@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv1538c: (2016-05-02 )
MGANHVRNDPIMARLTVITTGGTISTTAGPDGVLRPTHCGATLIAGLDMDSDIEVVDLMALDSSKLTPADWDRIGAAVQEAFRGGADGVVITHGTDTLEETALWLDLTYAGSRPVVLTGAMLSADAPGADGPANLRDALAVAADPAARDLGVLVSFGGRVLQPLGLHKVANPDLCGFAGESLGFTSGGVRLTRTKTRPYLGDLGAAVAPRVDIVAVYPGSDAVAMDACVAAGARAVVLEALGSGNAGAAVIEGVRRHCRDGSDPVVIAVSTRVAGARVGAGYGPGHDLVEAGAVMVPRLPPSQARVLLMAALAANSPVADVIDRWG
Atome Classification :
(43 SA)
.........10........20........30.---........40------.-------..-...-..---.----50-----------......---...-60........70........80.-.-..-....90........100.......110.-.......120.......130.......140.......150......-------.-------160.......170.......---180.----------..-.-...----------190......-.----200--.--..-.....-------------.210.......220-........230.......240......--.---250.......260.......270.......280-.....-...290------........300.......310....--.-..320....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGANHVRNDP
I
M
A
R
L
T
V
I
TTG
G
T
I
STTAGP-D---GVLRPTHCG-------
A
-------
T
L
-
I
AG-LD---M----D------------SD
I
E
V
V
---
D
L
M
-ALDSSKLTP
A
D
W
D
R
I
G
A
A
V
Q
E
A
F
-R-GG-AD
G
V
V
I
THGTD
T
L
E
E
T
A
L
W
L
D
L
TYA-GS-R
P
V
V
L
TG
A
M
LSADAPGADG
P
A
N
L
R
D
A
L
AVAADP
A
A
R
D
L
G
V
L
V
SFGG-------R-------VLQPLGLHKVANPDLCGFAG---ESLG----------FT-S-GG
V
----------
R
L
T
R
TKTRP-Y----L----G--DL-GAAVA-------------PR
V
D
I
V
A
V
YPGS-
D
-
A
V
A
M
D
A
C
V
AAG
A
R
A
V
V
L
E
A
LGSGN
A
G
A
--
A
---
V
I
E
G
V
R
R
H
CRDGSD
P
V
V
I
A
V
STRVA
G
A
RVGA-G-YGP
G
H
-
D
L
V
EA-------G
A
V
MVPRLPP
S
Q
A
R
V
L
L
M
A
A
L
AANS--
P
-
V
A
D
V
I
DRWG--
67
HHSearch
96.85
30%
-117
- C10 -
3NXK
5
?
A:
[8-333]
-----------
K
S
R
I
A
I
L
G
T
G
G
T
I
A
G
F
I
D
S
T
I
ATT
G
Y
A
A
G
A
I
D
I
-------
D
-------
V
L
-
I
K
A
-
V
P
Q
I
R
D
----
L
------------
A
D
I
S
W
E
---
Q
I
A
-
N
I
D
S
S
N
M
C
D
E
I
W
L
R
L
A
K
K
I
A
K
L
F
-
A
-
E
G
-
I
D
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
N
L
T
I
K
-
S
D
-
K
P
V
V
L
V
G
A
M
R
P
S
T
A
I
S
A
D
G
P
K
N
L
Y
N
A
V
A
L
V
V
N
K
E
A
K
N
K
G
V
M
V
A
I
N
D
-------
K
-------
I
L
S
A
R
G
V
V
K
T
H
S
L
N
V
D
A
F
S
S
PDF
G
D
L
G
----------
Y
I
V
D
-
G
K
V
----------
F
F
Y
N
N
V
I
K
A
H
T
KNAP
F
----
D
--
V
S
-
K
L
T
S
L
-------------
P
K
V
D
I
L
Y
S
Y
S
N
D
-
G
S
G
V
A
A
K
A
L
F
E
H
G
T
K
G
I
V
V
A
G
S
G
A
G
S
I
H
K
--
N
---
Q
K
D
V
L
K
E
L
L
-
K
K
G
L
K
V
V
V
--
S
S
R
V
V
A
G
C
V
A
V
-
S
-
D
-----
S
D
E
K
L
-------
G
F
I
S
A
E
D
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
D
P
K
K
I
Q
E
Y
F
L
K
----
3
PsiBlast_PDB
95.36
28%
-114
- C10 -
2WLT
1
ASPG_HELPJ
A:
[5-329]
--------
L
P
T
I
A
---
L
L
A
T
G
G
T
I
A
G
S
-
G
------
A
S
L
G
S
Y
K
S
G
