@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2376: (2016-04-03 )
MTYPQLSKEVAPNEIEAEMITNRGTIRIKLFPEIAPKTVENFVTHSKNGYYDGLIFHRVIPEFMIQGGDPDGRGTGGESIWGESFEDEFSTEAFNLRGALSMANAGPNTNGSQFFIVQKPDMPADMLGQMEQAGFPVEVIEAYKQGGTPWLDGRHTVFGHVIEGMDVVDEIANLPTGMQDKPVNDVVIEKINIK
Atome Classification :
(98 SA)
------.........10........-20-----.-----.......30........40.---.-----------.----------..-----------..-----------.-----------50-------.........60........-70.-.-.-..-....80----.......-.-90.-..-.-.-.----..100...-.----...110....-...120.......130.......140.......150.--------......160..-.....170..--...-..--180.......---.190..------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MTY
P
Q
L
SKEVAPN
E
I
E
A
E
M
-IT-----N-----R
G
T
I
R
I
K
LFPEI
A
P
K
T
V
E
N
F
---
V
-----------T----------HS-----------KN-----------G-----------Y--------YD
G
L
I
F
H
R
V
I
P
E
F
M
IQGGD-P-D-G-R-GT-GGESIW----GES
F
E
D
E-F-STE-
A
F
-N-L-R----G
A
L
S
MANA-G----PNTNG
S
Q
F
F
I
-
V
QKPDM
P
A
D
M
L
G
Q
M
E
QAGF
P
V
E
V
I
E
A
Y
K
QGGTPWLDG--------R
H
T
V
F
G
H
V
I
E
G
-
M
D
V
V
D
E
I
ANL--PTG-MQ--D-KPVN
D
V
V
I
---
E
K
INIK------------------------------------------------------------------------------------------------------------------
117
HHSearch
91.89
54%
-73
- C7 -
2A2N
1
PPWD1_HUMAN
A:
[13-176]
----------
Q
A
E
G
P
-
K
R
V
S
D
S
A
I
I
-
H
T
-----
S
-----
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
---
C
-----------
V
----------
H
S
-----------
R
N
-----------
G
-----------
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
M
-
G
G
E
S
I
W
----
G
G
E
F
E
D
E
-
F
-
H
S
T
-
L
R
-
H
D
R
-
P
----
Y
T
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
-
T
V
V
P
T
P
---------------------------
W
L
D
N
--------
K
H
T
V
F
G
R
V
T
K
G
-
M
E
V
V
Q
R
I
S
N
V
--
K
V
N
P
K
T
--
D
-
K
P
Y
E
D
V
S
I
---
I
N
I
T
V
K
------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.50
51%
-75
- C7 -
2A2N
1
PPWD1_HUMAN
A:
[28-176]
---------------------------
T
-----
S
-----
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
---
C
-----------
V
----------
H
S
-----------
R
N
-----------
G
-----------
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
M
-
G
G
E
S
I
W
----
G
G
E
F
E
D
E
-
F
H
S
T
L
-
R
H
-
D
-
R
-
P
----
Y
T
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
-
T
V
V
P
---------------------------
T
P
W
L
D
N
--------
K
H
T
V
F
G
R
V
T
K
G
-
M
E
V
V
Q
R
I
S
N
V
--
K
V
N
-
P
K
T-
D
-
K
P
Y
E
D
V
S
I
---
I
N
I
T
V
K
------------------------------------------------------------------------------------------------------------------
116
HHSearch
91.30
53%
-84
- C7 -
2FU0
-
?
A:
[5-159]
-------------------
P
K
S
A
I
I
-
Y
T
-----
T
-----
M
G
D
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
---
S
-----------
V
----------
H
S
-----------
I
N
-----------
G
-----------
Y
--------
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
D
-
P
-
S
-
G
-
D
-
G
T
-
G
G
E
S
I
W
----
G
N
E
F
E
D
E
-
F
-
F
D
H
-
L
N
-
H
S
K
-
P
----
F
M
V
S
M
A
N
C
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
C
P
---------------------------
W
L
D
F
--------
K
H
T
V
F
G
K
V
T
Q
G
-
S
K
I
V
L
D
I
E
K
V
--
R
T
D
-
K
R
--
D
-
K
P
L
E
D
I
K
I
---
L
N
I
K
I
N
------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.05
51%
-75
- C7 -
2A2N
1
C:
[28-176]
---------------------------
T
-----
S
-----
M
G
D
I
H
T
K
L
F
P
V
E
C
P
K
T
V
E
N
F
---
C
-----------
V
----------
H
S
-----------
R
N
-----------
G
-----------
Y
--------
Y
N
G
H
T
F
H
R
I
I
K
G
F
M
I
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
M
-
G
G
E
S
I
W
----
G
G
E
F
E
D
E
-
F
H
S
T
L
-
R
H
-
D
-
R
-
P
----
Y
T
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
-
T
V
V
P
---------------------------
T
P
W
L
D
N
--------
K
H
T
V
F
G
R
V
T
K
G
-
M
E
V
V
Q
R
I
S
N
V
--
K
V
N
-
P
K
T-
D
-
K
P
Y
E
D
V
S
I
---
I
N
I
T
V
K
------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.77
45%
-89
- C7 -
2FU0
-
?
