@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0079: (2015-11-28 )
MNLLIMGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLIERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPILEHYRKLGLVTDIEGNQEITEVFADVEKALLELK
Atome Classification :
(93 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140...-----.-----.-------.-----.150.......-160.......170.....---..180....-----...190---...---......200.......210
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
L
L
I
MGLPGAGKG
T
Q
A
A
K
I
V
E
E
FGVAHIST
G
D
M
F
R
A
A
MA
N
Q
T
E
M
G
R
L
A
K
S
YIDKGEL
V
P
D
E
V
T
N
G
I
V
K
E
R
LAE
D
D
I
AEK
G
F
LLDGYP
R
T
I
E
Q
A
H
A
L
D
A
T
L
E
E
LGLRLD
G
V
I
N
I
KV
D
P
S
C
L
I
E
R
L
SG
R
I
INRKT
G
E
T
F
H
K
VFNPP-----V-----D-------Y-----KEEDYYQREDD-
K
P
E
T
V
K
R
R
LDVNIAQG
E
P
---
I
L
E
H
Y
R
KLG-----
L
V
TD-----IEG---
N
Q
E
I
T
E
V
F
A
D
V
E
K
A
L
LELK
2
PsiBlast_PDB
92.99
84%
-107
- C3 -
4W5H
3
KAD_STRP2
A:
[6-216]
M
N
L
L
I
M
G
L
P
G
A
G
K
G
T
Q
A
A
K
I
V
E
Q
F
H
V
A
H
I
S
T
G
D
M
F
R
A
A
M
A
N
Q
T
E
M
G
V
L
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
N
G
I
V
K
E
R
L
S
Q
D
D
I
K
E
T
G
F
L
L
D
G
Y
P
R
T
I
E
Q
A
H
A
L
D
K
T
L
A
E
L
G
I
E
L
E
G
I
I
N
I
E
V
N
P
D
S
L
L
E
R
L
S
G
R
I
I
H
R
V
T
G
E
T
F
H
-----
P
-----
V
-----
D
-------
Y
-----
K
E
E
D
Y
Y
Q
R
E
D
D
-
K
P
E
T
V
K
R
R
L
D
V
N
I
A
Q
G
E
P
---
I
I
A
H
Y
R
A
K
G
-----
L
V
H
D
-----
I
E
G
---
N
Q
D
I
N
D
V
F
S
D
I
E
K
V
L
T
N
L
-
23
PsiBlast_CBE
92.46
84%
-98
- C3 -
4W5J
2
KAD_STRP2
B:
[6-217]
M
N
L
L
I
M
G
L
P
G
A
G
K
G
T
Q
A
A
K
I
V
E
Q
F
H
V
A
H
I
S
T
G
D
M
F
R
A
A
M
A
N
Q
T
E
M
G
V
L
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
N
G
I
V
K
E
R
L
S
Q
D
D
I
K
E
T
G
F
L
L
D
G
Y
P
R
T
I
E
Q
A
H
A
L
D
K
T
L
A
E
L
G
I
E
L
E
G
I
I
N
I
E
V
N
P
D
S
L
L
E
R
L
S
G
R
I
I
H
R
V
T
G
E
T
F
H
K
V
F
N
P
P
-----
V
-------------
Y
-----
K
E
E
D
Y
Y
Q
R
E
D
D
-
K
P
E
T
V
K
R
R
L
D
V
N
I
A
Q
G
E
P
---
I
I
A
H
Y
R
A
K
G
-----
L
V
H
D
-----
I
E
G
---
N
Q
D
I
N
D
V
F
S
D
I
E
K
V
L
T
N
L
K
21
PsiBlast_CBE
91.42
84%
-95
- C3 -
4W5J
2
KAD_STRP2
D:
[6-217]
M
N
L
L
I
M
G
L
P
G
A
G
K
G
T
Q
A
A
K
I
V
E
Q
F
H
V
A
H
I
S
T
G
D
M
F
R
A
A
M
A
N
Q
T
E
M
G
V
L
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
N
G
I
V
K
E
R
L
S
Q
D
D
I
K
E
T
G
F
L
L
D
G
Y
P
R
T
I
E
Q
A
H
A
L
D
K
T
L
A
E
L
G
I
E
L
E
G
I
I
N
I
E
V
N
P
D
S
L
L
E
R
L
S
G
R
I
I
H
R
V
T
G
E
T
F
H
K
V
F
N
P
P
-----
V
-------------
Y
-----
K
E
E
D
Y
Y
Q
R
E
D
D
-
K
P
E
T
V
K
R
R
L
D
V
N
I
A
Q
G
E
P
---
I
I
A
H
Y
R
A
K
G
-----
L
V
H
D
-----
I
E
G
---
N
Q
D
I
N
D
V
F
S
D
I
E
K
V
L
T
N
L
K
1
PsiBlast_PDB
91.30
84%
-96
- C3 -
4NTZ
1
KAD_STRP2
A:
[6-217]
M
N
L
L
I
M
G
L
P
G
A
G
K
G
T
Q
A
A
K
I
V
E
Q
F
H
V
A
H
I
S
T
G
D
M
F
R
A
A
M
A
N
Q
T
E
M
G
V
L
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
N
G
I
V
K
E
R
L
S
Q
D
D
I
K
E
T
G
F
L
L
D
G
Y
P
R
T
I
E
Q
A
H
A
L
D
K
T
L
A
E
L
G
I
E
L
E
G
I
I
N
I
E
V
N
P
D
S
L
L
E
R
L
S
G
R
I
I
H
R
V
T
G
E
T
F
H
K
V
F
N
P
P
-----
V
-----
D
-------
Y
-----
K
E
E
D
Y
Y
Q
R
E
D
D
-
K
P
E
T
V
K
R
R
L
D
V
N
I
A
Q
G
E
P
---
I
I
A
H
Y
R
A
K
G
-----
L
V
H
D
-----
I
E
G
---
N
Q
D
I
N
D
V
F
S
D
I
E
K
V
L
T
N
L
K
22
PsiBlast_CBE
90.96
84%
-96
- C3 -
4W5J
2
KAD_STRP2
C:
[6-217]
M
N
L
L
I
M
G
L
P
G
A
G
K
G
T
Q
A
A
K
I
V
E
Q
F
H
V
A
H
I
S
T
G
D
M
F
R
A
A
M
A
N
Q
T
E
M
G
V
L
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
N
G
I
V
K
E
R
L
S
Q
D
D
I
K
E
T
G
F
L
L
D
G
Y
P
R
T
I
E
Q
A
H
A
L
D
K
T
L
A
E
L
G
I
E
L
E
G
I
I
N
I
E
V
N
P
D
S
L
L
E
R
L
S
G
R
I
I
H
R
V
T
G
E
T
F
H
K
V
F
N
P
P
-----
V
-------------
Y
-----
K
E
E
D
Y
Y
Q
R
E
D
D
-
K
P
E
T
V
K
R
R
L
D
V
N
I
A
Q
G
E
P
---
I
I
A
H
Y
R
A
K
G
-----
L
V
H
D
-----
I
E
G
---
N
Q
D
I
N
D
V
F
S
D
I
E
K
V
L
T
N
L
K
24
PsiBlast_CBE
89.63
84%
-92
- C3 -
4NU0
2
KAD_STRP2
B:
[6-217]
M
N
L
L
I
M
G
L
P
G
A
G
K
G
T
Q
A
A
K
I
V
E
Q
F
H
V
A
H
I
S
T
G
D
M
F
R
A
A
M
A
N
Q
T
E
M
G
V
L
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
N
G
I
V
K
E
R
L
S
Q
D
D
I
K
E
T
G
F
L
L
D
G
Y
P
R
T
I
E
