@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0017: (2016-03-11 )
MKSRKKGIILVLSVILIFSIGLLVNNLMTNNKDTAKPKKKTVAAVKKKKETPPKPKEPFNIDFTGDIMFDWDLRPVLAEKGMDYPFNNVREELKSSDYTFVDLETAITTRTKKVPYQEFWIKSDPSSLTALKNAGVDMVNISNNHILDYYEDGLLDTTAALRANNLAYVGAGKNEDEAYQLKVADIKGNKVGFMSFCHFFPNTGWIADEDTPGVTNGYDLNLVEEKIKEERAKNKDIDYMVVYFHWGVEKTNTPVDYQTQYVKKLVDDNLVDAIVASHPHWLQGFEVYKDVPIAYSLGNFLFPDYVSGHSAETGIYKLNFDQGKVTAHFDPGIISGNQINMLEGSSKTAQLNYLQSISPNATINSNGDISAK
Atome Classification :
(20 SA)
-------------------------------------------------------.........10.---.......20........30.-......--.40........50........60........70.....-.---.-.------80.........90....--....--.--100.......110....-..---.---120------------.--------.......130..------.....140....-...150..-.----------------------...--...160.....--..170.....------.-----.180.-..-----.-----.----..----.190.......200.........210.......220-...-.---...230--....---------------...240....--...250---.--..------..---.-------.----.-------.260...-.--...270.......280.--..---------------..-..290----------.....---------....300.--------.--....----.----.310-------......-..320.-.-.-....330.....--..340....----...350.......360.......370-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------MKSRKK
G
I
I
L
V
L
---
S
V
I
L
I
F
S
I
G
L
L
V
N
N
L
MTNNK-DTAKP
K
--
K
K
T
V
A
A
V
K
K
KKETPPKPKE
P
F
N
I
D
FT
G
D
I
M
F
DWDL
R
P
V
-
L
---
A
-E------K-GMDYP
F
N
N
V
R
-
E
E
LK--SSD
Y
--
T
--
F
V
D
L
E
TAITTRTKKV
P
Y
-
Q
E
---F---W-I------------K--------SDP
S
S
L
T
A
L
K
NA------GV
D
M
V
NISNNH
I
-
L
D
Y
Y
--ED-G----------------------LL
D
--
T
T
A
A
LRAN
N
L
A
--
Y
VGAGKNED
E
------
A
-----
Y
Q
L
-
K
-
V
A
-----D-----I----KG----NK
V
G
F
M
S
F
C
H
FF--PNTGWIADEDTPGVTNGY
D
L
N
L
-
V
E
E
-
K
---
I
K
E
E
RA--KNKD---------------I
D
Y
M
V
V
Y
F
HW--GVEK-----T--NT------P
V
---
D
-------
Y
----
Q
-------
T
Q
Y
V
K
K
L
-V--DD
N
L
V
D
A
I
V
ASHP
H
W
L
Q
--
G
F
---------------
E
V
-
Y
KD------------V
P
I
A
Y
---------
S
L
GNF-LF--------P--DYVS----G----HSA--------ET
G
I
Y
K
-
L
NFDQ
G
-
K
-
V
-
T
A
HFDPGIISG
N
--
Q
I
N
M
LEGSS----K
T
A
Q
L
N
Y
L
QSISPN
A
T
INSNGDISAK-
22
HHSearch
85.49
21%
-65
- C4 -
2Z06
3
?
