@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0067: (2016-03-12 )
MRGQEEIDKEQYQVLFIKERLIPCVLGAVIGDCLGVPVEFKDREYLKQNPIVEMIGYGTYNQPKGTWSDDSSLTFALMESLISGYDINRIVNNMVSFMDDGFWTPYGEVFDIGSVTRESLNRYKNGVSVFECGGKDNFDNGNGAIMRIMPLVFYLGKDFSFGKKNKITEEVTRITHAHPRSILGSYVYIELLQNLFANMDKKLAYEEMQNYIRKNYSDYPFKDELQYYNNILEGNLYELKESNIKSSGYVVDTLEASIWAFLTTNSYKEAVLKAVNLGGDTDTIAFITGSLAGIYYKMEQIPVNWIDQIAKKEDILNLCNRFIESLIKQ
Atome Classification :
(20 SA)
.........10........20........30......---..40..----------.-...--.-----.50.--...-.--...---60........70........80.-.--.--.-.----.----..90........100.......110.......120...----...-----.130.-----......140.......150..-..--...160...-....170--.....-...180...-----....190--------.......---.-200--..---.-....210..-------.---..-----------..220--.-.-----------...---..230.----.-.-...----.240-.-------.....-..250.......260-----------.-.-----------.....270.......280.......290.......300.......310.--......320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
G
Q
E
E
I
D
K
E
Q
Y
Q
V
L
F
I
K
E
R
L
I
P
C
V
L
G
A
V
I
G
D
CLGVP---VEFK
D
R
----------
E
-
Y
L
K--Q-----NP
I
V
--
E
M
I-G--YGT---YNQPKGTWSDDS
S
L
T
F
A
L
M
E
S
L
I
-S--G--Y-
D
----
I
----
N
R
I
V
N
N
M
V
S
F
M
DDGFWTPYGEVF
D
I
G
S
V
T
R
E
S
L
N
R
Y
KN----G
V
S
-----
V
F
ECG-----GKDNFDNGN
G
A
I
M
R
I
M
P
L
V
F
Y
-LG--KDFSFGKKN-
K
I
T
E
E
V
---
T
R
I
TH-A
H
P
R
S
I
L
G
S
-----
Y
V
Y
I
E
L
---------
L
Q
N
L
F
A
N
---
M
-
D
K
K
--
L
A
---
Y
-
E
E
M
Q
N
Y
I
R
K-------N---YS-----------DYP
F
K
--
D
-
E
-----------
L
Q
Y
---
Y
N
N
ILE----G-
N
-
L
Y
E
----
L
K
E--S-------NIKSS-
G
Y
V
V
D
TLEA
S
I
W
A
F
L-----------T-T-----------N
S
Y
K
E
A
V
L
K
A
VNLGGDT
D
T
I
A
F
ITGS
L
A
G
I
Y
Y
K
M
E
QI
P
V
N
W
I
D
Q
I
A
K
K
E
--
D
I
L
N
L
C
N
R
F
I
E
S
L
IKQ
21
HHSearch
96.61
28%
-87
- C9 -
2YZV
2
?
A:
[3-298]
------------
G
L
K
E
R
Q
D
R
R
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
Q
---
V
E
G
L
P
K
----------
G
-
T
F
P
---------
E
V
R
--
E
M
K
-
G
--
G
G
P
---
H
R
L
P
P
G
F
W
T
D
D
T
S
Q
A
L
C
L
A
E
S
L
L
Q
R
--
G
--
F
-
D
----
P
----
K
D
Q
M
D
R
Y
L
R
W
Y
R
E
G
Y
------------
A
T
R
R
A
L
E
R
Y
A
A
----
T
G
D
-----
P
Y
A
--------
G
D
E
A
G
A
G
N
G
P
L
M
R
L
A
P
L
V
L
A
Y
E
N
--
H
---
P
--
D
L
L
S
L
A
R
R
A
---
A
R
T
T
H
-
G
A
R
E
A
L
E
A
T
-----
E
V
L
A
W
L
---------
L
R
E
A
L
R
G
---
A
-
P
K
E
--
A
----
L
-
L
A
L
E
P
F
R
G
--------------------------
A
D
L
---
H
-
P
-------------
A
---
L
R
R
V
V
E
----
G
-
G
-
F
W
------
E
A
----------
P
E
E
G
P
-
G
Y
A
P
G
T
L
A
A
A
L
W
A
F
A
-----------
R
-
G
-----------
R
D
F
E
E
G
M
R
L
A
V
N
L
G
G
D
A
D
T
V
G
A
V
Y
G
Q
L
A
G
A
Y
Y
G
L
G
A
I
P
G
R
W
L
R
A
L
H
L
R
E
--
E
M
E
A
L
A
L
A
L
Y
R
M
S
M
--
7
PsiBlast_PDB
96.23
26%
-98
- C9 -
3G9D
2
?
