@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2457: (2016-04-03 )
MRKPIIAGNWKMNKTAAKAGQFAEDVKNNVPSSDAVESVVAAPALFLQELVRLTEGTDLRVSAQNCYFEDEGAFTGEISPFALADLGVSYVIIGHSERREYFHETDEDINKKAHAIFKHGMTPIICCGETLDQREAGQTDTWVRGQIRAALAGLTEEQVIKSVIAYEPIWAIGTGKSSTSADANETCAVIRAEVADAVSQKAADAVRIQYGGSVKPENIADYLAESDIDGALVGGASLEPASFLALLEAVK
Atome Classification :
(54 SA)
-.........10........20........30........40.....-...50--...--...---...60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MRK
P
I
I
AGN
W
K
MN
K
T
A
AK
A
G
Q
F
A
E
D
V
K
NNVP
S
S
D
A
V
E
S
V
V
A
A
P
A
L
F
-
L
Q
E
L
---
V
R
L--TEG---T
D
L
R
V
S
A
QN
C
Y
FEDEGAFTGEIS
P
F
A
L
A
DL
G
V
S
Y
V
I
I
G
H
S
E
R
R
E
Y
F
HET
D
E
D
I
N
K
K
A
H
A
I
F
KHG
M
T
P
I
I
CCGETL
D
Q
REAGQTD
T
W
V
R
G
Q
I
R
A
A
L
AGL
T
E
E
Q
V
I
K
S
V
I
AYEP
I
W
A
IGTGKSSTSADAN
E
T
C
A
V
I
R
A
E
V
A
D
A
V
S
Q
KAA
D
A
V
R
I
Q
YGGSV
K
P
E
N
I
A
D
Y
L
A
ESDID
G
A
LVGGASL
E
P
A
S
F
L
A
L
L
E
AVK
101
HHSearch
98.15
65%
-87
- C8 -
2BTM
1
TPIS_GEOSE
A:
[1-249]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
V
I
S
V
V
C
A
P
F
L
F
-
L
D
R
L
---
V
Q
A
--
A
D
G
---
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
-
123
Fugue
98.07
65%
-88
- C8 -
2BTM
1
TPIS_GEOSE
A:
[1-250]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
V
I
S
V
V
C
A
P
F
L
F
-
L
D
R
L
---
V
Q
A
A
D--
G
---
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
1
PsiBlast_PDB
97.78
65%
-86
- C8 -
2BTM
1
TPIS_GEOSE
A:
[1-248]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
V
I
S
V
V
C
A
P
F
L
F
-
L
D
R
L
---
V
Q
A
--
A
D
G
---
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
--
7
PsiBlast_PDB
97.47
62%
-92
- C8 -
3UWY
-
TPIS_STAAR
A:
[1-253]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
5
PsiBlast_PDB
97.32
62%
-91
- C8 -
3UWV
5
TPIS_STAAR
A:
[9-261]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
21
PsiBlast_CBE
97.04
65%
-84
- C8 -
2BTM
1
TPIS_GEOSE
B:
[1-248]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
V
I
S
V
V
C
A
P
F
L
F
-
L
D
R
L
---
V
Q
A
--
A
D
G
---
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
--
6
PsiBlast_PDB
96.82
62%
-93
- C8 -
3UWW
3
TPIS_STAAR
A:
[9-261]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
2
PsiBlast_PDB
96.76
64%
-85
- C8 -
1BTM
1
TPIS_GEOSE
A:
[1-248]
--
R
K
P
I
I
A
G
N
W
K
M
H
K
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
V
I
S
V
V
C
A
P
F
L
F
-
L
D
R
L
---
V
Q
A
--
A
D
G
---
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
--
4
PsiBlast_PDB
96.74
62%
-91
- C8 -
3UWU
2
TPIS_STAAR
A:
[9-261]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
108
HHSearch
96.68
63%
-91
- C8 -
3M9Y
2
TPIS_STAAR
A:
[2-254]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
-
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
---
T
T
A
--
V
K
E
GKA
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
--
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
8
PsiBlast_PDB
96.47
62%
-91
- C8 -
3UWZ
1
TPIS_STAAR
A:
[9-261]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
26
PsiBlast_CBE
96.44
62%
-90
- C8 -
3UWV
4
TPIS_STAAR
B:
[9-261]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
25
PsiBlast_CBE
96.41
62%
-92
- C8 -
3UWW
3
TPIS_STAAR
B:
[10-260]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
23
PsiBlast_CBE
96.34
62%
-91
- C8 -
3M9Y
3
TPIS_STAAR
B:
[2-254]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
27
PsiBlast_CBE
95.86
62%
-92
- C8 -
3UWU
1
TPIS_STAAR
B:
[9-260]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
TTA
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
3
PsiBlast_PDB
95.83
62%
-93
- C8 -
3M9Y
2
TPIS_STAAR
A:
[2-254]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
--
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
22
PsiBlast_CBE
95.44
64%
-83
- C8 -
1BTM
1
TPIS_GEOSE
B:
[1-248]
--
R
K
P
I
I
A
G
N
W
K
M
H
K
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
H
V
P
P
A
D
E
V
I
S
V
V
C
A
P
F
L
F
-
L
D
R
L
---
V
Q
A
--
A
D
G
---
T
D
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
--
24
PsiBlast_CBE
94.61
62%
-92
- C8 -
3UWZ
2
TPIS_STAAR
B:
[9-261]
-
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
-
L
P
D
S
K
E
V
E
S
V
I
C
A
P
A
I
Q
-
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
---
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
9
PsiBlast_PDB
92.66
58%
-90
- C8 -
4Y8F
5
?
