@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3001: (2016-02-12 )
MIPLIGQLYRNNNVVTSIHGRGLINRSVIAIMKAHRFARHRMADDAELSVHETFPILKAMSELKLGAASVDLGKMVAKFKAEGNGRSIEDFVKAELAEVVGKQNGDAREGTDVVLYGFGRIGRLLARILIEKTGGGDGLRLRAIVVRKGAENDLVKRASLLRRDSVHGPFDGTITIDEENNTLTANGNLIQVIYSNDPASIDYTQYGIKNALLVDNTGKWRDAEGLGQHLKCPGIDRVVLTAPGKGALKNIVHGINHTDIGADDKIISAASCTTNAIVPVLKAVNDQYGIVNGHVETVHSYTNDQNLIDNFHKGSRRGRSAPLNMVITETGAATAAAKALPVLKGKLTGNAIRVPTPNVSMAILNLNLEKATTREEINEYLRQMAMHSDLQKQIDFVSSQEVVSTDFVGSRHAGVVDAEATICNDNRVVLYVWYDNEFGYSCQVVRVMEDMAGVNPPAFPR
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.----.---...---..-160.......170.-.......180.......190.......200.......210.......220.----......230........240....-...250.......260-..-.....270.......280.......290.......300.......310.---.-..--....320.......330.......340.......350.......360.......370-........380.....------..-----390.......400.......410.......420..-......-430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIP
L
I
G
Q
L
YRNN
N
V
V
T
S
IHGRGL
I
N
R
S
V
I
A
I
M
K
A
H
R
F
A
R
H
RMADDA
E
L
S
V
H
E
T
F
P
I
L
K
A
M
S
E
LKLGAAS
V
D
L
G
K
M
V
A
K
FKAEGNGR
S
I
E
D
F
V
K
A
E
L
A
E
V
V
GKQNGDAREG
T
D
V
V
L
Y
G
F
G
R
I
G
R
L
L
A
R
I
L
I
EKTGGGD
G
L
R
L
R
A
I
V
V
RKGAE
N
D
----
L
---
V
K
R
---
A
S
-
L
L
R
RDSVHGPF-D
G
-
T
I
T
I
DEEN
N
T
L
TANG
N
L
I
Q
V
I
YSNDPASI
D
Y
T
QYGIK
N
A
L
L
VDNTGKWR
D
A
----
E
GLGQHL-KCPGI
D
R
V
V
L
TAPG
K
G
-
A
L
K
N
I
V
HGINHTDIGA-DD-
K
I
I
S
AASC
T
T
N
A
I
V
P
V
L
K
A
VNDQYGIVNGH
V
E
T
V
H
SYTN
D
Q
N
L
I
D
N
-
F
H
---K-GS--RRGRSAP
L
N
M
V
I
TETGAA
T
A
A
A
K
AL
P
V
L
KGKLTG
N
A
I
RVPTPN
V
S
M
A
I
L
N
LNLEK-A-T
T
R
E
E
I
N
E
Y
L
R
Q
M
A
M
H
------
S
D
-----
L
Q
K
Q
I
D
FVSSQE
V
V
STDFVGSRHA
G
V
V
D
A
E
A
T
-
I
C-ND
N
R
V
V
-
L
Y
V
W
YDNEFGY
S
C
Q
V
V
R
V
M
E
D
M
AGVNPPAFPR
111
HHSearch
93.98
37%
-98
- C8 -
3HJA
6
G3P_BORBU
A:
[22-355]
--------------------------------------------------------------------------------------------------------------
M
K
L
A
I
N
G
F
G
R
I
G
R
N
V
F
K
I
A
F
E
R
-----
G
I
D
I
V
A
I
N
D
L
T
----
D
----
P
---
K
T
L
---
A
H
-
L
L
K
Y
D
S
T
F
G
V
Y
-
N
K
-
K
V
E
S
--
R
D
G
A
I
V
V
D
G
R
E
I
K
I
I
A
E
R
D
P
K
N
L
P
W
A
K
L
G
I
D
--
V
V
I
E
S
T
G
V
F
S
S
A
TSDK
G
G
Y
L
D
H
V
N
H
A
-
G
A
K
K
V
I
L
T
V
P
A
K
D
-
E
I
K
T
I
V
L
G
V
N
D
H
D
I
N
S
-
D
L
-
K
A
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
H
E
S
F
G
I
E
Q
G
L
M
T
T
V
H
A
Y
T
N
D
Q
R
I
L
D
L
-
P
H
---
S
-
D
L
--
R
R
A
R
A
A
A
L
S
I
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
N
G
T
S
M
R
V
P
V
P
T
G
S
I
V
D
L
T
V
Q
L
K
K
K
D
-
V
T
K
E
E
I
N
S
V
L
R
K
A
S
E
T
------
P
E
-----
L
K
G
I
L
G
Y
T
E
-
D
P
I
V
S
S
D
I
K
G
N
S
H
S
S
I
V
D
G
L
E
T
-
M
V
L
E
N
G
F
A
K
-
I
L
S
W
Y
D
N
E
F
G
Y
S
T
R
V
V
D
L
A
Q
K
L
V
---------
84
PsiBlast_CBE
93.26
41%
-86
- C8 -
4O59
2
G3P_BOVIN
O:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
107
HHSearch
93.05
36%
-103
- C8 -
2B4R
4
?
