@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2127: (2016-04-01 )
MKDVKALKLMTLNDVLSQINGDMTLGIGTGSTMELLLPQMAQLIKERGYNITGVCTSNKIAFLAKELGIKICEINDVDHIDLAIDGADEVDPSLNIIKGGGGALFREKVIDEMASRFVVVVDETKIVQYLGETFKLPVEVDKFNWYHILRKIESYADIKVERRVNEDVAFITDNGNYILDCKLPKGIDPYKFHEYLIHLTGVFETGYFLDMADQVIVGTQEGVKILEK
Atome Classification :
(43 SA)
.........10........20........30........40...-..-..--.-50..-......60........70......-..80........90.-.-.......100.......110.......120.......-130.......140.......150...---.----..-----.-----160.---------..--....170........180.....-..190.......200......-.-210........220-......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKDV
K
A
L
K
L
M
T
L
N
D
V
L
S
QING
D
M
T
L
GIGTG
S
T
M
E
L
L
L
P
Q
M
A
Q
L
I
-
K
E-RG--Y-
N
I
T
G
-
V
CTS
N
K
I
A
F
L
A
K
E
LG
I
K
I
C
EINDV-
D
H
I
D
L
A
IDGADEV-D-P-S
L
N
I
I
KGG
G
G
A
L
F
R
E
K
V
I
D
E
M
AS
R
F
V
V
V
VD
E
T
K
I
V
Q
Y
-
L
G
E
TFKLP
V
E
VDK
F
N
W
Y
H
I
L
R
K
I
E
S
Y---A----D
I
-----
K
-----
V
E
R
R---------VN--E
D
V
A
F
I
-TDNG
N
Y
I
L
DCKLPKGI-
D
P
Y
K
F
H
E
Y
L
I
H
L
T
G
VFETG
Y
F
-L-DM-AD
Q
V
I
VG
T
Q
E
G
-
V
K
I
LEK
27
PsiBlast_CBE
96.32
41%
-120
- C6 -
4GMK
3
?
B:
[7-226]
------
L
K
Q
L
V
G
T
K
A
V
E
W
I
K
D
G
M
I
V
G
L
G
T
G
S
T
V
K
Y
M
V
D
A
L
G
K
R
V
-
N
E
-
E
G
--
L
-
D
I
V
G
-
V
T
T
S
I
R
T
A
E
Q
A
K
S
L
G
I
V
I
K
D
I
D
E
V
-
D
H
I
D
L
T
I
D
G
A
D
E
I
-
S
-
S
-
D
F
Q
G
I
K
G
G
G
A
A
L
L
Y
E
K
I
V
A
T
K
S
N
K
N
M
W
I
V
D
E
S
K
M
V
D
D
-
L
G
Q
-
F
P
L
P
V
E
V
I
P
Y
G
S
G
T
V
F
K
R
F
E
E
K
---
G
-----
L
-----
N
-----
P
E
F
R
---------
K
N
--
E
D
G
S
L
L
H
T
D
S
D
N
Y
I
I
D
L
H
L
G
K
I
E
-
N
P
K
E
L
G
D
Y
L
I
N
Q
V
G
V
V
E
H
G
L
F
-
L
-
D
I
-
V
N
T
V
I
V
G
R
Q
D
G
-
P
E
V
L
E
-
1
PsiBlast_PDB
94.84
44%
-104
- C6 -
1LK5
5
RPIA_PYRHO
A:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
3
PsiBlast_PDB
94.75
41%
-114
- C6 -
4GMK
4
?