A:
[1-193]
-----------------------------------------------------------------------------------------------------------------------
M
R
V
L
F
I
G
D
V
M
A
E
P
G
L
R
A
------------------
V
G
L
H
L
P
D
I
R
----
D
--
R
Y
D
L
--
V
--
I
A
N
G
E
N
A
A
R
G
K
G
---------------------------------------
L
D
R
R
S
Y
R
L
L
R
E
A
------
G
V
D
L
V
S
L
G
-
N
H
A
-
W
D
H
K
--
E
V
Y
A
----------------------
L
L
E
--
S
E
P
V
V
R
P
L
N
Y
P
--
P
G
T
P
G
K
-----------------
G
F
-
W
-
R
L
-----
E
-----
V
----
G
G
----
E
S
L
L
F
V
Q
V
M
G
R
I
--
F
-
M
D
P
----------
L
D
D
P
F
R
A
-
L
--------
D
R
-
L
L
--
E
E
E
K
---------------
A
D
Y
V
L
V
E
V
H
A
--
E
A
-------------------
T
---
S
-------
E
----
K
-------
M
A
L
A
H
Y
--
L
--
D
G
R
-
A
S
A
V
L
G
T
H
T
H
V
P
T
LD
A
T
---------------
R
L
-
P
K
G
------------
T
L
Y
Q
T
---------
D
V
G
M
---------------------------------------------------------------------------------------------------------------
41
Fugue
78.55
15%
-40
- C4 -
1T71
2
Y349_MYCPN
A:
[1-281]
-------------------------------------------------------------------------------------------------------------------
M
M
N
S
I
K
F
I
F
L
G
D
V
Y
-------------
G
-
K
------
A
-
G
R
N
I
I
K
N
N
L
A
-
Q
L
K
S
--
K
Y
Q
A
--
D
--
L
V
I
V
N
A
E
N
T
T
H
G
K
G
L
-------------------------------------
S
L
K
H
Y
E
F
L
K
E
A
------
G
V
N
Y
I
T
M
G
N
H
T
W
F
Q
K
L
D
--
L
A
-
V
----------------------
V
I
N
--
K
K
D
L
V
R
P
L
N
L
D
--
T
S
F
A
F
H
N
L
G
Q
------
G
-----
S
L
V
-
F
-
E
F
-----
N
-----------
K
----
A
K
I
R
I
T
N
L
L
---------------
G
T
S
V
P
L
P
F
K
T
T
N
-
P
F
K
-
V
---
L
K
E
L
I
L
--
K
R
D
C
----------------
D
L
H
I
V
D
F
H
A
--
E
T
T
S
-----
E
--
K
N
------
A
F
---
C
-------
M
----
A
-------
F
-----------
D
G
Y
V
T
T
I
F
G
T
H
T
H
V
P
S
--
A
D
---------------
L
R
-
I
T
P
------------
K
G
S
A
Y
I
T-------
D
V
G
M
C
G
P
G
--------
F
--
G
S
V
I
----
G
----
A
N
P
--------
E
Q
S
I
R
L
F
C
A
G
S
R
E
-
H
-
F
-
E
V
S
K
C
G
A
Q
L
N
G
V
--
F
F
E
V
D
V
N
T
K
----
K
V
I
K
T
E
A
I
R
I
V
E
D
D
P
R
Y
L
K
Q
D
Y
F
N
L
I
-
44
Fugue
75.39
15%
-14
- C4 -
1UTE
4
PPA5_PIG
A:
[3-304]
-------------------------------------------------------
P
T
P
I
-------
L
---
R
F
V
A
V
G
D
W
G
---------
G
V
-
P
N
A
P
F
H
--
T
A
R
E
M
A
N
A
K
A
I
A
T
T
V
K
T
L
G
A
D
F
I
L
S
L
G
D
N
F
Y
F
--------------------
T
-
G
V
H
D
A
K
D
K
R
F
-
Q
E
T
F
--
E
D
V
F
--
S
------
D
P
S
L
R
N
V
P
W
H
V
L
A
-
G
N
---
H
---
D
-
H
------------
L
--------
G
N
V
S
A
Q
I
A
Y
S
K
I
------
S
K
R
W
N
F
P
S
P
Y
Y
R
-
L
R
F
K
--
I
P
-
R
----------------------
S
N
V
--
S
V
A
I
F
M
L
D
T
V
T
--
L
C
G
N
S
D
D
F
V
S
-----------------------------------------------------------------
Q
Q
P
E
R
P
R
N
L
A
L
A
R
-
T
Q
L
-
A
---
W
I
K
K
Q
L
--
A
A
A
K
---------------
E
D
Y
V
L
V
A
G
H
Y
--
P
V
W
S
-----
I
AE
H
G
------
P
T
---
H
-------
C
----
L
-------
V
K
Q
L
L
P
L
-
L
--
T
T
H
K
V
T
A
Y
L
C
G
H
D
H
N
L
Q
--
Y
L
---------------
Q
D
-
E
N
G
L
-----------
G
F
V
L
S
---------
G
A
G
N
F
-
M
D
--------
P
--
S
K
K
H
----
L
----
R
K
V
--------
P
N
G
Y
L
R
-
F
H
F
G
A
E
-
N
-
S
-
L
G
G
F
A
Y
V
E
I
T
P
K
E
M
S
V
T
Y
I
E
A
S
G
----
K
S
L
F
K
T
K
L
P
R
R
A
---------------
26
HHSearch
75.00
15%
-48
- C4 -
2Z1A
4
?