O:
[11-344]
-------------------------------------------------------------------------------------------------------------
A
T
K
L
G
I
N
G
F
G
R
I
G
R
L
V
F
R
A
A
F
G
R
----
K
D
I
E
V
V
A
I
N
D
P
F
M
---
D
----
L
---
N
H
L
---
C
Y
-
L
L
K
Y
D
S
V
H
G
Q
F
-
P
C
-
E
V
T
H
--
A
D
G
F
L
L
I
G
E
K
K
V
S
V
F
A
E
K
D
P
S
Q
I
P
W
G
K
C
Q
V
D
--
V
V
C
E
S
T
G
V
F
L
T
K
----
E
L
A
S
S
H
L
-
K
G
-
G
A
K
K
V
I
M
S
A
P
P
K
D
-
D
T
P
I
Y
V
M
G
I
N
H
H
Q
Y
D
T
-
K
Q
-
L
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
R
F
G
I
V
E
G
L
M
T
T
V
H
A
S
T
A
N
Q
L
V
V
D
G
-
P
S
KGG
K
-
D
W
--
R
A
G
R
C
A
L
S
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
V
A
F
R
V
P
I
G
T
V
S
V
V
D
L
V
C
R
L
Q
K
-
P
-
A
K
Y
E
E
V
A
L
E
I
K
K
A
A
-
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
-
D
E
V
V
S
Q
D
F
V
H
D
N
R
S
S
I
F
D
M
K
A
G
-
L
A
L
N
D
N
F
F
K
-
L
V
S
W
Y
D
N
E
W
G
Y
S
N
R
V
L
D
L
A
V
H
I
T
T
--------
80
PsiBlast_CBE
93.04
41%
-86
- C8 -
4O63
1
G3P_BOVIN
O:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
77
PsiBlast_CBE
92.72
41%
-87
- C8 -
4O63
1
G3P_BOVIN
R:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
81
PsiBlast_CBE
92.71
41%
-87
- C8 -
4O59
2
G3P_BOVIN
R:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
83
PsiBlast_CBE
92.69
41%
-89
- C8 -
4O59
2
G3P_BOVIN
P:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
78
PsiBlast_CBE
92.67
41%
-88
- C8 -
4O63
1
G3P_BOVIN
Q:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
82
PsiBlast_CBE
92.50
41%
-85
- C8 -
4O59
2
G3P_BOVIN
Q:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
79
PsiBlast_CBE
92.49
41%
-86
- C8 -
4O63
2
G3P_BOVIN
P:
[7-329]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
-
S
G
K
V
D
------
I
V
A
I
N
D
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
N
G
-
T
V
--
K
A
E
N
G
K
L
V
I
N
G
K
A
I
T
I
F
Q
E
R
D
P
A
N
I
K
W
G
D
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
G
-
G
A
K
R
V
I
I
S
A
P
S
A
D
-
A
-
P
M
F
V
M
G
V
N
H
E
K
Y
N
N
-
T
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
G--
K
-
L
W
--
R
D
G
R
G
A
A
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
E
I
K
K
V
V
K
Q
-
A
S
E
------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
Q
-
V
V
S
C
D
F
N
S
D
T
H
S
S
T
F
D
A
G
A
G
-
I
A
L
N
D
H
F
V
K
-
L
I
S
W
Y
D
N
E
F
G
Y
S
N
R
V
V
D
L
M
V
H
M
A
---------
112
HHSearch
92.11
40%
-102
- C8 -
1HDG
3
G3P_THEMA
O:
[1-332]
--------------------------------------------------------------------------------------------------------------
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
