@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09650: (2016-06-15 )
METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFARSLGMKK
Atome Classification :
(72 SA)
----------------------------------------------------------------------------------.........10--........20........30.-..-.-...----.40-----.------...------....-.50........60...---..-...70.....--...80........----90........100.......110.--........120.......130-.---...----.-------------.------------------.---.--------.140----........150.------------....-----.-----.160.......170--..-----...-...-180-----...---.....190.......200........210.....-...220-..-----------.----..-...230.......240.....-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------
M
E
T
F
K
S
I
L
H
EA--
Q
R
I
V
V
L
TGAGMSTESGIPDFR-SA-G-GIW----TE------
D
------
A
S
R
------
M
E
A
M
-
S
L
D
Y
F
LS
Y
P
R
L
F
W
P
K
F
---
K
E
-
L
F
Q
M
K
MSGSF--EPNEG
H
L
L
L
A
E
L
E
----KQG
K
Q
V
D
I
F
TQNI
D
G
L
H
K
KAG--S--
R
H
V
Y
E
LHGSIQTAACPACG---A---RYD----
L
-------------
P
------------------
H
---
L
--------
L
E
-
R
----EVPECTAAGNNG------------DI
C
G
-----
T
-----
V
L
KT
D
V
V
L
FG
D
A
V
---
M
H
-----
F
D
T
-
L
Y
E
-KL------DQA---
D
L
L
L
V
IGTSLEVAPAR-FVP
E
D
A
S
LIP-
G
M
K
K
V
I
-
I
NLEP--
T
Y
-----------
C
----
D
S
-
L
F
D
M
V
I
H
Q
K
I
G
E
F
A
R
SLGMKK-------------------------
30
PsiBlast_CBE
93.26
33%
0
- C- -
5BTR
4
?
B:
[103-365]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
S
--
K
K
I
I
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L
T
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A
G
V
S
V
S
S
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
F
P
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
41
PsiBlast_CBE
91.78
32%
0
- C- -
4ZZH
1
?
A:
[61-327]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
F
P
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
-
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
40
PsiBlast_CBE
91.78
32%
0
- C- -
4ZZI
2
SIR1_HUMAN
A:
[61-328]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
LAVDFP
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
39
PsiBlast_CBE
91.78
32%
0
- C- -
4ZZJ
4
?
A:
[61-324]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
FP
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
132
Fugue
88.51
35%
-114
- C3 -
5BTR
6
SIR1_HUMAN
A:
[4-390]
DNLLFGD
E
I
I
T
N
GSDWTP
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
M
I
GTD
P
R
T
I
L
K
D
L
LPETIPPPELD
D
M
T
L
W
Q
I
V
I
N
I
L
S
E
P
P
K
R
K
KRKDINT
I
E
D
A
V
K
L
L
Q
E
S
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
S
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
------
L
------
A
V
D
F
PDLPD
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
------------------
A
---
V
--------
R
G
-
D
I
F
N
Q
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
A
------------
I
M
K
P
E
I
V
F
F
G
E
N
L
P--
E
Q
-----
F
H
R
-
A
M
K
-
Y
D
K
-----
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
S
S
--
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
L
S
S
N
P
V
K
L
S
E
ITE
Q
Y
L
F
L
P
P
N
R
Y
I
F
H
GAEVY
4
PsiBlast_PDB
88.00
35%
-130
- C3 -
1YC5
3
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------------------------
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
SS
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
6
PsiBlast_PDB
87.61
35%
-129
- C3 -
2H4J
4
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-----------------------------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
38
PsiBlast_CBE
87.46
32%
-118
- C3 -
4IF6
2
SIR1_HUMAN
A:
[14-270]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
F
P
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
34
PsiBlast_CBE
87.22
32%
-123
- C3 -
4IG9
2
?
G:
[14-270]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
LAVDFP
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
-
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AVRG--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
PEQ
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFDVELLGD
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
18
PsiBlast_PDB
87.03
35%
-117
- C3 -
2H59
4
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
G
P
-
N
-
G
I
Y
----
K
K
------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
32
PsiBlast_CBE
86.95
32%
-118
- C3 -
4I5I
3
SIR1_HUMAN
A:
[6-262]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
F
P
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
37
PsiBlast_CBE
86.87
32%
-118
- C3 -
4IG9
2
?