-------
E
LG
V
K
E
L
L
K
A
-
I
P
S
-
L
N
---
K
----
I
------------
A
R
I
Q
G
E
---
Q
V
S
-
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
L
L
-
D
-
D
S
R
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
-
S
T
-
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
-------
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
-------
A
----------
L
N
-
S
-
G
A
I
G
---------
S
V
Y
Y
G
K
T
R
Y
-
Y
----
M
----
Q
--
P
L
-
R
K
H
T
T
ESEFSLSQLKTPL
P
K
V
D
I
I
Y
T
H
A
G
M
-
T
-
P
D
L
F
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
--
G
---
F
L
K
A
M
Q
E
A
S
Q
M
G
---
V
V
I
V
R
S
S
R
V
G
S
G
G
V
T
S
-
G
----
E
I
-
D
D
K
A
Y
-------
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
--
D
-
K
A
K
I
Q
E
M
F
---
4
PsiBlast_PDB
95.19
28%
-120
- C10 -
2WT4
1
ASPG_HELPJ
A:
[5-329]
--------
L
P
T
I
A
---
L
L
A
T
G
G
T
I
A
G
S
-
G
-----------------------GVK
E
L
L
-
K
A
-
I
P
S
-
L
N
---
K
----
I
------------
A
R
I
Q
G
E
---
Q
V
S
-
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
L
L
-
D
-
D
S
R
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
-
S
T
-
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
-------
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
-------
A
----------
L
N
-
S
-
G
A
I
G
---------
S
V
Y
Y
G
K
T
R
Y
-
Y
----
M
----
Q
--
P
L
-
R
K
H
T
T
ESEFSLSQLKTPL
P
K
V
D
I
I
Y
T
H
A
G
M
-
T
-
P
D
L
F
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
--
G
---
F
L
K
A
M
Q
E
A
S
Q
M
G
---
V
V
I
V
R
S
S
R
V
G
S
G
G
V
T
S
-
G
----
E
I
-
D
D
K
A
Y
-------
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
--
D
-
K
A
K
I
Q
E
M
F
---
63
HHSearch
94.84
27%
-115
- C10 -
2WLT
1
ASPG_HELPJ
A:
[5-332]
-----------
L
P
T
I
A
L
L
A
T
G
G
T
I
A
G
S
G
--A
S
L
G
-
S
Y
K
S
G
E
L
G
V
-------
K
-------
E
L
-
L
K
A
-
I
P
S--
L
NK--
I
------------
A
R
I
Q
G
E
---
Q
V
S
-
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
L
L
-
D
D
S
R
-
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
-
S
T
-
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
-------
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
LNS
G
A
I
G
----------
S
V
Y
Y
-
G
K
T
----------
R
Y
Y
M
Q
P
L
R
K
H
T
TESE
F
----
S
L-
S
Q
-
L
K
T
P
L
-------------
P
K
V
D
I
I
Y
T
H
A
G
M
-
T
-
P
D
L
F
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
--
G
---
F
L
K
A
M
Q
E
A
S
-
Q
M
G
V
V
I
V
R
--
S
S
R
V
G
S
G
G
V
T
S
-
G
E
I
-----
D
D
K
A
Y
-------
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
D
K
A
K
I
Q
E
M
F
E
E
Y
---
77
Fugue
94.39
29%
-115
- C10 -
3ECA
2
ASPG2_ECOLI
A:
[1-326]
-----------
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
-
A
---
T
K
S
-
N
Y
T
V
G
KVG
V
E
N
L