A:
[6-290]
----------------
I
R
S
R
A
L
G
A
Y
L
G
L
A
C
G
D
A
L
G
A
T
---
V
E
F
L
T
K
G
---------
E
-
I
A
H
--
Q
-----
Y
G
V
H
--
K
H
I
K
G
--
G
G
W
---
L
K
L
P
A
G
Q
V
T
D
D
T
E
M
S
I
H
L
G
R
A
I
L
-
A
--
A
PE
W
-
D
----
A
----
R
R
A
A
E
E
F
A
V
W
L
K
-------
G
V
P
V
D
V
G
D
T
T
R
R
G
I
R
R
F
I
M
----
H
G
T
-----
L
S
E
P
-------
E
S
E
Y
H
A
G
N
G
A
A
M
R
N
L
P
V
A
L
A
T
L
G
--
D
D
A
A
F
---
E
-
R
W
T
V
E
Q
---
A
H
I
T
H
-
C
N
A
M
S
D
A
A
T
-----
L
T
L
G
H
M
---------
V
R
R
L
V
L
G
---
G
-
D
V
R
--
D
V
---
R
-
D
E
S
N
K
L
I
A
K
-------
H
---
R
Q
--------------
F
K
----------------
F
Q
P
---
Y
R
G
L
---------------------------------
A
T
-
A
Y
I
V
D
T
M
Q
T
V
M
H
Y
Y
F
-----------
Q
-
T
-----------
D
S
V
E
S
C
V
V
E
T
V
N
Q
G
G
D
A
D
T
T
G
A
I
A
G
M
L
A
G
A
T
Y
G
V
E
T
I
P
P
R
W
L
R
K
L
D
R
----
D
V
Y
N
E
I
C
A
Q
V
D
G
L
L
A
R
1
PsiBlast_PDB
96.01
28%
-86
- C9 -
2CWC
-
?
A:
[8-290]
-----------------
Q
D
R
R
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
Q
---
V
E
G
L
P
K
----------
G
-
T
F
P
--
E
-------
V
R
--
E
M
K
-
G
--
G
G
P
---
H
R
L
P
P
G
F
W
T
D
D
T
S
Q
A
L
C
L
A
E
S
L
L
-
Q
R-
G
--
F
-
D
----
P
----
K
D
Q
M
D
R
Y
L
R
W
Y
R
E
G
Y
------------
A
T
R
R
A
L
E
R
Y
-------
A
A
-----
T
G
D
P
Y
-----
A
G
D
E
A
G
A
G
N
G
P
L
M
R
L
A
P
L
V
L
A
-
Y
E
--
N
H
P
D
L
---
L
-
S
L
A
R
R
A
---
A
R
T
T
H
-
G
A
R
E
A
L
E
A
T
-----
E
V
L
A
W
L
---------
L
R
E
A
L
R
G
---
A
-
P
K
E
A
L
L
A
---
L
-
E
----------------------------------
P
F
R
GA
D
-
L
-----------
H
P
A
---
L
R
R
V
V
E
----
G
-
G
-
F
W
E
----
A
P
E
------------
E
G
P
-
G
Y
A
P
G
T
L
A
A
A
L
W
A
F
A
-----------
R
-
G
-----------
R
D
F
E
E
G
M
R
L
A
V
N
L
G
G
D
A
D
T
V
G
A
V
Y
G
Q
L
A
G
A
Y
Y
G
L
G
A
I
P
G
R
W
L
R
A
L
H
L
R
E
--
E
M
E
A
L
A
----------
8
PsiBlast_PDB
95.74
26%
-96
- C9 -
3O5T
2
?
A:
[6-290]
----------------
I
R
S
R
A
L
G
A
Y
L
G
L
A
C
G
D
A
L
G
A
T
---
V
E
F
L
T
K
G
---------
E
-
I
A
H
--
Q
-----
Y
G
V
H
--
K
H
I
K
G
--
G
G
W
---
L
K
L
P
A
G
Q
V
T
D
D
T
E
M
S
I
H
L
G
R
A
I
L
-
A
--
A
PE
W
-
D
----
A
----
R
R
A
A
E
E
F
A
V
W
L
K
-------
G
V
P
V
D
V
G
D
T
T
R
R
G
I
R
R
F
I
M
----
H
G
T
-----
L
S
E
P
-------
E
S
E
Y
H
A
G
N
G
A
A
M
R
N
L
P
V
A
L
A
T
L
G
--
D
D
A
A
F
---
E
-
R
W
T
V
E
Q
---
A
H
I
T
H
-
C
N
A
M
S
D
A
A
T
-----
L
T
L
G
H
M
---------
V
R
R
L
V
L
G
---
G
-
D
V
R
--
D
V
---
R
-
D
E
S
N
K
L
I
A
K
-------
H
---
R
Q
--------------
F
K
----------------
F
Q
P
---
Y
R
G
L
---------------------------------
A
T
-
A
Y
I
V
D
T
M
Q
T
V
M
H
Y
Y
F
-----------
Q
-
T
-----------
D
S
V
E
S
C
V
V
E
T
V
N
Q
G
G
D
A
D
T
T
G
A
I
A
G
M
L
A
G
A
T
Y
G
V
E
T
I
P
P
R
W
L
R
K
L
D
R
----
D
V
Y
N
E
I
C
A
Q
V
D
G
L
L
A
R
2
PsiBlast_PDB
95.70
28%
-84
- C9 -
2YZV
2
?