A:
[28-245]
---------------------------------------------------------------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
-
T
L
--
S
G
E
------
K
-
T
P
V
G
G
V
A
R
R
V
-
A
L
F
D
--
R
V
W
A
------
R
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
-
T
L
---
Y
F
--
N
-
Q
------------
Y
--------
R
G
L
A
D
R
Y
F
M
H
R
L
------
R
Y
R
A
M
A
L
G
-
N
H
E
-
F
D
L
G
--
P
G
-
P
----------------------
L
A
D
--
F
L
---
K
G
A
R
F
K
--
V
V
S
A
N
V
D
A
S
R
EPRLKG
L
-----
F
A
P
Y
A
-
V
V
-----
V
-----
V
----
G
G
----
E
R
V
G
I
I
G
L
T
T
P
D
--
T
-
R
E
I
S
N
P
--
G
P
T
V
A
F
L
D
P
Y
E
S
-
A
Q
K
-
A
---
V
Y
E
-
L
---
L
A
K
G
---------------
V
N
K
I
V
V
L
S
H
L
--
G
Y
G
E
-----
D
------------------------------------
L
K
L
A
R
R
L
-----
V
G
-
V
Q
V
I
V
G
G
H
S
H
T
L
L
--
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
74.45
16%
-58
- C4 -
1T71
2
Y349_MYCPN
A:
[2-275]
--------------------------------------------------------------------------------------------------------------------
M
N
S
I
K
F
I
F
L
G
D
V
Y
G
K
A
G
R
N
I
------------------
I
K
N
N
L
A
Q
L
K
-
S
K
Y
---
Q
A
D
L
--
V
--
I
V
N
A
E
N
T
T
H
G
K
G
---------------------------------------
L
S
L
K
H
Y
E
F
L
K
E
A
------
G
V
N
Y
I
T
M
G
-
N
H
T
-
W
F
Q
K
LD
L
A
-
V
----------------------
V
I
N
--
K
K
D
L
V
R
P
L
N
L
D
--
T
S
F
A
F
H
N
--
L
------
G
-----
Q
G
S
-
L
-
V
F
-----
E
-----
F
----
N
K
----
A
K
I
R
I
T
N
L
L
G
T
S
--
V
P
L
P
F
---------
K
T
T
N
P
F
K
V
-
L
K
E
-
L
---
I
L
K
------
R
-
D
---------------
C
D
L
H
I
V
D
F
H
A
--
E
T
T
S
-----------------------------
E
----
K
-------
N
A
F
C
M
-
A
-
F
--
D
G
Y
-
V
T
T
I
F
G
T
H
T
H
V
P
S
--
A
D
---------------
L
R
-
I
T
P
KG
S
A
Y
I
TDVGMC
G
P
G
F
G
SVIGAN
P
E
Q
S
I
R
L
F
-
C
A
--------
G
SR
E
H
F
E
V
S
KC
G
----
A
Q
L
--------
N
G
V
F
F
E
-
V
D
V
N
T
K
---
K
-
V
I
K
T
E
A
I
R
I
V
E
D
--
D
P
R
Y
L
K
Q
---------------------------------
28
HHSearch
72.48
15%
-48
- C4 -
3IVE
5
?
A:
[4-250]
--------------------------------------------------------------------------------------------------------------------
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
-
P
WIA
D
-
G
------
K
-
R
D
I
G
G
W
A
N
I
T
-
T
L
V
K
--
Q
E
----
K
--
A
K
N
K
A
T
W
F
F
D
A
G
D
Y
F
T
G
-
P
Y
I
--
S
---
S
-
L
------------
T
--------
K
G
K
A
I
I
D
I
M
N
T
M
------
P
F
D
A
V
T
I
G
-
N
H
E
-
F
D
H
G
--
W
D
-
N
----------------------
T
L
L
-----
Q
L
S
Q
A
K
F
P
--
I
V
Q
G
N
I
F
Y
Q
N
------
S
SKSFW
D
K
P
Y
T
-
I
I
-----
E
-----
K
----
D
G
----
V
K
I
G
V
I
G
L
H
G
V
F
--
A
F
N
D
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
-
L
Q
R
-
Y
---
I
D
E
-
L
----
K
G
K
---------------
V
D
L
T
V
A
L
I
H
E
--
G
V
P
A
-----
R
--
Q
S
------
S
M
----D
V
R
R
A
L
D
K
----
D
-------
I
Q
T
A
S
Q
-----
V
K
G
-
L
D
I
L
I
T
G
H
A
H
V
G
T
--
P
E
---------------
P
I
K
V
G
N
------------
T
L
I
L
-----------------------------------------------------------------------------------------------------------------------------
23
HHSearch
69.51
15%
-55
- C4 -
1T70
-
?
