@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0652: (2016-01-13 )
MVAITHTPKLKHLDKLLAHCHRRRYTAKSTIIYAGDRCETLFFIIKGSVTILIEDDDGREMIIGYLNSGDFFGELGLFEKEGSEQERSAWVRAKVECEVAEISYAKFRELSQQDSEILYTLGSQMADRLRKTTRKVGDLAFLDVTGRVARTLLDLCQQPDAMTHPDGMQIKITRQEIGRIVGCSREMVGRVLKSLEEQGLVHVKGKTMVVFGTR
Atome Classification :
(60 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
A
ITHT
P
K
L
K
H
L
D
K
L
L
A
H
C
H
R
RRYTAK
S
T
I
I
Y
AGDR
C
E
T
L
F
F
I
I
KG
S
V
T
I
L
I
EDDDG
R
E
M
I
I
G
Y
LNSGDFFGELGLFEKEGS
E
Q
E
R
S
A
W
V
R
A
K
V
E
C
E
V
A
E
I
S
Y
A
K
F
R
E
L
S
QQ
D
S
E
I
L
Y
T
L
G
S
Q
M
A
D
R
L
R
K
T
T
R
KVG
D
L
A
F
LDV
T
G
R
V
A
R
T
L
L
D
L
CQQPDAMTHPDG
M
Q
I
K
I
T
R
Q
E
I
G
R
I
VGC
S
R
E
M
V
G
R
V
L
K
S
L
E
EQ
G
L
V
H
VKG
K
T
M
V
V
F
GTR
90
HHSearch
95.03
100%
-142
- C2 -
2OZ6
2
VFR_PSEAE
A:
[3-206]
---------
L
K
H
L
D
K
L
L
A
H
C
H
R
R
R
Y
T
A
K
S
T
I
I
Y
A
G
D
R
C
E
T
L
F
F
I
I
K
G
S
V
T
I
L
I
E
D
D
D
G
R
E
M
I
I
G
Y
L
N
S
G
D
F
F
G
E
L
G
L
F
E
-----
Q
E
R
S
A
W
V
R
A
K
V
E
C
E
V
A
E
I
S
Y
A
K
F
R
E
L
S
Q
Q
D
S
E
I
L
Y
T
L
G
S
Q
M
A
D
R
L
R
K
T
T
R
K
V
G
D
L
A
F
L
D
V
T
G
R
V
A
R
T
L
L
D
L
C
Q
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
R
I
V
G
C
S
R
E
M
V
G
R
V
L
K
S
L
E
E
Q
G
L
V
H
V
K
G
K
T
M
V
V
F
G
T
-
1
PsiBlast_PDB
94.80
100%
-141
- C2 -
2OZ6
2
VFR_PSEAE
A:
[2-206]
--------
K
L
K
H
L
D
K
L
L
A
H
C
H
R
R
R
Y
T
A
K
S
T
I
I
Y
A
G
D
R
C
E
T
L
F
F
I
I
K
G
S
V
T
I
L
I
E
D
D
D
G
R
E
M
I
I
G
Y
L
N
S
G
D
F
F
G
E
L
G
L
F
E
-----
Q
E
R
S
A
W
V
R
A
K
V
E
C
E
V
A
E
I
S
Y
A
K
F
R
E
L
S
Q
Q
D
S
E
I
L
Y
T
L
G
S
Q
M
A
D
R
L
R
K
T
T
R
K
V
G
D
L
A
F
L
D
V
T
G
R
V
A
R
T
L
L
D
L
C
Q
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
R
I
V
G
C
S
R
E
M
V
G
R
V
L
K
S
L
E
E
Q
G
L
V
H
V
K
G
K
T
M
V
V
F
G
T
-
77
PsiBlast_CBE
87.46
66%
-147
- C2 -
4I0B
3
CRP_ECOLI
A:
[24-219]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
L
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
27
PsiBlast_CBE
86.06
66%
-142
- C2 -
4FT8
10
CRP_ECOLI
B:
[11-206]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
44
PsiBlast_CBE
86.05
66%
-137
- C2 -
4I09
2
CRP_ECOLI
A:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
L
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
38
PsiBlast_CBE
85.96
66%
-140
- C2 -
1I5Z
3
CRP_ECOLI
B:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
55
PsiBlast_CBE
85.69
66%
-141
- C2 -
4I0A
3
CRP_ECOLI
B:
[24-220]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
A
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
53
PsiBlast_CBE
85.65
66%
-139
- C2 -
3QOP
3
CRP_ECOLI
B:
[12-208]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
F
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
39
PsiBlast_CBE
85.31
66%
-141
- C2 -
4R8H
6
?
B:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
15
PsiBlast_PDB
85.06
66%
-136
- C2 -
1ZRF
9
CRP_ECOLI
A:
[11-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
R
61
PsiBlast_CBE
84.91
66%
-141
- C2 -
4I02
2
CRP_ECOLI
B:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
A
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
---
T
I
V
V
Y
G
T
-
70
PsiBlast_CBE
84.89
66%
-139
- C2 -
3KCC
4
CRP_ECOLI
B:
[62-257]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
L
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
32
PsiBlast_CBE
84.65
66%
-139
- C2 -
1ZRF
8
CRP_ECOLI
B:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
50
PsiBlast_CBE
84.64
66%
-137
- C2 -
3ROU
3
CRP_ECOLI
A:
[12-208]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
F
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
63
PsiBlast_CBE
84.58
66%
-142
- C2 -
1I6X
3
CRP_ECOLI
B:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
H
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
56
PsiBlast_CBE
84.52
66%
-137
- C2 -
4I0A
4
CRP_ECOLI
A:
[24-219]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
A
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
76
PsiBlast_CBE
84.50
66%
-135
- C2 -
4I0B
3
CRP_ECOLI
B:
[24-220]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
L
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
24
PsiBlast_CBE
84.46
66%
-136
- C2 -
3RYR
3
CRP_ECOLI
B:
[12-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
43
PsiBlast_CBE
84.39
66%
-138
- C2 -
4I09
2
CRP_ECOLI
B:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
L
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
60
PsiBlast_CBE
84.34
66%
-140
- C2 -
4I02
1
CRP_ECOLI
C:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
A
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
71
PsiBlast_CBE
84.32
66%
-138
- C2 -
3KCC
3
CRP_ECOLI
A:
[62-257]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
L
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
58
PsiBlast_CBE
84.19
66%
-138
- C2 -
4I02
3
CRP_ECOLI
E:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
A
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
14
PsiBlast_PDB
84.17
66%
-134
- C2 -
1ZRE
4
CRP_ECOLI
A:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
6
PsiBlast_PDB
84.17
66%
-141
- C2 -
3RYR
3
CRP_ECOLI
A:
[12-208]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
19
PsiBlast_PDB
84.06
66%
-135
- C2 -
3N4M
5
CRP_ECOLI
A:
[11-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
R
42
PsiBlast_CBE
84.04
66%
-136
- C2 -
4HZF
7
CRP_ECOLI
A:
[24-220]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
40
PsiBlast_CBE
83.92
66%
-138
- C2 -
4R8H
8
?
A:
[24-220]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
94
HHSearch
83.77
63%
-133
- C2 -
3KCC
3
CRP_ECOLI
A:
[59-257]
---------
D
P
T
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
E
G
---
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
L
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
59
PsiBlast_CBE
83.66
66%
-139
- C2 -
4I02
2
CRP_ECOLI
D:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
A
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
--
T
I
V
V
Y
G
T
-
45
PsiBlast_CBE
83.55
66%
-143
- C2 -
4I01
3
CRP_ECOLI
B:
[24-220]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
L
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
12
PsiBlast_PDB
83.55
66%
-131
- C2 -
1ZRC
4
CRP_ECOLI
A:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
46
PsiBlast_CBE
83.51
66%
-134
- C2 -
4I01
3
CRP_ECOLI
A:
[24-219]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
L
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
62
PsiBlast_CBE
83.47
66%
-141
- C2 -
4I02
3
CRP_ECOLI
A:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
A
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
---
T
I
V
V
Y
G
T
-
2
PsiBlast_PDB
83.42
66%
-133
- C2 -
2CGP
4
CRP_ECOLI
A:
[12-208]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
10
PsiBlast_PDB
83.31
66%
-136
- C2 -
1LB2
3
CRP_ECOLI
A:
