@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv0139: (2016-04-19 )
MNAPKLVIGANGFLGSHVTRQLVADCAPQKGEVRAMVRPAANTRSIDDLPLTRFHGDVFDTATVAEAMAGCDDVYYCVVDTRAWLRDPSPLFRTNVAGLRNVLDVATDASLRRFVFTSSYATVGRRRGHVATEEDRVDTRKVTPYVRSRVAAEDLVLQYAHDAGLPAVAMCVSTTYGGGDWGRTPHGAFIAGAVFGRLPFTMRGIRLEAVGVDDAARALILAAERGRNGERYLISERMMPLQEVVRIAADEAGVPPPRWSISVPVLYALGALGSLRARLTGKDTELSLASVRMMRSEADVDHGKAVRELGWQPRPVEESIREAARFWAAMRTVGKDPAAS
Atome Classification :
(20 SA)
.........10........20........30-.------.-.--.....-.40------.-.-..---.---.---.----..--------50----..-..---.....60.......--.--70--....--....80..--.-.---..-.-.90.........100.-......-110........120..-----.------.--.----.------------.----------------130..--------..--..--.-------140-------------..-------.....150.......160.......170.......180.---------......190..----..--.--..-200------.--.---.....-..210.......220...--.--...230..--...---.-.240.......250.......260.......270.......280.......290.......300.......310..--.....-320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNAP
K
L
V
I
GANGF
L
G
S
H
V
T
R
Q
L
V
A
DCAPQK--G------
E
-
V
--
R
A
M
VR-PA-------A-N-TR---S---I---D----DL--------P-----LT-RF---HGDVF
D
T
A
T
V
A
E
A
M--A--GC--D
D
V
Y
--
Y
C
V
VD
T
R
A
--W-L---RD-P-S
P
-
L
F
R
T
N
V
A
G
L
R
N
V
L
-
D
VAT
D
A
-
S
-
L
R
R
F
V
F
TS
S
Y
A
T
V
G-----R------R--R----G------------H----------------VATEE--------DR--VD--T-------RKV-------------
T
P
-------
Y
V
R
S
R
V
A
A
E
D
L
V
L
Q
Y
AHDAG
L
P
A
V
A
M
C
VSTTYGGGDWGR---------TPH
G
A
F
I
A
G
A
V
----
F
G--R--LP-
F
--------
T
--
M
---R
G
I
R
L
-
E
A
VGV
D
D
A
A
R
A
L
I
L
A
AER--G--RNG
E
R
Y
L
I
--
S
E
R---M-M
P
L
Q
E
V
V
R
I
AADEAGVPPPR
W
S
I
S
V
P
V
L
Y
A
L
G
A
L
G
S
L
R
A
RLTGKDTE
L
S
L
A
S
V
R
M
M
RSEADVD
H
G
K
A
V
R
E
LGWQPR--
P
V
E
E
S
-
I
R
E
A
A
R
F
W
A
A
M
R
T
VGKDPAAS
25
HHSearch
87.56
31%
-92
- C1 -
3WJ7
2
?
A:
[13-339]
-
N
D
V
T
L
V
T
G
A
T
G
F
V
G
S
A
V
A
R
V
L
E
E
----
R
G
--
H
------
R
-
L
--
R
L
L
V
R
P
T
S
-------
D
---
R
S
---
N
---
I
---
A
----
E
L
--------
N
-----
A
E
-
L
A
---
V
G
D
L
S
D
P
D
T
L
A
P
A
L
--
K
--
G
V
--
K
I
L
F
--
H
V
A
A
D
Y
R
L
--
W
-
V
---
P
D
-
P
-
E
T
-
M
M
K
A
N
V
E
G
T
R
N
L
M
-
L
A
A
L
E
A
-
G
-
V
E
K
I
I
Y
C
S
S
V
A
A
L
G
-----
L
------
R
--
S
D---
G
------------
V
----------------
P
A
D
E
T
--------
T
P
--
V
S
--
E
S------
Q
V
I
-------------
G
I
-------
Y
K
L
S
K
Y
R
A
E
Q
E
V
L
R
L
I
R
E
K
N
L
P
A
I
I
V
N
P
S
T
P
V
G
P
R
D
I
K
P
---------
T
P
T
G
Q
M
I
L
D
C
A
----
S
G
--
N
--
M
P
-
A
--------
Y
--
V
---
E
T
G
L
N
--
I
V
H
V
D
D
V
A
E
G
H
A
L
A
L
E
R
--
G
--
K
I
G
E
K
Y
I
L
--
G
G
E
---
N
-
I
M
L
G
D
L
F
R
M
V
S
Q
I
A
G
V
K
P
P
A
V
K
L
K
Q
S
W
L
Y
P
V
A
L
V
S
E
W
L
A
R
G
F
G
I
E
P
R
V
T
R
E
T
L
A
M
S
K
K
L
M
F
F
S
S
D
K
A
K
K
E
L
G
Y
A
P
R
--
P
A
R
D
A
-
V
T
D
A
I
A
W
F
R
Q
H
G
---------
1
PsiBlast_PDB
83.76
30%
-93
- C1 -
3WJ7
2
?
