@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1490: (2016-03-25 )
LEKYVVIGNPIRHSLSPAMQNRIFQELGMNAEYNSVLIEEDAFETEIKKLMDSGVRGFNITTPFKERILPFLDELDNLAAASGAVNTVLKKEDKWYGFNTDGKGYLEGLEEIRSITEDDSILITGAGGASKAIYLALSTHTDAKITVANRTTEKAIEMTKDNNNHHAITLEEAEKQLADFTIIIQTTSIGLEASKNKSPISLANVKQGTICSDIIYNPAETAFLKEAKKNGAITQNGLPMFVNQGALAFEIWTGIKPERSLMKEAVLEQLGGN
Atome Classification :
(53 SA)
.........10........20...----.....----30.....-...40-.......-.50-..----......60........70........80.......-.90.-.--..-....100.......110.-......-.120.......130...-----------....140.......150----..---.......160------.------..---.------...--..170---...---......180.......190-......-..--200-.----.-.-.....210.......220.......230.-.-......240.......250.....-..260.......270.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
L
E
K
Y
V
V
IGN
P
I
R
H
SL
S
P
A
M
Q
N
R
I
F
----
Q
E
LGM----NAEY
N
S
V
-
L
IEE
D
-
A
F
E
T
E
I
K
-
K
L
M
-
D
S----GVRGFNITT
P
F
K
E
R
I
L
P
F
L
D
E
L
D
N
L
A
AAS
G
A
V
N
T
V
-LKKE-D--KW-YGFNTD
G
K
G
Y
L
E
G
L
E
E
-
I
-
R
S
ITED-D
S
I
L
I
TGAGGA
S
K
A
I
Y
L
-----------
A
LSTHT
D
A
K
I
T
V
ANR------TT---
E
K
A
I
E
MTK--------D------NN---N------
H
H
A
--
I
T
L
-----
E
E
A
---
E
K
QLA
D
F
T
I
I
I
Q
T
T
SIGL--EASKNK-SP--
I
-
S
-
L
----
A
-N-VKQGT
I
C
S
D
I
IYNP
A
E
T
A
F
L
K
E
A
KKNG-A-I-TQNGL
P
M
F
VNQ
G
A
L
A
F
E
I
WTGIK
P
-
E
R
S
L
M
K
E
A
V
L
E
Q
LGGN
1
PsiBlast_PDB
96.54
45%
-88
- C5 -
3DON
1
AROE_STAEQ
A:
[2-267]
--
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
-
N
V
P
V
N
-
Q
F
Q
-
D
I
K
-
K
I
I
S
E
K
----
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
V
K
D
-
G
--
K
W
-
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
-
I
-
Y
E
G
I
E
D
-
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
-----------
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
------
T
---------
M
S
R
--------
F
------
N
N
WSL
N
------
I
N
K
--
I
N
L
-----
S
H
A
---
E
S
H
L
D
E
F
D
I
I
I
N
T
T
P
---------
D
--
S
V
--
I
-
S
-
L
----
N
-
R
-
L
A
S
H
T
L
V
S
D
I
V
Y
N
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
-
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
-
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
-
3
PsiBlast_PDB
95.66
44%
-86
- C5 -
2EGG
2
AROE_GEOKA
A:
[26-295]
---
Y
G
L
I
G
F
P
V
E
H
S
L
S
P
L
M
H
N
D
A
F
----
A
R
L
G
I
----
P
A
R
Y
H
L
F
-
S
V
E
P
G
-
Q
V
G
A
A
I
A
-
G
V
R
-
A
L
----
G
I
A
G
V
N
V
T
I
P
H
K
L
A
V
I
P
F
L
D
E
V
D
E
H
A
R
R
I
G
A
V
N
T
I
-
I
N
N
D
-
G
--
R
L
-
V
G
Y
N
T
D
G
L
G
Y
V
Q
A
L
E
E
-
E
-
M
N
I
T
L
D
G
K
R
I
L
V
I
G
A
G
G
G
A
R
G
I
Y
F
-----------
S
L
L
S
T
A
A
E
R
I
D
M
A
N
R
------
T
V
---
E
K
A
E
R
L
V
R
--------
E
------
G
D
---
E
------
R
R
S
A
Y
F
S
L
-----
A
E
A
---
E
T
R
L
A
E
Y
D
I
I
I
N
T
T
S
V
G
M
--
H
P
R
V
E
V
-
Q
P
--
L
-
S
-
L
----
E
-
R
-
L
R
P
G
V
I
V
S
D
I