A:
[4-249]
-
M
R
T
P
I
I
A
G
N
W
K
M
H
Y
T
I
D
E
A
V
K
L
V
E
E
L
K
P
L
V
--
K
D
A
K
C
E
V
V
V
C
P
T
F
V
C
L
D
A
V
---
K
K
A
--
V
E
G
---
T
N
I
K
V
G
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
Y
F
N
E
T
D
E
T
C
N
K
K
V
K
A
A
F
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
T
A
D
L
E
G
L
T
K
E
Q
A
E
K
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
T
A
T
S
D
Q
A
N
E
T
I
A
A
I
R
A
M
V
A
E
M
F
G
Q
E
V
A
D
K
V
R
I
Q
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
----
103
HHSearch
91.49
47%
-86
- C8 -
1B9B
1
PGKT_THEMA
A:
[2-250]
-
T
R
K
L
I
L
A
G
N
W
K
M
H
K
T
I
S
E
A
K
K
F
V
S
L
L
V
N
E
L
H
D
V
K
E
F
E
I
V
V
C
P
P
F
T
A
-
L
S
E
V
---
G
E
I
--
L
S
G
---
R
N
I
K
L
G
A
Q
N
V
F
Y
E
D
Q
G
A
F
T
G
E
I
S
P
L
M
L
Q
E
I
G
V
E
Y
V
I
V
G
H
S
E
R
R
R
I
F
K
E
D
D
E
F
I
N
R
K
V
K
A
V
L
E
K
G
M
T
P
I
L
C
V
G
E
T
L
E
E
R
E
K
G
L
T
F
C
V
V
E
K
Q
V
R
E
G
F
Y
G
L
D
K
E
E
A
K
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
T
P
Q
Q
A
Q
E
V
H
A
F
I
R
K
L
L
S
E
M
Y
D
E
E
T
A
G
S
I
R
I
L
Y
G
G
S
I
K
P
D
N
F
L
G
L
I
V
Q
K
D
I
D
G
G
L
V
G
G
A
S
L
K
E
-
S
F
I
E
L
A
R
I
M
-
49
PsiBlast_CBE
85.36
41%
-79
- C8 -
4MVA
4
?
A:
[25-272]
-
M
R
H
P
L
V
M
G
N
W
K
L
N
G
S
R
H
M
V
H
E
L
V
S
N
L
R
K
E
L
A
G
V
A
G
C
A
V
A
I
A
P
P
E
M
Y
-
I
D
M
A
---
K
R
E
--
A
E
G
---
S
H
I
M
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
A
K
-
V
D
A
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
--
122
Fugue
85.13
42%
-75
- C8 -
1IF2
1
TPIS_LEIME
A:
[3-251]
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
97
PsiBlast_CBE
85.04
42%
-78
- C8 -
1N55
6
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
91
PsiBlast_CBE
84.90
41%
-71
- C8 -
1TPV
1
TPIS_CHICK
A:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
P
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
T
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
109
HHSearch
84.85
42%
-77
- C8 -
2VXN
7
TPIS_LEIME
A:
[4-250]
-
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
-
S
H
D
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
-
46
PsiBlast_CBE
84.80
43%
-81
- C8 -
2I9E
2
?
B:
[3-245]
--
R
K
F
V
V
G
G
N
W
K
M
N
G
D
K
K
Q
I
N
E
I
I
G
F
L
K
S
G
-
P
L
N
Q
D
T
E
V
V
V
G
V
P
A
I
Y
-
L
-
E
L
---
V
R
T
--
C
V
P
---
A
S
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
D
W
S
N
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
D
A
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
92
PsiBlast_CBE
84.78
42%
-77
- C8 -
2Y63
1
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
94
PsiBlast_CBE
84.64
42%
-76
- C8 -
2Y61
3
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
93
PsiBlast_CBE
84.64
42%
-78
- C8 -
2Y62
3
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
95
PsiBlast_CBE
84.52
42%
-77
- C8 -
2VXN
7
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
44
PsiBlast_CBE
84.49
43%
-84
- C8 -
2I9E
3
?
D:
[3-245]
--
R
K
F
V
V
G
G
N
W
K
M
N
G
D
K
K
Q
I
N
E
I
I
G
F
L
K
S
G
-
P
L
N
Q
D
T
E
V
V
V
G
V
P
A
I
Y
-
L
-
E
L
---
V
R
T
--
C
V
P
---
A
S
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
D
W
S
N
V
--
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
D
A
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
98
PsiBlast_CBE
84.42
42%
-77
- C8 -
1IF2
1
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
48
PsiBlast_CBE
84.10
41%
-81
- C8 -
4MVA
3
?