A:
[13-335]
-
N
D
V
T
L
V
T
G
A
T
G
F
V
G
S
A
V
A
R
V
L
-----
E
E
R
--
G
------
H
R
L
--
R
L
L
V
R
-
P
T
-------
S
-
D
-
R
S
---
N
---
I
---
A
----
E
L
--------
N
-----
A
E
-
L
A
---
V
G
D
L
S
D
P
D
T
L
A
P
A
L
--
K
--
G
V
--
K
I
L
F
--
H
V
A
A
D
Y
R
L
--
W
-
V
---
P
D
-
P
-
E
T
-
M
M
K
A
N
V
E
G
T
R
N
L
M
-
L
A
A
L
E
A
-
G
-
V
E
K
I
I
Y
C
S
S
V
A
A
L
G
-----
L
------
R
--
S
----
D
------------
G
----------------
V
P
A
D
E
--------
T
T
PV
S
E
--
S
-------
Q
V
I
-------------
G
I
-------
Y
K
L
S
K
Y
R
A
E
Q
E
V
L
R
L
I
R
E
K
N
L
P
A
I
I
V
N
P
S
T
P
V
G
P
R
D
I
K
P
---------
T
P
T
G
Q
M
I
L
D
C
A
----
S
G
--
N
--
M
P
A
Y
--------
V
--
E
---
T
G
L
N
I
---
V
H
V
D
D
V
A
E
G
H
A
L
A
L
E
R
--
G
--
K
I
G
E
K
Y
I
L
--
G
G
E
---
N
-
I
M
L
G
D
L
F
R
M
V
S
Q
I
A
G
V
K
P
P
A
V
K
L
K
Q
S
W
L
Y
P
V
A
L
V
S
E
W
L
A
R
G
F
G
I
E
P
R
V
T
R
E
T
L
A
M
S
K
K
L
M
F
F
S
S
D
K
A
K
K
E
L
G
Y
A
P
R
--
P
A
R
D
A
-
V
T
D
A
I
A
W
F
-------------
31
HHSearch
76.53
27%
-86
- C1 -
1R6D
2
?
A:
[1-315]
--
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
----
G
A
--
Y
PDVPAD
E
-
V
--
I
V
L
D
S
L
T
Y
-------
A
G
N
-
R
A
---
N
---
L
---
A
PVDA
D
P
--------
R
-----
L
R
-
F
V
---
H
G
D
I
R
D
A
G
L
L
A
R
E
L
--
R
--
G
V
--
D
A
I
V
--
H
F
A
A
E
S
H
V
--
D
-
R
S
I
-
A
G
-
A
-
S
V
-
F
T
E
T
N
V
Q
G
T
Q
T
L
L
-
Q
C
A
V
D
A
-
G
-
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
-----
S
------
I
--
D
----
S
------------
G
----------------
S
W
T
E
S
--------
S
P
--
L
-----------
E
P
N
-------------
S
P
-------
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
E
---------
K
L
I
P
L
F
V
T
N
L
L
----
D
G
--
G
T-
L
P
-
L
--------
Y
--
G
DG-
A
N
V
R
E
--
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
--
G
--
R
A
G
E
I
Y
H
I
--
G
G
G
L
--
E
-
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
W
S
--
S
V
R
K
V
-
A
-------
D
--------
R
K
--------
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V-
S
F
A
D
G
-
L
A
R
T
V
R
W
Y
R
E
N
R
---------
21
HHSearch
70.58
24%
-96
- C1 -
2X4G
-
?