I
Y
N
P
L
E
T
K
W
L
K
E
A
K
A
R
G
-
A
-
R
-
V
Q
N
G
V
G
M
L
V
Y
Q
G
A
L
A
F
E
K
W
T
G
Q
W
P
-
D
V
N
R
M
K
Q
L
V
I
E
A
L
---
95
HHSearch
94.85
44%
-78
- C5 -
2EGG
2
AROE_GEOKA
A:
[24-296]
-
K
V
Y
G
L
I
G
F
P
V
E
H
S
L
S
P
L
M
H
N
D
A
F
----
A
R
L
G
I
----
P
A
R
Y
H
L
F
-
S
V
E
P
G
-
Q
V
G
A
A
I
A
-
G
V
R
-
A
L
----
G
I
A
G
V
N
V
T
I
P
H
K
L
A
V
I
P
F
L
D
E
V
D
E
H
A
R
R
I
G
A
V
N
T
I
-
I
N
N
--
D
--
G
R
L
V
G
Y
N
T
D
G
L
G
Y
V
Q
A
L
E
E
-
E
M
N
I
T
L
D
G
-
K
R
I
L
V
I
G
A
G
G
G
A
R
G
I
Y
F
-----------
S
L
L
S
T
A
A
E
R
I
D
M
A
N
R
------
T
V
---
E
K
A
E
R
L
V
R
--------
E
------
G
D
---
E
RR----
S
A
Y
--
F
S
L
-----
A
E
A
---
E
T
R
L
A
E
Y
D
I
I
I
N
T
T
S
V
G
M
--
H
P
R
V
E
V
-
Q
P
--
L
-
S
-
L
----
E
-
R
-
L
R
P
G
V
I
V
S
D
I
I
Y
N
P
L
E
T
K
W
L
K
E
A
K
A
R
G
-
A
-
R
-
V
Q
N
G
V
G
M
L
V
Y
Q
G
A
L
A
F
E
K
W
T
G
Q
W
P
-
D
V
N
R
M
K
Q
L
V
I
E
A
L
R
--
2
PsiBlast_PDB
94.84
45%
-88
- C5 -
3DOO
1
AROE_STAEQ
A:
[2-267]
--
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
-
N
V
P
V
N
-
Q
F
Q
-
D
I
K
-
K
I
I
S
E
K
----
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
V
K
D
-
G
--
K
W
-
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
-
I
-
Y
E
G
I
E
D
-
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
-----------
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
------
T
---------
M
S
R
--------
F
------
N
N
WSL
N
------
I
N
K
--
I
N
L
-----
S
H
A
---
E
S
H
L
D
E
F
D
I
I
I
N
T
T
P
-------------
V
--
I
-
S
-
L
----
N
-
R
-
L
A
S
H
T
L
V
S
D
I
V
Y
N
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
-
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
-
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
-
6
PsiBlast_PDB
92.80
37%
-87
- C5 -
2HK9
3
AROE_AQUAE
A:
[15-275]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
L
R
G
--
4
PsiBlast_PDB
92.05
37%
-86
- C5 -
2HK7
2
AROE_AQUAE
A:
[9-269]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
L
R
G
--
23
PsiBlast_CBE
91.63
37%
-84
- C5 -
2HK9
2
AROE_AQUAE
B:
[15-273]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
L
----
5
PsiBlast_PDB
91.24
37%
-87
- C5 -
2HK8
-
AROE_AQUAE
A:
[9-266]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
-----
24
PsiBlast_CBE
90.87
37%
-88
- C5 -
2HK7
2
AROE_AQUAE
B:
[9-268]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
L
R
---
84
HHSearch
90.51
44%
-67
- C5 -
3DON
1
AROE_STAEQ
A:
[1-267]
-
M
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
N
F
----
Q
S
L
N
L
----
E
N
T
Y
E
A
I
-
N
V
P
V
N
-
Q
F
Q
D
I
K
K
-
I
I
S
-
E
K
----
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
V
K
--
D
--
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
-
I
-
Y
E
G
I
E
D
-
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
-----------
E
L
Y
K
I
V
R
P
T
L
T
V
A
N
R
------
T
M
---
S
R
F
N
N
W
S
L
--------