A:
[14-270]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
FP
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
-
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFDVELLGD
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
31
PsiBlast_CBE
86.87
32%
-119
- C3 -
4I5I
3
SIR1_HUMAN
B:
[6-262]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
LAVDFP
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AVRG--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
PEQ
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFDVELLGD
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
20
PsiBlast_PDB
86.87
33%
-112
- C3 -
5BTR
5
SIR1_HUMAN
A:
[103-359]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
S
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
S
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
F
P
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFD
V
E
L
L
G
D
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
16
PsiBlast_PDB
86.85
35%
-122
- C3 -
4BV2
5
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
SS
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
33
PsiBlast_CBE
86.83
32%
-120
- C3 -
4KXQ
4
SIR1_HUMAN
A:
[14-270]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
V
D
F
P
D
------
L
P
D
------
P
Q
A
M
F
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
----
P
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
----
C
-------------
E
AV
R
G
--------------
D
---
I
--------
F
N
-
Q
----
V
V
P
R
C
P
R
C
P
A
D
E
------------
P
L
-------
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
P
E
Q
F
H
-----
R
A
M
-
K
Y
D
-
K
-------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
--
S
S
I
P
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
HLHFDVELLGD
C
----
D
V
-
I
I
N
E
L
C
H
R
L
G
G
E
Y
A
K
-------------------------------
9
PsiBlast_PDB
86.72
35%
-125
- C3 -
2H2G
3
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
29
PsiBlast_CBE
86.57
35%
-117
- C3 -
2H59
4
NPD_THEMA
B:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
G
P
-
N
-
G
I
Y
----
K
K
------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
A
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
LESS
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
GLS---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
122
HHSearch
86.33
34%
-126
- C3 -
4KXQ
4
SIR1_HUMAN
A:
[14-262]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L
A
----
V
D
F
PDL-
P
D
P
------
Q
A
M
F
-
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
P
----
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
C---
E
-------------
A
------------------
V
R
G
D
I
F
-------
N
Q
------
V
V
P
R
C
-
P
------------------
R
C
P
-----
A
DEPLA
I
M
K
P
E
I
V
F
F
G
E
N
L
---
P
E
Q
----
F
H
R
-
A
M
K
Y
D
K
------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
S
S
I
P
--
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
-----------
H
-----
L
-
H
F
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
---------------------------
12
PsiBlast_PDB
86.30
35%
-126
- C3 -
3D4B
3
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------------------------
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
11
PsiBlast_PDB
86.09
35%
-116
- C3 -
2H2I
2
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
G
P
-
N
-
G
I
Y
----
K
K
------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
5
PsiBlast_PDB
86.05
35%
-121
- C3 -
2H4F
3
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
G
P
------------------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
28
PsiBlast_CBE
85.82
35%
-126
- C3 -
4BV2
5
NPD_THEMA
B:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------------------------
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E---
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
15
PsiBlast_PDB
85.61
35%
-121
- C3 -
4BUZ
4
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
----------------------
Y
------
S
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
SS
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
13
PsiBlast_PDB
85.34
35%
-125
- C3 -
3D81
2
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
------------------------------
Q
N
------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
110
HHSearch