A:
[7-158]
---------------------
S
A
I
I
-
Y
T
-----
T
-----
M
G
D
I
H
I
S
L
F
Y
K
E
C
K
K
T
V
Q
N
F
---
S
-----------
V
----------
H
S
-----------
I
N
-----------
G
-----------
Y
--------
Y
N
N
C
I
F
H
R
V
I
K
H
F
M
V
Q
T
G
D
-
P
-
S
-
G
-
D
-
G
T
-
G
G
E
S
I
W
----
G
N
E
F
E
D
E
-
F
-
F
D
H
-
L
N
-
H
-
S
-
K
P---
F
M
V
S
M
A
N
C
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
C
P
W
L
D
F
--------
K
H
T
V
F
G
K
V
T
Q
G
-
S
K
I
V
L
D
I
E
K
V
--
R
T
D
-
K
R
--
D
-
K
P
L
E
D
I
K
I
---
L
N
I
K
I
-------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.85
43%
-81
- C7 -
1XYH
-
PPIL3_HUMAN
A:
[1-154]
--------------------
M
S
V
T
L
-
H
T
-----
D
-----
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
---
L
-----------
A
----------
L
C
-----------
A
S
-----------
N
-----------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
R
-
G
G
N
S
I
W
----
G
K
K
F
E
D
E
-
Y
-
S
E
Y
L
K
H
-
N
-
V
-
R
----
G
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
---------------------------
Y
G
K
Q
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
G
-
L
E
T
L
D
E
L
E
K
L
--
P
V
N
-
E
K
--
T
Y
R
P
L
N
D
V
H
I
---
K
D
I
T
I
-------------------------------------------------------------------------------------------------------------------
122
HHSearch
89.72
45%
-74
- C7 -
1ZKC
1
PPIL2_HUMAN
A:
[16-174]
----------------
P
R
G
S
G
Y
V
R
L
-
H
T
-----
N
-----
K
G
D
L
N
L
E
L
H
C
D
L
T
P
K
T
C
E
N
F
---
I
-----------
R
----------
L
C
-----------
K
K
-----------
H
-----------
Y
--------
Y
D
G
T
I
F
H
R
S
I
R
N
F
V
I
Q
G
G
D
-
P
-
T
-
G
-
T
-
G
T
-
G
G
E
S
Y
W
----
G
K
P
F
K
D
E
-
F
-
R
P
N
-
L
S
-
H
T
G
-
R
----
G
I
L
S
M
A
N
S
-
G
----
P
N
S
N
R
S
Q
F
F
I
-
T
F
R
S
C
A
---------------------------
Y
L
D
K
--------
K
H
T
I
F
G
R
V
V
G
G
-
F
D
V
L
T
A
M
E
N
V
--
E
S
D
P
K
T
--
D
-
R
P
K
E
E
I
R
I
---
D
A
T
T
V
F
------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.71
43%
-87
- C7 -
2OJU
1
PPIL3_HUMAN
B:
[7-160]
--------------------
M
S
V
T
L
-
H
T
-----
D
-----
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
---
L
-----------
A
----------
L
C
-----------
A
S
-----------
N
-----------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
R
-
G
G
N
S
I
W
----
G
K
K
F
E
D
E
-
Y
-
S
E
Y
L
K
H
-
N
-
V
-
R
----
G
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
---------------------------
Y
G
K
Q
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
G
-
L
E
T
L
D
E
L
E
K
L
--
P
V
N
-
E
K
--
T
Y
R
P
L
N
D
V
H
I
---
K
D
I
T
I
-------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.07
43%
-81
- C7 -
2OK3
2
PPIL3_HUMAN
A:
[1-154]
--------------------
M
S
V
T
L
-
H
T
-----
D
-----