--
K
N
P
D
I
E
V
V
A
I
N
D
L
T
----
D
----
T
---
K
T
L
---
A
H
-
L
L
K
Y
D
S
V
H
K
K
F
-
P
G
-
K
V
E
Y
--
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
--
F
V
I
E
S
T
G
V
F
R
N
R
----
E
K
A
E
L
H
L
-
Q
A
-
G
A
K
K
V
I
I
T
A
P
A
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
-
P
H
---
K
-
D
L
--
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-
E
------
G
R
-----
L
K
G
I
I
G
Y
N
D
-
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
-
N
V
I
G
G
K
L
V
K
-
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
-------
121
HHSearch
91.91
37%
-102
- C8 -
3V1Y
2
G3PC1_ORYSJ
O:
[2-336]
------------------------------------------------------------------------------------------------------------
G
K
I
K
I
G
I
N
G
F
G
R
I
G
R
L
V
A
R
V
A
L
Q
S
----
E
D
V
E
L
V
A
V
N
D
P
F
---
I
T
----
T
---
D
Y
M
---
T
Y
-
M
F
K
Y
D
T
V
H
G
Q
W
-
K
H
S
D
I
K
I
K
-
D
S
K
T
L
L
L
G
E
K
P
V
T
V
F
G
I
R
N
P
D
E
I
P
W
A
E
A
G
A
E
--
Y
V
V
E
S
T
G
V
F
T
D
K
----
E
K
A
A
A
H
L
-
K
G
-
G
A
K
K
V
V
I
S
A
P
S
K
D
--
A
P
M
F
V
C
G
V
N
E
D
K
Y
T
S
-
D
I
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
-
P
S
---
S
K
D
W
--
R
G
G
R
A
A
S
F
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
D
L
N
G
K
L
T
G
M
S
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
R
I
E
K
-
A
-
A
S
Y
D
A
I
K
S
A
I
K
S
A
S
-
E
------
G
K
-----
L
K
G
I
I
G
Y
V
E
-
E
D
L
V
S
T
D
F
V
G
D
S
R
S
S
I
F
D
A
K
A
G
-
I
A
L
N
D
N
F
V
K
-
L
V
A
W
Y
D
N
E
W
G
Y
S
N
R
V
I
D
L
I
R
H
M
A
K
T
-------
9
PsiBlast_PDB
91.89
39%
-101
- C8 -
1RM3
5
G3PA_SPIOL
O:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
G
G
----------
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
113
HHSearch
91.80
39%
-104
- C8 -
3CPS
1
?
A:
[18-353]
--------------------------------------------------------------------------------------------------------------
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
R
----
N
D
I
T
V
V
A
I
N
D
P
F
M
---
D
----
V
---
E
Y
M
---
A
Y
-
L
L
K
Y
D
S
V
H
G
N
F
-
N
G
-
T
V
E
V
--
S
G
-
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
--
I
V
C
E
S
T
G
V
F
T
T
E
----
E
K
A
S
L
H
L
-
K
G
-
G
A
K
K
V
I
I
S
A
P
P
K
D
-
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
-
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
-
P
S
KG---
D
W
--
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
-
N
------
G
P
-----
M
K
G
I
M
G
Y
T
S
-
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
-
I
A
L
N
D
S
F
V
K
-
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
------
109
HHSearch
91.50
36%
-102
- C8 -
3DOC
2
?