Q
A
H
A
L
D
K
T
L
A
E
L
G
I
E
L
E
G
I
I
N
I
E
V
N
P
D
S
L
L
E
R
L
S
G
R
I
I
H
R
V
T
G
E
T
F
H
K
V
F
N
P
P
-----
V
-----
D
-------
Y
-----
K
E
E
D
Y
Y
Q
R
E
D
D
-
K
P
E
T
V
K
R
R
L
D
V
N
I
A
Q
G
E
P
---
I
I
A
H
Y
R
A
K
G
-----
L
V
H
D
-----
I
E
G
---
N
Q
D
I
N
D
V
F
S
D
I
E
K
V
L
T
N
L
K
12
PsiBlast_PDB
80.13
57%
-85
- C3 -
4MKF
5
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
K
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
R
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
M
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
E
Q
D
I
E
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
19
PsiBlast_PDB
79.50
56%
-81
- C3 -
4QBF
2
KAD_BACSU
A:
[1-216]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
E
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
L
L
E
E
M
G
R
P
I
D
Y
V
I
N
I
Q
V
D
K
E
E
L
I
A
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
T
K
R
L
E
V
N
M
K
Q
T
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
V
N
G
---
Q
Q
D
I
Q
D
V
F
A
D
V
K
V
I
L
G
G
L
K
14
PsiBlast_PDB
78.25
56%
-84
- C3 -
3DKV
6
KAD_BACSU
A:
[1-216]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
E
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
P
I
D
Y
V
I
N
I
Q
V
D
K
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
T
K
R
L
E
V
N
M
K
Q
T
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
V
N
G
---
Q
Q
D
I
Q
D
V
F
A
D
V
K
V
I
L
G
G
L
K
30
PsiBlast_CBE
77.62
57%
-79
- C3 -
2OO7
2
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
I
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
29
PsiBlast_CBE
77.58
57%
-79
- C3 -
3DL0
2
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
K
P
I
D
Y
V
I
N
I
Q
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
T
K
R
L
E
V
N
M
K
Q
T
A
P
---
L
L
D
F
Y
D
E
K
G
-----
Y
L
V
N
-----
V
N
G
---
Q
Q
D
I
Q
D
V
Y
A
D
L
K
V
L
L
G
G
L
K
38
PsiBlast_CBE
77.52
53%
-77
- C3 -
4QBG
2
KAD_BACSU
B:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
A
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
K
L
E
H
V
I
H
I
E
V
R
Q
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
R
N
-----
V
N
G
---
Q
Q
D
M
E
K
V
F
K
D
L
R
E
L
L
Q
G
L
A
15
PsiBlast_PDB
77.00
56%
-78
- C3 -
4MKG
3
KAD_BACSU
A:
[1-216]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
E
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
P
I
D
Y
V
I
N
I
Q
V
D
K
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
T
K
R
L
E
V
N
M
K
Q
T
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
V
N
G
---
Q
Q
D
I
Q
D
V
F
A
D
V
K
V
I
L
G
G
L
K
40
PsiBlast_CBE
76.97
53%
-83
- C3 -
4TYQ
3
KAD_BACSU
A:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
A
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
K
L
E
Y
V
I
H
I
E
V
R
Q
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
V
N
G
---
Q
Q
D
M
E
K
V
F
K
D
L
R
E
I
L
Q
G
L
-
6
PsiBlast_PDB
76.80
57%
-81
- C3 -
2P3S
2
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
R
L
K
32
PsiBlast_CBE
76.46
56%
-80
- C3 -
2OSB
2
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
L
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
27
PsiBlast_CBE
76.34
57%
-80
- C3 -
2EU8
3
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
28
PsiBlast_CBE
76.30
57%
-81
- C3 -
2QAJ
2
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
E
G
L
K
10
PsiBlast_PDB
76.06
57%
-80
- C3 -
3DL0
3
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
K
P
I
D
Y
V
I
N
I
Q
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
T
K
R
L
E
V
N
M
K
Q
T
A
P
---
L
L
D
F
Y
D
E
K
G
-----
Y
L
V
N
-----
V
N
G
---
Q
Q
D
I
Q
D
V
Y
A
D
L
K
V
L
L
G
G
L
K
31
PsiBlast_CBE
76.03
57%
-80
- C3 -
4MKF
6
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
K
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
R
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
M
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
E
Q
D
I
E
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
20
PsiBlast_PDB
75.94
56%
-79