A:
[8-290]
-----------------
Q
D
R
R
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
Q
---
V
E
G
L
P
K
----------
G
-
T
F
P
--
E
-------
V
R
--
E
M
K
-
G
--
G
G
P
---
H
R
L
P
P
G
F
W
T
D
D
T
S
Q
A
L
C
L
A
E
S
L
L
-
Q
R-
G
--
F
-
D
----
P
----
K
D
Q
M
D
R
Y
L
R
W
Y
R
E
G
Y
------------
A
T
R
R
A
L
E
R
Y
-------
A
A
-----
T
G
D
P
Y
-----
A
G
D
E
A
G
A
G
N
G
P
L
M
R
L
A
P
L
V
L
A
-
Y
E
--
N
H
P
D
L
---
L
-
S
L
A
R
R
A
---
A
R
T
T
H
-
G
A
R
E
A
L
E
A
T
-----
E
V
L
A
W
L
---------
L
R
E
A
L
R
G
---
A
-
P
K
E
A
L
L
A
---
L
-
E
----------------------------------
P
F
R
GA
D
-
L
-----------
H
P
A
---
L
R
R
V
V
E
----
G
-
G
-
F
W
E
----
A
P
E
------------
E
G
P
-
G
Y
A
P
G
T
L
A
A
A
L
W
A
F
A
-----------
R
-
G
-----------
R
D
F
E
E
G
M
R
L
A
V
N
L
G
G
D
A
D
T
V
G
A
V
Y
G
Q
L
A
G
A
Y
Y
G
L
G
A
I
P
G
R
W
L
R
A
L
H
L
R
E
--
E
M
E
A
L
A
----------
3
PsiBlast_PDB
95.59
28%
-84
- C9 -
2YZW
2
?
A:
[8-290]
-----------------
Q
D
R
R
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
Q
---
V
E
G
L
P
K
----------
G
-
T
F
P
--
E
-------
V
R
--
E
M
K
-
G
--
G
G
P
---
H
R
L
P
P
G
F
W
T
D
D
T
S
Q
A
L
C
L
A
E
S
L
L
-
Q
R-
G
--
F
-
D
----
P
----
K
D
Q
M
D
R
Y
L
R
W
Y
R
E
G
Y
------------
A
T
R
R
A
L
E
R
Y
-------
A
A
-----
T
G
D
P
Y
-----
A
G
D
E
A
G
A
G
N
G
P
L
M
R
L
A
P
L
V
L
A
-
Y
E
--
N
H
P
D
L
---
L
-
S
L
A
R
R
A
---
A
R
T
T
H
-
G
A
R
E
A
L
E
A
T
-----
E
V
L
A
W
L
---------
L
R
E
A
L
R
G
---
A
-
P
K
E
A
L
L
A
---
L
-
E
----------------------------------
P
F
R
GA
D
-
L
-----------
H
P
A
---
L
R
R
V
V
E
----
G
-
G
-
F
W
E
----
A
P
E
------------
E
G
P
-
G
Y
A
P
G
T
L
A
A
A
L
W
A
F
A
-----------
R
-
G
-----------
R
D
F
E
E
G
M
R
L
A
V
N
L
G
G
D
A
D
T
V
G
A
V
Y
G
Q
L
A
G
A
Y
Y
G
L
G
A
I
P
G
R
W
L
R
A
L
H
L
R
E
--
E
M
E
A
L
A
----------
4
PsiBlast_PDB
94.47
28%
-82
- C9 -
1T5J
1
Y1187_METJA
A:
[6-297]
----------------
M
R
D
K
I
L
G
S
V
F
G
A
V
I
G
D
A
L
G
M
P
---
T
E
N
L
T
K
----------
E
-
E
I
K
--
K
L
YGFV
D
S
Y
V
--
E
P
K
-
N
--
Y
L
A
---
G
K
L
N
K
G
E
W
T
D
D
T
E
Q
A
I
C
L
I
K
S
L
T
-
K
E-
G
--
I
-
D
----
I
----
K
K
F
A
N
C
L
I
A
W
K
N
K
N
--
P
P
-----
D
I
G
L
T
S
L
M
A
I
D
K
L
E
N
NDYS
G
V
D
-----
S
S
S
C
G
---------------
A
A
M
R
I
Y
P
L
G
I
V
-
F
H
--
N
N
L
K
------
K
L
K
E
E
V
I
K
A
S
K
I
T
H
-
N
N
K
T
A
I
A
G
A
-----
L
A
I
A