A:
[1-334]
------------------------------------------------------------------------------------------------------------
M
A
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
V
E
S
--
G
R
T
D
I
Q
V
V
A
I
N
D
L
G
----
P
----
V
---
E
T
N
---
A
H
-
L
L
R
Y
D
S
V
H
G
R
F
-
P
K
-
E
V
E
V
--
A
G
D
T
I
D
V
G
Y
G
P
I
K
V
H
A
V
R
N
P
A
E
L
P
W
K
E
E
N
V
D
--
I
A
L
E
C
T
G
I
F
T
S
R
----
D
K
A
A
L
H
L
-
E
A
-
G
A
K
R
V
I
V
S
A
P
A
D
G
-
A
D
L
T
V
V
Y
G
V
N
N
D
K
L
T
K
-
D
H
-
L
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
N
D
T
I
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
T
L
D
T
-
M
H
---
K
-
D
L
--
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
K
L
D
G
V
A
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
I
A
K
R
-
E
-
T
T
V
E
E
V
N
N
A
I
R
E
A
A
-
N
------
G
R
-----
L
K
G
I
L
G
Y
T
D
-
E
K
L
V
S
H
D
F
N
H
D
S
H
S
S
V
F
H
T
D
Q
T
-
K
V
M
D
G
T
M
V
R
-
I
L
S
W
Y
D
N
E
W
G
F
S
S
R
M
S
D
T
A
V
A
L
G
K
L
-------
38
PsiBlast_CBE
91.21
39%
-102
- C8 -
1RM3
6
G3PA_SPIOL
A:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
G
G
----------
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
122
HHSearch
90.69
39%
-98
- C8 -
2D2I
3
?
A:
[1-338]
------------------------------------------------------------------------------------------------------------
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
--
Q
N
T
D
L
E
V
V
A
I
N
N
T
S
----
D
----
A
---
R
T
A
---
A
H
-
L
L
E
Y
D
S
V
L
G
R
F
-
N
A
-
D
I
S
Y
--
D
E
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
--
L
V
I
E
S
T
G
V
F
V
T
A
----
E
G
A
S
K
H
I
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
A
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
-
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
-
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-
Q
------
T
T
-----
M
K
G
I
I
K
Y
S
D
-
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
-
L
V
M
D
G
D
L
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
S
G
-----
93
PsiBlast_CBE
90.45
36%
-91
- C8 -
4BOY
1
?
A:
[21-350]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
N
S
-----
K
L
E
I
V
G
I
N
D
T
S
D
----
P
---
R
T
N
---
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
-
E
I
T
A
D
D
D
--
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
----
E
G
A
S
K
H
L
-
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
--------
E
T
-----
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
V
K
-
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
---------
11
PsiBlast_PDB
90.39
39%
-101
- C8 -
1RM4
3
G3PA_SPIOL
O:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
115
HHSearch
90.33
39%
-96
- C8 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--------------------------------------------------------------------------------------------------------------
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
----
E
E
I
E
I
V
A
I
N
D
L
T
----
D
----
A
---
K
H
L
---
A
H
-
L
L
K
Y
D
S
V
H
G
I
F
-
K
G
-
S
V
E
A
--
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
--
V
V
I
E
A
T
G
V
F
R
D
R
----
E
N
A
S
K
H
L
-
Q
G
-
G
A
K
K
V
I
I
T
A
P
A
K
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
-
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
-
P
H
---
K
-
D
F
--
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGK
V
Y
-----
L
K
E
I
L
Q
Y
C
E
-
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
-
Q
V
-
I
D
N
L
V
H
-
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
-------
45
PsiBlast_CBE
90.18
39%
-102
- C8 -
1RM5
5
G3PA_SPIOL
B:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
A
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
37
PsiBlast_CBE
89.93
39%
-99
- C8 -
1RM3
5
G3PA_SPIOL
B:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
N
D
A
G
G
----------
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
96
PsiBlast_CBE
89.86
36%
-88
- C8 -
3ZCX
1
?
B:
[21-350]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
N
S
-----
K
L
E
I
V
G
I
N
D
T
S
D
----
P
---
R
T
N
---
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
-
E
I
T
A
D
D
D
--
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
----
E
G
A
S
K
H
L
-
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
--------
E
T
-----
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
V
K
-
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
---------
95
PsiBlast_CBE
89.79
36%
-92
- C8 -
3ZDF
2
?