N
------
I
N
---
K
-----------
I
N
L
-----
S
H
A
---
E
S
H
L
D
E
F
D
I
I
I
N
T
T
P
---------
D
S
--
V
--
I
-
S
-
L
----
N
-
R
-
L
A
S
H
T
L
V
S
D
I
V
Y
N
P
Y
K
T
P
I
L
I
E
A
E
Q
R
G
-
N
-
P
-
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
-
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
-
22
PsiBlast_CBE
90.35
37%
-82
- C5 -
2HK9
2
AROE_AQUAE
C:
[15-272]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
-----
21
PsiBlast_CBE
89.60
37%
-83
- C5 -
2HK9
2
AROE_AQUAE
D:
[15-272]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
N
-
G
--
K
A
-
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
-
V
K
E
G
A
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------------------
K
------
F
P
L
--
E
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
-----
K
D
E
-
D
P
EI
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
-----
27
PsiBlast_CBE
89.24
36%
-71
- C5 -
1NYT
6
AROE_ECOLI
C:
[1-266]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
-
L
A
P
I
N
-
D
F
I
N
T
L
N
-
A
F
F
-
S
A
----
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
-
D
G-
R
L
-
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
P
G
-
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
------
T
V
---
S
R
A
E
E
L
A
K
LFA-----
H
------
T
G
---
S
------
I
Q
A
--
L
S
M
-----
D
E
L
---
E
G
H
--
E
F
D
L
I
I
N
A
T
S
S
G
I
--
S
G
D
I
P
A
-
I
P
--
S
-
S
-
L
--------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
-
D
----
V
E
P
V
I
K
Q
L
---
28
PsiBlast_CBE
88.64
36%
-69
- C5 -
1NYT
5
AROE_ECOLI
B:
[1-266]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
-
L
A
P
I
N
-
D
F
I
N
T
L
N
-
A
F
F
-
S
A
----
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
-
D
G-
R
L
-
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
P
G
-
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
------
T
V
---
S
R
A
E
E
L
A
K
LFA-----
H
------
T
G
---
S
------
I
Q
A
--
L
S
M
-----
D
E
L
---
E
G
H
--
E
F
D
L
I
I
N
A
T
S
S
G
I
--
S
G
D
I
P
A
-
I
P
--
S
-
S
-
L
--------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
-
D
----
V
E
P
V
I
K
Q
L
---
26
PsiBlast_CBE
88.01
36%
-70
- C5 -
1NYT
5
AROE_ECOLI
D:
[1-266]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
-
L
A
P
I
N
-
D
F
I
N
T
L
N
-
A
F
F
-
S
A
----
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
-
D
G-
R
L
-
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
P
G
-
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
------
T
V
---
S
R
A
E
E
L
A
K
LFA-----
H
------
T
G
---
S
------
I
Q
A
--
L
S
M
-----
D
E
L
---
E
G
H
--
E
F
D
L
I
I
N
A
T
S
S
G
I
--
S
G
D
I
P
A
-
I
P
--
S
-
S
-
L
--------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
-
D
----
V
E
P
V
I
K
Q
L
---
10
PsiBlast_PDB
87.23
36%
-67
- C5 -
2CY0
2
AROE_THET8
A:
[3-262]
--
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