A:
[11-337]
A
H
V
K
Y
A
V
L
G
A
T
G
L
L
G
H
H
A
A
R
A
I
R
A
----
A
G
--
H
------
D
-
L
--
V
L
I
H
R
P
S
S
-------
Q
---
I
Q
---
R
---
L
---
A
----
Y
L
--------
E
-----
P
E
-
C
R
---
V
A
E
M
L
D
H
A
G
L
E
R
A
L
--
R
--
G
L
--
D
G
V
I
--
F
S
--------------------
E
-
E
V
A
S
A
L
G
Q
T
N
P
F
Y
-
A
A
C
L
Q
A
-
R
-
V
P
R
I
L
Y
V
G
S
A
Y
A
M
P
-----
R
------
H
--
P
Q---
G
------------
L
----------------
P
G
H
E
G
--------
L
F
--
Y
D
SL
P
-------
S
G
K
-------------
S
S
-------
Y
V
L
C
K
W
A
L
D
E
Q
A
R
E
Q
A
R
-
N
G
L
P
V
V
I
G
I
P
G
M
V
L
G
E
L
D
I
G
P
----------
T
T
G
R
V
I
T
A
I
G
----
N
G
--
E
--
M
T
-
H
--------
Y
--
V
---
A
G
Q
R
N
--
V
I
D
A
A
E
A
G
R
G
L
L
M
A
L
E
R
--
G
--
R
I
G
E
R
Y
L
L
--
T
G
H
---
N
-
L
E
M
A
D
L
T
R
R
I
A
E
L
L
G
Q
P
A
P
Q
-
P
M
S
M
A
M
A
R
A
L
A
T
L
G
R
L
----------------
E
V
M
A
G
G
Q
F
L
D
G
R
K
A
R
E
E
L
G
F
F
S
T
T-
A
L
D
D
T
-
L
L
R
A
I
D
W
F
R
D
N
G
---------
46
Fugue
70.41
25%
-98
- C1 -
4QTZ
-
?
A:
[6-326]
L
G
N
V
V
C
V
T
G
A
S
G
Y
I
A
S
W
L
V
R
L
L
L
H
R
G
Y
------------
T
-
V
--
K
A
T
V
R
-
D
P
-------
N
-
D
-
P
K
---
K
---
V
---
D
----
H
L
V
K
LDGAKE
R
-----
L
Q
-
L
F
---
K
A
N
L
L
E
E
G
A
F
D
S
V
V
--
Q
--
G
C
--
H
G
V
F
--
H
T
A
S
P
F
Y
H
--
D
-
V
---
K
D
-
P
-
Q
A
E
L
I
D
P
A
L
K
G
T
L
N
V
L
-
N
S
C
A
K
S
P
S
-
L
K
R
V
V
L
T
S
S
I
A
A
V
A
YNGKP
R
------
T
--
P
----
D
------------
V
----------------
V
V
D
E
T
--------
W
F
--
T
D
--
A
-------
D
F
C
-------------
A
K
S
NL
W
---
Y
V
V
S
K
T
L
A
E
E
A
A
W
K
F
V
K
E
N
N
I
D
M
V
T
I
N
P
A
M
V
I
G
P
L
L
Q
P
V
L--------
N
T
S
A
A
A
I
L
N
L
I
----
N
G
--
A
--
Q
T
-
F
--------
P
--
N
---
A
--
S
F
-
G
W
V
N
V
K
D
V
A
N
A
H
I
L
A
Y
E
N
--
A
--
S
A
S
G
R
H
C
L
--
V
E
R
---
V
-
A
H
Y
S
E
V
V
R
I
L
R
E
L
Y
P
------
S
L
Q
L
P
E
K
C
A
D
D
K
P
Y
V
P
I
Y
Q
V
S
K
----------------------
E
K
A
K
S
L
G
L
E
Y
T
--
P
L
E
V
S
-
I
K
E
T
V
E
S
L
K
E
K
K
F
A
N
L
-----
36
HHSearch
66.72
24%
-83
* C1 *
2HUN
1
?
A:
[3-317]
-
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
----
K
H
P
D
W
------
E
-
V
--
I
N
I
D
K
L
G
Y
-------
G
S
N
-
P
A
---
N
---
L
KDL
E
D---
D
P
--------
R
-----
Y
T
-
F
V
---
K
G
D
V
A
D
Y
E
L
V
K
E
L
V
--
R
--
K
V
--
D
G
V
V
--
H
L
A
A
E
S
H
V
--
D
-
R
S
I
-
S
S
-
P
-
E
I
-
F
L
H
S
N
V
I
G
T
Y
T
L
L
-
E
S
I
R
R
E
N
P
-
E
V
R
F
V
H
V
S
T
D
E
V
Y
G
-----
D
------
I
--
L
----
K
------------
G
----------------
S
F
T
E
N
--------
D
R
--
L
-----------
M
P
S
-------------
S
P
-------
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
P
Y
Q
F
P
E
---------
K
L
I
P
K
T
I
I
R
A
S
----
L
G
--
L
K
-
I
P
-
I
--------
Y
GT------
V
R
D
--
W
L
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
--
G
--
E
S
R
E
I
Y
N
I
--
S
A
G
E--
E
-
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
G
E
E
L
I
E
L
V
E
D
------------------
R
P
---
G
-----
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
P
K
Y-
T
F
D
E
G
-
I
K
K
T
I
D
W
Y
L
K
N
E
W
W
-------
2
PsiBlast_PDB
66.47
27%
-88
- C1 -
1R6D
2
?