- C3 -
4MKH
5
KAD_BACSU
A:
[3-216]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
L
A
E
K
I
V
E
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
P
I
D
Y
V
I
N
I
Q
V
R
K
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
T
K
R
L
E
V
N
M
K
Q
M
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
V
N
G
---
E
R
D
I
E
D
V
F
A
D
V
D
V
I
L
L
E
H
H
8
PsiBlast_PDB
75.72
57%
-76
- C3 -
2ORI
3
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
V
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
5
PsiBlast_PDB
75.30
57%
-75
- C3 -
1P3J
2
KAD_BACSU
A:
[1-212]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
Q
D
I
Q
D
V
Y
A
D
V
K
D
L
L
----
39
PsiBlast_CBE
75.12
53%
-78
- C3 -
4TYQ
2
KAD_BACSU
B:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
A
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
K
L
E
Y
V
I
H
I
E
V
R
Q
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
V
N
G
---
Q
Q
D
M
E
K
V
F
K
D
L
R
E
I
L
Q
G
L
-
3
PsiBlast_PDB
74.77
56%
-77
- C3 -
3FB4
2
?
A:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
Q
I
I
E
K
Y
E
I
P
H
I
S
T
G
D
M
F
R
A
A
I
K
N
G
T
E
L
G
L
K
A
K
S
F
M
D
Q
G
N
L
V
P
D
E
V
T
I
G
I
V
H
E
R
L
S
K
D
D
-
C
Q
K
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
D
A
L
D
S
L
L
T
D
L
G
K
K
L
D
Y
V
L
N
I
K
V
E
Q
E
E
L
M
K
R
L
T
G
R
W
I
C
K
T
C
G
A
T
Y
H
T
I
F
N
P
P
AVEGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
I
D
D
-
K
P
E
T
V
K
N
R
L
D
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
Q
K
G
-----
V
L
K
D
-----
I
D
G
---
Q
Q
D
I
K
K
V
F
V
D
I
N
D
L
L
G
G
L
-
16
PsiBlast_PDB
74.75
52%
-81
- C3 -
1ZIN
2
KAD_GEOSE
A:
[1-212]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
A
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
D
D
-
C
Q
N
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
T
M
L
A
D
I
G
R
K
L
D
Y
V
I
H
I
D
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
A
T
V
A
N
R
L
E
V
N
M
K
Q
M
K
P
---
L
V
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
I
N
G
---
E
Q
D
M
E
K
V
F
A
D
I
R
E
L
L
G
G
L
A
18
PsiBlast_PDB
74.33
52%
-82
- C3 -
1ZIP
2
KAD_GEOSE
A:
[1-212]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
A
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
D
D
-
C
Q
N
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
T
M
L
A
D
I
G
R
K
L
D
Y
V
I
H
I
D
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
A
T
V
A
N
R
L
E
V
N
M
K
Q
M
K
P
---
L
V
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
I
N
G
---
E
Q
D
M
E
K
V
F
A
D
I
R
E
L
L
G
G
L
A
7
PsiBlast_PDB
74.16
57%
-74
- C3 -
2EU8
4
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
26
PsiBlast_CBE
74.14
57%
-80
- C3 -
2ORI
2
KAD_BACSU
B:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
V
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
11
PsiBlast_PDB
74.08
57%
-79
- C3 -
2OO7
3
KAD_BACSU
A:
[1-215]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
I
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
-
9
PsiBlast_PDB
73.52
57%
-80
- C3 -
2QAJ
2
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
E
G
L
K
36
PsiBlast_CBE
73.49
54%
-79
- C3 -
4TYP
2
KAD_BACSU
B:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
A
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
-------
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
K
L
E
H
V
I
H
I
D
V
R
Q
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
K
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
R
N
-----
V
N
G
---
E
Q
D
M
E
K
V
F
K
D
L
R
E
L
L
----
17
PsiBlast_PDB
73.25
52%
-81
- C3 -
1ZIO
2
KAD_GEOSE
A:
[1-212]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
A
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
D
D
-
C
Q
N
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
T
M
L
A
D
I
G
R
K
L
D
Y
V
I
H
I
D
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
A
T
V
A
N
R
L
E
V
N
M
K
Q
M
K
P
---
L
V
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
I
N
G
---
E
Q
D
M
E
K
V
F
A
D
I
R
E
L
L
G
G