84.00
34%
-121
- C3 -
4ZZI
2
SIR1_HUMAN
A:
[61-320]
----------------------------------------------------------------------------------
I
E
D
A
V
K
L
L
Q
E
C
--
K
K
I
I
V
L
T
G
A
G
V
S
V
S
C
G
I
P
D
F
R
-
S
R
-
D
-
G
I
Y
----
A
R
L-----
A
VDFPDL
P
D
P
------
Q
A
M
F
-
D
I
E
Y
F
R
K
D
P
R
P
F
F
K
F
A
---
K
E
-
I
Y
P
----
G
Q
F
--
Q
P
S
L
C
H
K
F
I
A
L
S
D
----
K
E
G
K
L
L
R
N
Y
T
Q
N
I
D
T
L
E
Q
V
A
G
--
I
--
Q
R
I
I
Q
C
H
G
S
F
A
T
A
S
C
L
I
C
K
---
Y
---
K
V
D
C---
E
-------------
A
------------------
V
R
G
D
I
F
-------
N
Q
------
V
V
P
R
C
-
P
------------------
R
C
P
ADEPL
A
-----
I
M
K
P
E
I
V
F
F
G
E
N
L
---
P
E
Q
----
F
H
R
A
M
K
Y
-
D
K
------
D
E
V
---
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
A
-
L
I
P
S
S
I
P
--
H
-
E
V
P
Q
I
L
-
I
N
R
E
P
--
L
P
-----------
H
-----
L
-
H
F
D
V
E
L
L
G
D
C
D
V
I
I
N
E
L
C
H
---------------------------
113
HHSearch
83.42
37%
-129
- C3 -
1YC5
3
NPD_THEMA
A:
[3-241]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
--------------------------------------
Q
N
V
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
-
G
I
F
P
--
M
L
Q
A
--
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
V
---
E
-------------
D
------------------
V
---
I
K
K
L
E
----
S
S
------
D
V
P
L
C
-
D
------------------
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
D
A
---
L
R
E
-
A
I
G
-
L
S
------
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
I
T
V
-
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
M
E
---------------------------
17
PsiBlast_PDB
82.96
35%
-114
- C3 -
2H4H
3
NPD_THEMA
A:
[3-239]
----------------------------------------------------------------------------------
M
K
E
F
L
D
L
L
N
E
S
--
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
G
P
-
N
--------------------------------
V
--
F
-
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
---
K
E
G
I
F
P
M
L
Q
A
-----
K
P
N
L
A
H
V
L
L
A
K
L
E
----
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
--
K
K
V
I
E
L
Y
G
N
V
E
E
Y
Y
C
V
R
C
E
---
K
---
K
Y
T
----
V
-------------
E
------------------
D
---
V
--------
I
K
-
K
L
E
S
S
D
V
P
L
C
-------------------
D
D
C
N
-----
S
-----
L
I
R
P
N
I
V
F
F
G
E
N
L
---
P
Q
------
D
A
-
L
R
E
-
A
I
G
L
S
---
S
R
A
---
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
L
-
I
T
V
R
S
-
G
G
K
L
V
I
-
V
N
L
G
E
--
T
P
-----------
F
----
D
D
-
I
A
T
L
K
Y
N
M
D
V
V
E
F
A
R
R
V
-----------------------------
119
HHSearch
82.65
31%
-124
- C3 -
2HJH
3
SIR2_YEAST
A:
[36-314]
----------------------------------------------------------------------------------
I
D
H
F
I
Q
K
L
H
T
A
--
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
-
S
S
-
E
-
G
F
Y
----
S
K
I
-----
K
HLGL--
D
D
P
------
Q
D
V
F
-
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
---
N
M
-
V
L
P
----
P
E
K
--
I
Y
S
P
L
H
S
F
I
K
M
L
Q
----
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
--
I
ST
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
C
H
---
W
---
N
L
P
G---
E
-------------
R
------------------
I
---
F
N
K
I
R
----
N
L
------
E
L
P
L
C
-
P
Y
C
Y
K
K
R
R
E
Y
F
PERPPYI
L
N
S
Y
-----
G
-----
V
L
K
P
D
I
T
F
F
G
E
A
L
---
P
N
K
F
---
H
K
S
-
I
R
E
-
D
I
------
L
E
C
---
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
-
E
I
V
N
M
V
---
P
S
H
V
P
Q
V
L
-
I
N
R
D
P
--
V
K
-----------
H
----
A
--
E
F
D
L
S
L
L
G
Y
C
D
D
I
A
A
M
V
A
Q
---------------------------
120
HHSearch
80.84
32%
-126
- C3 -
1Q1A
3
HST2_YEAST
A:
[8-275]
----------------------------------------------------------------------------------
V
R
K
I
A
A
H
M
K
S
N
PN
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
-
S
P
G
T
-
G
L
Y
----
H
N
L-----
A
RLKL--
P
Y
P
------
E
A
V
F
-
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
---
K
E
-
L
Y
P
----
G
N
F
--
R
P
S
K
F
H
Y
L
L
K
L
F
Q
----
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
--
V
KD
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
C
G
---
K
---
V
Y
P
P
---
Q
-------------
V
------------------
F
---
K
S
K
L
A
EHP-
I
K
------
D
F
V
K
C
-
D
------------------
V
C
G
-----
E
-----
L
V
K
P
A
I
V
F
F
G
E
D
L
---
P
D
S
F
S
E
T
W
L
N
-
D
S
E
-
W
L
R
E
K
I
T
T
P
Q
Q
---
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
-
S
L
P
E
E
I
P
--
R
-
K
V
K
R
V
L
-
C
N
L