A:
[7-226]
------
L
K
Q
L
V
G
T
K
A
V
E
W
I
K
D
G
M
I
V
G
L
G
T
G
S
T
V
K
Y
M
V
D
A
L
G
K
R
V
-
N
E
-
E
G
--
L
-
D
I
V
G
-
V
T
T
S
I
R
T
A
E
Q
A
K
S
L
G
I
V
I
K
D
I
D
E
V
-
D
H
I
D
L
T
I
D
G
A
D
E
I
-
S
-
S
-
D
F
Q
G
I
K
G
G
G
A
A
L
L
Y
E
K
I
V
A
T
K
S
N
K
N
M
W
I
V
D
E
S
K
M
V
D
D
-
L
G
Q
-
F
P
L
P
V
E
V
I
P
Y
G
S
G
T
V
F
K
R
F
E
E
K
---
G
-----
L
-----
N
-----
P
E
F
R
---------
K
N
--
E
D
G
S
L
L
H
T
D
S
D
N
Y
I
I
D
L
H
L
G
K
I
E
-
N
P
K
E
L
G
D
Y
L
I
N
Q
V
G
V
V
E
H
G
L
F
-
L
-
D
I
-
V
N
T
V
I
V
G
R
Q
D
G
-
P
E
V
L
E
-
2
PsiBlast_PDB
94.37
44%
-102
- C6 -
1LK7
6
RPIA_PYRHO
A:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
22
PsiBlast_CBE
93.85
44%
-100
- C6 -
1LK7
6
RPIA_PYRHO
C:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
24
PsiBlast_CBE
93.68
44%
-104
- C6 -
1LK5
5
RPIA_PYRHO
D:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
21
PsiBlast_CBE
93.58
44%
-103
- C6 -
1LK7
6
RPIA_PYRHO
D:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
26
PsiBlast_CBE
93.54
44%
-99
- C6 -
1LK5
5
RPIA_PYRHO
B:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
25
PsiBlast_CBE
93.32
44%
-102
- C6 -
1LK5
5
RPIA_PYRHO
C:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
23
PsiBlast_CBE
93.22
44%
-98
- C6 -
1LK7
6
RPIA_PYRHO
B:
[2-229]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
--
R
G
EI
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
-
S
I
---
F
----
N
A
-----
K
-----
A
E
L
R
MG-------
V
N
--
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
R
47
HHSearch
92.11
43%
-102
* C6 *
1LK5
5
RPIA_PYRHO
A:
[2-228]
--
N
V
E
E
M
K
K
I
A
A
K
E
A
L
K
F
I
E
D
D
M
V
I
G
L
G
T
G
S
T
T
A
Y
F
I
K
L
L
G
E
K
L
-
K
R
-
G
E
I-
S
-
D
I
V
G
-
V
P
T
S
Y
Q
A
K
L
L
A
I
E
H
D
I
P
I
A
S
L
D
Q
V
-
D
A
I
D
V
A
V
D
G
A
D
E
V
-
D
-
P
-
N
L
N
L
I
K
G
R
G
A
A
L
T
M
E
K
I
I
E
Y
R
A
G
T
F
I
V
L
V
D
E
R
K
L
V
D
Y
-
L
C
Q
K
M
P
V
P
I
E
V
I
P
Q
A
W
K
A
I
I
E
E
L
S
I
F
---
N
----
A
K
-----------
A
E
L
R
---------
M
G
VN
K
D
G
P
V
I
-
T
D
N
G
N
F
I
I
D
A
K
F
P
R
I
D
-
D
P
L
D
M
E
I
E
L
N
T
I
P
G
V
I
E
N
G
I
F
-
A
-
D
I
-
A
D
I
V
I
V
G
T
R
E
G
-
V
K
K
L
E
-
28
PsiBlast_CBE
91.59
36%
-115
- C6 -
3HHE
3
RPIA_BARHE
B:
[23-251]
--
N
V
Q
Q
L
K
K
M
A
A
L
K
A
L
E
F
V
E
D
D
M
R
L
G
I
G
S
G
S
T
V
N
E
F
I
P
L
L
G
E
R
V
-
A
--
N
G
--
L
-
R
V
T
C
-
V
A
T
S
Q
Y
S
E
Q
L
C
H
K
F
G
V
P
I
S
T
L
E
K
I
-
P
E
L
D
L
D
I
D
G
A
D
E
I
-
G
-
P
-
E
M
T
L
I
K
G
G
G
G
A
L
L
H
E
K
I
V
A
S
A
S
R
A
M
F
V
I
A
D
E
T
K
M
V
K
T
-
L
G
-
A
F
A
L
P
I
E
V
N
P
F
G
I
H
A
T
R
I
A
I
E
K
A
---
A
----
D
N
LGLSG
E
-----
I
T
L
R
---------
M
N
--
G
D
D
P
F
K
-
T
D
G
G
H
F
I
F
D
A
F
W
G
R
I
L
-
Q
P
K
L
L
S
E
A
L
L
A
I
P
G
V
V
E
H
G
L
F
-
L
-
G
L
-
A
S
R
A
I
V
A
M
A
D
S
Q
I
K
V
L
E
-
5
PsiBlast_PDB
90.95
36%
-111
- C6 -
3HHE
4
RPIA_BARHE
A:
[23-251]
--
N
V
Q
Q
L
K
K
M
A
A
L
K
A
L
E
F
V
E
D
D
M
R
L
G
I
G
S
G
S
T
V
N
E
F
I
P
L
L
G
E
R
V
-
A
--
N
G
--
L
-
R
V
T
C
-
V
A
T
S
Q
Y
S
E
Q
L
C
H
K
F
G
V
P
I
S
T
L
E
K
I
-
P
E
L
D
L
D
I
D
G
A
D
E
I
-
G
-
P
-
E
M
T
L
I
K
G
G
G
G
A
L
L
H
E
K
I
V
A
S
A
S
R
A
M
F
V
I
A
D
E
T
K
M
V
K
T
-
L
G
-
A
F
A
L
P