L
A
13
PsiBlast_PDB
73.14
56%
-76
- C3 -
2OSB
2
KAD_BACSU
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
L
G
E
R
I
V
E
D
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
K
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
Y
G
K
P
I
D
Y
V
I
N
I
E
V
D
K
D
V
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
S
K
R
L
E
V
N
M
K
Q
T
Q
P
---
L
L
D
F
Y
S
E
K
G
-----
Y
L
A
N
-----
V
N
G
---
Q
R
D
I
Q
D
V
Y
A
D
V
K
D
L
L
G
G
L
K
37
PsiBlast_CBE
73.01
54%
-83
- C3 -
4TYP
2
KAD_BACSU
A:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
A
K
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
E
T
P
L
G
L
E
A
K
S
Y
I
D
K
G
E
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
------
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
M
G
R
K
L
E
H
V
I
H
I
D
V
R
Q
E
E
L
M
E
R
L
T
G
R
R
I
C
S
V
C
G
T
T
Y
H
L
V
F
N
P
P
KTPGI
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
K
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
R
N
-----
V
N
G
---
E
Q
D
M
E
K
V
F
K
D
L
R
E
L
L
Q
---
4
PsiBlast_PDB
72.22
54%
-80
- C3 -
4QBI
2
KAD_GEOSE
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
E
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
D
I
G
R
K
I
D
Y
V
I
H
I
D
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
K
P
---
L
L
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
V
N
G
---
E
Q
D
I
E
K
V
F
A
D
V
R
E
L
L
G
G
L
K
33
PsiBlast_CBE
72.07
54%
-80
- C3 -
4QBH
2
KAD_GEOSE
B:
[1-215]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
E
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
I
G
R
P
I
D
Y
V
I
H
I
E
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
K
P
---
L
L
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
V
N
G
---
Q
Q
D
M
Q
D
V
F
A
D
V
R
E
L
L
G
G
L
-
25
PsiBlast_CBE
71.76
54%
-79
- C3 -
4QBI
2
KAD_GEOSE
B:
[1-214]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
K
I
V
E
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
D
I
G
R
K
I
D
Y
V
I
H
I
D
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
K
P
---
L
L
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
V
N
G
---
E
Q
D
I
E
K
V
F
A
D
V
R
E
L
L
G
G
--
35
PsiBlast_CBE
70.75
50%
-77
- C3 -
1S3G
2
KAD_SPOGL
A:
[1-212]
M
N
I
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
D
R
I
V
E
K
Y
G
T
P
H
I
S
T
G
D
M
F
R
A
A
I
Q
E
G
T
E
L
G
V
K
A
K
S
F
M
D
Q
G
A
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
S
K
S
D
-
C
D
N
G
F
L
L
D
G
F
P
R
T
V
P
Q
A
E
A
L
D
Q
L
L
A
D
M
G
R
K
I
E
H
V
L
N
I
Q
V
E
K
E
E
L
I
A
R
L
T
G
R
R
I
C
K
V
C
G
T
S
Y
H
L
L
F
N
P
P
QVEGK
C
-----
D
-------
K
-----
D
G
G
E
L
Y
Q
R
A
D
D
-
N
P
D
T
V
T
N
R
L
E
V
N
M
N
Q
T
A
P
---
L
L
A
F
Y
D
S
K
E
-----
V
L
V
N
-----
I
N
G
---
Q
K
D
I
K
D
V
F
K
D
L
D
V
I
L
Q
G
N
G
34
PsiBlast_CBE
70.60
54%
-72
- C3 -
4QBH
2
KAD_GEOSE
A:
[1-216]
M
N
L
V
L
M
G
L
P
G
A
G
K
G
T
Q
A
E
R
I
V
E
A
Y
G
I
P
H
I
S
T
G
D
M
F
R
A
A
M
K
E
G
T
P
L
G
L
Q
A
K
Q
Y
M
D
R
G
D
L
V
P
D
E
V
T
I
G
I
V
R
E
R
L
G
K
D
D
-
C
E
R
G
F
L
L
D
G
F
P
R
T
V
A
Q
A
E
A
L
E
E
I
L
E
E
I
G
R
P
I
D
Y
V
I
H
I
E
V
R
Q
D
V
L
M
E
R
L
T
G
R
R
I
C
R
N
C
G
A
T
Y
H
L
I
F
H
P
P
AKPGV
C
-----
D
-------
K
-----
C
G
G
E
L
Y
Q
R
A
D
D
-
N
E
E
T
V
A
K
R
L
E
V
N
M
K
Q
M
K
P
---
L
L
D
F
Y
E
Q
K
G
-----
Y
L
R
N
-----
V
N
G
---
Q
Q
D
M
Q
D
V
F
A
D
V
R
E
L
L
G
G
L
K
67
PsiBlast_CBE
68.94
40%
-87
- C3 -
2C9Y
3
KAD2_HUMAN
A:
[20-228]
---
V
L
L
G
P
P
G
A
G
K
G
T
Q
A
P
R
L
A
E
N
F
C
V
C
H
L
A
T
G
D
M
L
R
A
M
V
A
S
G
S
E
L
G
K
K
L
K
A
T
M
D
A
G
K
L
V
S
D
E
M
V
V
E
L
I
E
K
N
L
-
E
T
P
L
C
K
N
G
F
L
L
D
G
F
P
R
T
V
R
Q
A
E
M
L
D
D
L
M
E
K
R
K
E
K
L
D
S
V
I
E
F
S
I
P
D
S
L
L
I
R
R
I
T
G
R
L
I
H
P
K
S
G
R
S
Y
H
E
E
F
N
P
P
-----
K
EPMKD
D
-------
I
-----
T
G
E
P
L
I
R
R
S
D
D
-
N
E
K
A
L
K
I
R
L
Q
A
Y
H
T
Q
T
T
P
---
L
I
E
Y
Y
R
K
R
G
-----
I
H
S
A
-----
I
D
A
---
S
Q
T
P
D
V
V
F
A
S
I
L
A
A
F
S
K
A
T
56
PsiBlast_CBE
68.73
43%
-78
- C3 -
4IKE
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
D
G
N
102
HHSearch
68.67
43%
-75
- C3 -
3BE4
3
?