A:
[4-297]
-----
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
Y
P
D
V
--
P
------
A
-
D
--
E
V
I
V
L
-
D
S
LTYAGNR
A
-
N
-
L
A
---
P
---
V
---
D
----
A
D
--------
P
-----
R
L
-
R
F
V
--
H
G
D
I
R
D
A
G
L
L
A
R
E
L
--
R
--
G
V
--
D
A
I
V
--
H
F
A
A
E
S
H
V
D
R
S
-
I
---
A
G
-
A
-
S
V
-
F
T
E
T
N
V
Q
G
T
Q
T
L
L
-
Q
C
A
V
D
A
-
G
-
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
-----
S
------
I
--
D
----
S
------------
G
----------------
S
W
T
E
S
--------
S
P
--
L
E
--
P
-------
N
---------------
S
P
-------
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
E
---------
K
L
I
P
L
F
V
T
N
L
L
D
---
G
G
--
T
--
L
P
-
L
--------
Y
--
G
---
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
--
G
--
R
A
G
E
I
Y
H
I
--
G
G
G
---
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
---
W
S
S
V
R
K
V
-----------
A
D
R
K
G
H
D
L
R
Y
S
L
------------
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
-----------------------------
3
PsiBlast_PDB
64.74
27%
-87
- C1 -
1R66
3
?
A:
[4-297]
-----
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
Y
P
D
V
--
P
------
A
-
D
--
E
V
I
V
L
-
D
S
LTYAGNR
A
-
N
-
L
A
---
P
---
V
---
D
----
A
D
--------
P
-----
R
L
-
R
F
V
--
H
G
D
I
R
D
A
G
L
L
A
R
E
L
--
R
--
G
V
--
D
A
I
V
--
H
F
A
A
E
S
H
V
D
R
S
-
I
---
A
G
-
A
-
S
V
-
F
T
E
T
N
V
Q
G
T
Q
T
L
L
-
Q
C
A
V
D
A
-
G
-
V
G
R
V
V
H
V
S
T
D
E
V
Y
G
-----
S
------
I
--
D
----
S
------------
G
----------------
S
W
T
E
S
--------
S
P
--
L
E
--
P
-------
N
---------------
S
P
-------
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
E
---------
K
L
I
P
L
F
V
T
N
L
L
D
---
G
G
--
T
--
L
P
-
L
--------
Y
--
G
---
D
G
A
N
V
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
--
G
--
R
A
G
E
I
Y
H
I
--
G
G
G
---
L
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
---
W
S
S
V
R
K
V
-----------
A
D
R
K
G
H
D
L
R
Y
S
L
------------
D
G
G
K
I
E
R
E
L
G
Y
R
P
Q
-----------------------------
33
HHSearch
64.07
21%
-78
- C1 -
1OC2
4
?
A:
[3-329]
Q
F
K
N
I
I
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
V
Y
N
----
N
H
--
P
------
D
-
V
H
V
T
V
L
D
K
L
T
Y
-------
A
-
G
N
K
A
---
N
---
L
---
E
AIL-
G
D
--------
R
-----
V
E
-
L
V
---
V
G
D
I
A
D
A
E
L
V
D
K
L
A
--
A
--
K
A
--
D
A
I
V
--
H
Y
A
A
E
S
H
N
--
D
-
N
S
L
-
N
D
-
P
-
S
P
-
F
I
H
T
N
F
I
G
T
Y
T
L
L
-
E
A
A
R
K
Y
-
D
-
I
-
R
F
H
H
V
S
T
D
E
V
Y
G
-----
D
------
L
--
P
----
L
REDLPGHGEGPG
E
----------------
K
F
T
A
E
--------
T
N
--
Y
-----------
N
P
S
-------------
S
P
-------
Y
S
S
T
K
A
A
S
D
L
I
V
K
A
W
V
R
S
F
G
V
K
A
T
I
S
N
C
S
N
N
Y
G
P
Y
Q
H
I
E
---------
K
F
I
P
R
Q
I
T
N
I
L
----
A
G
--
I
--
K
P
-
K
--------
L
--
Y
GEG
K
N
V
R
D
--
W
I
H
T
N
D
H
S
T
G
V
W
A
I
L
T
K
--
G
--
R
M
G
E
T
Y
L
I
--
G
A
D
G
--
E
-
K
N
N
K
E
V
L
E
L
I
L
E
K
M
G
Q
P
K
D
A
--
Y
D
H
V
-
T
-------
D
--------
R
A
---
G
-----
H
D
L
R
Y
A
I
D
A
S
K
L
R
D
E
L
G
W
T
P
Q
FT
D
F
S
E
G
-
L
E
E
T
I
Q
W
Y
T
D
N
Q
D
W
W
------
44
Fugue
63.37
22%
-94
- C1 -
2P4H
-
VESTR_MEDSA