V
-------
N
A
-
V
P
Q
-
L
K
---
D
----
I
------------
A
N
V
K
G
E
---
Q
V
V
-
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
D
C
-
D
K---
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PL
G
Y
------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
-
T
G
T
A
V
V
R
S
S
R
V
P
T
-
G
A
---
T
-
T
-
Q
D
A
E
V
-
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
--
D
-
P
Q
Q
I
Q
Q
I
F
N
Q
Y
66
HHSearch
94.28
28%
-121
- C10 -
1WSA
-
ASPG_WOLSU
A:
[3-330]
-----------
K
P
Q
V
T
I
L
A
T
G
G
T
I
A
G
----------
Y
S
A
G
A
V
T
V
-------
D
-------
K
L
-
L
A
A
-
V
P
A
--
I
N
D
--
L
------------
A
T
I
K
G
E
---
Q
I
S
-
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
-
A
Q
K
E
-
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
-
S
Q
-
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
-------
E
-------
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
PNT
G
K
I
G
----------
T
V
Y
Y
-
G
K
V
----------
E
Y
F
T
Q
S
V
R
P
H
T
LASE
F
----
D
--
I
S
-
K
I
E
E
L
-------------
P
R
V
D
I
L
Y
A
H
P
D
D
-
T
-
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
--
L
---
T
Q
N
A
L
E
K
A
A
-
K
S
G
V
V
V
A
R
--
S
S
R
V
G
S
G
S
T
T
----
Q
E
A
E
V
-
D
D
K
K
L
-------
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
D
R
E
A
I
Q
K
I
F
S
T
Y
---
59
HHSearch
92.58
29%
-112
* C10 *
1NNS
1
ASPG2_ECOLI
A:
[1-325]
-----------
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
-
A
TKS
N
Y
T
V
G
K
V
G
V
-------
E
-------
N
L
-
V
N
A
-
V
P
QLK
D
----
I
------------
A
N
V
K
G
E
---
Q
V
V
-
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
D
C
---
D
K
-
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
VNY
G
P
L
G
----------
Y
I
H
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
H
T
SDTP
F
----
D
--
V
S
-
K
L
N
E
L
-------------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
-
K
T
G
T
A
V
V
R
--
S
S
R
V
P
T
G
A
T
T
Q
-
D
-
A
--
E
V
-
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
----
64
HHSearch
92.48
27%
-111
- C10 -
4PGA
3
ASPQ_PSES7
A:
[8-337]
----------
K
L
A
N
V
V
I
L
A
T
G
G
T
I
A
G
A
G
A
S
A
A
NSA
T
Y
Q
A
A
K
V
G
V
-------
D
-------
K
L
-
I
A
G
-
V
P
E--
L
AD--
L
------------
A
N
V
R
G
E
---
Q
V
M
-
Q
I
A
S
E
S
I
T
N
D
D
L
L
K
L
G
K
R
V
A
E
L
A
-
D
S
N
D
-
V
D
G
I
V
I
T
H
G
T
D
T
L
E
E
T
A
Y
F
L
N
L
V
Q
K
-
T
D
-
K
P
I
V
V
V
G
S
M
R
P
G
T
A
M
S
A
D
G
M
L
N
L
Y
N
A
V
A
V
A
S
N
K
D
S
R
G
K
G
V
L
V
T
M
N
D
-------
E
-------
I
Q
S
G
R
D
V
S
K
S
I
N
I
K
T
E
A
F
K
S
AW-
G
P
L
G
----------
M
V
V
E
-
G
K
S
----------
Y
W
F
R
L
P
A
K
R
H
T
VNSE
F
----
D
--
I
K
-
Q
I
S
S
L
-------------
P
Q
V
D
I
A
Y
S
Y
G
N
V
-
T
-
D
T
A
Y
K
A
L
A
Q
N
G
A
K
A
L
I
H
A
G
T
G
N