F
F
---------
V
S
S
A
L
K
D
---
R
-
K
D
F
--
S
L
---
L
-
D
E
C
Y
N
Y
I
K
D
-------
I
---
D
E
-----------
E
F
A
K
K
--
L
L
E
-----------
I
K
N
---
F
N
N
L
------
D
-
Y
-
I
Y
D
----
Y
F
G
--
T
-------
G
V
K
T
D
-----
E
V
V
P
S
A
I
A
T
Y
L
-----------
L
-
T
-----------
D
N
F
K
E
G
M
L
K
C
I
N
A
G
G
D
T
D
S
L
A
S
M
Y
G
A
M
A
G
A
Y
Y
G
F
K
N
I
P
K
E
W
I
D
G
L
K
N
K
E
--
V
I
F
E
L
A
E
R
L
-------
30
Fugue
93.75
27%
-75
- C9 -
1T5J
1
Y1187_METJA
A:
[3-303]
-------------
L
V
K
M
R
D
K
I
L
G
S
V
F
G
A
V
I
G
D
A
L
G
M
P
---
T
E
N
L
T
K
----------
E
-
E
I
K
--
K
L
YGFV
D
S
Y
V
--
E
P
K
-
N
--
Y
L
A
---
G
K
L
N
K
G
E
W
T
D
D
T
E
Q
A
I
C
L
I
K
S
L
T
K
E
--
G
--
I
-
D
----
I
----
K
K
F
A
N
C
L
I
A
W
K
N
K
N
-------
P
P
D
I
G
L
T
S
L
M
A
I
D
K
L
E
N
----
N
-----------
D
-----
Y
S
G
V
D
S
S
S
C
G
A
A
M
R
I
Y
P
L
G
I
V
-
F
H
--
N
N
--
L
K
K
L
K
-
E
E
V
I
K
A
---
S
K
I
T
H
-
N
N
K
T
A
I
A
G
A
-----
L
A
I
A
F
F
---------
V
S
S
A
L
K
D
---
R
-
K
D
F
--
S
L
---
L
-
D
E
C
Y
N
Y
I
K
D
-------
I
---
D
----------------
E
--
E
-
F
-----------
A
K
K
---
L
L
E
I
K
N
----
F
-
N
-
N
L
D
----
Y
I
Y
--
D
-------
Y
F
G
T
G
-
V
K
T
D
E
V
V
P
S
A
I
A
T
Y
L
-----------
L
-
T
-----------
D
N
F
K
E
G
M
L
K
C
I
N
A
G
G
D
T
D
S
L
A
S
M
Y
G
A
M
A
G
A
Y
Y
G
F
K
N
I
P
K
E
W
I
D
G
L
K
N
K
E
--
V
I
F
E
L
A
E
R
L
Y
H
L
A
T
E
-
20
HHSearch
93.62
28%
-83
- C9 -
1T5J
1
Y1187_METJA
A:
[3-303]
-------------
L
V
K
M
R
D
K
I
L
G
S
V
F
G
A
V
I
G
D
A
L
G
M
P
---
T
E
N
L
T
K
----------
E
-
E
I
K
K
L
Y
-----
G
F
V
D
--
S
Y
V
-
E
--
P
K
N
YLA
G
K
L
N
K
G
E
W
T
D
D
T
E
Q
A
I
C
L
I
K
S
L
T
K
E
--
G
--
I
-
D
----
I
----
K
K
F
A
N
C
L
I
A
W
K
N
K
N
-------
P
P
D
I
G
L
T
S
L
M
A
I
D
K
L
E
N
----
N
D
----------------
Y
S
G
V
D
S
S
S
C
G
A
A
M
R
I
Y
P
L
G
I
V
F
H
N
--
N
---
L
-
K
K
L
K
E
E
V
I
K
A
---
S
K
I
T
H
-
N
N
K
T
A
I
A
G
A
-----
L
A
I
A
F
F
---------
V
S
S
A
L
K
D
---
R
-
K
D
F
--
S
L
---
L
-
D
E
C
Y
N
Y
I
K
D
-------
I
---
D
-------------
E
E
F
A
--
K
-
K
-----------
L
L
E
---
I
K
N
F
N
-------
N
-
L
-
D
----
Y
I
Y
--
D
-------
Y
F
G
T
G
-
V
K
T
D
E
V
V
P
S
A
I
A
T
Y
L
-----------
L
-
T
-----------
D
N
F
K
E
G
M
L
K
C
I
N
A
G
G
D
T
D
S
L
A
S
M
Y
G
A
M
A
G
A
Y
Y
G
F
K
N
I
P
K
E
W
I
D
G
L
K
N
K
E
--
V
I
F
E
L
A
E
R
L
Y
H
L
A
T
E
-
24
HHSearch
93.00
25%
-87
- C9 -
3O5T
2
?