X:
[5-326]
-
K
G
R
V
C
V
T
G
G
T
G
F
L
G
S
W
I
I
K
S
L
L
E
----
N
G
--
Y
------
S
-
V
--
N
T
T
I
R
-
A
D
-------
R
-
D
-
V
S
---
F
---
L
---
T
----
N
L
--------
P
GASEK
L
H
-
F
F
---
N
A
D
L
S
N
P
D
S
F
A
A
A
I
--
E
--
G
C
--
V
G
I
F
--
H
T
A
-------------
S
P
-
I
-
E
I
-
V
T
K
R
T
V
D
G
A
L
G
I
L
-
K
A
C
V
N
S
K
T
-
V
K
R
F
I
Y
T
S
S
G
S
A
V
S
-----
F
------
N
GK
D
----
K
------------
D
----------------
V
L
D
E
S
--------
D
W
--
S
D
--
V
-------
D
L
L
-------------
R
S
VKPFGWN
Y
A
V
S
K
T
L
A
E
K
A
V
L
E
F
G
E
Q
N
G
I
D
V
V
T
L
I
L
P
F
I
V
G
R
F
V
C
P
K
---------
L
P
D
S
I
E
K
A
L
V
L
----
V
L
--
G
--
K
K
-
E
--------
Q
--
I
---
G
V
T
R
F
-
H
M
V
H
V
D
D
V
A
R
A
H
I
Y
L
L
E
N
--
S
--
V
P
G
G
R
Y
N
C
--
S
P
F
---
I
-
V
P
I
E
E
M
S
Q
L
L
S
A
K
----
Y
P
E
Y
Q
I
L
T
V
-
D
E
L
K
E
I
K
G
A
R
L
P
D
L
N
T
----------------------
K
K
L
V
D
A
G
F
D
F
K
Y-
T
I
E
D
M
-
F
D
D
A
I
Q
C
C
K
E
K
G
Y
L
-------
28
HHSearch
62.20
22%
-79
- C1 -
2PK3
2
RMD_ANETH
A:
[13-320]
--
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
----
Q
N
--
V
------
E
-
V
--
F
G
T
S
R
N
N
E
-------
A
---
K
-----------------
L
P
--------
N
-----
V
E
-
M
I
---
S
L
D
I
M
D
S
Q
R
V
K
K
V
I
S
D
I
--
K
P
--
D
Y
I
F
--
H
L
A
A
K
S
S
V
--
K
-
D
S
W
-
L
N
-
K
-
K
G
-
T
F
S
T
N
V
F
G
T
L
H
V
L
-
D
A
V
R
D
S
-
N
L
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
-----
M
------
I
--
L
PE--
E
------------
S
----------------
P
V
S
E
E
--------
N
Q
--
L
-----------
R
P
M
-------------
S
P
-------
Y
G
V
S
K
A
S
V
G
M
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
G
P
G
Q
S
L
G
---------
F
V
T
Q
D
F
A
K
Q
I
V
D
I
E
M
E
K
--
Q
--
E
P
-
I
--------
I
K
-
V
G
NL
E
A
V
R
D
--
F
T
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
--
G
--
K
T
G
D
V
Y
N
V
--
C
S
G
I
--
G
-
T
R
I
Q
D
V
L
D
L
L
L
A
M
A
N
V
K
I
D
T
-
E
L
N
P
L
-
Q
------------
L
---
R
P
---
S
-----
E
V
P
T
L
I
G
S
N
K
R
L
K
D
S
T
G
W
K
P
R
I
-
P
L
E
K
S
-
L
F
E
I
L
Q
S
Y
R
Q
-----------
24
HHSearch
58.79
21%
-81
- C1 -
4EGB
19
?
A:
[24-339]
-
A
M
N
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
----
S
Y
--
E
T
Y
----
K
-
I
--
I
N
F
D
A
L
T
Y
-------
S
G
N
-
L
N
NVK
S
---
I
Q--
D
----
H
P
--------
N
-----
Y
Y
-
F
V
---
K
G
E
I
Q
N
G
E
L
L
E
H
V
I
K
E
R
--
D
V
--
Q
V
I
V
--
N
F
A
A
E
S
---------------
I
P
-
F
Y
D
T
N
V
I
G
T
V
T
L
L
-
E
L
V
K
K
Y
-
P
-
H
I
K
L
V
Q
V
S
T
D
E
V
Y
G
-----
S
------
L
--
G
----
K
T
-----------
G
----------------
R
F
T
E
E
--------
T
P
--
L
-----------
A
P
N
-------------
S
P
-------
Y
S
S
S
K
A
S
A
D
M
I
A
L
A
Y
Y
K
T
Y
Q
L
P
V
I
V
T
R
C
S
N
N
Y
G
P
Y
Q
Y
P
E
---------
K
L
I
P
L
M
V
T
N
A
L
----
E
G
--
K
K
-
L
P
-
L
--------
Y
--
G
DG-
L
N
V
R
D
--
W
L
H
V
T
D
H
C
S
A
I
D
V
V
L
H
K
--
G
--
R
V
G
E
V
Y
N
I
--
G
G
N
N
--
E
-
K
T
N
V
E
V
V
E
Q
I
I
T
L
L
G
K
T
K
K
D
--
I
E
-
Y
V
T
-------
D
------------------
G
H
D
R
R
Y
A
I
N
A
E
K
M
K
N
E
F
D
W
E
P
K
Y-
T
F
E
Q
G
-
L
Q
E
T
V
Q
W
Y
E
K
N
E
E
--------
5
PsiBlast_PDB
58.77
27%
-81
- C1 -
2X4G
-
?