G
S
V
S
S
--
R
---
V
V
P
A
L
Q
Q
L
R
-
K
N
G
T
Q
I
I
R
--
S
S
H
V
N
Q
G
G
F
V
L
R
N
-
A
E
Q
---
P
D
D
K
N
-------
D
W
V
V
A
H
D
L
N
P
E
K
A
R
I
L
A
M
V
A
M
T
K
T
Q
D
S
K
E
L
Q
R
I
F
W
E
Y
---
1
PsiBlast_PDB
92.40
30%
-120
- C10 -
1WSA
-
ASPG_WOLSU
A:
[5-318]
-------------
Q
V
T
I
L
A
T
G
G
T
I
A
G
--------------
Y
S
A
G
-------
A
V
T
V
D
---
K
L
-
L
A
A
-
V
P
---
A
----
I
------------
N
D
L
A
T
I
K
G
E
Q
I
S
-
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
A
Q
-
K
E
-
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
-
S
Q
-
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
-------
E
-------
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
---
P
N
T
G
KI
G
T
------
V
Y
-
Y
-
G
K
V
----------
E
Y
F
T
Q
S
V
R
P
-
H
----
T
LASE
F
--
D
I
-
S
K
I
E
E
L
------------
P
R
V
D
I
L
Y
A
H
P
D
D
-
T
-
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
--
L
---
T
Q
N
A
L
E
K
A
A
K
S
G
---
V
V
V
A
R
S
S
R
V
-----------
G
S
G
S
-
T
T
Q
E
A
EVDDKKL
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
---------------
68
HHSearch
92.17
29%
-112
- C10 -
1O7J
9
ASPG_DICCH
A:
[3-327]
----------
K
L
P
N
I
V
I
L
A
T
G
G
T
I
A
G
S
A
A
T
G
T
QTT
G
Y
K
A
G
A
L
G
V
-------
D
-------
T
L
-
I
N
A
-
V
P
E--
V
KK--
L
------------
A
N
V
K
G
E
---
Q
F
S
-
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
L
L
-
A
R
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
NEE
G
Y
L
G
----------
V
I
I
G
-
N
R
I
----------
Y
Y
Q
N
R
I
D
K
L
H
T
TRSV
F
----
D
--
V
R
-
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
-
E
K
G
V
V
V
M
R
--
S
T
R
T
G
N
G
I
V
P
P
-
D
-
E
--------
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
H
T
Y
---
2
PsiBlast_PDB
89.28
30%
-99
- C10 -
3NXK
5
?
A:
[9-322]
------------
S
R
I
A
I
L
G
T
G
G
T
I
A
----------
G
F
I
D
S
T
I
A
T
-------
T
-------
G
Y
-
A
A
G
A
I
D
---
I
----
D
V
L
I
K
A
V
P
Q
I
R
D
L
A
D
I
S
W
E
---
Q
I
A
-
N
I
D
S
S
N
M
C
D
E
I
W
L
R
L
A
K
K
I
A
K
L
F
-
A
-
E
G
-
I
D
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
N
L
T
I
K
-
S
D
-
K
P
V
V
L
V
G
A
M
R
P
S
T
A
I
S
A
D
G
P
K
N
L
Y
N
A
V
A
L
V
V
N
K
E
A
K
N
K
G
V
M
V
A
I
N
D
-------
K
-------
I
L
S
A
R
G
V
V
K
T
H
S
L
N
V
D
A
F
S
S
---
P
D
F
G
DL
G
Y
I
V
DG
K
V
F
F
-
Y
-
N
N
V
----------
I
K
A
H
T
K
N
A
P
-
F
------------
D
V
-
S
K
L
T
S
L------------
P
K
V
D
I
L
Y
S
Y
S
N
D
G
S
-
G
V
A
A
K
A
L
F
E
H
G
T
K
G
I
V
V
A
G
S
G
A
G
S
-------------
I
H
K
N
Q
K
D
V
L
K
E
L
L
K
K
G
L
K
V
V
V
S
S
R
V
V
A
-
G
-
C
V
A
V
S
-
D
S
D
E
K
L
------
G
F
I
S
A
E
D
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
---------------
61
HHSearch
88.07
26%
-110
- C10 -
1AGX
-
ASPQ_ACIGL
A:
[1-331]
-----------