E
T
--
V
G
-----------
D
FKAN
K
R
-
P
T
D
L
I
V
H
Q
Y
S
D
E
F
A
E
Q
L
V
E
---------------------------
49
PsiBlast_CBE
80.84
33%
-94
- C3 -
3RIY
3
SIR5_HUMAN
B:
[11-256]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
--
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
A
-
G
-
G
Y
W
----
R
K
------
W
------
Q
A
Q
------
D
L
A
T
-
P
L
A
-
F
A
H
N
P
S
R
V
W
E
F
Y
---
H
---
Y
R
R
E
V
M
G
S
K
--
E
P
N
A
G
H
R
A
I
A
E
C
E
TRLG
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
---
V
VAE
N
Y
K
----
S
-------------
P
ICPALSGKGAPEPGTQDA
S
---
I
--------
P
V
-
E
----
K
L
P
R
C
E
E
A
G
-----------------
C
G
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
N
L
DP-
A
I
-----
L
E
E
-
V
D
R
-
E
L
------
A
H
C
---
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
---
G
V
P
V
A
E
-
F
N
T
E
T
--
T
P
-----------
A
----
T
N
-
R
F
--------------------------------------------
50
PsiBlast_CBE
80.19
33%
-99
- C3 -
3RIY
3
SIR5_HUMAN
A:
[11-256]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
--
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
A
-
G
-
G
Y
W
----
R
K
------
W
------
Q
A
Q
------
D
L
A
T
-
P
L
A
-
F
A
H
N
P
S
R
V
W
E
F
Y
---
H
---
Y
R
R
E
V
M
G
S
K
--
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
---
V
V
A
E
N
Y
K
----
S
-------------
P
ICPALSGKGAPEPGTQDA
S
---
I
--------
P
V
-
E
----
K
L
P
R
C
E
E
A
G
-----------------
C
G
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
-
A
I
-----
L
E
E
-
V
D
R
-
E
L
------
A
H
C
---
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
---
G
V
P
V
A
E
-
F
N
T
E
T
--
T
P
-----------
A
----
T
N
-
R
F
--------------------------------------------
46
PsiBlast_CBE
80.02
33%
-98
- C3 -
4F56
3
SIR5_HUMAN
B:
[11-256]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
--
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
A
-
G
-
G
Y
W
----
R
K
------
W
------
Q
A
Q
------
D
L
A
T
-
P
L
A
-
F
A
H
N
P
S
R
V
W
E
F
Y
---
H
---
Y
R
R
E
V
M
G
S
K
--
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
---
V
V
A
E
N
Y
K
----
S
-------------
P
ICPALSGKGAPEPGTQDA
S
---
I
--------
P
V
-
E
----
K
L
P
R
C
E
E
A
G
-----------------
C
G
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
-
A
I
-----
L
E
E
-
V
D
R
-
E
L
------
A
H
C
---
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
---
G
V
P
V
A
E
-
F
N
T
E
T
--
T
P
-----------
A
----
T
N
-
R
F
--------------------------------------------
116
HHSearch
79.49
33%
-119
- C3 -
3U31
4
SIR5_PLAF7
A:
[35-277]
----------------------------------------------------------------------------------
L
E
E
L
A
K
I
I
K
K
C
--
K
H
V
V
A
L
T
G
S
G
T
S
A
E
S
N
I
P
S
F
R
-
G
S
S
N
-
S
I
W
----
S
K
-------------
Y
D
P
------
R
I
Y
G
-
T
I
W
G
F
W
K
Y
P
E
K
I
W
E
V
I
---
R
D
-
I
S
S
D
---
Y
E
I
--
E
I
N
N
G
H
V
A
L
S
T
L
E
----
S
L
G
Y
L
K
S
V
V
T
Q
N
V
D
G
L
H
E
A
S
G
--
N
--
T
K
V
I
S
L
H
G
N
V
F
E
A
V
C
C
T
C
N
---
K
---
I
V
K
L
---
N
-------------
K
------------------
I
---
M
LQKTSHFM
H
Q
------
L
P
P
E
C
--------------------
P
C
G
-----
G
-----
I
F
K
P
N
I
I
L
F
G
E
V
V
---
S
S
D
L
---
L
K
E
-
A
E
E
-
E
I
------
A
K
C
---
D
L
L
L
V
I
G
T
S
S
T
V
S
T
A
T
-
N
L
C
H
F
A
C
--
K
K
K
K
K
I
V
E
-
I
N
I
S
K
--
T
Y
-----------
I
----
T
N
K
M
S
D
Y
H
V
C
A
K
F
S
E
-
L
T
K
V
A
N
---------------------------
47
PsiBlast_CBE
78.98
33%
-97
- C3 -
4F56
3
SIR5_HUMAN
A:
[11-256]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
--
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
A
-
G
-
G
Y
W
----
R
K
------
W
------
Q
A
Q
------
D
L
A
T
-
P
L
A
-
F
A
H
N
P
S
R
V
W
E
F
Y
---
H
---
Y
R
R
E
V
M
G
S
K
--
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
---
V
V
A
E
N
Y
K
----
S
-------------
P
ICPALSGKGAPEPGTQDA
S
---
I
--------
P
V
-
E
----
K
L
P
R
C
E
E
A
G
-----------------
C
G
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
-
A
I
-----
L
E
E
-
V
D
R
-
E
L
------
A
H
C
---
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
---
G
V
P
V
A
E
-
F
N
T
E
T
--
T
P
-----------
A
----
T
N
-
R
F
--------------------------------------------
43
PsiBlast_CBE
78.35
33%
-95
- C3 -
4G1C
4
SIR5_HUMAN
A:
[5-250]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
--
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
A
-
G
-
G
Y
W
----
R
K
------
W
------
Q