A:
[17-316]
------
V
L
G
A
T
G
L
L
G
H
H
A
A
R
A
I
R
A
A
G
H
------------
D
-
L
--
V
L
I
H
R
-
P
S
-------
S
-
Q
-
I
Q
---
R
---
L
---
A
----
Y
L
--------
E
-----
P
E
-
C
R
---
V
A
E
M
L
D
H
A
G
L
E
R
A
L
--
R
--
G
L
--
D
G
V
I
F
S----------------
E
E
V
A
-
S
A
-
L
G
Q
T
N
-----
P
F
Y
-
A
A
C
L
Q
A
-
R
-
V
P
R
I
L
Y
V
G
S
A
Y
A
M
P
-----
R
------
H
--
P
QGLP
G
------------
H
----------------
E
G
L
F
Y
--------
D
S
--
L
P
--
S
-------
G
K
--------------
S
S
-------
Y
V
L
C
K
W
A
L
D
E
Q
A
R
E
Q
A
R
N
-
G
L
P
V
V
I
G
I
P
G
M
V
L
G
E
L
D
I
G
P
---------
T
T
-
G
R
V
I
T
A
I
G
----
N
G
--
E
--
M
T
-
H
--------
Y
--
V
---
A
G
Q
R
--
N
V
I
D
A
A
E
A
G
R
G
L
L
M
A
L
E
R
--
G
--
R
I
G
E
R
Y
L
L
--
T
G
H
---
N
-
L
E
M
A
D
L
T
R
R
I
A
E
L
L
G
Q
P
A
P
Q
-
P
M
S
M
A
M
A
R
A
L
A
T
L
G
R
L
----------------
E
V
M
A
G
G
Q
F
L
D
G
R
K
A
R
E
E
L
G
F
--------------------------------
7
PsiBlast_PDB
57.30
23%
-76
- C1 -
1KEU
2
RMLB_SALTY
A:
[4-336]
-----
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
V
--
V
------
N
-
I
--
D
K
L
T
Y
--
A
-------
G
-
N
-
L
E
---
S
---
L
---
S
----
D
I
--------
S
-----
E
S
N
R
Y
N
F
E
H
A
D
I
C
D
S
A
E
I
T
R
I
F
--
E
--
Q
Y
QP
D
A
V
M
--
H
L
A
A
E
S
H
V
D
R
S
-
I
---
T
G
-
P
-
A
A
-
F
I
E
T
N
I
V
G
T
Y
A
L
L
-
E
V
A
-------
R
K
Y
-----
W
S
A
L
G
-----
E
D
K
K
N
N
F
R
--
F
----
H
------------
H
----------------
I
S
T
D
E
VYGDLPHP
D
E
--
V
E
--
N
-------
S
V
T
L
P
L
F
T
ETT
A
Y
A
P
S
S
P
-------
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
Y
H
F
P
E
---------
K
L
I
P
L
V
I
L
N
A
L
----
E
G
--
K
P-
L
P
-
I
--------
Y
--
G
---
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
--
G
--
K
A
G
E
T
Y
N
I
G
G
H
N
E
---
K
-
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
--------
A
D
R
P
G
H
D
R
R
Y
A
------------
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
--
E
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
-----------
26
HHSearch
56.76
24%
-74
- C1 -
4WOK
3
?