K
N
N
V
V
I
V
A
T
G
G
T
I
A
G
A
G
A
S
S
T
NSA
T
Y
S
A
A
K
V
P
V
-------
D
-------
A
L
-
I
K
A
-
V
P
QVN
D
----
L
------------
A
N
I
T
G
I
---
Q
A
L
-
Q
V
A
S
E
S
I
T
D
K
E
L
L
S
L
A
R
Q
V
N
D
L
V
-
K
K
P
S
-
V
N
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
V
V
H
-
T
D
-
K
P
I
V
L
V
G
S
M
R
P
S
T
A
L
S
A
D
G
P
L
N
L
Y
S
A
V
A
L
A
S
S
N
E
A
K
N
K
G
V
M
V
L
M
N
D
-------
S
-------
I
F
A
A
R
D
V
T
K
G
I
N
I
H
T
H
A
F
V
S
QW-
G
A
L
G
----------
T
L
V
E
-
G
K
P
----------
Y
W
F
R
S
S
V
K
K
H
T
NNSE
F
----
N
IE
K
I
-
Q
G
D
A
L
-------------
P
G
V
Q
I
V
Y
G
S
D
N
M
-
M
-
P
D
A
Y
Q
A
F
A
K
A
G
V
K
A
I
I
H
A
G
T
G
N
G
S
M
A
N
--
Y
---
L
V
P
E
V
R
K
L
H
D
E
Q
G
L
Q
I
V
R
--
S
S
R
V
A
Q
G
F
V
L
R
-
N
-
A
E
--
Q
-
P
D
D
K
Y
-------
G
W
I
A
A
H
D
L
N
P
Q
K
A
R
L
L
M
A
L
A
L
T
K
T
N
D
A
K
E
I
Q
N
M
F
W
N
Y
---
57
HHSearch
87.56
24%
-103
- C10 -
2D6F
-
GATD_METTH
A:
[85-419]
------
A
E
D
P
E
L
P
D
V
S
I
I
S
T
G
G
T
V
A
S
I
I
D
Y
R
T
---
G
A
V
H
P
A
F
T
A
-------
D
-------
D
L
-
L
R
A
-
N
P
E--
L
LD--
I
------------
A
N
I
R
G
R
---
A
V
F
-
N
I
L
S
E
N
M
K
P
E
Y
W
V
E
T
A
R
A
V
Y
G
E
I
-
K
-
D
G
-
A
D
G
V
V
V
A
H
G
T
D
T
M
H
Y
T
S
A
A
L
S
F
M
L
R
-
T
P
-
V
P
V
V
F
T
G
A
Q
R
S
S
D
R
P
S
S
D
A
S
L
N
I
Q
C
S
V
R
A
A
T
S
E
---
I
A
E
V
T
V
C
M
H
A
TMDDLSC
H
-------
L
H
R
G
V
K
V
R
K
M
H
T
S
R
R
D
T
F
R
S
M
NA
L
P
L
A
----------
E
V
T
P
-
D
G
I
----------
K
I
L
E
E
N
Y
R
K
R
G
----
S
DE--
L
--
E
L
-
S
D
R
V
E
-------------
E
R
V
A
F
I
K
S
Y
P
G
I
-
S
-
P
D
I
I
K
W
H
L
D
E
G
Y
R
G
I
V
I
E
G
T
G
L
G
H
C
P
D
--
T
---
L
I
P
V
I
G
E
A
H
-
D
M
G
V
P
V
A
M
--
T
S
Q
C
L
N
G
R
V
N
M
N
V
-
Y
S
T
G
R
-
R
L
L
Q
A
-------
G
V
I
P
C
D
D
M
L
P
E
V
A
Y
V
K
M
C
W
V
L
G
Q
T
D
D
P
E
M
A
R
E
M
M
R
E
N
---
58
HHSearch
87.52
26%
-106
- C10 -
1ZQ1
2
GATD_PYRAB
A:
[86-422]
------
E
G
K
P
G
L
P
E
V
T
I
I
G
T
G
G
T
I
A
S
R
I
D
Y
E
T
---
G
A
V
Y
P
A
F
T
A
-------
E
-------
E
L
-
A
K
A
-
L
P
E
I
F
E
----
V
------------
A
N
V
K
P
K
---
L
L
F
-
N
I
F
S
E
D
M
K
P
K
H
W
V
K
I
A
H
E
V
A
K
A
L
-
N
-
S
G
-
D
Y
G
V
V
V
A
H
G
T
D
T
M
G
Y
T
A
A
A
L
S
F
M
L
R
N
L
G
-
K
P
V
V
L
V
G
A
Q
R
S
S
D
R
P
S
S
D
A
A
M
N
L
I
C
S
V
R
M
A
T
S
E
---
V
A
E
V
M
V
V
M
H
G
-------
E
TGD
T
Y
C
L
A
H
R
G
T
K
V
R
K
M
H
T
S
R
R
D
A
F
R
S
I
ND
V
P
I
A
----------
K
I
W
P
N
G
E
I
----------
E
F
L
R
K
D
Y
R
K
R
S
----
D
E
E
--
V
--
E
V
-
D
D
K
I
E
-------------
E
K
V
A
L
V
K
V
Y
P
G
I
-
S
-
S
E
I
I
D
F
L
V
D
K
G
Y
K
G
I
V
I
E
G
T
G
L
G
H
T
P
N
--
D
---
I
I
P
S
I
E
R
A
V
-
E
E
G
V
A
V
C
M
--
T
S
Q
C
I
Y
G
R
V
N
L
N
V
-
Y
S
T
G
R
-
K
L
L
K
A
-------
G
V
I
P
C
E
D
M
L
P
E
T
A
Y
V
K
L
M
W
V
L
G
H
T
Q
N
L
E
E
V
R
K
M
M
L
T
N
---
11
PsiBlast_PDB
84.84
33%
-118