-
R
A
-----
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
E
-
G
--
R
L
-
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
---
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
-
E
A
G
L
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
----------
L
R
A
--
V
P
L
-----
E
K
A
---
R
E
A
----
R
L
L
V
N
A
T
R
V
G
L
--
E
-
D
P
S
A
-
S
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
G
--
11
PsiBlast_PDB
86.83
36%
-69
- C5 -
2D5C
4
AROE_THET8
A:
[3-261]
--
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
-
R
A
-----
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
E
-
G
--
R
L
-
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
---
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
-
E
A
G
L
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
----------
L
R
A
--
V
P
L
-----
E
K
A
---
R
E
A
----
R
L
L
V
N
A
T
R
V
G
L
--
E
-
D
P
S
A
-
S
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
---
94
HHSearch
86.74
37%
-70
- C5 -
2HK9
3
AROE_AQUAE
A:
[13-272]
-
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
L
I
----
R
Y
A
G
L
----
N
A
V
Y
L
A
F
-
E
I
N
P
E
-
E
L
K
K
A
F
E
-
G
F
K
-
A
L
----
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
F
E
--
N
--
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
E
V
K
E
-
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
-----------
A
L
V
K
E
G
A
-
K
V
F
L
W
N
R
------
T
K
---
E
K
A
I
K
L
A
Q
--------
K
------
F
P
---
L
-------
E
----
V
V
-----
N
S
P
---
E
E
V
I
D
K
V
Q
V
I
V
N
T
T
S
V
G
L
--
K
D
E
D
P
E
--
I
--
F
-
N
-
Y
----
D
-
L
-
I
K
K
D
H
V
V
V
D
I
I
Y
K
--
E
T
K
L
L
K
K
A
K
E
K
G
-
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
-
P
Y
S
V
A
E
R
S
V
R
D
-----
31
PsiBlast_CBE
86.67
36%
-64
- C5 -
2CY0
1
AROE_THET8
B:
[3-262]
--
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
-
R
A
-----
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
E
-
G
--
R
L
-
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
---
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
-
E
A
G
L
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
----------
L
R
A
--
V
P
L
-----
E
K
A
---
R
E
A
----
R
L
L
V
N
A
T
R
V
G
L
--
E
-
D
P
S
A
-
S
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
G
--
8
PsiBlast_PDB
86.64
36%
-70
- C5 -
1NYT
7
AROE_ECOLI
A:
[1-266]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
-
L
A
P
I
N
-
D
F
I
N
T
L
N
-
A
F
F
-
S
A
----
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
-
D
G-
R
L
-
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
P
G
-
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
S
-
L
D
C
A
V
T
I
T
N
R
------
T
V
---
S
R
A
E
E
L
A
K
L
F
A-----
H
------
T
G
---
S
------
I
Q
A
--
L
S
M
-----
D
E
L
---
E
G
H
--
E
F
D
L
I
I
N
A
T
S
S
G
I
--
S
G
D
I
P
A
-
I