A:
[1-184]
-----------------------------------------------------------------------------------------------------------------------
M
R
V
L
F
I
G
D
V
F
G
Q
P
G
R
R
V
------------------
L
Q
N
H
L
P
T
I
----
R
P
--
Q
F
D
F
--
V
--
I
V
N
M
E
N
S
A
G
G
F
G
---------------------------------------
M
H
R
D
A
A
R
G
A
L
E
A
------
G
A
G
C
L
T
L
G
-
N
H
A
-
W
H
H
K
D
-
I
Y
-
P
----------------------
M
L
S
E
D
T
Y
P
I
V
R
P
L
N
Y
A
--
D
P
G
-----
T
P
------
G
-----
V
G
W
-
R
-
T
F
-----
D
-----
V
----
N
G
----
E
K
L
T
V
V
N
L
L
G
R
V
--
F
-
M
E
-------
A
---
V
D
N
P
F
R
T
-
M
D
A
-
L
---
L
E
R
------
D
-
D
---------------
L
G
T
V
F
V
D
F
H
A
--
E
A
T
S
-----
E
----------------------------
K
-------
E
A
M
G
W
-
H
-
L
--
A
G
R
-
V
A
A
V
I
G
T
H
T
H
V
P
T
--
A
D
---------------
T
R
-
I
L
----------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.34
14%
-45
- C4 -
3THO
6
RAD50_THEMA
B:
[1-262]
-----------------------------------------------------------------------------------------------------------------------
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
W
T
S
-
S
RPV
D
R
R
------
E
-
E
L
K
K
A
L
D
K
V
V
-
E
E
A
E
K
R
E
V
D
L
--
I
--
L
--------
L
T
G
D
L
L
H
S
R
N
N
---
P
---
S
-
V
------------
V
--------
A
L
H
D
L
L
D
Y
L
K
R
M
M
R
----
T
A
P
V
V
V
L
P
G
N
Q
D
-
W
K
G
L
--
K
L
-
F
-----------------------
G
N
------
F
---
V
-
T
--
S
I
S
S
D
I
T
F
V
M
------
S
-----
F
E
P
-
V
-
D
V
-----
E
A
----
K
----
R
G
----
Q
K
V
R
I
L
P
F
P
Y
P
D
--
E
-
S
------
K
N
E
G
--
D
F
--
R
F
F
-
L
E
S
-
R
---
L
N
K
-
L
Y
E
E
A
L
K
K
---------------
E
D
F
A
I
F
M
G
H
F
--
T
V
E
G
-----
L
--
A
G
-------------------
R
----
E
-------
I
I
I
N
R
A
L
-
I
--
P
S
V
-
V
D
Y
A
A
L
G
H
I
H
S
F
R
--
E
I
---------------
Q
K
---
Q
------------
P
L
T
I
Y
---------
P
-
G
S
L
-
I
R
--------
I
--
D
F
G
E
----
E
----
A
D
---------
E
K
G
A
V
F
-
V
E
L
K
R
G
E
P
-
P
-
R
Y
E
R
I
D
A
S
----------------------------------------------
42
Fugue
67.75
12%
-27
- C4 -
1USH
6
?
?:
[26-362]
----------------------------------------------------------
Y
E
Q
D
K
T
Y
K
I
---
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
G
E
Y
-
G
L
A
A
Q
K
--
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
---
S
V
L
L
L
S
-
G
G
D
I
N
T
G
-----------------------------------------------------
V
P
E
S
D
L
Q
D
---------------------------------------
A
E
P
D
F
R
G
M
N
L
V
------
G
Y
D
A
M
A
I
G
-
N
H
E
-
F
D
N
P
--
L
T
-
V
----------------------
L
R
Q
--
Q
E
K
W
A
K
F
P
L
L
S
AN
I
Y
Q
K
S
T
G
E
R
L
------
F
-----
K
P
W
-
A
-
L
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
-------
T
D
D
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
-
P
A
D
-
E
---
A
K
L
V
I
Q
--
E
L
Q
Q
TEK------------
P
D
I
I
I
A
A
T
H
M
--
G
H
Y
D
-----
N
--
G
E
------
H
G
---
S
-------
N
----
A
-------
P
G
D
V
E
M
A
-
R
A
L
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
--
C
M
---------------
A
A
-
E
N
K
------------
K
Q
V
D
Y
---------
V
P
G
T
P
-
C
K
--------
P
--
D
Q
Q
N
----
G
----
I
W
I
V
Q
AHEWGK
Y
V
G
R
A
D
-
F
E
F
R
N
G
-
E
-
M
-
K
M
V
N
Y
Q
L
I
P
V
N
L
--
K
K
R
V
L
Y
T
P
E
----
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
---
45
Fugue
67.52
15%
-19