B:
[25-272]
-
M
R
H
P
L
V
M
G
N
W
K
L
N
G
S
R
H
M
V
H
E
L
V
S
N
L
R
K
E
L
A
G
V
A
G
C
A
V
A
I
A
P
P
E
M
Y
-
I
D
M
A
---
K
R
E
--
A
E
G
---
S
H
I
M
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
A
K
-
V
D
A
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
--
64
PsiBlast_CBE
83.81
42%
-73
- C8 -
1SW7
1
TPIS_CHICK
B:
[4-246]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
N
S
S
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
96
PsiBlast_CBE
83.62
42%
-77
- C8 -
1QDS
1
TPIS_LEIME
A:
[6-251]
---
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
-
V
Q
C
V
V
A
P
T
F
V
H
-
I
P
L
V
---
Q
A
K
--
L
R
N
---
P
K
Y
V
I
S
A
Q
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
-
E
F
R
D
I
I
D
A
T
R
90
PsiBlast_CBE
83.50
41%
-70
- C8 -
1TPV
1
TPIS_CHICK
B:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
P
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
T
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
104
HHSearch
83.38
38%
-82
- C8 -
2J27
1
TPIS_TRYBB
A:
[3-250]
-
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
-
N
H
D
V
Q
C
V
V
A
S
T
F
V
H
-
L
A
M
T
---
K
E
R
--
L
S
H
---
P
K
F
V
I
A
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
A
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
K
A
T
Q
71
PsiBlast_CBE
83.19
41%
-72
- C8 -
1SW3
1
TPIS_CHICK
A:
[4-246]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
82
PsiBlast_CBE
83.12
41%
-67
- C8 -
1TPU
1
TPIS_CHICK
B:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
T
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
75
PsiBlast_CBE
83.11
41%
-73
- C8 -
1SSG
4
TPIS_CHICK
A:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
Y
S
L
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
65
PsiBlast_CBE
83.09
42%
-71
- C8 -
1SW7
1
TPIS_CHICK
A:
[4-246]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
N
S
S
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
85
PsiBlast_CBE
83.02
41%
-73
- C8 -
1SW0
1
TPIS_CHICK
A:
[4-246]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
L
W
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
81
PsiBlast_CBE
82.92
41%
-72
- C8 -
1SU5
7
TPIS_CHICK
A:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
N
P
N
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
99
PsiBlast_CBE
82.88
40%
-73
- C8 -
7TIM
1
TPIS_YEAST
B:
[2-237]
--
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
-
N
T
A
S
I
P
E
N
V
E
V
V
I
C
P
P
A
T
Y
-
L
D
Y
S
---
V
S
L
--
V
K
K
---
P
Q
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-----------
83
PsiBlast_CBE
82.85
41%
-72
- C8 -
1TPU
1
TPIS_CHICK
A:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
T
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
69
PsiBlast_CBE
82.77
41%
-76
- C8 -
1SPQ
3
TPIS_CHICK
A:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
--
K
T
K
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
72
PsiBlast_CBE
82.58
41%
-74
- C8 -
1TPW
1
TPIS_CHICK
B:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
P
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
T
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
70
PsiBlast_CBE
82.40
41%
-72
- C8 -
1SW3
1
TPIS_CHICK
B:
[4-246]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
80
PsiBlast_CBE
82.34
41%
-69
- C8 -
1SU5
8
TPIS_CHICK
B:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
N
P
N
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
73
PsiBlast_CBE
82.14
41%
-70
- C8 -
1TPW
1
TPIS_CHICK
A:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
P
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
T
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
84
PsiBlast_CBE
82.01
41%
-70
- C8 -
1SW0
1
TPIS_CHICK
B:
[4-246]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
L
W
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
100
PsiBlast_CBE
81.81
40%
-75
- C8 -
7TIM
1
TPIS_YEAST
A:
[2-237]
--
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
-
N
T
A
S
I
P
E
N
V
E
V
V
I
C
P
P
A
T
Y
-
L
D
Y
S
---
V
S
L
--
V
K
K
---
P
Q
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
T
N
V
--
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-----------
74
PsiBlast_CBE
81.75
41%
-71
- C8 -
1SSG
6
TPIS_CHICK
B:
[3-245]
--
R
K
F
F
V
G
G
N
W
K
M
N
G
D
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
S
A
D
-
T
E
V
V
C
G
A
P
S
I
Y
-
L
-
D
F
---
A
R
Q
--
K
L
D
---
A
K
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
S
--
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
Y
S
L
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
S
D
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
-
E
F
V
D
I
I
N
A
--
111
HHSearch
80.27
37%
-82
- C8 -
1O5X
2
TPIS_PLAFA
A:
[3-247]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
N
N
L
D
F
D
P
S
K
L
D
V
V
V
F
P
V
S
V
H
-
Y
D
H
T
---
R
K
L
--
L
-
Q
---
S
K
F
S
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
D
--
N
F
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
-
S
F
V
D
I
I
K
S
A
-