A:
[3-290]
-------------
D
H
S
I
R
S
R
A
L
G
A
Y
L
G
L
A
C
G
D
A
L
G
A
T
---
V
E
F
L
T
K
----------
G
-
E
I
A
H
Q
Y
-----
G
V
H
K
--
H
I
K
-
G
--
G
G
W
---
L
K
L
P
A
G
Q
V
T
D
D
T
E
M
S
I
H
L
G
R
A
I
L
A
A
P-
E
--
W
-
D
----
A
----
R
R
A
A
E
E
F
A
V
W
L
K
G
V
-------
P
V
D
V
G
D
T
T
R
R
G
I
R
R
F
I
M
----
H
G
T
-----
L
--
S
E
-----
P
E
S
E
Y
H
A
G
N
G
A
A
M
R
N
L
P
V
A
L
A
T
L
G
--
D
---
D
-
A
A
F
E
R
W
T
V
E
Q
---
A
H
I
T
H
-
C
N
A
M
S
D
A
A
T
-----
L
T
L
G
H
M
---------
V
R
R
L
V
L
G
---
G
-
D
V
R
--
D
V
---
R
-
D
E
S
N
K
L
I
A
----------------------------------
K
-----------
H
R
Q
---
F
-----------
K
-
F
Q
------
P
Y
----------
R
G
L
A
T
-
A
Y
I
V
D
T
M
Q
T
V
M
H
Y
Y
F
-----------
Q
-
T
-----------
D
S
V
E
S
C
V
V
E
T
V
N
Q
G
G
D
A
D
T
T
G
A
I
A
G
M
L
A
G
A
T
Y
G
V
E
T
I
P
P
R
W
L
R
K
L
D
R
D
V
---
Y
N
E
I
C
A
Q
V
D
G
L
L
A
R
-
23
HHSearch
92.78
26%
-82
- C9 -
2WOE
4
DRAG_RHORU
A:
[8-296]
-------------
G
P
S
V
H
D
R
A
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
T
---
V
E
F
M
T
K
----------
G
-
E
I
A
Q
Q
Y
-----
G
I
H
R
--
K
M
T
-
G
--
G
G
W
---
L
R
L
K
P
G
Q
I
T
D
D
T
E
M
S
L
A
L
G
R
S
L
A
A
K
G-
T
--
L
-
D
----
V
----
A
D
I
C
E
E
F
A
L
W
L
K
S
R
-------
P
V
N
V
G
N
T
C
R
R
G
I
R
R
Y
M
H
E---
G
T
T
-----
T
A
--------
P
Y
S
E
G
D
A
G
N
G
A
A
M
R
C
L
P
A
A
L
A
T
L
G
--
H
---
P
-
A
D
L
E
P
W
V
L
A
Q
---
A
R
I
T
H
-
N
H
P
L
S
D
A
A
C
-----
L
T
L
G
R
M
---------
V
H
H
L
I
G
G
---
R
-
G
M
K
--
A
C
---
R
-
E
E
A
N
R
L
-------------------------------
V
--
H
-
Q
-----------------
H
---------
R
-
D
-
F
H
-----
F
E
P
--
Y
-------
K
G
Q
S
S
-
A
Y
I
V
D
T
M
Q
T
V
L
H
Y
Y
F
-----------
V
-
T
-----------
D
T
F
K
S
C
L
I
Q
T
V
N
Q
G
G
D
A
D
T
T
G
A
L
A
G
M
L
A
G
A
T
Y
G
V
D
D
I
P
S
G
W
L
S
K
L
D
M
K
V
E
R
E
I
R
R
Q
V
D
A
L
L
A
L
A
---
6
PsiBlast_PDB
89.83
25%
-74
- C9 -
2WOD
3
DRAG_RHORU
A:
[11-280]
----------------
V
H
D
R
A
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
T
---
V
E
F
M
T
K
----------
G
-
E
I
A
--
Q
-----
Q
Y
G
I
HR
K
M
T
-
G
--
G
G
W
---
L
R
L
K
P
G
Q
I
T
D
D
T
E
M
S
L
A
L
G
R
S
L
A
-
A
K
G
T
--
L
-
D
----
V
----
A
D
I
C
E
E
F
A
L
W
L
K
S
-------
R
P
V
D
V
G
N
T
C
R
R
G
I
R
R
Y
M
H
E---
G
T
T
-----
T
A
P
--------
Y
S
E
G
D
A
G
N
G
A
A
M
R
C
L
P
A
A
L
A
--------
T
L
G
H
P
A
-
D
L
E
P
W
V
L
A
Q
A
R
I
T
H
-
N
H
P
L
S
D
A
A
C
-----
L
T
L
G
R
M
---------
V
H
H
L
I
G
G
---
R
-
G
M
K
--
A
C
---
R
-
E
E
-
A
N
R
L
V
H
-------
Q
---
H
R
-----------
D
F
H
F
------------------
E
P
---
Y
K
G
---------------------------------
Q