* C2 *
2OCC
-
COX1_BOVIN
A:
[1-514]
MFINRWLFSTN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
GQPGTLLGD
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
F
FMV
M
P
I
M
I
G
G
F
G
N
W
L
V
P
L
M
I
G
A
P
-
D
M
A
F
P
R
M
N
N
M
S
F
W
L
L
P
P
S
F
L
L
L
L
A
S
S
M
V
E
-----
A
G
A
G
T
G
W
T
V
Y
P
P
-
L
---
A
-
G
NLAHAG
A
-
S
V
D
L
T
I
F
S
L
H
-
L
A
G
V
--
S
S
I
L
--
G
--
A
I
N
F
I
T
T
I
I
N
M
K
P
P
A
M
S
-
Q
Y
QTP
L
---
F
-
V
------------
W
--------
S
V
M
I
T
A
V
L
L
L
L
S
L
P
V
L
A
A
G
I
T
M
L
L
T
D
R
N
L
N
-
T
T
F
F
--
D
P
-
A
GGGD
P
I
L
Y
Q
H
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
--
P
G
F
G
M
I
S
H
I
V
T
--
Y
Y
S
G
K
K
E
P
F
G
------
Y
-----
M
G
M
-
V
-
W
A
-----
M
-----
M
----
S
I
----
G
F
L
G
F
I
V
W
A
H
H
M
--
F
T
V
G
M
D
V
D
T
R
A
Y
F
T
S
A
T
M
I
I
A
I
P
T
G
V
-
K
---
V
F
S
W
L
A
--
T
L
H
G
GNIKWS
P
A
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
L
T
--
G
I
V
L
-----
A
--
N
S
------
S
L
---
D
-------
I
----
V
LHDTY
Y
V
V
A
H
F
H
Y
V
-
L
--
S
M
G
A
V
F
A
I
M
G
G
F
V
H
W
F
P
--
L
F
SGYTLN
D
T
W
A
K
I
H
F
A
I
M
-
F
V
G
------------
V
N
M
T
F
---------
F
P
Q
H
F
-
L
G
L
S
G
M
P
R
RY
S
--
D
Y
P
D
----
A
----
Y
T
M
--------
W
N
T
I
S
S
-
M
G
S
F
I
S
-
L
-
T
-
A
V
M
L
M
V
F
I
I
W
E
A
--
F
A
S
K
R
E
V
L
-TVDL
T
T
T
N
L
E
W
L
N
G
C
P
P
P
Y
H
T
F
E
E
P
T
Y
V
N
L
K
25
HHSearch
66.34
16%
-32
- C4 -
3JYF
10
?
A:
[4-252]
------------------------------------------------------------------------------------------------------------------
A
A
T
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
-
Y
---
K
D
A
------
A
-
T
E
K
F
G
L
V
R
T
A
-
S
L
I
E
--
Q
A
R
A
------
E
V
K
N
S
V
L
V
D
N
G
D
V
I
Q
G
-
S
P
---
L
G
--
D
-
Y
------------
M
A
A
K
GLKEG
D
V
H
P
V
Y
K
A
M
N
T
L
------
N
Y
A
V
G
N
L
G
-
N
H
E
-
F
N
Y
G
--
L
D
-
F
----------------------
L
H
K
--
A
L
A
---
G
A
K
F
P
--
Y
V
N
A
N
I
I
D
A
K
TGKP--
M
-----
F
T
P
-
Y
L
I
Q
D
T
R
V
V
D
-----
S
----
D
G
Q
I
H
T
L
R
I
G
Y
I
G
F
V
P
P
Q
--
I
-
M
T
W
D
K
A
N
L
N
G
K
V
T
V
N
D
I
T
E
T
-
A
R
K
-
Y
---
I
P
E
-
M
---
R
A
K
G
---------------
A
D
V
V
V
V
V
A
H
S
--
G
L
S
A
-----
D
--
P
Y
------
Q
A
MA-
E
-------
N
----
S
-------
V
Y
Y
L
S
Q
-----
V
P
G
-
V
D
A
I
M
F
G
H
A
H
A
V
F
--
P
G
---------------
K
D
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
65.66
13%
-55
* C4 *
3AV0
4
MRE11_METJA
A:
[18-251]
--------------------------------------------------------------------------------------------------------------------
G
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
Y
N
L
-
D
D
--
R
-
E
------
K
-
D
I
Y
D
S
F
K
L
C
I
-
K
K
I
L
E
I
K
P
D
V
--
V
--
L
H
--------
S
G
D
L
F
N
D
-
L
R
---
P
P
V
K
A
-
L
------------
R
--------
I
A
M
Q
A
F
K
K
L
H
E
N
------
N
I
K
V
Y
I
V
A
G
N
H
E
-
M
P
R
R
--
L
G
-
E
----------------------
E
-
S
--
P
L
A
L
L
K
D
-
Y
V
K
--
I
L
D
--------------------
G
K
-
D
-
V
I
-----
N
-----
V
----
N
G
----
E
E
I
F
I
C
G
T
Y
Y
H
K
--
K
---
S
K
---
R
------
E
E
M
L
D
K
-
L
K
N
-
F
---
E
S
E
------
A
K
N
---------------
Y
K
K
K
I
L
M
L
H
Q
--
G
I
N
P
-----
Y
---
I
------
P
L
---
D
-------
Y
----
E
---------
L
-
E
H
F
-
D
--
L
P
K
-
F
S
Y
Y
A
L
G
H
I
H
K
R
I
--
L
E
---------------
R
--
F
N
D
------------
G
I
L
A