A:
[11-334]
-
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
----
Q
G
--
Y
------
A
-
P
--
V
V
Y
D
N
L
S
T
-------
G
---
H
Q
---
S
---
A
--------
V
R
--------
W
-----
G
D
-
F
V
---
E
G
D
I
L
D
Q
A
R
L
V
E
T
M
--
E
K
Y
A
P
--
V
A
V
I
--
H
F
A
A
S
A
Y
V
--
G
E
S
V
--
E
D
-
P
-
A
K
-
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
-
D
A
C
R
L
T
-
R
-
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
-----
V
------
P
--
S
----
R
------------
L
----------------
P
I
G
E
G
--------
E
A
--
Q
-----------
N
P
I
-------------
N
P
-------
Y
G
R
T
K
L
I
A
E
H
M
L
A
D
Y
A
V
A
Y
G
L
R
Y
V
A
L
R
Y
F
N
A
S
G
A
D
I
D
G
E
L
G
E
K
H
DPET
H
L
I
P
R
A
M
M
A
A
A
----
G
R
--
L
D
V
L
E
-
V
Y
G
DDYETP
D
--
G
---
T
C
I
R
D
--
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
-
K
E
A
G
G
N
L
A
V
N
L
--
G
T
G
R
--
G
-
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
V
---
A
M
R
--
A
--------------
R
R
A
---
G
-----
D
P
P
A
L
Y
A
D
P
A
L
A
A
E
K
L
G
F
H
T
V
YS
D
L
D
T
I
-
I
R
T
A
A
P
H
F
G
L
E
V
---------
6
PsiBlast_PDB
56.75
23%
-80
- C1 -
1G1A
3
RMLB_SALTY
A:
[4-336]
-----
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
V
--
V
------
N
-
I
--
D
K
L
T
Y
--
A
-------
G
-
N
-
L
E
---
S
---
L
---
S
----
D
I
--------
S
-----
E
S
N
R
Y
N
F
E
H
A
D
I
C
D
S
A
E
I
T
R
I
F
--
E
--
Q
Y
QP
D
A
V
M
--
H
L
A
A
E
S
H
V
D
R
S
-
I
---
T
G
-
P
-
A
A
-
F
I
E
T
N
I
V
G
T
Y
A
L
L
-
E
V
A
-------
R
K
Y
-----
W
S
A
L
G
-----
E
D
K
K
N
N
F
R
--
F
----
H
------------
H
----------------
I
S
T
D
E
VYGDLPHP
D
E
--
V
E
--
N
-------
S
V
T
L
P
L
F
T
ETT
A
Y
A
P
S
S
P
-------
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
Y
H
F
P
E
---------
K
L
I
P
L
V
I
L
N
A
L
----
E
G
--
K
P-
L
P
-
I
--------
Y
--
G
---
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
--
G
--
K
A
G
E
T
Y
N
I
G
G
H
N
E
---
K
-
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
--------
A
D
R
P
G
H
D
R
R
Y
A
------------
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
--
E
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
-----------
8
PsiBlast_PDB
56.15
23%
-75
- C1 -
1KEW
5
RMLB_SALTY
A:
[4-336]
-----
L
I
T
G
G
A
G
F
I
G
S
A
V
V
R
H
I
I
K
N
T
Q
D
T
V
--
V
------
N
-
I
--
D
K
L
T
Y
--
A
-------
G
-
N
-
L
E
---
S
---
L
---
S
----
D
I
--------
S
-----
E
S
N
R
Y
N
F
E
H
A
D
I
C
D
S
A
E
I
T
R
I
F
--
E
--
Q
Y
QP
D
A
V
M
--
H
L
A
A
E
S
H
V
D
R
S
-
I
---
T
G
-
P
-
A
A
-
F
I
E
T
N
I
V
G
T
Y
A
L
L
-
E
V
A
-------
R
K
Y
-----
W
S
A
L
G
-----
E
D
K
K
N
N
F
R
--
F
----
H
------------
H
----------------
I
S
T
D
E
VYGDLPHP
D
E
--
V
E
--
N
-------
S
V
T
L
P
L
F
T
ETT
A
Y
A
P
S
S
P
-------
Y
S
A
S
K
A
S
S
D
H
L
V
R
A
W
R
R
T
Y
G
L
P
T
I
V
T
N
C
S
N
N
Y
G
P
Y
H
F
P
E
---------
K
L
I
P
L
V
I
L
N
A
L
----
E
G
--
K
P-
L
P
-
I
--------
Y
--
G
---
K
G
D
Q
I
R
D
W
L
Y
V
E
D
H
A
R
A
L
H
M
V
V
T
E
--
G
--
K
A
G
E
T
Y
N
I
G
G
H
N
E
---
K
-
K
N
L
D
V
V
F
T
I
C
D
L
L
D
E
I
V
P
K
A
T
S
Y
R
E
Q
I
T
Y
V
--------
A
D
R
P
G
H
D
R
R
Y
A
------------
I
D
A
G
K
I
S
R
E
L
G
W
K
P
L
