAFIHNKKTGQFFDQAKLH-
R
-
L
N
H
K
G
K
Y
F
-
Q
V
E
-
G
-
P
L
---------
N
I
G
R
S
K
Q
G-
E
--
P
V
V
F
Q
A
G
S
-
S
--
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
---
H
--
S
N
--
S
L
-
E
E
T
K
-
A
--
F
-
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
-
S
P
I
V
A
--
D
T
E
E
E
A
E
K
K
Y
R
E
---
F
-----------
A
E
L
IPIENAVT---------------------------------------------------------------------------
E
AK------
A
--------
R
--
N
LT
L
R
E
V
A
Q
--
E
-----------
M
A
F
--------
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
--
A
A
D
G
F
-
I
-
V
G
------
S
--------------
D
I
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
------------------------
37
HHSearch
73.89
18%
-77
- C6 -
3B9O
1
?
A:
[17-398]
----------------------------------------
H
I
A
H
G
L
W
R
H
P
E
NQRHR-----------
Y
------------
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
V
G
I
Y
D
V
YRQSR
D
T
A
V
R
E
A
V
Q
I
P
V
N
D
---
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
-
S
T
T
Y
-
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
--
D
K
-----
N
F
G
--
I
K
K
I
L
E
H
D
--------------
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
---------------------
S
WEDNAVIRDIENNIYTDPSKVH
E
-
I
N
H
S
G
K
Y
F
-
E
V
P
-
G
-
P
H
---------
L
C
E
P
S
P
Q
R-
T
--
P
V
I
Y
Q
A
G
M
-
S
--
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
---
G
--
G
K
--
D
V
-
E
T
L
K
-
F
--
F
-
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
-
C
V
I
V
G
--
K
T
H
D
E
A
M
E
K
L
N
S
---
F
-----------
Q
K
Y
WS
L
E
G
H
L
A
H
-
Y
---
G
------------
G
-------------
G
T
G---
Y
----
D
-------
L
----
S
-------
K
Y
SS
N
----
D
Y
--------
I
--------
G
--
S
----
I
S
V
G
--
E
-----------
I
I
N
N
M
S
KLDGK
W
F
K
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
--
G
I
D
G
F
-
N
-
L
V
------
Q
------
Y
------
V
-
S
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
------------------------
32
HHSearch
73.76
17%
-72
- C6 -
4UWM
5
C16MO_PSEPU
A:
[2-374]
----------------------------------------
A
M
E
T
G
L
I
F
H
P
Y
----------------
M
RPGRS
A
R
-----
Q
T
F
D
W
G
I
K
S
A
V
Q
A
D
S
V
G
I
D
S
M
M
I
S
E
H
A
S
Q
I
W
---------------
E
N
I
P
N
---
P
E
L
L
I
A
A
A
A
L
Q
T
K
N
I
K
F
A
P
M
A
H
L
L
P
H
-
Q
H
P
A
K
L
A
T
M
I
G
W
L
S
Q
I
L
E
G
R
Y
F
L
G
I
G
A
G
A
Y
P
Q
A
--
S
Y
-----
M
H
G
--
I
RNAG-
T
K
--------------
N
L
N
D
M
V
R
E
S
L
F
I
M
E
K
I
W
K
R
---------------------
E
----------------------
P
-
F
F
H
E
G
K
Y
W
-
D
A
G
-
Y
-
P
E
E
LEDEQHKL
A
D
F
S
P
W
G
GK
A
--
P
E
I
A
V
T
G
F
-
S
YN
S
P
S
M
R
L
A
G
E
R
N
F
K
P
V
S
---
I
--
F
S
--
G
L
-
D
A
L
K
-
R
--
H
-
W
E
V
Y
S
E
A
A
I
E
A
G
H
T
P
D
R
S
R
H
A
V
S
H
-
T
V
F
C
A
--
D
T
D
K
E
A
K
R
L
V
M
E
---
G
-----------
P
I
G
--------
Y
-
C
---
F
E
R
Y
L
I
-------
P
I
W
R
----------
R
-----
F
----
G
-------
M
----
M
D
------
G
Y
--
A
----
K
D
A
-------
G
IDP-----
V
--
D
----
A
D
L
E
--
F
-----------
L
V
---------
D
N
V
F
L
V
G
S
P
D
T
V
T
E
K
I
N
A
L
F
E
-
A
TG
G
W
G
T
L
-
Q
-
V
E
------
A
------
H
DYYDDP
A
P
W
F
Q
S
L
E
L
I
S
K
E
V
A
P
K
I
L
------------------------
30
HHSearch
73.22
21%
-90
- C6 -
2B81
6
?