Y
---------
S
-
G
S
T
-
E
I
--------
I
--
Y
R
N
E
----
Y
E
D
Y
K
K
E
G
---------
K
G
F
Y
L
-
V
D
F
S
G
------------------------------------------------------------
24
HHSearch
65.39
17%
-35
- C4 -
3GVE
3
NTPES_BACSU
A:
[8-261]
-------------------------------------------------------------------------------------------------------------------
P
Q
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
M
D
Y
D
Y
-
Y
S--
D
-
K
------
E
-
T
A
D
F
G
L
A
R
T
A
-
Q
L
I
Q
--
K
H
R
E
------
Q
N
P
N
T
L
L
V
D
N
G
D
L
I
Q
G
-
N
P
---
L
G
--
E
-
Y
A
V
K
YQ
K
D
D
I
I
S
G
T
--------
K
T
H
P
I
I
S
V
M
N
A
L
------
K
Y
D
A
G
T
L
G
-
N
H
E
-
F
N
Y
G
--
L
D
-
F
----------------------
L
D
G
--
T
I
K
---
G
A
D
F
P
--
I
V
N
A
N
V
K
T
T
S
GEN---
R
-----
Y
T
P
Y
V
-
I
N
-----
E
K
TLID
E
NG
N
E
Q
K
----
V
K
V
G
Y
I
G
F
V
P
P
Q
---
I
M
T
W
D
K
K
N
L
E
G
Q
V
Q
V
Q
D
I
V
E
S
-
A
N
E
-
T
---
I
P
K
-
M
---
K
A
E
G
---------------
A
D
V
I
I
A
L
A
H
T
--
G
I
E
K
-----
Q
--
A
Q
------
S
S
---
G
-------
A
----
E
-------
N
A
V
F
D
L
A
T
K
--
T
K
G
-
I
D
A
I
I
S
G
H
Q
H
G
L
F
--
P
S
---------------
A
E
-
Y
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
59.99
13%
-45
- C4 -
3C9F
2
?
A:
[9-271]
----------------------------------------------------------------------------------------------------------------
R
N
L
T
W
N
D
I
N
F
V
H
T
T
D
T
H
G
W
Y
S
G
H
I
N
-
Q
---
P
-
L
------
Y
H
A
N
W
G
D
F
I
S
F
T
-
T
H
M
R
--
R
I
A
H
-----
S
R
N
Q
D
L
L
L
I
D
S
G
D
R
H
D
G
-
N
G
---
L
---
S
D
I
------------
T
SP------
N
G
L
K
S
T
P
I
F
I
K
Q
------
D
Y
D
L
L
T
I
G
-
N
H
E
-
L
Y
L
W
--
E
N
-
S
----------------------
K
Q
E
--
Y
E
T
V
V
N
H
F
Q
D
K
--
Y
V
C
S
N
V
D
I
R
L
DNG---
L
FVPLG
L
K
Y
-
K
-
Y
F
T
T
---
P
-----
I
----
R
G
----
I
R
V
M
A
F
G
F
L
F
D
F
--
K
--
R
F
-----
N
S
G
T
R
V
T
P
M
A
E
T
-
I
H
E
P
W
---
F
Q
E
A
L
----
K
H
E
---------------
V
D
L
I
I
I
V
G
H
T
--
P
I
S
H
-----
N
--
W
G
------
E
F
---
Y
-------
Q
----
V
-------
H
Q
Y
L
R
Q
F
-
F
--
P
D
T
-
I
I
Q
Y
F
G
G
H
S
H
I
R
D
--
F
T
---------------
V
F
-
D
S
L
------------
S
T
G
L
Q
---------
S
------------------------------------------------------------------------------------------------------------------
27
HHSearch
59.64
10%
-38
- C4 -
1HP1
5
USHA_ECOLI
A:
[4-234]
------------------------------------------------------------------------------------------------------------------
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
---------------
Y
--
G
E
Y
G
L
A
A
Q
K
-
T
L
V
D
--
G
I
R
K
--
E
V
A
A
E
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
-
V
P
E
--
S
---
D
-
L
------------
Q
--------
D
A
E
P
D
F
R
G
M
N
L
V
------
G
Y
D
A
M
A
I
G
-
N
H
E
-
F
D
N
P
--
L
T
-
V
----------------------
L
R
Q
--
Q
E
---
K
W
A
K
F
P
--
L
L
S
A
N
I
Y
Q
K
S
TGER--
L
-----
F
K
P
W
A
-
L
F
-----
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
-
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
-
A
K
L
-
V
---
I
Q
E
-
L
Q
--
Q
T
E
K
---------------
P
D
I
I
I
A
A
T
H
M
--
G
H
Y
D
-----
N
--
G
E
------
H
G
SNA
P
-------
G
----
D
-------
V
E
M
A
R
A
L
-
P
--
A
G
S
-
L
A
M
I
V
G
G
H
S
Q
D
P
V
--
C
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
58.05
12%
-24
- C4 -
2DXN
2
?