A:
[6-217]
H
N
L
I
L
I
G
A
P
G
S
G
K
G
T
Q
C
E
F
I
K
K
E
Y
G
L
A
H
L
S
T
G
D
M
L
R
E
A
I
K
N
G
--
I
G
L
E
A
K
S
I
I
E
S
G
N
F
V
G
D
E
I
V
L
G
L
V
K
E
K
F
D
L
G
V
C
-
V
N
G
F
V
L
D
G
F
P
R
T
I
P
Q
A
E
G
L
A
K
I
L
S
E
I
G
D
S
L
T
S
V
I
Y
F
E
I
D
D
S
E
I
I
E
R
I
S
G
R
C
T
H
P
A
S
G
R
I
Y
H
V
K
Y
N
P
P
-----
K
-----
Q
PGIDD--
V
-----
T
G
E
P
L
V
W
R
D
D
D
-
N
A
E
A
V
K
V
R
L
D
V
F
H
K
Q
T
A
P
---
L
V
K
F
Y
E
D
L
G
-----
I
L
K
R
-----
V
N
A
---
K
L
P
P
K
E
V
T
E
Q
I
K
K
I
L
----
46
PsiBlast_CBE
68.67
43%
-78
- C3 -
4JLA
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
55
PsiBlast_CBE
68.33
43%
-83
- C3 -
4IKE
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
D
G
N
103
HHSearch
68.06
35%
-73
- C3 -
3TLX
4
?
A:
[30-242]
G
R
Y
I
F
L
G
A
P
G
S
G
K
G
T
Q
S
L
N
L
K
K
S
H
C
Y
C
H
L
S
T
G
D
L
L
R
E
A
A
E
K
K
T
E
L
G
L
K
I
K
N
I
I
N
E
G
K
L
V
D
D
Q
M
V
L
S
L
V
D
E
K
L
K
T
P
Q
C
-
K
K
G
F
I
L
D
G
Y
P
R
N
V
K
Q
A
E
D
L
N
K
L
L
Q
K
N
Q
T
K
L
D
G
V
F
Y
F
N
V
P
D
E
V
L
V
N
R
I
S
G
R
L
I
H
K
P
S
G
R
I
Y
H
K
I
F
N
P
P
-----
K
-----
V
-------
P
FRDDV
T
N
E
P
L
I
Q
R
E
D
D
-
N
E
D
V
L
K
K
R
L
T
V
F
K
S
E
T
S
P
---
L
I
S
Y
Y
K
N
K
N
-----
L
L
I
N
-----
L
D
A
---
T
Q
P
A
N
D
L
E
K
K
I
S
Q
H
I
D
G
--
48
PsiBlast_CBE
67.62
43%
-78
- C3 -
4JL8
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
64
PsiBlast_CBE
67.52
43%
-80
- C3 -
4JLO
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
K
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
68
PsiBlast_CBE
67.38
41%
-72
- C3 -
3BE4
3
?