- C10 -
5F52
4
?
A:
[73-316]
-------------------------------------------------------------------------------------------------------------------
K
L
S
Q
R
V
N
E
L
L
A
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
L
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
K
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
M
E
K
G
---
V
V
V
I
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
12
PsiBlast_PDB
84.53
33%
-119
- C10 -
5HW0
2
?
A:
[73-316]
-------------------------------------------------------------------------------------------------------------------
K
L
S
Q
R
V
N
E
L
L
A
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
L
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
K
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
M
E
K
G
---
V
V
V
I
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
60
HHSearch
83.92
23%
-96
- C10 -
4Q0M
5
?
A:
[1-320]
-----------
M
M
K
I
L
L
I
G
M
G
G
T
I
A
S
V
K
G
E
-----
N
G
Y
E
A
S
L
S
V
-------
K
-------
E
V
-
L
D
I
-
A
G
IK-
D
----
C
------------
E
D
C
D
F
L
---
D
L
K
-
N
V
D
S
T
L
I
Q
P
E
D
W
V
D
L
A
E
T
L
Y
K
N
V
---
K
K
-
Y
D
G
I
I
V
T
H
G
T
D
T
L
A
Y
T
S
S
M
I
S
F
M
L
R
N
P
P
-
I
P
I
V
F
T
G
S
M
I
P
A
T
E
E
N
S
D
A
P
L
N
L
Q
T
A
I
K
F
A
T
S
G
---
I
R
G
V
Y
V
A
F
N
G
-------
K
-------
V
M
L
G
V
R
T
S
K
V
R
T
M
S
R
D
A
F
E
S
INY
P
I
I
A
----------
E
L
R
G
-
E
D
L
----------
V
V
N
F
I
P
K
F
N
-
N
G---
E
----
V
--
T
L
-
D
L
R
H
D
-------------
P
K
V
L
V
I
K
L
I
P
G
L
-
S
-
G
D
I
F
R
A
A
V
E
L
G
Y
R
G
I
V
I
E
G
Y
G
A
G
G
I
P
Y
--
R
GSD
L
L
Q
T
I
E
E
L
--
S
K
E
I
P
I
V
M
--
T
T
Q
A
M
Y
D
G
V
D
L
T
R
-
Y
K
V
G
R
-
L
A
L
R
A
-------
G
V
I
P
A
G
D
M
T
K
E
A
T
V
T
K
L
M
W
I
L
G
H
T
N
N
V
E
E
I
K
V
L
M
R
K
N
---
65
HHSearch
82.81
25%
-104
- C10 -
2HIM
8
ASPG1_ECOLI
A:
[23-349]
-----------
K
K
S
I
Y
V
A
Y
T
G
G
T
I
G
M
Q
R
---------
I
P
V
S
G
H
L
-------
Q
-------
R
Q
-
L
A
L
-
M
P
E--
F
HRPE
M
------------
P
D
F
T
I
H
---
E
Y
T
P
L
M
D
S
S
D
M
T
P
E
D
W
Q
H
I
A
E
D
I
K
A
H
Y
---
D
D
-
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
F
M
L
E
N
L
G
-
K
P
V
I
V
T
G
S
Q
I
P
L
A
E
L
R
S
D
G
Q
I
N
L
L
N
A
L
Y
V
A
A
N
Y
P
--
I
N
E
V
T
L
F
F
N
N
-------
R
-------
L
Y
R
G
N
R
T
A
K
A
H
A
D
G
F
D
A
F
A
S
PNL
P
P
L
L
----------
E
A
-
G
-
I
H
I
----------
R
R
L
N
T
P
P
A
P
H
G
----
E
G
E
--
L
--
I
V
-
H
P
I
T
P
-------------
Q
P
I
G
V
V
T
I
Y
P
G
I
-
S
-
A
D
V
V
R
N
F
L
R
Q
P
V
K
A
L
I
L
R
S
Y
G
V
G
N
A
P
Q
N
K
A
---
F
L
Q
E
L
Q
E
A
S
-
D
R
G
I
V
V
V
N
--
L
T
Q
C
M
S
G
K
V
N
M
G------
N
-
A
L
A
H
A
-------
G
V
I
G
G
A
D
M
T
V
E
A
T
L
T
K
L
H
Y
L
L
S
Q
E
L
D
T
E
T
I
R
K
A
M
S
Q
N
---
17
PsiBlast_PDB
82.67
34%
-113
- C10 -