I
E
V
N
P
F
G
I
H
A
T
R
I
A
I
E
K
A
---
A
----
D
N
L
G
L
S
G
E
-----
I
T
L
R
---------
M
N
--
G
D
D
P
F
K
-
T
D
G
G
H
F
I
F
D
A
F
W
G
R
I
L
-
Q
P
K
L
L
S
E
A
L
L
A
I
P
G
V
V
E
H
G
L
F
-
L
-
G
L
-
A
S
R
A
I
V
A
M
A
D
S
Q
I
K
V
L
E
-
53
HHSearch
90.01
36%
-104
- C6 -
3HHE
4
RPIA_BARHE
A:
[23-250]
--
N
V
Q
Q
L
K
K
M
A
A
L
K
A
L
E
F
V
E
D
D
M
R
L
G
I
G
S
G
S
T
V
N
E
F
I
P
L
L
G
E
R
V
-
A
N
--
G
--
L
-
R
V
T
C
-
V
A
T
S
Q
Y
S
E
Q
L
C
H
K
F
G
V
P
I
S
T
L
E
K
I
-
P
E
L
D
L
D
I
D
G
A
D
E
I
-
G
-
P
-
E
M
T
L
I
K
G
G
G
G
A
L
L
H
E
K
I
V
A
S
A
S
R
A
M
F
V
I
A
D
E
T
K
M
V
K
T
-
L
G
-
A
F
A
L
P
I
E
V
N
P
F
G
I
H
A
T
R
I
A
I
E
K
A
---
A
D
N
L
G
L
S
G
----
E
-----
I
T
L
R
---------
M
N
--
G
D
D
P
F
K
-
T
D
G
G
H
F
I
F
D
A
F
W
G
R
I
L
-
Q
P
K
L
L
S
E
A
L
L
A
I
P
G
V
V
E
H
G
L
F
-
L
-
G
L
-
A
S
R
A
I
V
A
M
A
D
S
-
Q
I
K
V
L
-
50
HHSearch
89.72
39%
-105
- C6 -
3L7O
-
RPIA_STRMU
A:
[2-222]
----
E
E
L
K
K
I
A
G
V
R
A
A
Q
Y
V
E
D
G
M
I
V
G
L
G
T
G
S
T
A
Y
Y
F
V
E
E
V
G
R
R
V
-
Q
E
-
E
G
--
L
-
Q
V
I
G
-
V
T
T
S
S
R
T
T
A
Q
A
Q
A
L
G
I
P
L
K
S
I
D
E
V
-
D
S
V
D
V
T
V
D
G
A
D
E
V
-
D
-
P
-
N
F
N
G
I
K
G
G
G
G
A
L
L
M
E
K
I
V
G
T
L
T
K
D
Y
I
W
V
V
D
E
S
K
M
V
D
T
-
L
G
-
A
F
R
L
P
V
E
V
V
Q
Y
G
A
E
R
L
F
R
E
F
E
K
K
---
G
----
Y
K
-----------
P
S
F
R
---------
E
Y
--
D
G
V
R
F
V
-
T
D
M
K
N
F
I
I
D
L
D
L
G
S
I
P
-
D
P
I
A
F
G
N
M
L
D
H
Q
V
G
V
V
E
H
G
L
F
-
N
-
G
M
-
V
N
R
V
I
V
A
G
----
V
R
I
L
E
-
48
HHSearch
88.96
36%
-102
- C6 -
1UJ6
3
RPIA_THET2
A:
[3-226]
-
R
P
L
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
V
Q
D
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
R
L
-
R
E
-
G
E
L-
K
-
G
V
V
G
-
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
--
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
-
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
-
L
G
-
R
G
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
D
L
---
G
----
G
E
-----------
P
E
L
R
---------
M
D
--
G
D
E
F
Y
F
-
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
-
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
M
-
A
T
R
A
L
V
A
G
P
F
G
-
V
E
E
L
L
-
8
PsiBlast_PDB
88.72
34%
-101
- C6 -
1UJ6
3
RPIA_THET2
A:
[3-225]
-
R
P
L
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
V
Q
D
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
R
L
-
R
E
-
G
E
--
L
K
G
V
V
G
-
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
--
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
-
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
-
L
G
R
G
-
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
D
L
---
G
----
G
------
E
-----
P
E
L
R
---------
M
D
--
G
D
E
F
Y
F
-
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
-
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
M
-
A
T
R
A
L
V
A
G
P
F
G
-
V
E
E
L
--
4
PsiBlast_PDB
88.10
41%
-111
- C6 -
3L7O
-
RPIA_STRMU
A:
[20-222]
----------------------
M
I
V
G
L
G
T
G
S
T
A
Y
Y
F
V
E
E
V
G
R
R
V
-
Q
E
-
E
G
--
L
-
Q
V
I
G
-
V
T
T
S
S
R
T
T
A
Q
A
Q
A
L
G
I
P
L
K
S
I
D
E
V
-
D
S
V
D
V
T
V
D
G
A
D
E
V
-
D
-
P
-
N
F
N
G
I
K
G
G
G
G
A
L
L
M
E
K
I
V