A:
[1-271]
------------------------------------------------------------------
M
---
L
L
A
H
I
S
D
T
H
F
R
S
R
G
E
K
L
Y
G
F
I
D
V
N
A
A
N
--
A
D
V
V
S
Q
L
N
A
L
R
E
R
P
D
------
A
V
V
V
S
G
D
-----------
I
---
V
-
N
------
C
-
G
R
P
E
E
Y
Q
V
A
R
-
Q
I
L
G
------------------------------------------------------------------------
S
L
------
N
Y
P
L
Y
L
I
P
G
N
H
------------------------------------
D
--
D
K
A
L
F
L
E
Y
L
Q
P
--
L
C
P
Q
L
G
S
D
A
N
------
N
-----
M
R
C
-
A
-
V
------
D
-----
D
----
F
A
----
T
R
L
L
F
I
---------------
D
S
S
R
A
G
T
S
K
G
W
L
T
D
E
-
T
I
S
-
W
---
L
E
A
Q
L
F
--
E
G
G
D
---------------
K
P
A
T
I
F
M
H
H
P
--
P
L
P
L
GNAQM
D
--
P
I
------
A
C
---
E
-------
N
----
G
-------
H
R
L
L
A
L
V
-
E
--
R
F
P
S
L
T
R
I
F
C
G
H
N
H
-
S
L
--
T
M
---------------
T
Q
-
Y
R
Q
------------
A
L
I
S
T
---------
L
P
G
T
V
-
H
Q
---------------------------------------
V
P
-
Y
C
H
E
D
T
-
D
-
P
-
Y
Y
D
L
S
P
---
A
S
C
--
L
M
H
R
Q
V
G
E
Q
----
W
V
S
Y
Q
H
S
L
A
H
Y
A
G
P
W
L
Y
D
E
N
I
S
C
P
T
--
29
HHSearch
57.34
10%
-43
- C4 -
2WDC
10
?
A:
[78-304]
------------------------------------------------------------------------------------------------------------------
R
G
T
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
-----------------
F
-
G
P
I
G
G
M
G
A
L
T
-
A
L
I
R
--
D
Q
K
A
R
V
E
--
A
E
G
G
K
A
L
V
L
D
G
G
D
T
W
T
N
-
S
G
---
L
S
--
L
-
L
------------
T
--------
R
G
E
A
V
V
R
W
Q
N
L
V
------
G
V
D
H
M
V
-
S
-
H
W
E
-
W
T
L
G
--
R
E
-
R
----------------------
V
E
E
--
L
---
L
G
L
F
R
G
E
--
F
L
S
Y
N
I
V
D
D
L
------
F
GDPL-
F
P
A
Y
R
-
I
H
-----
R
-----
V
----
G
P
----
Y
A
L
A
V
V
G
A
S
Y
P
Y
--
V
-
K
V
S
H
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
-
L
Q
E
-
A
---
V
D
K
-
A
---
R
A
E
G
---------------
A
N
A
V
V
L
L
S
H
N
--
G
M
Q
L
-----
D
------------------------------------
A
A
L
A
E
R
I
-----
R
G
-
I
D
L
I
L
S
G
H
T
H
D
L
T
--
P
R
---------------
P
W
R
V
G
K
------------
T
W
I
V
A
----------------------------------------------------------------------------------------------------------------------------
48
Fugue
54.69
10%
-21
- C4 -
2NXF
6
ADPRM_DANRE
A:
[3-322]
----------------------------------------------------------
D
P
V
F
T
F
G
L
I
---
A
D
V
Q
Y
A
D
I
E
D
G
E
N
Y
L
R
T
R
R
R
-
Y
Y
R
G
S
A
--
D
L
L
R
D
A
V
L
Q
W
R
R
E
R
V
Q
-----
C
V
V
Q
L
G
D
I
-----
I
D
G
H
-
N
---
R
-
R
------
R
-
D
A
S
D
R
A
L
D
T
V
M
A
E
L
D
--