P
--
S
-
S
-
L
--------
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
-
D
----
V
E
P
V
I
K
Q
L
---
29
PsiBlast_CBE
86.46
36%
-64
- C5 -
2EV9
2
AROE_THET8
B:
[3-262]
--
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
-
R
A
-----
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
E
-
G
--
R
L
-
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
---
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
-
E
A
G
L
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
----------
L
R
A
--
V
P
L
-----
E
K
A
---
R
E
A
----
R
L
L
V
N
A
T
R
V
G
L
--
E
-
D
P
S
A
-
S
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
G
--
88
HHSearch
85.97
38%
-74
- C5 -
1NVT
2
AROE_METJA
A:
[12-285]
-
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
V
A
F
-
D
V
L
P
E
-
N
L
K
Y
V
I
D
-
G
A
K
-
A
L
----
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
-
K
I
E
--
D
--
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
-
E
-
I
G
R
V
K
D
-
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
-----------
E
L
A
K
D
N
--
N
I
I
I
A
N
R
------
T
V
---
E
K
A
E
A
L
A
K
--------
E
------
I
A
---
E
K
L
NKKF
G
E
E
--
V
K
F
-----
S
G
L
---
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
--
Y
P
N
I
D
V
-
E
P
--
I
V
K
-
A
----
E
-
K
-
L
R
E
D
M
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
-
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
-
N
I
E
V
M
K
N
A
I
I
D
K
I
---
25
PsiBlast_CBE
85.88
38%
-71
- C5 -
1NVT
2
AROE_METJA
B:
[16-285]
-----
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
-----
V
A
F
D
-
V
L
P
E
N
L
K
-
Y
V
I
-
D
G
AKAL
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
-
K
I
E
D
-
G
--
K
A
-
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
-
E
-
I
G
R
V
K
D
-
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
-----------
E
L
A
K
--
D
N
N
I
I
I
A
N
R
------
T
V
---
E
K
A
E
A
L
A
K
--------
E
IAEKLN
K
K
---
F
------
G
E
E
--
V
K
F
-----
S
G
L
---
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
--
Y
P
N
I
D
V
-
E
P
--
I
-
V
-
K
----
A
E
K
-
L
R
E
D
M
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
-
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
-
N
I
E
V
M
K
N
A
I
I
D
K
I
---
12
PsiBlast_PDB
85.86
36%
-64
- C5 -
2EV9
3
AROE_THET8
A:
[3-261]
--
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
-
R
A
-----
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
E
-
G
--
R
L
-
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
---
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
-
E
A
G
L
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
----------
L
R
A
--
V
P
L
-----
E
K
A
---
R
E
A
----
R
L
L
V
N
A
T
R
V
G
L
--
E
-
D
P
S
A
-
S
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
---
7
PsiBlast_PDB
85.58
38%
-73
- C5 -
1NVT
2
AROE_METJA
A:
[16-285]
-----
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
A
A
F
----
K
D
K
G
L
----
N
Y
V
Y
-----
V
A
F
D
-
V
L
P
E
N
L
K
-
Y
V
I
-
D
G
A
K
A
L
G
I
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
-
K
I
E
D
-
G
--
K
A
-
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
E
E
-
E
-
I
G
R
V
K
D
-
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
-----------
E
L
A
K
--
D
N
N
I
I
I
A
N
R
------
T
V
---
E
K
A
E
A
L
A
K
--------
E
I
A
E
K
L
N
K
K
---
F
------
G
E
E
--
V
K
F
-----
S
G
L
---
D
V
D
L
D
G
V
D
I
I
I
N
A
T
P
I
G
M
--
Y
P
N
I
D
V
-
E
P
--
I
-
V
-
K
----
A
E
K
-
L
R
E
D
M
V
V
M
D
L
I
Y
N
P
L
E
T
V
L
L
K
E
A
K
K
V
N
-
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
-
N
I
E
V
M
K
N
A
I
I
D
K
I
---
87
HHSearch
84.94
36%
-70
- C5 -
1NYT
7
AROE_ECOLI
A:
[2-270]
-
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
F
A
----
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
-
L
A
P
I
N
-
D
F
I
N
T
L
N
-
A
F
F
-
S
A
----
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
-
D
--
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
P
G
-
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
-----------
P
L
L
S
L
D
C
-
A
V
T
I
T
N
R
------
T
V
---
S
R
A
E
E
L
A
K
--------
L
------
F
A
---
H
TG
S
---
I
Q
A
--
L
S
M
-----
D
E
L
---
E
--
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
--
S
G
D
I
P
---
A
--
I
-
P
-
S
----
S
-
L
-
I
H
P
G
I
Y
C
Y
D
M
F
Y
Q
K
G
K
T
P
F
L
A
W
C
E
Q
R
G
-
S
-
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
-
D
V
E
P
V
I
K
Q
L
Q
E
E
L
---
30
PsiBlast_CBE
84.19
36%
-67
- C5 -
2D5C
3
AROE_THET8
B:
[3-262]
--
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
-
R
A
-----
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
E
-
G
--
R
L
-
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
---
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
-
E
A
G
L
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
----------
L
R
A
--
V
P
L
-----
E
K
A
---
R
E
A
----
R
L
L
V
N
A
T
R
V
G
L
-------
A
-
S
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
G
--
37
PsiBlast_CBE
83.95
31%
-65
- C5 -
3PGJ
1
AROE_VIBCH
C:
[29-293]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
-
C
V
P
V
D
-
G
F
T
E
A
A
K
-
H
F
F
-
A
Q
----
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
L
D
-
D
G-
E
I
-
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
V
L
L
K
G
-
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
------
T
F
---
A
K
A
E
Q
L
A
E
--------
L
------
V
A
---
A
------
Y
G
E
--
V
K
A
-----
Q
A
F
---
E
Q
L
K
Q
S
Y
D
V
I
I
N
S
T
S
---------
P
A
I
D
P
--
V
-
I
-
F
----
S
-
S
-
R
---
S
V
C
Y
D
M
M
Y
G
K
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
---------
56
PsiBlast_CBE
82.13
31%
-70
- C5 -
2NLO
1
AROE_CORGL
A:
[28-300]
-----
L
I
G
Q
G
L
D
L
S
R