G
T
L
T
K
D
Y
I
W
V
V
D
E
S
K
M
V
D
T
-
L
G
-
A
F
R
L
P
V
E
V
V
Q
Y
G
A
E
R
L
F
R
E
F
E
K
K
---
G
-----
Y
-----
K
-----
P
S
F
R
---------
E
Y
--
D
G
V
R
F
V
-
T
D
M
K
N
F
I
I
D
L
D
L
G
S
I
P
-
D
P
I
A
F
G
N
M
L
D
H
Q
V
G
V
V
E
H
G
L
F
-
N
-
G
M
-
V
N
R
V
I
V
A
G
----
V
R
I
L
E
-
30
PsiBlast_CBE
87.87
37%
-106
- C6 -
3IXQ
5
RPIA_METJA
D:
[6-226]
------
L
K
L
K
V
A
K
E
A
V
K
L
V
K
D
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
R
I
-
R
E
-
E
E
--
L
-
T
V
F
G
-
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
-
D
-
V
D
I
A
F
D
G
A
D
E
V
-
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
-
L
G
E
K
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
E
M
GGE
A
----
V
I
-----
R
-----
L
G
D
R
---------
K
R
--
G
P
V
--
I
-
T
D
N
G
N
M
I
I
D
V
F
M
N
I
D
--
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
V
--
D
K
V
L
V
G
T
K
K
G
-
V
K
T
L
K
K
7
PsiBlast_PDB
87.60
34%
-99
- C6 -
1UJ4
3
RPIA_THET2
A:
[3-225]
-
R
P
L
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
V
Q
D
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
R
L
-
R
E
-
G
E
--
L
K
G
V
V
G
-
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
--
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
-
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
-
L
G
R
G
-
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
D
L
---
G
----
G
------
E
-----
P
E
L
R
---------
M
D
--
G
D
E
F
Y
F
-
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
-
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
M
-
A
T
R
A
L
V
A
G
P
F
G
-
V
E
E
L
--
10
PsiBlast_PDB
87.30
37%
-105
- C6 -
3IXQ
5
RPIA_METJA
A:
[6-226]
------
L
K
L
K
V
A
K
E
A
V
K
L
V
K
D
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
R
I
-
R
E
-
E
E
--
L
-
T
V
F
G
-
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
-
D
-
V
D
I
A
F
D
G
A
D
E
V
-
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
-
L
G
E
K
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
E
M
GGE
A
----
V
I
-----
R
-----
L
G
D
R
---------
K
R
--
G
P
V
--
I
-
T
D
N
G
N
M
I
I
D
V
F
M
N
I
D
--
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
V
--
D
K
V
L
V
G
T
K
K
G
-
V
K
T
L
K
K
32
PsiBlast_CBE
86.96
37%
-106
- C6 -
3IXQ
5
RPIA_METJA
B:
[6-226]
------
L
K
L
K
V
A
K
E
A
V
K
L
V
K
D
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
R
I
-
R
E
-
E
E
--
L
-
T
V
F
G
-
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
-
D
-
V
D
I
A
F
D
G
A
D
E
V
-
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
-
L
G
E
K
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
E
M
GGE
A
----
V
I
-----
R
-----
L
G
D
R
---------
K
R
--
G
P
V
--
I
-
T
D
N
G
N
M
I
I
D
V
F
M
N
I
D
--
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
V
--
D
K
V
L
V
G
T
K
K
G
-
V
K
T
L
K
K
31
PsiBlast_CBE
86.72
37%
-104
- C6 -
3IXQ
5
RPIA_METJA
C:
[6-226]
------
L
K
L
K
V
A
K
E
A
V
K
L
V
K
D
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
R
I
-
R
E
-
E
E
--
L
-
T
V
F
G
-
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
Y
-
D
-
V
D
I
A
F
D
G
A
D
E
V
-
E
E
T
-