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
---
L
-----------
A
----------
L
C
-----------
A
S
-----------
N
-----------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
R
-
G
G
N
S
I
W
----
G
K
K
F
E
D
E
-
Y
-
S
E
Y
L
K
H
-
N
-
V
-
R
----
G
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
---------------------------
Y
G
K
Q
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
G
-
L
E
T
L
D
E
L
E
K
L
--
P
V
N
-
E
K
--
T
Y
R
P
L
N
D
V
H
I
---
K
D
I
T
I
-------------------------------------------------------------------------------------------------------------------
124
HHSearch
89.04
50%
-72
- C7 -
2OK3
2
PPIL3_HUMAN
A:
[3-155]
----------------------
V
T
L
-
H
T
-----
D
-----
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
---
L
-----------
A
----------
L
C
-----------
A
S
-----------
N
-----------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
R
-
G
G
N
S
I
W
----
G
K
K
F
E
D
E
-
Y
-
S
E
Y
-
L
K
-
H
N
V
-
R
----
G
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
Y
G
K
Q
P
---------------------------
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
G
-
L
E
T
L
D
E
L
E
K
L
--
P
V
N
E
K
T
--
Y
-
R
P
L
N
D
V
H
I
---
K
D
I
T
I
H
------------------------------------------------------------------------------------------------------------------
137
HHSearch
88.83
46%
-77
- C7 -
1IHG
-
PPID_BOVIN
A:
[12-183]
----------------
N
P
S
N
P
R
V
F
F
-
D
V
-----
D
IGGER
V
G
R
I
V
L
E
L
F
A
D
I
V
P
K
T
A
E
N
F
---
R
-----------
A
----------
L
C
-----------
T
G
EKGIGPTTGKP
L
-----------
H
--------
F
K
G
C
P
F
H
R
I
I
K
K
F
M
I
Q
G
G
D
-
F
-
S
-
N
Q
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
H
Y
-
K
H
-
D
-
K
-
E
----
G
L
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
T
P
---------------------------
H
L
D
G
--------
K
H
V
V
F
G
Q
V
I
K
G
-
M
G
V
A
K
I
L
E
N
V
--
E
V
K
--
G
--
E
-
K
P
A
K
L
C
V
I
---
A
E
C
G
E
-------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.09
43%
-88
- C7 -
2OJU
1
PPIL3_HUMAN
A:
[7-160]
--------------------
M
S
V
T
L
-
H
T
-----
D
-----
V
G
D
I
K
I
E
V
F
C
E
R
T
P
K
T
C
E
N
F
---
L
-----------
A
----------
L
C
-----------
A
S
-----------
N
-----------
Y
--------
Y
N
G
C
I
F
H
R
N
I
K
G
F
M
V
Q
T
G
D
-
P
-
T
-
G
-
T
-
G
R
-
G
G
N
S
I
W
----
G
K
K
F
E
D
E
-
Y
-
S
E
Y
L
K
H
-
N
-
V
-
R
----
G
V
V
S
M
A
N
N
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
---------------------------
Y
G
K
Q
P
H
L
D
M
--------
K
Y
T
V
F
G
K
V
I
D
G
-
L
E
T
L
D
E
L
E
K
L
--
P
V
N
-
E
K
--
T
Y
R
P
L
N
D
V
H
I
---
K
D
I
T
I
-------------------------------------------------------------------------------------------------------------------
135
HHSearch
88.07
53%
-70
- C7 -
2HAQ
-
?