1HG1
2
ASPG_DICCH
A:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
38
PsiBlast_CBE
82.62
34%
-110
- C10 -
1HG1
2
ASPG_DICCH
C:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
25
PsiBlast_CBE
82.18
35%
-118
- C10 -
1NNS
1
ASPG2_ECOLI
B:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PLGY------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
39
PsiBlast_CBE
82.17
34%
-115
- C10 -
1HG1
1
ASPG_DICCH
B:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
41
PsiBlast_CBE
81.97
34%
-112
- C10 -
1HG0
1
ASPG_DICCH
C:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
7
PsiBlast_PDB
81.96
35%
-118
- C10 -
1NNS
1
ASPG2_ECOLI
A:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PL
G
Y
------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
36
PsiBlast_CBE
81.93
34%
-113
- C10 -
1JSL
2
ASPG_DICCH
B:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
24
PsiBlast_CBE
81.85
35%
-116
- C10 -
3ECA
2
ASPG2_ECOLI
B:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PLGY------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
23
PsiBlast_CBE
81.83
35%
-118
- C10 -
3ECA
2
ASPG2_ECOLI
C:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PLGY------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
22
PsiBlast_CBE
81.70
35%
-118
- C10 -
3ECA
2
ASPG2_ECOLI
D:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PLGY------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
37
PsiBlast_CBE
81.62
34%
-110
- C10 -
1HG1
1
ASPG_DICCH
D:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
6
PsiBlast_PDB
81.59
35%
-114
- C10 -
3ECA
2
ASPG2_ECOLI
A:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PL
G
Y
------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
18
PsiBlast_PDB
81.53
34%
-111
- C10 -
1JSL
2
ASPG_DICCH
A:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
35
PsiBlast_CBE
81.31
34%
-111
- C10 -
1JSL
4
ASPG_DICCH
C:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
16
PsiBlast_PDB
80.84
34%
-111
- C10 -
1HG0
1
ASPG_DICCH
A:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
40
PsiBlast_CBE
80.73
34%
-111
- C10 -
1HG0
1
ASPG_DICCH
D:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
45
PsiBlast_CBE
80.72
34%
-113
- C10 -
1HFW
2
ASPG_DICCH
B:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
44
PsiBlast_CBE
80.68
34%
-113
- C10 -
1HFW
2
ASPG_DICCH
C:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
42
PsiBlast_CBE
80.65
34%
-112
- C10 -
1HG0
1
ASPG_DICCH
B:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
21
PsiBlast_CBE
80.51
35%
-115
- C10 -
1HO3
1
ASPG2_ECOLI
B:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PLGY------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