T
P
A
M
H
E
A
E
G
----
L
A
Q
G
R
----
A
T
V
Y
R
R
I
D
T
L
G
S
R
-
A
S
G
Q
D
L
K
-
T
L
L
-
D
A
A
L
Y
L
G
F
N
G
L
N
I
T
H
P
Y
K
Q
A
V
L
P
L
L
D
E
V
S
E
Q
A
T
Q
L
G
A
V
N
T
V
V
I
D
A
T
-
G
--
H
T
-
T
G
H
N
T
D
V
S
G
F
G
R
G
M
E
E
-
G
-
L
P
N
A
K
L
-
D
S
V
V
Q
V
G
A
G
G
V
G
N
A
V
A
Y
-----------
A
L
V
T
H
G
V
Q
K
L
Q
V
A
D
L
------
D
T
---
S
R
A
Q
A
L
A
D
--------
V
------
I
N
---
N
A
V
G---
R
E
A
--
V
V
G
-----
V
D
A
RG
I
E
D
V
I
A
A
A
D
G
V
V
N
A
T
P
M
G
M
--
P
A
H
P
G
T
-
A
---
F
-
D
-
V
----
S
-
C
-
L
T
K
D
H
W
V
G
D
V
V
Y
M
P
I
E
T
E
L
L
K
A
A
R
A
L
G
-
C
-
E
-
T
L
D
G
T
R
M
A
I
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
-
D
V
S
R
M
R
E
T
F
L
------
57
PsiBlast_CBE
81.97
31%
-71
- C5 -
3JYQ
2
AROE_CORGL
A:
[9-281]
-----
L
I
G
Q
G
L
D
L
S
R
T
P
A
M
H
E
A
E
G
----
L
A
Q
G
R
----
A
T
V
Y
R
R
I
D
T
L
G
S
R
-
A
S
G
Q
D
L
K
-
T
L
L
-
D
A
A
L
Y
L
G
F
N
G
L
N
I
T
H
P
Y
K
Q
A
V
L
P
L
L
D
E
V
S
E
Q
A
T
Q
L
G
A
V
N
T
V
V
I
D
A
T
-
G
--
H
T
-
T
G
H
N
T
D
V
S
G
F
G
R
G
M
E
E
-
G
-
L
P
N
A
K
L
-
D
S
V
V
Q
V
G
A
G
G
V
G
N
A
V
A
Y
-----------
A
L
V
T
H
G
V
Q
K
L
Q
V
A
D
L
------
D
T
---
S
R
A
Q
A
L
A
D
--------
V
------
I
N
---
N
A
V
G---
R
E
A
--
V
V
G
-----
V
D
A
RG
I
E
D
V
I
A
A
A
D
G
V
V
N
A
T
P
M
G
M
--
P
A
H
P
G
T
-
A
---
F
-
D
-
V
----
S
-
C
-
L
T
K
D
H
W
V
G
D
V
V
Y
M
P
I
E
T
E
L
L
K
A
A
R
A
L
G
-
C
-
E
-
T
L
D
G
T
R
M
A
I
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
-
D
V
S
R
M
R
E
T
F
L
------
47
PsiBlast_CBE
81.72
32%
-69
- C5 -
3TNL
2
AROE_LISMO
C:
[42-301]
-----
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
-
E
V
G
D
K
-
E
L
K
D
V
V
Q
-
G
F
R
-
A
M
----
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
D
D
-
G
--
V
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
-
A
-
G
H
D
I
I
G
-
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
KDDFYA
N
A
---
E
K
T
V
E
K
I
N
--------
S
------
K
T
---
D
------
C
K
A
--
Q
L
F
DIEDH
E
Q
L
---
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
--
K
P
F
E
G
E
-
T
L
--
L
-
P
-
S
----
A
-
D
M
L
R
P
E
L
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
---------------------
58
PsiBlast_CBE
81.50
31%
-71
- C5 -
3JYP
2
AROE_CORGL
A:
[9-281]
-----
L
I
G
Q
G
L
D
L
S
R
T
P
A
M
H
E
A
E
G
----
L
A
Q
G
R
----
A
T
V
Y
R
R
I
D
T
L
G
S
R
-
A
S
G
Q
D
L
K
-
T
L
L
-
D
A
A
L
Y
L
G
F
N
G
L
N
I
T
H
P
Y
K
Q
A
V
L
P
L
L
D
E
V
S
E
Q
A
T
Q
L
G
A
V
N
T
V
V
I
D
A
T
-
G
--
H
T
-
T
G
H
N
T
D
V
S
G
F
G
R
G
M
E
E
-
G
-
L
P
N
A
K
L
-
D
S
V
V
Q
V
G
A
G
G
V
G
N
A
V
A
Y
-----------
A
L
V
T
H
G
V
Q
K
L
Q
V
A
D
L
------
D
T
---
S
R
A
Q
A
L
A
D
--------
V
------
I
N
---
N
A
V
G---
R
E
A
--
V
V
G
-----
V
D
A
RG
I
E
D
V
I
A
A
A
D
G
V
V
N
A
T
P
M
G
M
--
P
A
H
P
G
T
-
A
---
F
-
D
-
V
----
S
-
C
-
L
T
K
D
H
W
V
G
D
V
V
Y
M
P
I
E
T
E
L
L
K
A
A
R
A
L
G
-
C
-
E
-
T
L
D
G
T
R
M
A
I