A
Q
------
D
L
A
T
-
P
L
A
-
F
A
H
N
P
S
R
V
W
E
F
Y
---
H
---
Y
R
R
E
V
M
G
S
K
--
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
---
V
V
A
E
N
Y
K
----
S
-------------
P
ICPALSGKGAPEPGTQDA
S
---
I
--------
P
V
-
E
----
K
L
P
R
C
E
E
A
G
-----------------
C
G
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
-
A
I
-----
L
E
E
-
V
D
R
-
E
L
------
A
H
C
---
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
---
G
V
P
V
A
E
-
F
N
T
E
T
--
T
P
-----------
A
----
T
N
-
R
F
--------------------------------------------
66
PsiBlast_CBE
77.97
31%
-116
- C3 -
3U31
4
SIR5_PLAF7
A:
[35-274]
----------------------------------------------------------------------------------
L
E
E
L
A
K
I
I
K
K
C
--
K
H
V
V
A
L
T
G
S
G
T
S
A
E
S
N
I
P
S
F
R
G
S
S
-
N
-
S
I
W
----
S
K
------
Y
------
D
P
R
------
I
Y
G
--
T
I
W
G
F
W
K
Y
P
E
K
I
W
E
V
I
---
R
D
-
I
S
S
---
D
Y
E
I
--
E
I
N
N
G
H
V
A
L
S
T
L
E
----
S
L
G
Y
L
K
S
V
V
T
Q
N
V
D
G
L
H
E
A
S
G
--
N
--
T
K
V
I
S
L
H
G
N
V
F
E
A
V
C
C
T
C
N
---
K
---
I
V
K
----
L
N
KIMLQKT-----
S
------------------
H
---
F
--------
M
H
-
Q
----
L
P
P
E
C
P
--------------------
C
G
-----
G
-----
I
F
K
P
N
I
I
L
F
G
E
V
V
---
S
S
D
L
---
L
K
E
-
A
E
E
-
E
I
------
A
K
C
---
D
L
L
L
V
I
G
T
S
S
T
V
S
T
A
T
-
N
L
C
H
F
A
C
--
K
-
K
K
K
K
I
V
E
I
N
I
S
K
--
T
Y
I----------
T
----
N
K
-
M
S
D
Y
H
V
C
A
K
F
S
E
L
T
K
-------------------------------
64
PsiBlast_CBE
77.69
31%
-102
- C3 -
1M2J
2
NPD1_ARCFU
A:
[3-232]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
------
Y
------
R
P
E
-------
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
---
W
R
M
E
K
V
F
N
A
--
Q
P
N
K
A
N
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
----
V
E
S
A
----------
P
------------------
K
---
I
-----------
P
----
P
L
P
K
C
-------------------
D
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
F
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
---
L
I
V
K
-
Q
R
G
G
A
I
-
I
E
I
N
P
DE
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
---------------------------------
44
PsiBlast_CBE
77.67
33%
-90
- C3 -
4HDA
3
SIR5_HUMAN
B:
[13-258]
----------------------------------------------------------------------------------
M
A
D
F
R
K
F
F
A
K
A
--
K
H
I
V
I
I
S
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
A
-
G
-
G
Y
W
----
R
K
------
W
------
Q
A
Q
------
D
L
A
T
-
P
L
A
-
F
A
H
N
P
S
R
V
W
E
F
Y
---
H
---
Y
R
R
E
V
M
G
S
K
--
E
P
N
A
G
H
R
A
I
A
E
C
E
T
R
L
G
K
Q
G
R
R
V
V
V
I
T
Q
N
I
D
E
L
H
R
K
A
G
--
T
--
K
N
L
L
E
I
H
G
S
L
F
K
T
R
C
T
S
C
G
---
V
V
A
E
N
Y
K
----
S
-------------
P
ICPALSGKGAPEPGTQDA
S
---
I
--------
P
V
-
E
----
K
L
P
R
C
E
E
A
G
-----------------
C
G
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
N
L
D
P
-
A
I
-----
L
E
E
-
V
D
R
-
E
L
------
A
H
C
---
D
L
C
L
V
V
G
T
S
S
V
V
Y
P
A
A
M
F
A
P
Q
V
A
A
R
---
G
V
P
V
A
E
-
F
N
T
E
T
--
T
P
-----------
A
----
T
N
-
R
F
--------------------------------------------
108
HHSearch
76.94
32%
-100
- C3 -
1M2K
2
NPD1_ARCFU
A:
[3-238]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
-------------
Y
R
P
------
E
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
W
-
R
M
E
K
--
V
F
N
A
--
Q
P
N
K
A
H
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
V
---
E
-------------
S
------------------
A
---
P
K
-------
I
P
------
P
L
P
K
C
-
D
------------------
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
A
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
L
I
V
K
-
Q
R
-
G
G
A
I
I
E
-
I
N
P
D
E
--
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
M
D
E
L
V
R
---------------------------
65
PsiBlast_CBE
76.58
31%
-118
- C3 -
3U3D
3
SIR5_PLAF7
A:
[35-274]
----------------------------------------------------------------------------------
L
E
E
L
A
K
I
I
K
K
C
--
K
H
V
V
A
L
T
G
S
G
T
S
A
E
S
N
I
P
S
F
R
G
S
S
-
N
-
S
I
W
----
S
K
------
Y
------
D
P
R
------
I
Y
G
--
T
I
W
G
F
W
K
Y
P
E
K
I
W
E
V
I
---
R
D
-
I
S
S
---
D
Y
E
I
--
E
I
N
N
G
H
V
A
L
S
T
L
E
----
S
L
G
Y
L
K
S
V
V
T
Q
N
V
D
G
L
H
E
A
S
G
--
N
--
T
K
V
I
S
L
H
G
N
V
F
E
A
V
C
C
T
C
N
---
K
---
I
V
K
----
L
N
KIMLQKT-----
S
------------------
H
---
F
--------
M
H
-
Q
----
L
P
P
E
C
P
--------------------
C
G
-----
G
-----
I
F
K
P
N
I
I
L
F
G
E
V
V
---
S
S
D
L
---
L
K
E
-