A:
[20-321]
------------------------------------
F
A
K
D
Q
L
T
L
G
V
H
I
P
I
E
----------------
N
YQFHA-------
P
T
M
E
K
Q
V
E
L
V
Q
K
A
E
Q
Y
G
F
T
G
V
W
L
R
D
V
L
L
Q
D
P
D
FGDP-------
A
-
T
G
Q
I
Y
D
---
M
M
I
Y
L
T
Y
L
A
S
K
T
E
K
I
A
F
G
T
S
A
T
V
L
S
L
-
R
H
P
L
R
V
A
K
E
I
A
T
L
D
Q
L
F
P
E
R
I
M
L
G
V
S
S
G
D
R
R
A
D
--
F
K
-----
A
L
G
--
V
S----
H
E
--------------
T
R
G
E
K
F
R
E
A
F
A
Y
L
E
E
I
L
Y
K
---------------------
N
----------------------
F
-
P
S
I
Q
S
T
L
G
-
E
V
H
-
G
-
A
N
---------
L
V
P
K
P
S
K
--
R
--
V
P
T
F
I
T
G
F
-
S
--
Q
Q
N
M
E
W
F
A
E
H
G
D
G
W
M
Y
---
Y
--
P
R
--
S
P
V
H
-
Q
A
-
G
--
A
-
I
G
Q
W
R
E
L
V
E
D
Y
H
P
D
V
F
K
-
P
F
I
Q
P
M
-
H
L
D
L
S
--
E
D
P
N
E
--
R
P
T
-----------------
P
----------------------------------------------------------------------------------------------------------------------------------
I
----------
R
L
G
Y
R
T
G
R
K
A
L
I
E
L
L
D
I
Y
K
S
-
I
--
G
V
N
H
L
-
F
-
L
A
------
L
------
F
DGQ---
R
P
A
D
E
V
L
D
E
L
G
E
E
V
L
P
H
F
P
------------------------
33
HHSearch
72.80
20%
-85
- C6 -
1NQK
-
SSUD_ECOLI
A:
[27-350]
--------------------------------------------------------------------------------
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
I
P
T
G
R
S
--------------------
C
E
D
---
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
-
R
P
S
V
-
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
--
L
A
G
--
D
G
V
F
L
--
D
-----
H
S
--------------
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
L
Q
R
---------------------
E
----------------------
T
-
V
D
F
N
G
K
H
I
-
H
V
R
-
G
-
A
K
---------
L
L
F
P
A
I
Q
QP
Y
--
P
P
L
Y
F
G
G
S
-
S
--
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
---
W
--
G
E
--
P
P
-
E
L
V
K
-
E
--
K
-
I
E
Q
V
R
A
K
A
A
A
H
G
R
K
I
---
R
F
G
I
R
L
-
H
V
I
V
R
--
E
T
N
D
E
A
W
Q
A
A
E
R
---
L
-----------
I
S
H
--------
L
-
D
---
D
E
T
I
A
K
A
Q
A
A
F
AR---------------------------------------------------------D-------
N
--------
L
--
E
----
I
S
P
N
--
L
WAGVGLVR---
G
G
---------
A
G
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
A
-
L
--
G
I
D
S
F
-
V
-
L
S
------
G
-------------
Y
P
H
L
E
E
A
Y
R
V
G
E
L
L
F
P
L
L
D
------------------------
46
Fugue
72.29
16%
-72
- C6 -
1LUC
6
LUXA_VIBHA
A:
[1-355]
------
M
K
F
G
N
F
L
L
-------------------------
T
Y
-
Q
P
P
E
L
S
Q
T
E
----------------
V
------------
M
K
R
L
V
N
L
G
K
A
S
E
G
C
--
G
F
D
T
V
W
L
L
E
H
---
H
F
T
-----------
E
-
F
G
L
L
G
N
---
P
Y
V
A
A
A
H
L
L
G
A
T
E
T
L
N
V
G
T
A
A
I
V
L
P
T
A
-
H
P
V
R
Q
A
E
D
V
N
L
L
D
Q
M
S
K
G
R
F
R
F
G
I
C
R
G
L
Y
D
K
D
--
F
R
V
--
F
G
T
----
D
-----
M
D
--------------
N
S
R
A
L
M
D
C
W
Y
D
L
M
K
E
G
F
N
E
---------------------
G
----------------------
Y
-
I
A
A
D
N
E
H
I
-
K
F
P
-
K
-
I
Q
---------
L
N
P
S
A
Y
T
--
Q
GG
A
P
V
Y
V
V
A
E
-
S
--
A
S
T
T
E
W
A
A
E
R
G
L
P
M
I
L
---
S
WI
I
N
--
T
H
-
E
-
K
K
-
A
--
Q
-
L
D
L
Y
N
E
V
A
T
E
H
G
Y
D
V
T
K
I
D
H
C
L
S
Y
-
I
T
S
V
D
--
H
D
S
N
R
A
K
D
I
C
R
N
---
F
-----------
L
G
H
--------
W
-
Y
---
D
------------
S
-------------
Y
-----
V
----
N
-------
A
----
T
-------
K
---------------------------
I
--
F
-----
R
I
D
--
Y
-----------
S
Y
---------
E
I
N
P
V
G
T
P
E
E
C
I
A
I
I
Q
Q
D
I
D
A
-
T
---
G
I
D
N
-
I
-
C
C
G
FEANG
S
------
E
------
E
E
I
I
A
S
M
K
L
F
Q
S
D
V
M
P
Y
L
K
EKQ---------------------
28
HHSearch
72.22
16%
-92
* C6 *
3RAO
4
?