[11-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
R
78
PsiBlast_CBE
83.12
66%
-135
- C2 -
1O3S
4
CRP_ECOLI
A:
[4-200]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
D
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
49
PsiBlast_CBE
83.10
66%
-138
- C2 -
3ROU
3
CRP_ECOLI
B:
[12-208]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
F
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
13
PsiBlast_PDB
82.95
66%
-133
- C2 -
1ZRD
4
CRP_ECOLI
A:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
74
PsiBlast_CBE
82.81
66%
-135
- C2 -
1O3R
4
CRP_ECOLI
A:
[4-200]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
11
PsiBlast_PDB
82.74
66%
-139
- C2 -
1I5Z
5
CRP_ECOLI
A:
[11-206]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
41
PsiBlast_CBE
82.60
66%
-142
- C2 -
4HZF
7
CRP_ECOLI
B:
[24-221]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
47
PsiBlast_CBE
82.46
66%
-135
- C2 -
3RPQ
4
CRP_ECOLI
B:
[12-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
F
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
35
PsiBlast_CBE
82.38
66%
-138
- C2 -
1ZRC
4
CRP_ECOLI
B:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
75
PsiBlast_CBE
82.12
66%
-131
- C2 -
1O3Q
4
CRP_ECOLI
A:
[4-200]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
66
PsiBlast_CBE
82.09
66%
-131
- C2 -
1HW5
3
CRP_ECOLI
A:
[12-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
L
A
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
-
48
PsiBlast_CBE
81.96
66%
-140
- C2 -
3RPQ
5
CRP_ECOLI
A:
[12-208]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
F
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
33
PsiBlast_CBE
81.47
66%
-133
- C2 -
1ZRE
4
CRP_ECOLI
B:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
64
PsiBlast_CBE
81.32
66%
-138
- C2 -
1I6X
4
CRP_ECOLI
A:
[11-206]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
H
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
65
PsiBlast_CBE
81.07
66%
-139
- C2 -
1HW5
3
CRP_ECOLI
B:
[12-206]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
L
A
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
----
79
PsiBlast_CBE
80.55
66%
-135
- C2 -
1CGP
5
CRP_ECOLI
B:
[11-205]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
----
37
PsiBlast_CBE
80.40
66%
-129
- C2 -
1J59
4
CRP_ECOLI
B:
[11-205]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
----
8
PsiBlast_PDB
79.89
66%
-137
- C2 -
1RUN
4
CRP_ECOLI
A:
[11-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
R
34
PsiBlast_CBE
79.66
66%
-132
- C2 -
1ZRD
4
CRP_ECOLI
B:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
36
PsiBlast_CBE
79.10
66%
-131
- C2 -
1RUN
4
CRP_ECOLI
B:
[11-205]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
----
67
PsiBlast_CBE
78.49
66%
-129
- C2 -
1RUO
4
CRP_ECOLI
B:
[11-209]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
F
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
T
R
68
PsiBlast_CBE
77.65
66%
-129
- C2 -
1RUO
4
CRP_ECOLI
A:
[11-206]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
F
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
---
9
PsiBlast_PDB
77.23
66%
-130
- C2 -
1J59
4
CRP_ECOLI
A:
[11-207]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
73
PsiBlast_CBE
76.94
66%
-128
- C2 -
1O3T
4
CRP_ECOLI
A:
[4-200]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
109
Fugue
76.80
65%
-126
* C2 *
1O3T
4
CRP_ECOLI
A:
[2-200]
----------
P
T
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
---
E
G
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
Y
G
--
72
PsiBlast_CBE
74.62
66%
-130
- C2 -
1O3T
4
CRP_ECOLI
B:
[4-198]
------------
L
E
W
F
L
S
H
C
H
I
H
K
Y
P
S
K
S
T
L
I
H
Q
G
E
K
A
E
T
L
Y
Y
I
V
K
G
S
V
A
V
L
I
K
D
E
E
G
K
E
M
I
L
S
Y
L
N
Q
G
D
F
I
G
E
L
G
L
F
E
-
E
G
--
Q
E
R
S
A
W
V
R
A
K
T
A
C
E
V
A
E
I
S
Y
K
K
F
R
Q
L
I
Q
V
N
P
D
I
L
M
R
L
S
A
Q
M
A
R
R
L
Q
V
T
S
E
K
V
G
N
L
A
F
L
D
V
T
G
R
I
A
Q
T
L
L
N
L
A
K
Q
P
D
A
M
T
H
P
D
G
M
Q
I
K
I
T
R
Q
E
I
G
Q
I
V
G
C
S
R
E
T
V
G
R
I
L
K
M
L
E
D
Q
N
L
I
S
A
H
G
K
T
I
V
V
----