A:
[37-187]
--------------------------
S
E
-----
P
-----
L
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
---
R
-----------
Q
----------
L
C
-----------
T
G
-----------
E
-----------
H
GFG-----
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
-
F
-
T
-
N
F
D
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
-
N
-
L
-
N
-
V
K
-
H
-
F
-
V
----
G
A
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
A
P
T
P
---------------------------
W
L
D
G
--------
R
H
V
V
F
G
K
V
L
D
G
-
M
D
V
V
L
R
I
E
K
T
--
K
T
N
-
S
H
--
D
-
R
P
V
K
P
V
K
I
---
V
A
S
G
E
L
------------------------------------------------------------------------------------------------------------------
133
HHSearch
88.00
47%
-68
* C7 *
1A58
-
CYP1_BRUMA
A:
[19-176]
---------------------------------
L
-----
A
G
R
I
V
M
E
L
Y
N
D
I
A
P
R
T
C
N
N
F
---
L
-----------
M
----------
L
C
T
GMAGTGKISG
K
P
-----------
L
-----------
H
--------
Y
K
G
S
T
F
H
R
V
I
K
N
F
M
I
Q
G
G
D
-
F
-
T
K
G
-
D
-
G
T
-
G
G
E
S
I
Y
----
G
G
M
F
D
D
E
-
E
-
F
V
M
-
K
H
-
D
-
E
-
P
----
F
V
V
S
M
A
N
K
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
T
P
A
P
---------------------------
H
L
N
N
--------
I
H
V
V
F
G
K
V
V
S
G
-
Q
E
V
V
T
K
I
E
Y
L
--
K
T
N
-
S
K
--
N
-
R
P
L
A
D
V
V
I
---
L
N
C
G
E
L
------------------------------------------------------------------------------------------------------------------
129
HHSearch
87.79
45%
-74
- C7 -
1MZW
-
PPIH_HUMAN
A:
[7-176]
----------------
S
P
V
N
P
V
V
F
F
-
D
V
SIGGQ
E
-----
V
G
R
M
K
I
E
L
F
A
D
V
V
P
K
T
A
E
N
F
---
R
-----------
Q
----------
F
C
-----------
T
G
-----------
E
-----------
F
RKDGVPIG
Y
K
G
S
T
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
-
V
N
G
-
D
-
G
T
-
G
V
A
S
I
Y
----
R
G
P
F
A
D
E
-
N
-
F
K
L
-
R
H
-
S
-
A
-
P
----
G
L
L
S
M
A
N
S
-
G
----
P
S
T
N
G
C
Q
F
F
I
-
T
C
S
K
C
D
---------------------------
W
L
D
G
--------
K
H
V
V
F
G
K
I
I
D
G
-
L
L
V
M
R
K
I
E
N
V
--
P
T
G
-
P
N
--
N
-
K
P
K
L
P
V
V
I
---
S
Q
C
G
E
-------------------------------------------------------------------------------------------------------------------
121
HHSearch
87.58
43%
-66
- C7 -
2POE
4
?
A:
[15-174]
------------------
Y
F
Q
G
V
R
I
-
I
T
-----
N
-----
Y
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
---
L
-----------
A
----------
L
S
-----------
A
S
-----------
G
-----------
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
-
T
-
G
-
T
-
G
K
-
G
G
E
S
I
Y
----
G
R
Y
F
D
D
E
-
I
-
Y
P
E
-
L
K
-
Y
D
R
-
R
----
G
I
L
S
M
A
S
K
-
G
AKK-
P
N
T
N
G
S
Q
F
F
I
-
T
Y
S
S
L
P
---------------------------
Q
L
N
G
--------
E
Y
V
I
F
G
K
L
I
D
G
-
F
E
T
L
N
T
L
E
N
C
--
P
S
D
-
K
S
--
H
-
K
P
I
D
E
I
I
I
---
K
D
I
V
I
H
------------------------------------------------------------------------------------------------------------------
106
Fugue
87.30
44%
-55
- C7 -
1IIP
1
PPID_BOVIN
A:
[2-298]
SHPSPQ
A
K
P
S
N
P
S
N
P
R
V
F
F
D
V
D
I
G
G
--
E
-----
R
-----
V
G
R
I
V
L
E
L
F
A
D
I
V
P
K
T
A
E
N
F
---
R
-----------
A
----------
L
C
-----------
T
G
-----------
E
KGIGPTTGKPL
H
--------
F
K
G
C
P
F
H
R
I
I
K
K
F
M
I
Q
G
G
D
F
S
-
N
-
Q
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
H
Y
-
K
H
-
D
-
K
-
E
----
G
L
L
S
M
A
N
A
-
G
----
S
N
T
N
G
S
Q
F
F
I
-
T
T
---------------------------
V
P
T
P
H
L
D
G
--------
K
H
V
V
F
G
Q
V
I
K
G
-
M
G
V
A
K
I
L
E
N
V
--
E
V
K
--
G
--
E
-
K
P
A
K
L
C
V
I
---
A
E
C
G
E
L
K
EGDDWGIFPKDGSGDSHPDFPEDADVDLKD
V
D
K
I
L
L
I
S
E
D
L
K
N
I
G
N
T
F
F
K
S
QN
W
E
M
A
I
K
K
Y
T
K
V
L
R
Y
V
E
G
S
R
A
A
A
E
D
A
D
G
A
K
L
Q
P
V
A
L
S
C
V
L
N
I
G
A
C
K
L
K
M
S
D
W
Q
G
A
V
D
S
C
LE
11
PsiBlast_PDB
87.17
48%
-80
- C7 -
4S1J
-
?