S
S
-
A
Y
I
V
D
T
M
Q
T
V
L
H
Y
Y
F
-----------
V
-
T
-----------
D
T
F
K
S
C
L
I
Q
T
V
N
Q
G
G
D
A
D
T
T
G
A
L
A
G
M
L
A
G
A
T
Y
G
V
D
D
I
P
S
G
W
L
S
K
L
D
M
K
-------------------
5
PsiBlast_PDB
89.67
25%
-70
- C9 -
2WOC
6
DRAG_RHORU
A:
[11-280]
----------------
V
H
D
R
A
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
T
---
V
E
F
M
T
K
----------
G
-
E
I
A
--
Q
-----
Q
Y
G
I
HR
K
M
T
-
G
--
G
G
W
---
L
R
L
K
P
G
Q
I
T
D
D
T
E
M
S
L
A
L
G
R
S
L
A
-
A
K
G
T
--
L
-
D
----
V
----
A
D
I
C
E
E
F
A
L
W
L
K
S
-------
R
P
V
D
V
G
N
T
C
R
R
G
I
R
R
Y
M
H
E---
G
T
T
-----
T
A
P
--------
Y
S
E
G
D
A
G
N
G
A
A
M
R
C
L
P
A
A
L
A
--------
T
L
G
H
P
A
-
D
L
E
P
W
V
L
A
Q
A
R
I
T
H
-
N
H
P
L
S
D
A
A
C
-----
L
T
L
G
R
M
---------
V
H
H
L
I
G
G
---
R
-
G
M
K
--
A
C
---
R
-
E
E
-
A
N
R
L
V
H
-------
Q
---
H
R
-----------
D
F
H
F
------------------
E
P
---
Y
K
G
---------------------------------
Q
S
S
-
A
Y
I
V
D
T
M
Q
T
V
L
H
Y
Y
F
-----------
V
-
T
-----------
D
T
F
K
S
C
L
I
Q
T
V
N
Q
G
G
D
A
D
T
T
G
A
L
A
G
M
L
A
G
A
T
Y
G
V
D
D
I
P
S
G
W
L
S
K
L
D
M
K
-------------------
9
PsiBlast_PDB
88.46
25%
-68
- C9 -
2WOE
4
DRAG_RHORU
A:
[11-280]
----------------
V
H
D
R
A
L
G
A
F
L
G
L
A
V
G
D
A
L
G
A
T
---
V
E
F
M
T
K
----------
G
-
E
I
A
--
Q
-----
Q
Y
G
I
HR
K
M
T
-
G
--
G
G
W
---
L
R
L
K
P
G
Q
I
T
D
D
T
E
M
S
L
A
L
G
R
S
L
A
-
A
K
G
T
--
L
-
D
----
V
----
A
D
I
C
E
E
F
A
L
W
L
K
S
-------
R
P
V
N
V
G
N
T
C
R
R
G
I
R
R
Y
M
H
E---
G
T
T
-----
T
A
P
--------
Y
S
E
G
D
A
G
N
G
A
A
M
R
C
L
P
A
A
L
A
--------
T
L
G
H
P
A
-
D
L
E
P
W
V
L
A
Q
A
R
I
T
H
-
N
H
P
L
S
D
A
A
C
-----
L
T
L
G
R
M
---------
V
H
H
L
I
G
G
---
R
-
G
M
K
--
A
C
---
R
-
E
E
-
A
N
R
L
V
H
-------
Q
---
H
R
-----------
D
F
H
F
E
--
P
-------------------
Y
K
G
---------------------------------
Q
S
S
-
A
Y
I
V
D
T
M
Q
T
V
L
H
Y
Y
F
-----------
V
-
T
-----------
D
T
F
K
S
C
L
I
Q
T
V
N
Q
G
G
D
A
D
T
T
G
A
L
A
G
M
L
A
G
A
T
Y
G
V
D
D
I
P
S
G
W
L
S
K
L
D
M
K
-------------------
22
HHSearch
84.04
20%
-86
- C9 -
2FOZ
2
ARHL2_HUMAN
A:
[2-346]
---------------
A
S
L
S
R
F
R
G
C
L
A
G
A
L
L
G
D
C
V
G
S
F
---
Y
E
A
H
D
T
----------
V
-
D
L
T
S
V
L
-----
R
H
V
Q
--
S
L
E
-
P
DP---------
E
A
L
Y
Y
T
D
D
T
A
M
A
R
A
L
V
Q
S
L
L
A
K
E-
A
--
F
-
D
----
E
----
V
D
M
A
H
R
F
A
Q
E
Y
K
K
D
P
------
D
R
G
Y
G
A
G
V
V
T
V
F
K
K
L
L
N
----
P
K
C
RDVF
E
P
A
R
A
Q
-----
F
N
G
K
G
S
Y
G
N
G
G
A
M
R
V
A
G
I
S
L
A
-
Y
S
--
S
---
V
-
Q
D
V
Q
K
F
A
R
L
S
---
A
Q
L
T
H
-
A
S
S
L
G
Y
N
G
A
-----
I
L
Q
A
L
A
---------