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
-
D
V
S
R
M
R
E
T
F
L
------
17
PsiBlast_PDB
81.44
32%
-70
- C5 -
3TNL
2
AROE_LISMO
A:
[42-301]
-----
L
I
A
T
P
I
R
H
S
L
S
P
T
M
H
N
E
A
F
----
A
K
L
G
L
----
D
Y
V
Y
L
A
F
-
E
V
G
D
K
-
E
L
K
D
V
V
Q
-
G
F
R
-
A
M
----
N
L
R
G
W
N
V
S
M
P
N
K
T
N
I
H
K
Y
L
D
K
L
S
P
A
A
E
L
V
G
A
V
N
T
V
-
V
N
D
D
-
G
--
V
L
-
T
G
H
I
T
D
G
T
G
Y
M
R
A
L
K
E
-
A
-
G
H
D
I
I
G
-
K
K
M
T
I
C
G
A
G
G
A
A
T
A
I
C
I
-----------
Q
A
A
L
D
G
V
K
E
I
S
I
F
N
R
KDDF
Y
A
N
A
---
E
K
T
V
E
K
I
N
--------
S
------
K
T
---
D
------
C
K
A
--
Q
L
F
D
IED
H
E
Q
L
---
R
K
E
I
A
E
S
V
I
F
T
N
A
T
G
V
G
M
--
K
P
F
E
G
E
-
T
L
--
L
-
P
-
S
----
A
-
D
M
L
R
P
E
L
I
V
S
D
V
V
Y
K
P
T
K
T
R
L
L
E
I
A
E
E
Q
G
-
C
-
Q
-
T
L
N
G
L
G
M
M
L
W
Q
G
A
K
A
F
E
I
W
T
---------------------
91
HHSearch
81.17
33%
-68
- C5 -
2O7S
2
DHQSD_ARATH
A:
[235-514]
-
K
V
Y
G
I
I
G
K
P
V
S
H
S
K
S
P
I
V
H
N
Q
A
F
----
K
S
V
D
F
----
N
G
V
Y
V
H
L
-
L
V
D
---
N
L
V
S
F
L
Q
-
A
Y
S
-
S
S
----
D
F
A
G
F
S
C
T
I
P
H
K
E
A
A
L
Q
C
C
D
E
V
D
P
L
A
K
S
I
G
A
V
N
T
I
-
L
R
R
K
S
D
--
G
K
L
L
G
Y
N
T
D
C
I
G
S
I
S
A
I
E
D
-
G
L
--------
T
V
V
V
I
G
A
G
G
A
G
K
A
L
A
Y
-----------
G
A
K
E
K
G
A
--
V
V
I
A
N
R
------
T
Y
---
E
R
A
L
E
L
A
E
--------
A
------
I
G
---
G
--------
A
--
L
S
L
-----
T
D
L
---
D
N
Y
-
E
D
G
M
V
L
A
N
T
T
S
M
G
M
--
Q
P
N
V
E
E
-
T
P
--
I
-
S
-
K
----
D
-
A
-
L
K
H
Y
A
L
V
F
D
A
V
Y
T
P
R
I
T
R
L
L
R
E
A
E
E
S
G
-
A
-
I
-
T
V
S
G
S
E
M
F
V
R
Q
A
Y
E
Q
F
E
I
F
T
G
L
P
A
-
P
K
E
L
Y
W
Q
I
M
S
K
Y
----
85
HHSearch
81.04
36%
-59
- C5 -
2D5C
4
AROE_THET8
A:
[2-261]
-
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
A
L
----
E
S
L
G
L
----
E
G
S
Y
E
A
W
-
D
T
P
L
E
-
A
L
P
G
R
L
K
-
E
V
R
--
R
----
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
Q
V
--
E
--
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
-
G
I
P
-
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
-----------
A
L
R
E
A
G
L
-
E
V
W
V
W
N
R
------
T
P
---
Q
R
A
L
A
L
A
E
--------
E
------
F
G
---
L
-------
R
A
----------
V
P
L
----
E
K
A
R
E
A
R
L
L
V
N
A
T
R
V
G
L
--
E
D
P
S
A
S
--
P
--
L
-
P
-
A
----
E
-
L
-
F
P
E
E
G
A
A
V
D
L
V
Y
R
P
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
-
D
P
S
G
M
E
E
A
A
R
R
A
L
---
14
PsiBlast_PDB
79.96
31%
-61
- C5 -
3PGJ
1
AROE_VIBCH
A:
[29-293]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
F
A
----
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
-
C
V
P
V
D
-
G
F
T
E
A
A
K
-
H
F
F
-
A
Q
----
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
-
K
K
L
D
-
D
G-
E
I
-
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
V
L
L
K
G
-
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
-----------
P
L
L
D
Q
Q
P
A
S
I
T
V
T
N
R
------
T
F
---
A
K
A
E
Q
L
A
E
--------
L
------
V
A
---<