--
E
T
F
E
S
G
I
R
K
T
V
E
W
Y
L
A
-----------
39
HHSearch
54.99
19%
-82
- C1 -
2C5A
13
GME_ARATH
A:
[28-346]
E
N
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
K
H
----
E
G
--
H
------
Y
-
V
--
I
A
S
D
W
K
K
N
-------
E
---
H
M
---
T
---
E
---
D
----
M
F
--------
C
-----
D
E
-
F
H
---
L
V
D
L
R
V
M
E
N
C
L
K
V
T
--
E
--
G
V
--
D
H
V
F
--
N
L
A
A
D
M
G
G
--
M
-
G
FIQ
S
N
-
H
-
S
V
-
I
M
Y
N
N
T
M
I
S
F
N
M
I
-
E
A
A
R
I
N
-
G
-
I
K
R
F
F
Y
A
S
S
A
C
I
Y
P
-----
E
------
F
--
K
----
Q
LETTN-------
V
----------------
S
L
K
E
S
--------
D
A
--
W
P
--
A
-------
E
P
Q
-------------
D
A
-------
F
G
L
E
K
L
A
T
E
E
L
C
K
H
Y
N
K
D
F
G
I
E
C
R
I
G
R
F
H
N
I
Y
G
P
F
G
T
W
K
GGRE-----
K
A
P
A
A
F
C
R
K
A
Q
----
T
S
TD
R
--
F
E
-
M
--------
W
--
G
DG-
L
Q
T
R
S
--
F
T
F
I
D
E
C
V
E
G
V
L
R
L
T
K
S
--
D
---
F
R
E
P
V
N
I
--
G
S
D
E--
M
-
V
S
M
N
E
M
A
E
M
V
L
S
F
E
E
K
K
L
P
I
H
H
I
P
G
P
-------------------
E
---------
G
V
R
G
R
N
S
D
N
N
L
I
K
E
K
L
G
W
A
P
N
M-
R
L
K
E
G
-
L
R
I
T
Y
F
W
I
K
E
Q
I
E
K
E
K
-----
29
HHSearch
53.53
21%
-79
- C1 -
1ORR
2
RFBE_SALTI
A:
[2-339]
--
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
----
Q
G
--
I
------
D
-
L
--
I
V
F
D
N
L
S
R
-------
K
G
A
-
T
D
---
N
L
H
W
L
---
S
S
---
L
G
--------
N
-----
F
E
-
F
V
---
H
G
D
I
R
N
K
N
D
V
T
R
L
I
--
T
K
Y
M
P
--
D
S
C
F
--
H
L
A
G
Q
V
A
M
--
T
-
T
S
I
-
D
N
-
P
-
C
M
-
D
F
E
I
N
V
G
G
T
L
N
L
L
-
E
A
V
R
Q
Y
-
N
S
N
C
N
I
I
Y
S
S
T
N
K
V
Y
G
-----
D
------
L
--
E
----
Q
------------
Y
K
Y
N
E
T
ETRYTCVDKPN
G
Y
D
E
S
--------
T
Q
--
L
-----------
D
F
H
-------------
S
P
-------
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
G
R
Q
F
A
T
YDQ------
G
W
V
G
W
F
C
Q
K
A
V
E
I
K
-
N
G
--
I
N-
K
P
-
F
--------
T
I
-
S
G
NG
K
Q
V
R
D
--
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
VS
K
--
I
R
G
N
A
F
N
I
--
G
G
T
IVN
S
-
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
D
M
R
F
T
N
L
P
V
--------------------
R
--
E
-----
S
D
Q
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
P
K
V-
S
A
K
D
G
-
V
Q
K
M
Y
D
W
T
S
S
I
----------
13
PsiBlast_PDB
52.67
24%
-106
- C1 -
2NNL
2
DFRA_VITVI
D:
[10-277]
------
V
T
G
A
S
G
F
I
G
S
W
L
V
M
R
L
L
-----
E
R
--
G
Y-----
T
-
V
--
R
A
T
V
R
-
D
P
-------
T
-
N
-
V
K
---
K
---
V
---
K
HLL-
D
L
--------
P
KAETH
L
T
-
L
W
---
K
A
D
L
A
D
E
G
S
F
D
E
A
I
--
K
--
G
C
--
T
G
V
F
--
H
V
A
T
P
M
D
F
--
E
-
S
---
K
D
-
P
E
N
E
-
V
I
K
P
T
I
E
G
M
L
G
I
M
K
S
C
A
A
A
K
-
T
-
V
R
R
L
V
F
T
S
S
A
G
T
V
N
-----
I
------
Q
--
E
----
H
------------
Q
----------------
L
P
V
Y
D
--------
E
S
--
C
W
--
S
DMEFCRA
K
K
M
-------------
T
A
WM-----
Y
F
V
S
K
T
L
A
E
Q
A
A
W
K
Y
A
K
E
N
N
I
D
F
I
T
I
I
P
T
L
V
V
G
P
F
I
M
S
S
---------
M
P
P
S
L
I
T
A
L
S
P
----
I
T
--
G
--
N
E
-
A
--------
H
--
Y
---
S
I
I
R
Q
G
Q
F
V
H
L
D
D
L
C
N
A
H
I
Y
L
F
E
N
--
P
--
K
A
E
G
R
Y
I
C
--
S
S
H
DCI
I
-
L
D
L
A
K
M
L
R
E
K
Y
P
E
Y
N
I
P
----------------------------------------------------------------------------------------