A
E
E
-
E
I
------
A
K
C
---
D
L
L
L
V
I
G
T
S
S
T
V
S
T
A
T
-
N
L
C
H
F
A
C
--
K
-
K
K
K
K
I
V
E
I
N
I
S
K
--
T
Y
I----------
T
----
N
K
-
M
S
D
Y
H
V
C
A
K
F
S
E
L
T
K
-------------------------------
59
PsiBlast_CBE
75.85
31%
-104
- C3 -
1M2G
2
NPD1_ARCFU
A:
[3-232]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
------
Y
------
R
P
E
-------
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
---
W
R
M
E
K
V
F
N
A
--
Q
P
N
K
A
H
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
----
V
E
S
A
----------
P
------------------
K
---
I
-----------
P
----
P
L
P
K
C
-------------------
D
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
F
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
---
L
I
V
K
-
Q
R
G
G
A
I
-
I
E
I
N
P
DE
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
---------------------------------
54
PsiBlast_CBE
75.57
34%
-101
- C3 -
4UU8
5
SIR5_DANRE
B:
[13-258]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
--
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
P
-
G
-
G
F
W
RKWQ
A
Q
------
D
------
L
A
T
------
P
E
A
F
-
S
R
D
-----
P
S
L
V
W
E
F
Y
H
Y
R
R
E
-
V
M
R
S
K
M
-------
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
---
N
H
K
----
S
PICPALDGKGAPD
P
------------------
N
---
T
--------
K
E
-
A
----
R
I
P
V
E
L
L
P
R
C
E
R
------------
K
S
C
N
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
T
L
---
D
S
D
I
---
L
T
A
-
V
E
R
-
E
L
------
E
K
C
---
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
---
G
V
P
V
A
E
-
F
N
M
E
C
--
T
P
-----------
A
----
T
Q
-
R
F
--------------------------------------------
63
PsiBlast_CBE
75.34
31%
-103
- C3 -
1M2H
2
NPD1_ARCFU
A:
[3-232]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
A
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
------
Y
------
R
P
E
-------
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
---
W
R
M
E
K
V
F
N
A
--
Q
P
N
K
A
H
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
----
V
-------------
E
------------------
S
---
A
--------
P
K
I
P
----
P
L
P
K
C
-------------------
D
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
F
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
---
L
I
V
K
-
Q
R
G
G
A
I
-
I
E
I
N
P
DE
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
---------------------------------
55
PsiBlast_CBE
75.15
34%
-96
- C3 -
4UU7
5
SIR5_DANRE
B:
[13-258]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
--
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
P
-
G
-
G
F
W
RKWQ
A
Q
------
D
------
L
A
T
------
P
E
A
F
-
S
R
D
-----
P
S
L
V
W
E
F
Y
H
Y
R
R
E
-
V
M
R
S
K
M
-------
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
---
N
H
K
----
S
PICPALDGKGAPD
P
------------------
N
---
T
--------
K
E
-
A
----
R
I
P
V
E
L
L
P
R
C
E
R
------------
K
S
C
N
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
T
L
---
D
S
D
I
---
L
T
A
-
V
E
R
-
E
L
------
E
K
C
---
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
---
G
V
P
V
A
E
-
F
N
M
E
C
--
T
P
-----------
A
----
T
Q
-
R
F
--------------------------------------------
56
PsiBlast_CBE
74.51
34%
-97
- C3 -
4UTN
4
SIR5_DANRE
B:
[13-258]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
--
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
P
-
G
-
G
F
W
RKWQ
A
Q
------
D
------
L
A
T
------
P
E
A
F
-
S
R
D
-----
P
S
L
V
W
E
F
Y
H
Y
R
R
E
-
V
M
R
S
K
M
-------
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
---
N
H
K
----
S
PICPALDGKGAPD
P
------------------
N
---
T
--------
K
E
-
A
----
R
I
P
V
E
L
L
P
R
C
E
R
------------
K
S
C
N
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
T
L
---
D
S
D
I
---
L
T
A
-
V
E
R
-
E
L
------
E
K
C
---
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
---
G
V
P
V
A
E
-
F
N
M
E
C
--
T
P
-----------
A
----
T
Q
-
R
F
--------------------------------------------
67
PsiBlast_CBE
74.16
31%
-102
- C3 -
1M2K
2
NPD1_ARCFU
A:
[3-232]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
------
Y
------
R
P
E
-------
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
---
W
R
M
E
K
V
F
N
A
--
Q
P
N
K
A
H
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
----
V
-------------
E
------------------
S
---
A
--------
P
K
I
P
----
P
L
P
K
C
-------------------
D