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
-
L
G
E
K
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
E
M
GGE
A
----
V
I
-----
R
-----
L
G
D
R
---------
K
R
--
G
P
V
--
I
-
T
D
N
G
N
M
I
I
D
V
F
M
N
I
D
--
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
V
--
D
K
V
L
V
G
T
K
K
G
-
V
K
T
L
K
K
6
PsiBlast_PDB
86.61
35%
-98
- C6 -
1UJ5
3
RPIA_THET2
A:
[3-225]
-
R
P
L
E
S
Y
K
K
E
A
A
H
A
A
I
A
Y
V
Q
D
G
M
V
V
G
L
G
T
G
S
T
A
R
Y
A
V
L
E
L
A
R
R
L
-
R
E
-
G
E
--
L
K
G
V
V
G
-
V
P
T
S
R
A
T
E
E
L
A
K
R
E
G
I
P
L
V
D
L
P
P
--
E
G
V
D
L
A
I
D
G
A
D
E
I
-
A
-
P
-
G
L
A
L
I
K
G
M
G
G
A
L
L
R
E
K
I
V
E
R
V
A
K
E
F
I
V
I
A
D
H
T
K
K
V
P
V
-
L
G
R
G
-
P
V
P
V
E
I
V
P
F
G
Y
R
A
T
L
K
A
I
A
D
L
---
G
----
G
------
E
-----
P
E
L
R
---------
M
D
--
G
D
E
F
Y
F
-
T
D
G
G
H
L
I
A
D
C
R
F
G
P
I
G
-
D
P
L
G
L
H
R
A
L
L
E
I
P
G
V
V
E
T
G
L
F
-
V
-
G
M
-
A
T
R
A
L
V
A
G
P
F
G
-
V
E
E
L
--
56
HHSearch
86.24
36%
-102
- C6 -
3IXQ
5
RPIA_METJA
A:
[2-225]
--
S
N
E
D
L
K
L
K
V
A
K
E
A
V
K
L
V
K
D
G
M
V
I
G
L
G
T
G
S
T
A
A
L
F
I
R
E
L
G
N
R
I
-
R
E
-
E
E
--
L
-
T
V
F
G
-
I
P
T
S
F
E
A
K
M
L
A
M
Q
Y
E
I
P
L
V
T
L
D
E
--
Y
D
V
D
I
A
F
D
G
A
D
E
V
-
E
-
E
T
T
L
F
L
I
K
G
G
G
G
C
H
T
Q
E
K
I
V
D
Y
N
A
N
E
F
V
V
L
V
D
E
S
K
L
V
K
K
-
L
G
E
K
F
P
I
P
V
E
V
I
P
S
A
Y
R
V
V
I
R
A
L
S
E
M
---
G
----
G
E
-----------
A
V
I
R
---------
L
G
DR
K
R
G
P
V
I
-
T
D
N
G
N
M
I
I
D
V
F
M
N
-
I
D
-
D
A
I
E
L
E
K
E
I
N
N
I
P
G
V
V
E
N
G
I
F
-
T
-
K
--
V
D
K
V
L
V
G
T
K
K
G
-
V
K
T
L
K
-
12
PsiBlast_PDB
84.64
35%
-111
- C6 -
4NML
3
?
A:
[26-249]
------------------------
V
G
L
G
T
G
T
T
A
K
F
V
V
E
R
I
G
Q
R
M
-
Q
E
-
G
S
--
L
K
D
L
L
C
-
V
P
T
S
E
A
T
R
K
Q
A
E
S
L
G
I
P
L
T
T
L
D
G
I
A
D
C
L
D
V
A
I
D
G
A
D
E
I
L
P
-
P
-
T
L
G
L
V
K
G
R
G
G
A
L
L
R
E
K
M
I
A
A
A
A
K
T
F
I
V
A
A
D
E
T
K
L
V
S
N
G
I
G
S
T
G
A
L
P
V
E
V
V
V
F
S
G
S
H
T
K
R
L
L
S
A
L
---
P
----
S
V
-----
K
R
H
G
G
R
A
E
F
R
K
RAGAAQED
I
R
--
E
E
D
R
F
V
-
T
D
N
G
N
Y
I
V
D
L
Y
F
T
E
T
V
P
D
L
H
E
M
D
K
E
L
K
S
I
P
G
V
V
E
T
G
F
F
-
L
-
D
L
-
A
S
V
C
L
I
G
K
A
D
G
-------
29
PsiBlast_CBE
84.08
35%
-96
- C6 -
1M0S
1
RPIA_HAEIN
B:
[6-219]
------
M
K
K
L
A
A
Q
A
A
L
Q
Y
V
K
A
D
R
I
V
G
V
G
S
G
S
T
V
N
C
F
I
E
A
L
G
T
-
I
-
K
D
-
K
------
I
Q
G
A
V
A
A
S
K
E
S
E
E
L
L
R
K
Q
G
I
E
V
F
N
A
N
D
V
-
S
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
P
-
Q
K
M
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
L
A
K
K
F
I
C
I
V
D
S
S
K
Q
V
D
V
-
L
G
S
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Q
V
G
R
K
L
A
A
L
---
G
----
G
S
-----
P
-----
E
Y
R
E
----------------
G
V
V
-
T
D
N
G
N
V
I
L
D
V
H
N
F
S
I
L
-
N
P
V
E
I
E
K
E
L
N
N
V
A
G
V
V
T
N
G
I
F
A
L
-
R
G
-
A
D
V
V
I
V
G
T
P
E
G
-
A
K
V
I
D
-
55
HHSearch
84.04
35%
-95
- C6 -
1M0S
1
RPIA_HAEIN
A:
[2-218]
--
N
Q
L
E
M
K
K
L
A
A
Q
A
A
L
Q
Y
V
K
A
D
R
I
V
G
V
G
S
G
S
T
V
N
C
F
I
E
A
L
G
T
I
K
-
D
------
K
-
I
Q
G
A
-
V
A
A
S
K
E
S
E
E
L
L
R
K
Q
G
I
E
V
F
N
A
N
D
V
-
S
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
P
-
Q
K
M
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
L
A
K
K
F
I
C
I
V
D
S
S
K