A:
[7-217]
-
N
L
I
L
I
G
A
P
G
S
G
K
G
T
Q
C
E
F
I
K
K
E
Y
G
L
A
H
L
S
T
G
D
M
L
R
E
A
I
K
N
G
--
I
G
L
E
A
K
S
I
I
E
S
G
N
F
V
G
D
E
I
V
L
G
L
V
K
E
K
F
-
D
L
G
V
C
V
N
G
F
V
L
D
G
F
P
R
T
I
P
Q
A
E
G
L
A
K
I
L
S
E
I
G
D
S
L
T
S
V
I
Y
F
E
I
D
D
S
E
I
I
E
R
I
S
G
R
C
T
H
P
A
S
G
R
I
Y
H
V
K
Y
N
P
P
-----
K
QPGID
D
-------
V
-----
T
G
E
P
L
V
W
R
D
D
D
-
N
A
E
A
V
K
V
R
L
D
V
F
H
K
Q
T
A
P
---
L
V
K
F
Y
E
D
L
G
-----
I
L
K
R
-----
V
N
A
---
K
L
P
P
K
E
V
T
E
Q
I
K
K
I
L
----
52
PsiBlast_CBE
67.34
43%
-78
- C3 -
4JL5
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
43
PsiBlast_CBE
66.78
43%
-77
- C3 -
4JLD
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
47
PsiBlast_CBE
66.60
43%
-77
- C3 -
4JLA
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
50
PsiBlast_CBE
66.58
43%
-76
- C3 -
4JL6
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
63
PsiBlast_CBE
66.55
43%
-80
- C3 -
4JLO
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
K
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
59
PsiBlast_CBE
66.53
43%
-76
- C3 -
3SR0
3
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
45
PsiBlast_CBE
66.53
43%
-76
- C3 -
4JLB
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
72
PsiBlast_CBE
66.41
40%
-77
- C3 -
2AK3
2
KAD3_BOVIN
A:
[11-215]
----
I
M
G
A
P
G
S
G
K
G
T
V
S
S
R
I
T
K
H
F
E
L
K
H
L
S
S
G
D
L
L
R
D
N
M
L
R
G
T
E
I
G
V
L
A
K
T
F
I
D
Q
G
K
L
I
P
D
D
V
M
T
R
L
V
L
H
E
L
--
K
N
L
T
Q
Y
N
W
L
L
D
G
F
P
R
T
L
P
Q
A
E
A
L
D
R
A
Y
Q
-----
I
D
T
V
I
N
L
N
V
P
F
E
V
I
K
Q
R
L
T
A
R
W
I
H
P
G
S
G
R
V
Y
N
I
E
F
N
P
P
-----
K
TMGID
D
-------
L
-----
T
G
E
P
L
V
Q
R
E
D
D
-
R
P
E
T
V
V
K
R
L
K
A
Y
E
A
Q
T
E
P
---
V
L
E
Y
Y
R
K
K
G
-----
V
L
E
T
-----
F
S
G
TE
T
N
K
I
W
P
H
V
Y
A
F
L
Q
T
K
L
P
Q
R
S
54
PsiBlast_CBE
66.41
43%
-77
- C3 -
4JKY
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
62
PsiBlast_CBE
66.24
43%
-78
- C3 -
4JLP
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
K
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
61
PsiBlast_CBE
66.24
43%
-79
- C3 -
4JLP
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
K
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
51
PsiBlast_CBE
65.94
43%
-76
- C3 -
4JL6
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
44
PsiBlast_CBE
65.85
43%
-78
- C3 -
4JLB
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
41
PsiBlast_CBE
65.65
46%
-66
- C3 -
4K46
3
KAD_PHOPR
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
A
K
F
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
I
K
A
G
T
E
L
G
K
Q
A
K
S
V
I
D
A
G
Q
L
V
S
D
D
I
I
L
G
L
V
K
E
R
I
A
Q
D
D
C
A
-
K
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
G
----
L
K
E
V
G
V
V
V
D
Y
V
I
E
F
D
V
A
D
S
V
I
V
E
R
M
A
G
R
R
A
H
L
A
S
G
R
T
Y
H
N
V
Y
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
D
L
V
I
R
E
D
D
-
K
E
E
T
V
L
A
R
L
G
V
Y
H
N
Q
T
A
P
---
L
I
A
Y
Y
G
K
E
A
-----
E
A
G
N
T
Q
Y
L
K
F
D
G
---
T
K
A
V
A
E
V
S
A
E
L
E
K
A
L
A
---
58
PsiBlast_CBE
65.63
43%
-70
- C3 -
4CF7
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
96
PsiBlast_CBE
65.46
38%
-85
- C3 -
2CDN
3
KAD_MYCTU
A:
[21-199]
M
R
V
L
L
L
G
P
P
G
A
G
K
G
T
Q
A
V
K
L
A
E
K
L
G
I
P
Q
I
S
T
G
E
L
F
R
R
N
I
E
E
G
T
K
L
G
V
E
A
K
R
Y
L
D
A
G
D
L
V
P
S
D
L
T
N
E
L
V
D
D
R
L
N
N
P
D
A
A
-
N
G
F
I
L
D
G
Y
P
R
S
V
E
Q
A
K
A
L
H
E
M
L
E
R
R
G
T
D
I
D
A
V
L
E
F
R
V
S
E
E
V
L
L
E
R
L
K
G
R
------------------------------------------------
G
R
A
D
D
-
T
D
D
V
I
L
N
R
M
K
V
Y
R
D
E
T
A
P
---
L
L
E
Y
Y
R
D
Q
L
-----
K
T
V
D
-----
A
V
G
---
T
M
D
--
E
V
F
A
R
A
L
R
A
L
G
K
--
57
PsiBlast_CBE
65.43
43%
-74
- C3 -
4CF7
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
71
PsiBlast_CBE
65.37
40%
-74
- C3 -
2AK3
2
KAD3_BOVIN
B:
[11-215]
----
I
M
G
A
P
G
S
G
K
G
T
V
S
S
R
I
T
K