A:
[21-350]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
N
S
-----
K
L
E
I
V
G
I
N
D
T
S
D
----
P
---
R
T
N
---
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
-
E
I
T
A
D
D
D
--
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
----
E
G
A
S
K
H
L
-
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
--------
E
T
-----
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
V
K
-
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
---------
14
PsiBlast_PDB
89.77
39%
-104
- C8 -
1RM5
4
G3PA_SPIOL
O:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
A
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
94
PsiBlast_CBE
89.66
36%
-91
- C8 -
3ZDF
2
?
B:
[21-350]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
N
S
-----
K
L
E
I
V
G
I
N
D
T
S
D
----
P
---
R
T
N
---
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
-
E
I
T
A
D
D
D
--
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
----
E
G
A
S
K
H
L
-
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
--------
E
T
-----
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
V
K
-
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
---------
92
PsiBlast_CBE
89.60
36%
-89
- C8 -
4BOY
1
?
B:
[21-350]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
N
S
-----
K
L
E
I
V
G
I
N
D
T
S
D
----
P
---
R
T
N
---
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
-
E
I
T
A
D
D
D
--
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
----
E
G
A
S
K
H
L
-
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
--------
E
T
-----
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
V
K
-
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
---------
46
PsiBlast_CBE
89.58
39%
-102
- C8 -
1RM5
5
G3PA_SPIOL
A:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
A
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
97
PsiBlast_CBE
89.52
36%
-89
- C8 -
3ZCX
1
?
A:
[21-350]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
A
N
S
-----
K
L
E
I
V
G
I
N
D
T
S
D
----
P
---
R
T
N
---
A
H
-
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
-
E
I
T
A
D
D
D
--
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
--
L
V
I
E
A
T
G
V
F
T
S
R
----
E
G
A
S
K
H
L
-
S
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
N
I
P
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
-
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
-
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
--------
E
T
-----
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
-
G
G
N
L
V
K
-
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
---------
42
PsiBlast_CBE
89.42
39%
-100
- C8 -
1RM4
6
G3PA_SPIOL
A:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
43
PsiBlast_CBE
89.34
39%
-102
- C8 -
1NBO
4
G3PA_SPIOL
B:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
116
HHSearch
89.26
37%
-102
- C8 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-------------------------------------------------------------------------------------------------------------
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
R
----
P
N
V
E
V
V
A
L
N
D
P
F
---
I
T
----
N
---
D
Y
A
---
A
Y
-
M
F
K
Y
D
S
T
H
G
R
Y
-
A
G
-
E
V
S
H
--
D
D
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
--
I
A
I
D
S
T
G
V
F
K
E
L
----
D
T
A
Q
K
H
I
-
D
A
-
G
A
K
K
V
V
I
T
A
P
S
S
T
--
A
P
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
-
P
S
H--
K
-
D
W
--
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
-
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
-
E
------
G
K
-----
L
K
G
V
L
G
Y
T
E
-
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
-
I
Q
L
S
P
K
F
V
K
-
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
--------
41
PsiBlast_CBE
89.13
39%
-101
- C8 -
1RM4
5
G3PA_SPIOL
B:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
120
HHSearch
88.99
37%
-93
- C8 -
3H9E
10
G3PT_HUMAN
O:
[6-341]
------------------------------------------------------------------------------------------------------------