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
A
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
---
L
I
V
K
-
Q
R
G
G
A
I
-
I
E
I
N
P
DE
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
V
---------------------------------
53
PsiBlast_CBE
72.82
34%
-95
- C3 -
4UUA
5
SIR5_DANRE
B:
[13-258]
----------------------------------------------------------------------------------
L
T
A
F
R
E
H
F
A
K
A
--
K
H
I
A
I
I
T
G
A
G
V
S
A
E
S
G
V
P
T
F
R
-
G
P
-
G
-
G
F
W
RKWQ
A
Q
------
D
------
L
A
T
------
P
E
A
F
-
S
R
D
-----
P
S
L
V
W
E
F
Y
H
Y
R
R
E
-
V
M
R
S
K
M
-------
P
N
P
A
H
L
A
I
A
E
C
E
A
R
L
G
Q
Q
G
R
S
V
V
I
I
T
Q
N
I
D
E
L
H
H
R
A
G
--
S
--
K
H
V
Y
E
I
H
G
S
L
F
K
T
R
C
M
S
C
G
E
V
K
A
---
N
H
K
----
S
PICPALDGKGAPD
P
------------------
N
---
T
--------
K
E
-
A
----
R
I
P
V
E
L
L
P
R
C
E
R
------------
K
S
C
N
-----
G
-----
L
L
R
P
H
V
V
W
F
G
E
T
L
---
D
S
D
I
---
L
T
A
-
V
E
R
-
E
L
------
E
K
C
---
D
L
C
L
V
V
G
T
S
S
I
V
Y
P
A
A
M
F
A
P
Q
V
A
S
R
---
G
V
P
V
A
E
-
F
N
M
E
C
--
T
P
-----------
A
----
T
Q
-
R
F
--------------------------------------------
23
PsiBlast_CBE
72.48
40%
-86
- C3 -
1YC2
7
NPD2_ARCFU
C:
[11-237]
----------------------------------------------------------------------------------------
I
L
A
K
S
--
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
-
G
E
-
D
-
G
L
W
----
R
K
------
Y
------
D
P
E
-------
E
V
A
-
S
I
S
G
F
K
R
N
P
R
A
F
W
E
---------
F
S
M
E
M
K
D
K
L
FA
E
P
N
P
A
H
Y
A
I
A
E
L
E
----
R
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
--
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
---
E
---
T
Y
D
----
W
-------------
S
------------------
E
---
F
--------
V
E
-
D
FNKG
E
I
P
R
C
R
K
C
G
S
-----------------------
Y
-----
Y
V
K
P
R
V
V
L
F
G
E
P
L
---
P
Q
------
R
T
-
L
F
E
-
A
I
------
E
E
A
KHC
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
Y
I
A
K
K
A
--
G
A
K
M
I
I
-
V
N
A
E
P
--
T
M
-----------
A
----
D
P
-
I
F
D
V
K
I
I
G
K
A
G
E
----------------------------------
105
PsiBlast_CBE
71.93
36%
-103
- C3 -
4BVE
5
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.56
40%
-86
- C3 -
1YC2
7
NPD2_ARCFU
B:
[11-237]
----------------------------------------------------------------------------------------
I
L
A
K
S
--
K
H
A
V
V
F
T
G
A
G
I
S
A
E
S
G
I
P
T
F
R
-
G
E
-
D
-
G
L
W
----
R
K
------
Y
------
D
P
E
-------
E
V
A
-
S
I
S
G
F
K
R
N
P
R
A
F
W
E
---------
F
S
M
E
M
K
D
K
L
FA
E
P
N
P
A
H
Y
A
I
A
E
L
E
----
R
M
G
I
V
K
A
V
I
T
Q
N
I
D
M
L
H
Q
R
A
G
--
S
--
R
R
V
L
E
L
H
G
S
M
D
K
L
D
C
L
D
C
H
---
E
---
T
Y
D
----
W
-------------
S
------------------
E
---
F
--------
V
E
-
D
FNKG
E
I
P
R
C
R
K
C
G
S
-----------------------
Y
-----
Y
V
K
P
R
V
V
L
F
G
E
P
L
---
P
Q
------
R
T
-
L
F
E
-
A
I
------
E
E
A
KHC
D
A
F
M
V
V
G
S
S
L
V
V
Y
P
A
A
-
E
L
P
Y
I
A
K
K
A
--
G
A
K
M
I
I
-
V
N
A
E
P
--
T
M
-----------
A
----
D
P
-
I
F
D
V
K
I
I
G
K
A
G
E
----------------------------------
106
PsiBlast_CBE
71.08
36%
-95
- C3 -
4BVB
3
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
103
PsiBlast_CBE
70.91
36%
-94
- C3 -
4BVG
14
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
104
PsiBlast_CBE
70.84
36%
-98
- C3 -
4BVF
3
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
101
PsiBlast_CBE
70.70
36%
-94
- C3 -
4BVH
6
SIR3_HUMAN
B:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
G
E
D
I
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
61
PsiBlast_CBE
70.64
31%
-96
- C3 -
1ICI
2
NPD1_ARCFU
B:
[14-242]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
------
Y
------
R
P
E
-------
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
---
W
R
M
E
K
V
F
N
A
--
Q
P
N
K
A
H
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
----
V
-------------
E
------------------
S
---
A
--------
P
K
I
P
----
P
L
P
K
C
-------------------
D
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
F
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
---
L
I
V
K
-
Q
R
G
G
A
I
-
I
E
I
N
P
DE
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
----------------------------------
102
PsiBlast_CBE
70.08
36%
-90
- C3 -
4BVH
5
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
G
E
D
I
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
107
PsiBlast_CBE
69.81
36%
-93
- C3 -
4BV3
7