A:
[26-166]
----------------------------------------
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
-
L
-----------
C
----------
T
G
-----------
E
H
-----------
G
-----------
F
G-------
Y
K
D
S
I
F
H
R
V
I
P
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
---
N
L
K
-
V
K
-
H
-
F
-
V
----
G
A
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
L
D
G
-
M
D
V
V
L
R
I
E
K
T
--
K
T
N
-
S
H
--
D
-
R
P
V
K
P
V
K
I
---------------------------------------------------------------------------------------------------------------------------
134
HHSearch
87.00
46%
-70
- C7 -
3PMP
1
?
A:
[10-163]
----------------------
S
I
N
-
D
K
-----
P
-----
E
G
R
I
V
F
K
L
Y
D
E
A
V
P
K
T
A
K
N
F
---
R
-----------
E
----------
L
A
-----------
T
G
-----------
Q
-----------
H
GFG-----
Y
K
D
S
I
F
H
R
V
I
P
Q
F
M
L
Q
G
G
D
-
F
-
T
-
R
H
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
-
N
-
F
Q
V
-
K
H
-
T
-
K
-
P
----
G
L
L
S
M
A
N
A
-
G
----
A
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
T
S
---------------------------
W
L
D
G
--------
K
H
V
V
F
G
E
V
I
E
G
-
L
D
I
V
R
K
V
E
G
K
--
G
S
A
--
S
--
G
-
K
T
N
A
T
I
K
I
---
T
D
C
G
T
V
------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.47
46%
-85
- C7 -
1XO7
-
?
A:
[20-165]
----------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
-
L
-----------
A
----------
S
G
-----------
E
N
-----------
G
-----------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
T
R
F
D
D
E
---
N
L
K
-
I
K
-
H
-
F
-
V
----
G
A
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
G
-
M
D
V
V
K
K
V
E
N
T
--
K
T
G
-
L
N
--
D
-
K
P
K
K
A
V
K
I
---
N
D
C
G
V
-------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
86.42
37%
-71
- C7 -
2POE
4
?
A:
[19-173]
----------------------
V
R
I
-
I
T
-----
N
-----
Y
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
---
L
-----------
A
----------
L
S
-----------
A
S
-----------
G
-----------
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
-
T
-
G
-
T
-
G
K
-
G
G
E
S
I
Y
----
G
R
Y
F
D
D
E
-
I
-
Y
P
E
L
K
Y
-
D
-
R
-
R
----
G
I
L
S
M
A
S
K
-
G
AKK-
P
N
T
N
G
S
Q
F
F
I
-
T
Y
S
---------------------------
S
L
P
Q
L
N
G
--------
E
Y
V
I
F
G
K
L
I
D
G
-
F
E
T
L
N
T
L
E
N
C
--
P
S
D
-
K
S
--
H
-
K
P
I
D
E
I
I
I
---
K
D
I
V
I
-------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
86.15
46%
-80
- C7 -
1XQ7
1
?
B:
[20-165]
----------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
KQ-
L
-----------
A
----------
S
G
-----------
E
N
-----------
G
-----------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
T
R
F
D
D
E
---
N
L
K
-
I
K
-
H
-
F
-
V
----
G
A
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
G
-
M
D
V
V
K
K
V
E
N
T
--
K
T
G
-
L
N
--
D
-
K
P
K
K
A
V
K
I
---
N
D
C
G
V
-------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.09
46%
-79
- C7 -
1XQ7
1
?
C:
[20-165]
----------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
KQ-
L
-----------
A
----------
S
G
-----------
E
N
-----------
G
-----------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
T
R
F
D
D
E
---
N
L
K
-
I
K
-
H
-
F
-
V
----
G
A
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
G
-
M
D
V
V
K
K
V
E
N
T
--
K
T
G
-
L
N
--
D
-
K
P
K
K
A
V
K
I
---
N
D
C
G
V
-------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.92
46%
-79
- C7 -
1XQ7
1
?