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
K
-----
G
V
K
V
V
A
V
N
D
P
F
---
I
D
----
P
---
E
Y
M
---
V
Y
-
M
F
K
Y
D
S
T
H
G
R
Y
-
K
G
-
S
V
E
F
--
R
N
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
--
Y
V
V
E
S
T
G
V
Y
L
S
I
----
Q
A
A
S
D
H
I
-
S
A
-
G
A
Q
R
V
V
I
S
A
P
S
P
D
--
A
P
M
F
V
M
G
V
N
E
N
D
Y
N
P
G
S
M
-
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
-
P
S
---
R
K
A
W
--
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
-
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
-
K
------
G
P
-----
M
A
G
I
L
A
Y
T
E
-
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
-
I
A
L
N
D
N
F
V
K
-
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
A
E
----
108
HHSearch
88.89
38%
-100
- C8 -
1RM4
3
G3PA_SPIOL
O:
[1-336]
-------------------------------------------------------------------------------------------------------------
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
R
K
--
D
S
P
L
D
V
V
V
I
N
D
T
G
----
G
----
V
---
K
Q
A
---
S
H
-
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
A
-
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
-
D
------
N
E
-----
L
K
G
I
L
S
V
C
D
-
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
-
M
V
M
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
-----
85
PsiBlast_CBE
88.59
39%
-95
- C8 -
1JN0
3
G3PA_SPIOL
O:
[4-330]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
-----
H
G
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
--
T
A
G
D
S
A
I
S
V
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
Q
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
Q
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
10
PsiBlast_PDB
88.56
39%
-101
- C8 -
1NBO
3
G3PA_SPIOL
O:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
44
PsiBlast_CBE
88.19
39%
-100
- C8 -
1NBO
4
G3PA_SPIOL
A:
[4-332]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
----
H
G
R
K
D
S
P
L
D
V
V
V
I
-----
N
D
----
T
GG-
V
K
Q
---
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-
D
A
-
D
V
K
T
-
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
--
L
V
I
E
G
T
G
V
F
V
D
R
----
D
G
A
G
K
H
L
-
Q
A
-
G
A
K
K
V
L
I
T
A
P
G
K
G
-
D
I
P
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
-
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
-
S
H
---
R
-
D
L
--
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
-
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
N
------
E
-------
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
M
V
K
-
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
---------
128
Fugue
87.87
39%
-93
- C8 -
3GPD
3
G3P_HUMAN
R:
[1-334]
------------------------------------------------------------------------------------------------------------
G
K
V
K
V
G
V
D
G
F
G
R
I
G
R
L
V
T
R
A
A
F
N
S
G
K
V
----
D
I
V
A
I
N
D
---
P
F
I
D
----
L
---
H
Y
M
---
V
Y
-
M
F
Q
Y
D
S
T
H
G
K
F
-
H
G
-
T
V
K
A
E
--
D
G
K
L
V
I
D
G
K
A
I
T
I
F
Q
E
R
D
P
E
N
I
K
W
G
D
A
G
T
A
--
Y
V
V
E
S
T
G
V
F
T
T
M
----
E
K
A
G
A
H
L
-
K
-
G
G
A
K
R
I
V
I
S
A
P
S
A
D
-
A
P
-
M
F
V
M
G
V
N
H
F
K
Y
A
N
-
S
-L
K
I
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
H
F
G
I
V
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
S
P
S
G
---
K
-
L
W
--
R
G
G
R
G
A
A
Q
N
L
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
D
G
K
L
T
G
M
A
F
R
V
P
T
A
N
V
S
V
L
D
L
T
C
R
L
E
K
-
P
-
A
K
Y
D
D
I
K
K
V
V
K
E
A
S
E
-------
G
P
-----
L
K
G
I
L
G
Y
T
E
D
E
V
V
S
D
-
D
F
N
G
S
N
H
S
S
I
F
D
A
G
A
G
-
I
E
L
N
D
T
F
V
K
-
L
V
S
W
Y
D
N
E
F
G
Y
S
E
R
V
V
D
L
M
A
H
M
A
S
K
E
------
21
PsiBlast_CBE
87.42
39%
-97
- C8 -
1HDG
3
G3P_THEMA
Q:
[3-327]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
--
P
D
I
E
V
V
A
I
-------
N
D
----
L
---
T
D
T
KTL
A
H
-
L
L
K
Y
D
S
V
H
K
K
F
-
P
G
-
K
V
E
Y
T
E
--
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
--
F
V
I
E
S
T
G
V
F
R
N
R
----
E
K
A
E
L
H