V
H
L
A
L
Q
G
---
E
-
S
S
S
--
E
H
F
--
L
-
K
Q
L
L
G
H
M
E
D
-------
L
E
G
D
A
Q
S
V
L
D
A
R
E
L
GME
E
R
P
Y
S
--
S
-
R
-----------
L
K
K
---
I
G
E
L
L
D
----
Q
A
S
V
T
R
E
----
E
V
V
--
S
-------
E
L
G
N
G
-
I
A
A
F
E
S
V
P
T
A
I
Y
C
F
L
-----------
R
-
C
MEPDPEIPSAF
N
S
L
Q
R
T
L
I
Y
S
I
S
L
G
G
D
T
D
T
I
A
T
M
A
G
A
I
A
G
A
Y
Y
G
M
D
Q
V
P
E
S
W
Q
Q
S
C
E
G
Y
E
--
E
T
D
I
L
A
Q
S
L
H
R
V
F
Q
K
-
25
HHSearch
83.23
19%
-74
* C9 *
3HFW
4
ADPRH_HUMAN
A:
[1-350]
-----------------
M
E
K
Y
V
A
A
M
V
L
S
A
A
G
D
A
L
G
Y
Y
NGK
W
E
F
L
Q
D
----------
G
E
K
I
H
--
R
------
Q
L
A
--
Q
L
G
-
G
--
L
D
A
---
L
D
V
G
R
W
R
V
S
D
D
T
V
M
H
L
A
T
A
E
A
L
V
E
A
G-
K
--
A
P
K
----
L
T
Q
L
Y
Y
L
L
A
K
H
Y
Q
D
C
M
E
D
M
D
-----
G
R
A
P
G
G
A
S
V
H
N
A
M
Q
-
L
K
P
----
G
K
P
-----
N
G
W
R
I
-----
P
F
N
S
H
E
G
G
C
G
A
A
M
R
A
M
C
I
G
L
R
F
P
H
HS
Q
---
L
-
D
T
L
I
Q
V
S
I
E
S
---
G
R
M
T
H
-
H
H
P
T
G
Y
L
G
A
-----
L
A
S
A
L
F
---------
T
A
Y
A
V
N
S
---
R
-
P
P
L
--
Q
W
G
K
G
L
-
M
E
L
L
P
E
A
K
K
-------
Y
---
I
V
Q
----------
S
G
Y
F
V
--
E
-
E
N
L
Q
H
W
S
Y
F
Q
T
K
W
E
N
Y
L
K
L
R
G
I
L
D
GESA
P
-
T
-
F
P
E
SFG
V
K
E
R
--
D
Q
F
Y
T
S
L
S
Y
S
G
W
G
G
S
S
G
H
D
A
P
M
I
A
Y
D
A
V
L
-----------
A
A
G
-----------
D
S
W
K
E
L
A
H
R
A
F
F
H
G
G
D
S
D
S
T
A
A
I
A
G
C
W
W
G
V
M
Y
G
F
K
G
V
S
P
S
N
Y
E
K
L
E
Y
R
N
--
R
L
E
E
T
A
R
A
L
Y
S
L
G
S
K
-
11
PsiBlast_PDB
80.83
22%
-74
- C9 -
2G4K
4
ARHL2_HUMAN
A:
[6-323]
-------------------
R
F
R
G
C
L
A
G
A
L
L
G
D
C
V
G
S
F
---
Y
E
A
H
D
T
VD
L
T
S
V
L
R
H
V
Q
-
S
L
E
--
P
-----
D
P
--------------------
E
A
L
Y
Y
T
D
D
T
A
M
A
R
A
L
V
Q
S
L
L
-
A
K
E
A
--
F
-
D
E
V
D
M
A
----
H
R
F
A
Q
E
Y
K
K
D
P
D
R
G
Y
G
A
G
V
V
T
V
F
------
K
K
L
L
N
--
P
K
----
C
R
D
-----
V
F
E
P
A
R
A
QFN
G
K
G
S
Y
--
G
N
G
G
A
M
R
V
A
G
I
S
L
A
-
Y
S
-----
S
V
Q
D
V
Q
-
K
F
A
R
L
S
---
A
Q
L
T
H
-
A
S
S
L
G
Y
N
G
A
I
L
Q
A
L
A
V
H
L
A
L
Q
GESS
S
E
H
F
L
K
Q
L
L
G
H
---
M
E
D
L
E
--
G
D
---
A
-
Q
S
V
L
D
A
R
E
L
-------
G
---
M
E
-----------
E
R
P
Y
S
--
S
-
R
-----------
L
K
K
---
I
G
E
L
L
D
----
Q
-
A
-
S
V
T
----
R
E
E
V
V
S
-------
E
L
G
N
G
-
I
A
A
F
E
S
V
P
T
A
I
Y
C
F
L
-----------
R
-
C
MEPDPEIPSAF
N
S
L
Q
R
T
L
I
Y
S
I
S
L
G
G
D
T
D
T
I
A
T
M
A
G
A
I
A
G
A
Y
Y
G
M
D
Q
V
P
E
S
W
--------------------------
10
PsiBlast_PDB
80.70
22%
-66
- C9 -
2QTY
2
ARHL2_MOUSE
A:
[6-323]
-------------------
R
F
R
G
C
L
A
G
A
L
L
G
D
C
V
G
A
V
---
Y
E
A
H
D
T
VS
L
A
S
V
L
S
H
V
E
-
S
L
E
--
P
---------------------------
E
T
L
Y
Y
T
D
D
T
A
M
T
R
A