43
PsiBlast_CBE
80.41
34%
-114
- C10 -
1HFW
2
ASPG_DICCH
D:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
IIGNRIYYQN
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
5
PsiBlast_PDB
80.35
35%
-115
- C10 -
1HO3
1
ASPG2_ECOLI
A:
[81-310]
------------------------------------------------------------------------------------------------------------------------------------
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
-
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
---
V
N
Y
G
PL
G
Y
------
I
H
-
N
-
G
K
I
----------
D
Y
Q
R
T
P
A
R
K
-
H
----
T
----
S
--
D
T
-
P
F
D
V
S
KLNEL--------
P
K
V
G
I
V
Y
N
Y
A
N
A
-
S
-
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
--
S
---
V
F
D
T
L
A
T
A
A
K
T
G
T
---
A
V
V
R
S
S
R
V
P
---
T
G
A
-
T
-
T
Q
D
A
E
V
D
D
A
K
Y
-------
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
-------------------
20
PsiBlast_PDB
79.81
34%
-112
- C10 -
1HFW
2
ASPG_DICCH
A:
[83-315]
------------------------------------------------------------------------------------------------------------------------------
R
-
D
D
-
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
-
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
---
N
E
E
G
----------
Y
L
----
G
V
I
I
GN
R
I
Y
Y
Q
N
R
I
D
K
L
H
T
T
R
-
S
----
V
----
F
--
D
V
R
G
L
T
S
L
-------------
P
K
V
D
I
L
Y
G
Y
Q
D
D
-
P
-
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
--
R
---
G
I
A
G
M
R
K
A
L
E
K
G
---
V
V
V
M
R
S
T
-----
R
T
G
N
-
G
-
I
V
P
P
D
-
E
--
E
L
-------
P
G
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
---------------
48
PsiBlast_CBE
64.88
31%
-106
- C10 -
4RA9
5
?
A:
[24-177]
-------------
K
I
L
L
I
G
M
G
G
T
I
A
S
V
K
G
E
-
N
---
G
Y
E
A
S
L
S
V
K
-------
E
-------
V
L
D
I
A
G
-
I
K
---
D
----
C
------------
E
D
C
D
F
L
---
D
L
K
-
N
V
D
S
T
L
I
Q
P
E
D
W
V
D
L
A
E
T
L
Y
K
N
V
-
K
-
K
--
Y
D
G
I
I
V
T
H
G
T
D
T
L
A
Y
T
S
S
M
I
S
F
M
L
R
-
N
P
P
I
P
I
V
F
T
G
S
M
I
P
A
T
E
E
N
S
D
A
P
L
N
L
Q
T
A
I
K
F
A
T
S
G
I
R
---
G
V
Y
V
A
F
N
G
-------
K
-------
V
M
L
G
V
R
T
S
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.44
31%
-102
- C10 -
4NJE
1
?
A:
[24-177]
-------------
K
I
L
L
I
G
M
G
G
T
I
A
S
V
K
G
E
-
N
---
G
Y
E
A
S
L
S
V
K
-------
E
-------
V
L
D
I
A
G
-
I
K
---
D
----
C
------------
E
D
C
D
F
L
---
D
L
K
-
N
V
D
S
T
L
I
Q
P
E
D
W
V
D
L
A
E
T
L
Y
K
N
V
-
K
-
K
--
Y
D
G
I
I
V
T
H
G
T
D
T
L
A
Y
T
S
S
M
I
S
F
M
L
R
-
N
P
P
I
P
I
V
F
T
G
S
M
I
P
A
T
E
E
N
S
D
A
P
L
N
L
Q
T
A
I
K
F
A
T
S
G
I
R
---
G
V
Y
V
A
F
N
G
-------
K
-------
V
M
L
G
V
R
T
S
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------