Q
V
D
V
-
L
G
S
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Q
V
G
R
K
L
A
A
L
---
G
----
G
S
-----------
P
E
Y
R
---------
E
------
G
V
V
-
T
D
N
G
N
V
I
L
D
V
H
N
F
S
I
L
-
N
P
V
E
I
E
K
E
L
N
N
V
A
G
V
V
T
N
G
I
F
-
A
L
R
G
-
A
D
V
V
I
V
G
T
P
E
G
-
A
K
V
I
--
9
PsiBlast_PDB
83.19
35%
-93
- C6 -
1M0S
1
RPIA_HAEIN
A:
[6-219]
------
M
K
K
L
A
A
Q
A
A
L
Q
Y
V
K
A
D
R
I
V
G
V
G
S
G
S
T
V
N
C
F
I
E
A
L
G
T
-
I
-
K
D
-
K
------
I
Q
G
A
V
A
A
S
K
E
S
E
E
L
L
R
K
Q
G
I
E
V
F
N
A
N
D
V
-
S
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
P
-
Q
K
M
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
L
A
K
K
F
I
C
I
V
D
S
S
K
Q
V
D
V
-
L
G
S
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Q
V
G
R
K
L
A
A
L
---
G
----
G
S
-----
P
-----
E
Y
R
E
----------------
G
V
V
-
T
D
N
G
N
V
I
L
D
V
H
N
F
S
I
L
-
N
P
V
E
I
E
K
E
L
N
N
V
A
G
V
V
T
N
G
I
F
A
L
-
R
G
-
A
D
V
V
I
V
G
T
P
E
G
-
A
K
V
I
D
-
36
PsiBlast_CBE
81.16
33%
-90
- C6 -
4X84
1
RPIA_PSEAE
C:
[16-230]
----
Q
A
V
A
Q
A
A
V
D
H
I
L
P
H
L
D
S
K
S
I
V
G
V
G
T
G
S
T
A
N
F
F
I
D
A
L
A
----
R
H
-
K
A
--
E
-
F
D
G
A
-
V
A
S
S
E
A
T
A
K
R
L
K
E
H
G
I
P
V
Y
E
L
N
T
V
-
S
E
L
E
F
Y
V
D
G
A
D
E
S
-
N
-
E
-
R
L
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
V
A
K
T
F
I
C
I
A
D
A
S
K
L
V
P
I
-
L
G
Q
-
F
P
L
P
V
E
V
I
P
M
A
R
S
H
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
V
Y
R
E
----------------
G
V
L
-
T
D
N
G
N
I
I
L
D
V
H
N
L
R
I
D
-
S
P
V
E
L
E
E
K
I
N
A
I
V
G
V
V
T
N
G
L
F
-
A
-
A
R
P
A
D
L
L
L
L
G
T
A
D
G
-
V
K
T
L
K
-
37
PsiBlast_CBE
81.04
33%
-93
- C6 -
4X84
1
RPIA_PSEAE
B:
[16-230]
----
Q
A
V
A
Q
A
A
V
D
H
I
L
P
H
L
D
S
K
S
I
V
G
V
G
T
G
S
T
A
N
F
F
I
D
A
L
A
----
R
H
-
K
A
--
E
-
F
D
G
A
-
V
A
S
S
E
A
T
A
K
R
L
K
E
H
G
I
P
V
Y
E
L
N
T
V
-
S
E
L
E
F
Y
V
D
G
A
D
E
S
-
N
-
E
-
R
L
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
V
A
K
T
F
I
C
I
A
D
A
S
K
L
V
P
I
-
L
G
Q
-
F
P
L
P
V
E
V
I
P
M
A
R
S
H
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
V
Y
R
E
----------------
G
V
L
-
T
D
N
G
N
I
I
L
D
V
H
N
L
R
I
D
-
S
P
V
E
L
E
E
K
I
N
A
I
V
G
V
V
T
N
G
L
F
-
A
-
A
R
P
A
D
L
L
L
L
G
T
A
D
G
-
V
K
T
L
K
-
35
PsiBlast_CBE
80.72
33%
-90
- C6 -
4X84
1
RPIA_PSEAE
D:
[16-230]
----
Q
A
V
A
Q
A
A
V
D
H
I
L
P
H
L
D
S
K
S
I
V
G
V
G
T
G
S
T
A
N
F
F
I
D
A
L
A
----
R
H
-
K
A
--
E
-
F
D
G
A
-
V
A
S
S
E
A
T
A
K
R
L
K
E
H
G
I
P
V
Y
E
L
N
T
V
-
S
E
L
E
F
Y
V
D
G
A
D
E
S
-
N
-
E
-
R
L
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
V
A
K
T
F
I
C
I
A
D
A
S
K
L
V
P
I
-
L
G
Q
-
F
P
L
P
V
E
V
I
P
M
A
R
S
H
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
V
Y
R
E
----------------
G
V
L
-
T
D
N
G
N
I
I
L
D
V
H
N
L
R
I
D
-
S
P
V
E
L
E
E
K
I
N
A
I
V
G
V
V
T
N
G
L
F
-
A
-
A
R
P
A
D
L
L
L
L
G
T
A
D
G
-
V
K
T
L
K
-
40
PsiBlast_CBE
80.37
37%
-91
- C6 -
4M8L
5
RPIA_FRATW
B:
[12-219]
------
L
K
K
L
A
A
T
E
A
A
K
S
I
T
T
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
---
E
E
L
V
-
N
Y
-
R
D
--
K
-
I
K
T
V
-
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
-
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