L
V
Q
S
L
L
-
A
K
E
A
--
F
-
D
E
V
D
M
A
----
H
R
F
A
Q
E
Y
K
K
D
P
D
R
G
Y
G
A
G
V
I
T
V
F
K
-
K
L
L
N
P
K
C
R
D
V
Y
E
P
----
A
R
A
-----
Q
F
N
-------
G
K
G
S
Y
--
G
N
G
G
A
M
R
V
A
G
I
S
L
A
-
Y
S
--
S
V
Q
D
V
Q
K
F
A
-
R
L
S
A
Q
L
---
T
H
A
S
S
L
G
Y
N
G
A
I
L
Q
A
-----
L
A
V
H
L
A
---------
L
Q
G
V
S
S
S
E
H
F
L
-
E
Q
L
--
L
G
---
H
M
E
E
L
E
G
D
A
Q
S
V
L
D
A
K
E
L
G
---
M
E
-----------
E
R
P
Y
S
--
S
-
R
-----------
L
K
K
---
V
G
E
L
L
D
----
Q
-
D
-
V
V
S
----
R
E
E
V
V
S
-------
E
L
G
N
G
-
I
A
A
F
E
S
V
P
T
A
I
Y
C
F
L
R
C
MEPHPEIPS
T
-
F
-----------
N
S
L
Q
R
T
L
I
Y
S
I
S
L
G
G
D
T
D
T
I
A
T
M
A
G
A
I
A
G
A
Y
Y
G
M
E
Q
V
P
E
S
W
--------------------------
13
PsiBlast_PDB
80.20
22%
-76
- C9 -
2FP0
2
ARHL2_HUMAN
A:
[6-323]
-------------------
R
F
R
G
C
L
A
G
A
L
L
G
D
C
V
G
S
F
---
Y
E
A
H
D
T
VD
L
T
S
V
L
R
H
V
Q
-
S
L
E
--
P
-----
D
P
--------------------
E
A
L
Y
Y
T
D
D
T
A
M
A
R
A
L
V
Q
S
L
L
-
A
K
E
A
--
F
-
D
E
V
D
M
A
----
H
R
F
A
Q
E
Y
K
K
D
P
D
R
G
Y
G
A
G
V
V
T
V
F
------
K
K
L
L
N
--
P
K
----
C
R
D
-----
V
F
E
P
A
R
A
QFN
G
K
G
S
Y
--
G
N
G
G
A
M
R
V
A
G
I
S
L
A
-
Y
S
-----
S
V
Q
D
V
Q
-
K
F
A
R
L
S
---
A
Q
L
T
H
-
A
S
S
L
G
Y
N
G
A
I
L
Q
A
L
A
V
H
L
A
L
Q
GESS
S
E
H
F
L
K
Q
L
L
G
H
---
M
E
D
L
E
--
G
D
---
A
-
Q
S
V
L
D
A
R
E
L
-------
G
---
M
E
-----------
E
R
P
Y
S
--
S
-
R
-----------
L
K
K
---
I
G
E
L
L
D
----
Q
-
A
-
S
V
T
----
R
E
E
V
V
S
-------
E
L
G
N
G
-
I
A
A
F
E
S
V
P
T
A
I
Y
C
F
L
-----------
R
-
C
MEPDPEIPSAF
N
S
L
Q
R
T
L
I
Y
S
I
S
L
G
G
D
T
D
T
I
A
T
M
A
G
A
I
A
G
A
Y
Y
G
M
D
Q
V
P
E
S
W
--------------------------
12
PsiBlast_PDB
80.05
22%
-76
- C9 -
2FOZ
2
ARHL2_HUMAN
A:
[6-323]
-------------------
R
F
R
G
C
L
A
G
A
L
L
G
D
C
V
G
S
F
---
Y
E
A
H
D
T
VD
L
T
S
V
L
R
H
V
Q
-
S
L
E
--
P
-----
D
P
--------------------
E
A
L
Y
Y
T
D
D
T
A
M
A
R
A
L
V
Q
S
L
L
-
A
K
E
A
--
F
-
D
E
V
D
M
A
----
H
R
F
A
Q
E
Y
K
K
D
P
D
R
G
Y
G
A
G
V
V
T
V
F
------
K
K
L
L
N
--
P
K
----
C
R
D
-----
V
F
E
P
A
R
A
QFN
G
K
G
S
Y
--
G
N
G
G
A
M
R
V
A
G
I
S
L
A
-
Y
S
-----
S
V
Q
D
V
Q
-
K
F
A
R
L
S
---
A
Q
L
T
H
-
A
S
S
L
G
Y
N
G
A
I
L
Q
A
L
A
V
H
L
A
L
Q
GESS
S
E
H
F
L
K
Q
L
L
G
H
---
M
E
D
L
E
--
G
D
---
A
-
Q
S
V
L
D
A
R
E
L
-------
G
---
M
E
-----------
E
R
P
Y
S
--
S
-
R
-----------
L
K
K
---
I
G
E
L
L
D
----
Q
-
A
-
S
V
T
----
R
E
E
V
V
S
-------
E
L
G
N
G
-
I
A
A
F
E
S
V
P
T
A
I
Y
C
F
L
-----------
R
-
C
MEPDPEIPSAF
N
S
L
Q
R
T
L
I
Y
S
I
S
L
G
G
D
T
D
T
I
A
T
M
A
G
A
I
A
G
A
Y
Y
G
M
D
Q
V
P
E
S
W
--------------------------