L
-
Q
A
-
G
A
K
K
V
I
I
T
A
P
A
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
-
P
H
---
K
-
D
L
--
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
-
A
T
E
------
G
R
-----
L
K
G
I
I
G
Y
-
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
G
K
L
V
K
-
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
------------
101
PsiBlast_CBE
87.20
38%
-96
- C8 -
2I5P
2
G3P1_KLULA (first)
O:
[17-342]
----------------------------------------------------------------------------------------------------------------
I
A
I
N
G
F
G
R
I
G
R
L
V
L
R
I
A
L
E
R
K
N
----
I
D
V
V
A
I
-------
N
D
PFIS
V
---
D
Y
A
---
A
Y
-
M
F
K
Y
D
S
T
H
G
K
Y
-
K
G
-
E
V
S
H
D
G
S
N
--
L
I
I
N
G
K
K
V
A
V
F
Q
E
K
D
P
A
T
L
P
W
G
K
L
G
V
D
I
A
--
V
D
S
T
G
V
F
K
E
L
----
D
S
A
Q
K
H
I
-
D
A
-
G
A
K
K
V
V
I
T
A
P
S
K
T
-
A
P
M
F
V
V
-
G
V
N
E
-
D
K
Y
N
-
G
E
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
A
K
I
I
N
D
E
F
G
I
E
E
G
L
M
T
T
V
H
S
I
T
--------------------------
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
T
D
V
S
V
V
D
L
T
V
K
L
V
K
-
A
-
A
T
Y
D
E
I
K
A
A
V
K
K
V
S
-
E
------
G
K
-----
L
K
D
V
V
G
Y
-
T
E
D
A
V
V
S
S
D
F
L
G
D
T
H
S
T
I
F
D
A
A
A
G
-
I
Q
-
L
S
P
K
F
V
K
L
V
A
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
---------
100
PsiBlast_CBE
86.95
38%
-96
- C8 -
2I5P
2
G3P1_KLUMA
P:
[17-342]
----------------------------------------------------------------------------------------------------------------
I
A
I
N
G
F
G
R
I
G
R
L
V
L
R
I
A
L
E
R
K
N
----
I
D
V
V
A
I
-------
N
D
PFIS
V
---
D
Y
A
---
A
Y
-
M
F
K
Y
D
S
T
H
G
K
Y
-
K
G
-
E
V
S
H
D
G
S
N
--
L
I
I
N
G
K
K
V
A
V
F
Q
E
K
D
P
A
T
L
P
W
G
K
L
G
V
D
I
A
--
V
D
S
T
G
V
F
K
E
L
----
D
S
A
Q
K
H
I
-
D
A
-
G
A
K
K
V
V
I
T
A
P
S
K
T
-
A
P
M
F
V
V
-
G
V
N
E
-
D
K
Y
N
-
G
E
-
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
A
K
I
I
N
D
E
F
G
I
E
E
G
L
M
T
T
V
H
S
I
T
--------------------------
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
T
D
V
S
V
V
D
L
T
V
K
L
V
K
-
A
-
A
T
Y
D
E
I
K
A
A
V
K
K
V
S
-
E
------
G
K
-----
L
K
D
V
V
G
Y
-
T
E
D
A
V
V
S
S
D
F
L
G
D
T
H
S
T
I
F
D
A
A
A
G
-
I
Q
-
L
S
P
K
F
V
K
L
V
A
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
---------
1
PsiBlast_PDB
86.70
39%
-97
- C8 -
1HDG
3
G3P_THEMA
O:
[3-327]
----------------------------------------------------------------------------------------------------------------
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
--
P
D
I
E
V
V
A
I
-------
N
D
----
L
---
T
D
T
KTL
A
H
-
L
L
K
Y
D
S
V
H
K
K
F
-
P
G
-
K
V
E
Y
T
E
--
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
--
F
V
I
E
S
T
G
V
F
R
N
R
----
E
K
A
E
L
H
L
-
Q
A
-
G
A
K
K
V
I
I
T
A
P
A
K
G
-
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
-
P
H
---
K
-
D
L
--
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
-
A
T
E
------
G
R
-----
L
K
G
I
I
G
Y
-
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
G
K
L
V
K
-
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
------------
99
PsiBlast_CBE
84.36
37%
-89
- C8 -
3L0D
1
?
A:
[22-342]
------------------------------------------------------------------------------------------------------------
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
--
G
R
Q
D
I
E
V
V
A
L
-------
N
D
----
L
GS
V
E
T
N
---
A
H
-
L
L
R
Y
D
S
V
H
G
C
F
-
P
G
-
T
V
Q
V
--
V
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
--
E
C
T
G
I
F
T
A
R
----
D
K
A
S
A
H
L
-
D
A
-
G
A
K
R
V
L
V
S
A
P
S
E
G
-
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
K
-
E
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
-
M
H
---
R
-
D
L
--
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
-
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
G
------
S
------
L
K
G
I
L
D
Y
-
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
-
K
V
-
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
--------------------
98
PsiBlast_CBE
83.27
37%
-88
- C8 -
3L0D
1
?