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
97
PsiBlast_CBE
69.28
36%
-95
- C3 -
4JSR
2
SIR3_HUMAN
A:
[24-212]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
99
PsiBlast_CBE
68.80
36%
-97
- C3 -
4C78
3
SIR3_HUMAN
A:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
-------------------
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
95
PsiBlast_CBE
68.67
36%
-98
- C3 -
4JT9
5
SIR3_HUMAN
A:
[24-212]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
62
PsiBlast_CBE
68.54
31%
-97
- C3 -
1ICI
2
NPD1_ARCFU
A:
[14-242]
-----------------------------------------------------------------------------------
E
K
L
L
K
T
I
A
E
S
--
K
Y
L
V
A
L
T
G
A
G
V
S
A
E
S
G
I
P
T
F
R
-
G
K
-
D
-
G
L
W
----
N
R
------
Y
------
R
P
E
-------
E
L
A
-
N
P
Q
A
F
A
K
D
P
E
K
V
W
K
W
Y
---
A
---
W
R
M
E
K
V
F
N
A
--
Q
P
N
K
A
H
Q
A
F
A
E
L
E
----
R
L
G
V
L
K
C
L
I
T
Q
N
V
D
D
L
H
E
R
A
G
--
S
--
R
N
V
I
H
L
H
G
S
L
R
V
V
R
C
T
S
C
N
---
N
---
S
F
E
----
V
-------------
E
------------------
S
---
A
--------
P
K
I
P
----
P
L
P
K
C
-------------------
D
K
C
G
-----
S
-----
L
L
R
P
G
V
V
W
F
G
E
M
L
---
P
P
D
V
---
L
D
R
-
A
M
R
-
E
V
------
E
R
A
---
D
V
I
I
V
A
G
T
S
A
V
V
Q
P
A
A
-
S
L
P
---
L
I
V
K
-
Q
R
G
G
A
I
-
I
E
I
N
P
DE
T
P
-----------
L
----
T
P
-
I
A
D
Y
S
L
R
G
K
A
G
E
----------------------------------
75
PsiBlast_CBE
68.52
36%
-97
- C3 -
4C7B
7
SIR3_HUMAN
A:
[22-210]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
---------------QY----
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
68
PsiBlast_CBE
68.34
36%
-92
- C3 -
4V1C
2
SIR3_HUMAN
A:
[18-206]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-----
Y
----
S
N
L
Q
Q
Y
--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.14
36%
-96
- C3 -
4FVT
7
SIR3_HUMAN
A:
[17-205]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
L
Q
QY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
73
PsiBlast_CBE
67.20
36%
-97
- C3 -
4V1C
3
SIR3_HUMAN
B:
[18-206]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
------------Y-----
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GE
D
I
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
96
PsiBlast_CBE
66.90
36%
-89
- C3 -
4JT8
2
SIR3_HUMAN
A:
[24-212]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
100
PsiBlast_CBE
66.23
36%
-89
- C3 -
4BVH
5
SIR3_HUMAN
C:
[23-211]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-
S
P
-
G
S
G
L
Y
----
S
N
LQ-----------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
74
PsiBlast_CBE
65.08
36%
-85
- C3 -
4O8Z
2
SIR3_HUMAN
A:
[42-230]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
--
S
P
-
G
S
G
L
Y
----
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
72
PsiBlast_CBE
63.48
36%
-102
- C3 -
4V1C
5
SIR3_HUMAN
E:
[18-206]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
---------------
S
N
LQQY--
D
------
L
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
-
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
C
Q
---
R
---
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
71
PsiBlast_CBE
63.20
36%
-93
- C3 -
4V1C
3
SIR3_HUMAN
G:
[18-206]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
--------------------------------
P
Y
------
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
---
K
E
-
L
Y
----
P
G
N
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
----------
P
F
P
GEDI
R
-------------
A
------------------
D
---
V
--------
M
A
-
D
----
R
V
P
R
C
P
-------------------
V
C
T
-----
G
-----
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------
70
PsiBlast_CBE
46.14
36%
-92
- C3 -
4V1C
2
SIR3_HUMAN
K:
[18-206]
-----------------------------------------------------------------------------------------------
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
----------------------------------------------------------------------------
Y
--
K
P
N
V
T
H
Y
F
L
R
L
L
H
----
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
IP
A
--
S
K
L
V
E
A
H
G
T
F
A
-------------------------------------------------------------------------------------------------------------------
V
V
K
P
D
I
V
F
F
G
E
P
L
P--
Q
R
-----
F
L
L
-
H
V
V
-
D
F
------
P
M
A
---
D
L
L
L
I
L
G
T
S
L
E
V
E
P
-----------------------------------------------------------------------------------------------