H
F
E
L
K
H
L
S
S
G
D
L
L
R
D
N
M
L
R
G
T
E
I
G
V
L
A
K
T
F
I
D
Q
G
K
L
I
P
D
D
V
M
T
R
L
V
L
H
E
L
--
K
N
L
T
Q
Y
N
W
L
L
D
G
F
P
R
T
L
P
Q
A
E
A
L
D
R
A
Y
Q
-----
I
D
T
V
I
N
L
N
V
P
F
E
V
I
K
Q
R
L
T
A
R
W
I
H
P
G
S
G
R
V
Y
N
I
E
F
N
P
P
-----
K
TMGID
D
-------
L
-----
T
G
E
P
L
V
Q
R
E
D
D
-
R
P
E
T
V
V
K
R
L
K
A
Y
E
A
Q
T
E
P
---
V
L
E
Y
Y
R
K
K
G
-----
V
L
E
T
-----
F
S
G
TET
N
K
I
W
P
H
V
Y
A
F
L
Q
T
K
L
P
Q
R
S
113
HHSearch
65.33
43%
-87
* C3 *
2CDN
3
KAD_MYCTU
A:
[21-200]
M
R
V
L
L
L
G
P
P
G
A
G
K
G
T
Q
A
V
K
L
A
E
K
L
G
I
P
Q
I
S
T
G
E
L
F
R
R
N
I
E
E
G
T
K
L
G
V
E
A
K
R
Y
L
D
A
G
D
L
V
P
S
D
L
T
N
E
L
V
D
D
R
L
N
N
P
D
A
-
A
N
G
F
I
L
D
G
Y
P
R
S
V
E
Q
A
K
A
L
H
E
M
L
E
R
R
G
T
D
I
D
A
V
L
E
F
R
V
S
E
E
V
L
L
E
R
L
K
G
R
G
R
------------------------------------------------
A
D
D
-
T
D
D
V
I
L
N
R
M
K
V
Y
R
D
E
T
A
P
---
L
L
E
Y
Y
R
D
Q
-------
L
K
T
-----
V
D
A
---
V
G
T
M
D
E
V
F
A
R
A
L
R
A
L
G
K
--
49
PsiBlast_CBE
65.33
43%
-74
- C3 -
4JL8
2
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
53
PsiBlast_CBE
64.43
43%
-79
- C3 -
4JKY
2
KAD_AQUAE
B:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
87
PsiBlast_CBE
64.35
39%
-64
- C3 -
4X8L
3
?
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
A
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
73
PsiBlast_CBE
64.01
39%
-63
- C3 -
4X8O
2
?
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
W
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
60
PsiBlast_CBE
63.95
43%
-73
- C3 -
2RGX
4
KAD_AQUAE
A:
[1-198]
M
I
L
V
F
L
G
P
P
G
A
G
K
G
T
Q
A
K
R
L
A
K
E
K
G
F
V
H
I
S
T
G
D
I
L
R
E
A
V
Q
K
G
T
P
L
G
K
K
A
K
E
Y
M
E
R
G
E
L
V
P
D
D
L
I
I
A
L
I
E
E
V
F
P
K
H
G
----
N
V
I
F
D
G
F
P
R
T
V
K
Q
A
E
A
L
D
E
M
L
E
K
K
G
L
K
V
D
H
V
L
L
F
E
V
P
D
E
V
V
I
E
R
L
S
G
R
R
I
N
P
E
T
G
E
V
Y
H
V
K
Y
N
P
P
-----
P
-----
P
-------
G
-----
V
K
--
V
I
Q
R
E
D
D
-
K
P
E
V
I
K
K
R
L
E
V
Y
R
E
Q
T
A
P
---
L
I
E
Y
Y
K
K
K
G
-----
I
L
R
I
-----
I
D
A
---
S
K
P
V
E
E
V
Y
R
Q
V
L
E
V
I
G
---
76
PsiBlast_CBE
63.80
39%
-62
- C3 -
4JZK
2
?
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
78
PsiBlast_CBE
63.68
39%
-63
- C3 -
3HPQ
1
KAD_ECOLI
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
74
PsiBlast_CBE
63.68
39%
-65
- C3 -
4X8O
3
?
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
W
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
82
PsiBlast_CBE
63.46
39%
-65
- C3 -
1AKE
1
KAD_ECOLI
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
77
PsiBlast_CBE
63.06
39%
-65
- C3 -
3HPQ
1
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
92
PsiBlast_CBE
62.85
38%
-68
- C3 -
1E4Y
1
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
L
V
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
86
PsiBlast_CBE
62.75
39%
-62
- C3 -
3HPR
1
KAD_ECOLI
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
G
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
80
PsiBlast_CBE
62.73
39%
-61
- C3 -
1ANK
2
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
85
PsiBlast_CBE
62.70
39%
-62
- C3 -
3HPR
1
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
G
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
81
PsiBlast_CBE
62.27
39%
-63
- C3 -
1AKE
1
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
79
PsiBlast_CBE
61.99
39%
-61
- C3 -
2ECK
2
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
75
PsiBlast_CBE
61.63
39%
-61
- C3 -
4JZK
2
?
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
89
PsiBlast_CBE
61.57
39%
-62
- C3 -
1E4V
1
KAD_ECOLI
A:
[1-213]
M
R
I
I
L
L
G
A
P
V
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
93
PsiBlast_CBE
61.31
38%
-68
- C3 -
1E4Y
1
KAD_ECOLI
A:
[1-213]
M
R
I
I
L
L
G
A
L
V
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
90
PsiBlast_CBE
61.08
36%
-65
- C3 -
3TLX
3
?