A:
[18-363]
-------------------------------------
Y
F
Q
G
V
E
Y
G
F
W
L
P
I
F
----------------
G
GWLRNVNDESMP
P
T
F
E
Y
A
K
Q
T
A
Q
A
A
E
Q
L
G
F
S
T
T
L
I
A
E
L
N
L
N
D
I
K
G----------
V
-
S
A
P
S
L
E
---
A
W
T
T
A
A
A
L
A
A
V
T
D
R
L
E
I
M
T
A
V
R
-
P
G
F
-
H
N
P
A
V
T
A
K
M
A
A
N
I
D
Q
L
S
N
G
R
F
T
L
N
V
V
S
A
W
W
E
E
E
--
A
K
-----
Q
Y
G
--
G
VFTA-
H
D
--------------
E
R
Y
D
R
T
E
E
F
V
T
I
L
K
G
L
W
K
E
---------------------
E
----------------------
E
-
F
S
Y
K
G
N
F
Y
-
E
L
H
-
H
-
T
H
---------
L
S
P
K
P
V
Q
KQ
G
--
I
K
L
Y
A
G
G
E
-
S
--
K
R
G
K
E
V
I
V
N
H
A
D
A
Y
V
M
---
H
--
G
G
--
T
V
E
E
-
V
S
-
V
--
K
-
I
E
D
M
K
N
R
R
K
K
V
T
E
E
P
L
Q
-
S
F
G
L
A
A
-
Y
V
I
C
R
--
H
T
E
E
E
A
L
E
E
W
R
R
---
I
-----------
T
-
D
--------
V
-
K
--------------------------------------------------FVS
K
S
-------
Q
L
--
E
----
Q
Q
--------
V
--------
K
L
N
D
----
Y
S
V
S
--
N
-----------
R
G
---------
L
R
P
N
L
I
G
T
P
E
Q
I
A
E
R
I
L
A
F
E
K
-
V
--
G
V
T
L
L
-
L
-
L
Q
------
F
-------------
S
P
Q
L
E
E
M
K
R
F
S
E
K
V
M
P
L
V
E
------------------------
48
Fugue
71.85
20%
-81
- C6 -
1M41
-
SSUD_ECOLI
A:
[1-361]
-----
S
L
N
M
F
W
F
L
P
T
H
G
D
G
H
---------
Y
L
G
T
E
E
G
S
R
P
V
D
-----------------------------------------
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
I
P
T
G
R
S
C
E
D
-----------------------
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
--
K
F
L
V
A
L
R
P
S
V
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
--
L
A
G
--
D
G
V
F
L
--
D
-----
H
S
--------------
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
L
Q
R
---------------------
E
----------------------
T
-
V
D
F
N
G
K
H
I
-
H
V
R
-
G
-
A
K
---------
L
L
F
P
A
I
Q
--
Q
PY
P
P
L
Y
F
G
G
S
-
S
--
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
---
W
--
G
E
--
P
P
-
E
-
L
V
-
K
E
-
K
-
I
E
Q
V
R
A
K
A
A
A
H
G
R
K
I
R
F
G
I
R
---
L
-
H
V
I
V
R
--
E
T
N
D
E
A
W
Q
A
A
E
R
---
L
-----------
I
S
H
--------
L
-
L
---
E
------------
I
-------------
S
-----
P
----
N
-------
L
----
W
-------
A
G
--
V
----
G
L
--------
V
--------
R
--
G
----
G
A
---------------------------
G
T
A
L
V
G
D
G
P
T
V
A
-
A
R
I
N
E
Y
A
A
-
L
--
G
I
D
S
F
-
V
--
L
------
S
------
G
------
Y
P
H
L
E
E
A
Y
R
V
G
E
L
L
F
P
L
L
D
VA
I
P
E
I
P
QPQPL------------
22
PsiBlast_CBE
71.78
32%
-107
- C6 -
1Z69
2
MER_METBF
B:
[15-204]
------------------------------------------------------------------------------------
K
I
A
Y
Y
A
K
L
S
E
Q
Q
G
F
D
H
V
W
I
T
D
H
---
Y
N
N
-----------
R
-
D
V
Y
S
--------
T
L
T
V
L
A
L
N
T
N
S
I
K
I
G
P
G
V
T
N
S
-
Y
T
R
N
P
A
I
T
A
S
S
I
A
S
I
A
E
I
S
G
G
R
A
V
L
G
L
G
P
G
D
K
------
A
T
--
F
D
A
M
G
I-
A
-----
W
K
--------------
K
P
L
A
T
T
K
E
A
I
Q
A
I
R
D
F
I
S
G
---------------------
K
----------------------
K
-
V
S
M
D
G
E
M
I
-
K
F
A
-
G
-
A
K
---------
L
A
-
F
K
A
G
--
N
--
I
P
I
Y
M
G
A
Q
-
G
--
P
K
M
L
E
L
A
G
E
I
A
D
G
V
L
I
---
N
--
A
S
--
H
P
-
K
-
D
F
-
E
--
V
A
V
E
Q
I
K
K
G
A
E
K
A
G
R
D
P
S
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------