-
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
-
L
G
-
N
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
K
L
---
G
----
G
Q
-----
P
-----
V
Y
R
E
----------------
Q
T
I
-
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
-
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
A
L
-
K
P
-
A
D
T
V
I
M
A
T
K
D
S
-------
16
PsiBlast_PDB
79.77
33%
-90
- C6 -
4X84
1
RPIA_PSEAE
A:
[16-230]
----
Q
A
V
A
Q
A
A
V
D
H
I
L
P
H
L
D
S
K
S
I
V
G
V
G
T
G
S
T
A
N
F
F
I
D
A
L
A
----
R
H
-
K
A
--
E
-
F
D
G
A
-
V
A
S
S
E
A
T
A
K
R
L
K
E
H
G
I
P
V
Y
E
L
N
T
V
-
S
E
L
E
F
Y
V
D
G
A
D
E
S
-
N
-
E
-
R
L
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
V
A
K
T
F
I
C
I
A
D
A
S
K
L
V
P
I
-
L
G
Q
-
F
P
L
P
V
E
V
I
P
M
A
R
S
H
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
V
Y
R
E
----------------
G
V
L
-
T
D
N
G
N
I
I
L
D
V
H
N
L
R
I
D
-
S
P
V
E
L
E
E
K
I
N
A
I
V
G
V
V
T
N
G
L
F
-
A
-
A
R
P
A
D
L
L
L
L
G
T
A
D
G
-
V
K
T
L
K
-
19
PsiBlast_PDB
79.72
37%
-91
- C6 -
4M8L
16
RPIA_FRATW
A:
[12-219]
------
L
K
K
L
A
A
T
E
A
A
K
S
I
T
T
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
---
E
E
L
V
-
N
Y
-
R
D
--
K
-
I
K
T
V
-
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
-
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
-
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
-
L
G
-
N
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
K
L
---
G
----
G
Q
-----
P
-----
V
Y
R
E
----------------
Q
T
I
-
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
-
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
A
L
-
K
P
-
A
D
T
V
I
M
A
T
K
D
S
-------
43
PsiBlast_CBE
79.69
37%
-89
- C6 -
3KWM
5
RPIA_FRATT
C:
[12-219]
------
L
K
K
L
A
A
T
E
A
A
K
S
I
T
T
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
---
E
E
L
V
-
N
Y
-
R
D
--
K
-
I
K
T
V
-
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
-
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
-
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
-
L
G
-
N
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
K
L
---
G
----
G
Q
-----
P
-----
V
Y
R
E
----------------
Q
T
I
-
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
-
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
A
L
-
K
P
-
A
D
T
V
I
M
A
T
K
D
S
-------
42
PsiBlast_CBE
79.30
37%
-88
- C6 -
3KWM
3
RPIA_FRATT
D:
[12-219]
------
L
K
K
L
A
A
T
E
A
A
K
S
I
T
T
E
I
T
L
G
V
G
T
G
S
T
V
G
F
L
I
---
E
E
L
V
-
N
Y
-
R
D
--
K
-
I
K
T
V
-
V
S
S
S
E
D
S
T
R
K
L
K
A
L
G
F
D
V
V
D
L
N
Y
A
-
G
E
I
D
L
Y
I
D
G
A
D
E
C
-
N
-
N
-
H
K
E
L
I
K
G
G
G
A
A
L
T
R
E
K
I
C
V
A
A
A
K
K
F
I
C
I
I
D
E
S
K
K
V
N
T
-
L
G
-
N
F
P
L
P
I
E
V
I
P
M
A
R
S
Y
I
A
R
Q
I
V
K
L
---
G
----
G
Q
-----
P
-----
V
Y
R
E
----------------
Q
T
I
-
T
D
N
G
N
V
I
L
D
V
Y
N
L
K
I
D
-
N
P
L
K
L
E
T
E
L
N
Q
I
T
G
V
V
T
N
G
I
F
A
L
-
K
P
-
A
D
T
V
I
M
A
T
K
D
S
-------
14
PsiBlast_PDB
74.89
37%
-81
- C6 -
3ENV
1
RPIA_VIBVY
A:
[41-235]
------------------------
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
M
S
-
E
E
I
K
G
--
A
-
V
S
S
S
-
V
A
S
T
E
K
L
----
E
A
L
G
I
K
I