B:
[22-342]
------------------------------------------------------------------------------------------------------------
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
--
G
R
Q
D
I
E
V
V
A
L
-------
N
D
----
L
GSV
E
T
N
---
A
H
-
L
L
R
Y
D
S
V
H
G
C
F
-
P
G
-
T
V
Q
V
--
V
G
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
--
E
C
T
G
I
F
T
A
R
----
D
K
A
S
A
H
L
-
D
A
-
G
A
K
R
V
L
V
S
A
P
S
E
G
-
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
K
-
E
H
-
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
-
M
H
---
R
-
D
L
--
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
-
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
G
------
S
------
L
K
G
I
L
D
Y
-
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
-
K
V
-
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
--------------------
6
PsiBlast_PDB
82.70
39%
-82
- C8 -
3CPS
1
?
A:
[24-343]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
R
N
D
-------
I
T
V
V
A
I
N
D
P
F
M
D
----
V
---
E
Y
M
---
A
Y
-
L
L
K
Y
D
S
V
H
G
N
F
-
N
G
-
T
V
E
V
S
G
-
D
--
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
--
I
V
C
E
S
T
G
V
F
T
T
E
----
E
K
A
S
L
H
L
-
K
-
G
G
A
K
K
V
I
I
S
A
P
P
K
D
-
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
-
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
-
P
S
---
K
-
G
-DW
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
--------
N
G
-----
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
-
I
A
L
N
D
S
F
V
K
-
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
----------------
30
PsiBlast_CBE
82.36
39%
-82
- C8 -
3CPS
1
?
B:
[24-343]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
R
N
D
-------
I
T
V
V
A
I
N
D
P
F
M
D
----
V
---
E
Y
M
---
A
Y
-
L
L
K
Y
D
S
V
H
G
N
F
-
N
G
-
T
V
E
V
S
-
K
D
--
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
--
I
V
C
E
S
T
G
V
F
T
T
E
----
E
K
A
S
L
H
L
-
K
-
G
G
A
K
K
V
I
I
S
A
P
P
K
D
-
N
V
P
M
Y
V
M
G
V
N
N
T
E
Y
D
P
-
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
-
P
S
---
K
---DW
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
-
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
--------
N
G
-----
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
-
I
A
L
N
D
S
F
V
K
-
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
----------------
22
PsiBlast_CBE
81.55
38%
-74
- C8 -
2EP7
1
G3P_AQUAE
B:
[9-330]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
S
F
F
R
----
A
S
W
G
R
E
E
I
E
I
V
A
I
-------
N
D
----
L
---
T
D
A
K
H
L
A
H
-
L
L
K
Y
D
S
V
H
G
I
F
-
K
G
-
S
V
--
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
--
V
V
I
E
A
T
G
V
F
R
D
R
----
E
N
A
S
K
H
L
-
Q
G
-
G
A
K
K
V
I
I
T
A
P
A
K
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
-
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
-
P
H
---
K
-
D
F
--
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
------
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
-
Q
V
-
I
D
N
L
V
H
-
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
-----------------
2
PsiBlast_PDB
81.06
38%
-74
- C8 -
2EP7
1
G3P_AQUAE
A:
[9-330]
--------------------------------------------------------------------------------------------------------------------
G
F
G
R
I
G
R
S
F
F
R
----
A
S
W
G
R
E
E
I
E
I
V
A
I
-------
N
D
----
L
---
T
D
A
K
H
L
A
H
-
L
L
K
Y
D
S
V
H
G
I
F
-
K
G
-
S
V
--
E
A
K
D
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
--
V
V
I
E
A
T
G
V
F
R
D
R
----
E
N
A
S
K
H
L
-
Q
G
-
G
A
K
K
V
I
I
T
A
P
A
K
N
-
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
-
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
-
P
H
---
K
-
D
F
--
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
------
Y
R
E
SGKV
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
-
Q
V
-
I
D
N
L
V
H
-
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
-----------------