B:
[33-233]
---
I
F
L
G
A
P
G
S
G
K
G
T
Q
S
L
N
L
K
K
S
H
C
Y
C
H
L
S
T
G
D
L
L
R
E
A
A
E
K
K
T
E
L
G
L
K
I
K
N
I
I
N
E
G
K
L
V
D
D
Q
M
V
L
S
L
V
D
E
K
L
K
T
P
Q
-
C
K
K
G
F
I
L
D
G
Y
P
R
N
V
K
Q
A
E
D
L
N
K
L
L
Q
K
N
Q
T
K
L
D
G
V
F
Y
F
N
V
P
D
E
V
L
V
N
R
I
S
G
R
L
I
H
K
P
S
G
R
I
Y
H
K
I
F
N
P
P
-----
K
VPFRD
D
-------
V
-----
T
N
E
P
L
I
Q
R
E
D
D
-
N
E
D
V
L
K
K
R
L
T
V
F
K
S
E
T
S
P
---
L
I
S
Y
Y
K
N
K
N
-----
L
L
I
N
-----
L
D
A
---
T
Q
P
A
N
D
L
E
K
K
I
S
Q
H
I
D
G
--
88
PsiBlast_CBE
60.65
39%
-58
- C3 -
1E4V
1
KAD_ECOLI
B:
[1-213]
M
R
I
I
L
L
G
A
P
V
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
A
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
C
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
V
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
83
PsiBlast_CBE
60.41
39%
-60
- C3 -
3X2S
5
?
B:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
C
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
S
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
C
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
TKYAK
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---
115
HHSearch
60.27
31%
-72
- C3 -
1QF9
3
KCY_DICDI
A:
[7-192]
N
V
V
F
V
L
G
G
P
G
S
G
K
G
T
Q
C
A
N
I
V
R
D
F
G
W
V
H
L
S
A
G
D
L
L
R
Q
E
Q
Q
S
G
S
K
D
G
E
M
I
A
T
M
I
K
N
G
E
I
V
P
S
I
V
T
V
K
L
L
K
N
A
I
D
A
N
-
Q
-
G
K
N
F
L
V
D
G
F
P
R
N
E
E
N
N
N
S
W
E
E
N
M
K
D
F
-
V
D
T
K
F
V
L
F
F
D
C
P
E
E
V
M
T
Q
R
L
L
K
R
G
E
S
S
--------------------------------------------
G
R
S
D
D
-
N
I
E
S
I
K
K
R
F
N
T
F
N
V
Q
T
K
L
---
V
I
D
H
Y
N
K
F
D
-----
K
V
K
I
-----
I
P
A
---
N
R
D
V
N
E
V
Y
N
D
V
E
N
L
F
K
S
M
G
104
HHSearch
60.21
31%
-82
- C3 -
2XB4
2
?
A:
[1-222]
M
N
I
L
I
F
G
P
N
G
S
G
K
G
T
Q
G
N
L
V
K
D
K
Y
S
L
A
H
I
E
S
G
G
I
F
R
E
H
I
G
G
G
T
E
L
G
K
K
A
K
E
F
I
D
R
G
D
L
V
P
D
D
I
T
I
P
M
V
L
E
T
L
E
S
K
-
G
-
K
D
G
W
L
L
D
G
F
P
R
N
T
V
Q
A
Q
K
L
F
E
A
L
Q
E
K
G
M
K
I
N
F
V
I
E
I
L
L
P
R
E
V
A
K
N
R
I
M
G
R
R
I
C
K
N
N
P
N
H
P
N
N
I
F
I
D
A
-----
I
-----
K
P
NGDVCR
V
-----
C
G
G
A
L
S
A
R
A
D
D
Q
D
E
G
A
I
N
K
R
H
D
I
Y
Y
N
T
V
D
G
T
L
A
A
A
Y
Y
Y
K
N
M
A
AKEG
F
V
Y
I
E
-----
L
D
G
---
E
G
S
I
D
S
I
K
D
T
L
L
A
Q
L
A
---
84
PsiBlast_CBE
58.51
39%
-56
- C3 -
3X2S
5
?
A:
[1-213]
M
R
I
I
L
L
G
A
P
G
A
G
K
G
T
Q
A
Q
F
I
M
E
K
Y
G
I
P
Q
I
S
T
G
D
M
L
R
A
A
V
K
S
G
S
E
L
G
K
Q
A
K
D
I
M
D
C
G
K
L
V
T
D
E
L
V
I
A
L
V
K
E
R
I
A
Q
E
D
-
S
R
N
G
F
L
L
D
G
F
P
R
T
I
P
Q
A
D
A
----
M
K
E
A
G
I
N
V
D
Y
V
L
E
F
D
V
P
D
E
L
I
V
D
R
I
V
G
R
R
V
H
A
P
S
G
R
V
Y
H
V
K
F
N
P
P
-----
K
VEGKD
D
-------
V
-----
T
G
E
E
L
T
T
R
K
D
D
-
Q
E
E
T
V
R
K
R
L
C
E
Y
H
Q
M
T
A
P
---
L
I
G
Y
Y
S
K
E
A
-----
E
A
G
N
T
K
Y
A
K
V
D
G
---
T
K
P
V
A
E
V
R
A
D
L
E
K
I
L
G
---