F
D
C
N
E
V
-
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
-
L
G
-
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
C
Y
R
E
----------------
G
V
I
-
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
-
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
H
R
G
A
D
V
V
I
T
G
T
P
E
G
-
A
K
I
E
E
-
33
PsiBlast_CBE
74.82
37%
-88
- C6 -
3ENW
1
RPIA_VIBVY
B:
[41-235]
------------------------
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
M
S
-
E
E
I
K
G
--
A
-
V
S
S
S
-
V
A
S
T
E
K
L
----
E
A
L
G
I
K
I
F
D
C
N
E
V
-
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
-
L
G
-
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
C
Y
R
E
----------------
G
V
I
-
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
-
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
H
R
G
A
D
V
V
I
T
G
T
P
E
G
-
A
K
I
E
E
-
15
PsiBlast_PDB
74.70
37%
-83
- C6 -
3ENW
1
RPIA_VIBVY
A:
[41-235]
------------------------
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
M
S
-
E
E
I
K
G
--
A
-
V
S
S
S
-
V
A
S
T
E
K
L
----
E
A
L
G
I
K
I
F
D
C
N
E
V
-
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
-
L
G
-
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
C
Y
R
E
----------------
G
V
I
-
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
-
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
H
R
G
A
D
V
V
I
T
G
T
P
E
G
-
A
K
I
E
E
-
34
PsiBlast_CBE
74.23
37%
-85
- C6 -
3ENV
1
RPIA_VIBVY
B:
[41-235]
------------------------
V
G
V
G
T
G
S
T
V
N
H
F
I
D
A
L
G
T
M
S
-
E
E
I
K
G
--
A
-
V
S
S
S
-
V
A
S
T
E
K
L
----
E
A
L
G
I
K
I
F
D
C
N
E
V
-
A
S
L
D
I
Y
V
D
G
A
D
E
I
-
N
-
A
-
D
R
E
M
I
K
G
G
G
A
A
L
T
R
E
K
I
V
A
A
I
A
D
K
F
I
C
I
V
D
G
T
K
A
V
D
V
-
L
G
-
T
F
P
L
P
V
E
V
I
P
M
A
R
S
Y
V
A
R
Q
L
V
K
L
---
G
----
G
D
-----
P
-----
C
Y
R
E
----------------
G
V
I
-
T
D
N
G
N
V
I
L
D
V
Y
G
M
K
I
T
-
N
P
K
Q
L
E
D
Q
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
H
R
G
A
D
V
V
I
T
G
T
P
E
G
-
A
K
I
E
E
-
11
PsiBlast_PDB
73.96
35%
-83
- C6 -
3U7J
7
?
A:
[36-235]
------------------------
I
G
V
G
T
G
S
T
A
N
C
F
I
D
A
L
A
A
V
K
D
R
Y
-
R
G
--
A
-
V
S
S
S
-
V
A
T
T
E
R
L
----
K
S
H
G
I
R
V
F
D
L
N
E
I
-
E
S
L
Q
V
Y
V
D
G
A
D
E
I
-
D
-
E
-
S
G
A
M
I
K
G
G
G
G
A
L
T
R
E
K
I
V
A
S
V
A
E
T
F
V
C
I
A
D
A
S
K
R
V
A
M
-
L
G
Q
-
F
P
L
P
V
E
V
V
P
M
A
R
T
A
I
G
R
R
L
A
A
L
---
G
----
G
V
-----
P
-----
V
L
R
V
---------
K
Q
--
D
G
T
P
Y
V
-
T
D
N
G
N
E
I
L
D
V
K
G
L
R
I
D
-
D
P
R
A
L
E
A
A
I
N
G
W
P
G
V
V
T
V
G
L
F
-
A
-
Q
R
G
A
D
L
C
L
L
G
T
E
H
G
-
V
E
T
L
R
-
54
HHSearch
67.45
33%
-86
- C6 -
1O8B
1
RPIA_ECOLI
A:
[23-218]
-----------------------
I
V
G
V
G
T
G
S
T
-----------------------
E
G
A
-
V
S
S
S
D
A
------------
F
D
L
N
E
V
-
D
S
L
G
I
Y
V
D
G
A
D
E
I
-
N
-
G
-
H
M
Q
M
I
K
G
G
G
-
A
L
T
R
E
K
I
I
A
S
V
A
E
K
F
I
C
I
A
D
A
S
K
Q
V
D
I
-
L
G
-
K
F
P
L
P
V
E
V
I
P
M
A
R
S
A
V
A
R
Q
L
V
K
L
---
G
----
G
R
-----------
P
E
Y
R
---------
Q
------
G
V
V
-
T
D
N
G
N
V
I
L
D
V
H
G
M
E
I
L
-
D
P
I
A
M
E
N
A
I
N
A
I
P
G
V
V
T
V
G
L
F
-
A
-
N
R
G
A
D
V
A
L
I
G
T
P
D
G
-
V
K
T
I
V
-