A
C
S
V
--
D
--
V
H
H
V
W
G
N
H
E
F
Y
N
F
S
R
P
S
-
L
L
---
S
---
S
-
R
------------
L
--------
N
S
A
Q
G
S
D
L
I
G
D
D
------
I
Y
A
Y
E
F
S
P
A
P
N
F
-
R
F
V
L
--
L
D
-
A
----------------------
Y
-
D
--
L
S
V
I
G
R
E
E
E
S
E
--
K
H
T
H
S
W
R
I
L
T
------
Q
-----
H
N
H
-
N
-
L
Q
-----
D
-----
L
----
N
L
----
P
P
V
S
V
G
L
E
Q
R
F
V
--
K
F
N
G
G
F
---------
S
E
Q
Q
L
Q
W
-
L
D
A
-
V
---
L
T
L
S
D
H
--
K
Q
E
------------------
R
V
L
I
F
S
H
L
--
P
V
H
P
-----
C
--
A
A
------
D
P
---
I
-------
C
LAWN
H
-------
E
A
V
L
S
V
L
-
R
--
S
H
Q
S
V
L
C
F
I
A
G
H
D
H
-
D
G
--
G
R
---------------
C
T
-
D
S
S
--------------------------
G
A
Q
H
I
-
T
L
--------
E
--
G
V
I
E
----
T
----
P
P
H
--------
S
H
A
F
A
T
-
A
Y
L
Y
E
D
-
R
M
V
M
K
G
R
-----------------
G
R
V
----
E
D
L
T
I
T
Y
S
-------------------
46
Fugue
53.41
17%
3
- C2 -
4HNE
1
P4K2A_HUMAN
A:
[2-384]
--------------------------------------------------------------------------------------
P
L
G
S
-
P
E
F
A
A
Q
--
A
Q
A
L
A
A
Q
A
A
A
A
A
H
A
A
Q
A
H
R
E
R
N
-
E
F
P
E
D
P
E
F
E
A
V
V
R
Q
A
E
L
---
A
-
I
------
E
-
R
C
I
F
P
E
R
I
Y
Q
-
G
--
S
--
S
G
S
Y
--
F
--
V
K
D
P
Q
G
R
I
I
A
V
F
K
P
-
K
N
-
E
E
---
P
---
Y
-
G
------------
H
--------
L
N
P
K
W
T
K
W
L
Q
K
F
------
G
R
D
-
C
L
V
L
N
Q
G
Y
-
L
S
E
A
--
G
A
-
S
----------------------
L
V
D
--
Q
K
L
E
L
N
I
V
P
R
T
--
K
V
V
Y
L
A
S
E
T
F
------
N
-----
Y
S
A
-
I
-
D
R
-----
V
-----
K
----
S
R
----
G
K
R
L
A
L
R
F
N
R
I
G
L
P
P
K
V
G
S
F
Q
L
F
V
E
G
Y
K
D
A
D
Y
W
L
R
R
-
F
E
A
-
E
PLP
E
N
T
N
R
Q
--
L
L
L
Q
---------------
F
E
R
L
V
V
L
D
Y
I
I
R
N
T
D
R
-----
G
--
N
D
N
W
----
L
I
---
K
-------
Y
----
D
-------
C
P
P
V
I
K
V
-
A
--
A
I
D
N
G
L
A
F
P
L
K
H
P
D
S
W
R
--
A
Y
---------------
P
F
-
Y
W
A
WLPQAK------
V
P
F
S
Q
---------
E
I
K
D
L
-
I
L
--------
P
--
K
I
-
S
----
D
----
P
N
F
--------
V
K
D
L
E
E
-
D
L
Y
E
L
F
-
K
-
K
-
D
P
G
F
D
R
G
Q
F
H
-
K
--
Q
I
A
V
M
R
G
Q
I
----
L
N
L
T
Q
A
L
K
D
N
K
S
P
L
H
L
V
Q
M
P
P
V
I
V
E
T
-
35
HHSearch
52.42
19%
-91
- C4 -
3IB7
4
CPDA_MYCTU
A:
[173-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
T
I
L
A
L
H
H
--
P
P
I
P
-----
S
--
V
L
DMAVTV
E
L
---
R
-------
D
----
Q
-------
A
A
L
G
R
V
L
-
R
--
G
T
D
-
V
R
A
I
L
A
G
H
L
H
Y
S
T
--
N
A
---------------
T
--
F
V
G
------------
I
P
V
S
V
---------
A
------------------------------------------------------------------------------------------------------------------