A:
[20-165]
----------------------------------------
G
R
V
V
I
G
L
F
G
N
D
V
P
K
T
V
E
N
F
K
Q
-
L
-----------
A
----------
S
G
-----------
E
N
-----------
G
-----------
F
G-------
Y
K
G
S
I
F
H
R
V
I
R
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
T
R
F
D
D
E
---
N
L
K
-
I
K
-
H
-
F
-
V
----
G
A
V
S
M
A
N
A
-
G
----
P
N
S
N
G
S
Q
F
F
V
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
V
E
G
-
M
D
V
V
K
K
V
E
N
T
--
K
T
G
-
L
N
--
D
-
K
P
K
K
A
V
K
I
---
N
D
C
G
V
-------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.90
37%
-73
- C7 -
2QER
5
?
A:
[19-173]
----------------------
V
R
I
-
I
T
-----
N
-----
Y
G
D
L
K
F
E
L
F
C
S
Q
C
P
K
A
C
K
N
F
---
L
-----------
A
----------
L
S
-----------
A
S
-----------
G
-----------
Y
--------
Y
K
N
T
I
F
H
K
N
I
K
G
F
I
I
Q
G
G
D
-
P
-
T
-
G
-
T
-
G
K
-
G
G
E
S
I
Y
----
G
R
Y
F
D
D
E
-
I
-
Y
P
E
L
K
Y
-
D
-
R
-
R
----
G
I
L
S
M
A
S
---ASKK
P
N
T
N
G
S
Q
F
F
I
-
T
Y
S
---------------------------
S
L
P
Q
L
N
G
--------
E
Y
V
I
F
G
K
L
I
D
G
-
F
E
T
L
N
T
L
E
N
C
--
P
S
D
-
K
S
--
H
-
K
P
I
D
E
I
I
I
---
K
D
I
V
I
-------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.37
45%
-93
- C7 -
2CFE
3
?
A:
[16-161]
----------------------------------------
G
T
I
K
F
K
L
F
D
D
V
V
P
K
T
A
A
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
A
G
S
H
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
F
T
-
A
-
G
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
A
K
F
A
D
E
-
N
-
F
Q
L
-
K
H
-
N
-
K
-
P
----
G
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
--------------------
V
V
-------
T
S
W
L
D
G
--------
K
H
V
V
F
G
E
V
I
D
G
-
M
N
V
V
K
A
I
E
A
E
--
G
S
G
--
S
--
G
-
K
P
R
S
R
I
E
I
---
A
K
C
G
V
-------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
85.31
45%
-87
- C7 -
2ESL
6
PPIC_HUMAN
E:
[30-180]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
-
T
-
G
-
D
-
G
T
-
G
G
V
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
N
C
S
I
INS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
126
HHSearch
85.01
37%
-72
- C7 -
3BO7
13
?
A:
[5-172]
------------------
K
K
G
Y
L
R
I
-
V
T
-----
T
-----
Q
G
S
L
N
I
E
L
H
A
D
M
A
P
R
A
C
D
S
F
---
L
-----------
R
----------
L
C
-----------
A
V
-----------
K
-----------
Y
--------
F
D
D
T
I
F
H
R
C
I
R
N
F
M
I
Q
G
G
R
-
A
-
E
-
L
-
R
-
Q
P
Q
S
P
R
S
I
S
GFPG
G
A
P
F
E
D
E
-
F
-
D
N
R
-
L
V
-
H
-
Q
G
I
----
G
V
L
S
M
A
N
D
-
G
----
K
H
S
N
L
S
E
F
F
I
-
T
F
K
S
C
E
---------------------------
H
L
N
N
--------
K
H
T
I
F
G
R
V
V
G
G
-
L
D
V
L
R
Q
W
E
K
L
--
E
T
D
-
K
K
--
D
-
K
P
L
K
P
P
K
V
---
E
E
I
I
V
F
------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
84.88
45%
-87
- C7 -
2ESL
6
PPIC_HUMAN
D:
[30-180]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
-
T
-
G
-
D
-
G
T
-
G
G
V
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
N
C
S
I
INS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
84.84
45%
-88
- C7 -
2ESL
6
PPIC_HUMAN
B:
[30-180]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
-
T
-
G
-
D
-
G
T
-
G
G
V
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
N
C
S
I
INS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
84.77
45%
-89
- C7 -
2ESL
6
PPIC_HUMAN
C:
[30-180]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
-
T
-
G
-
D
-
G
T
-
G
G
V
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
N
C
S
I
INS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.67
46%
-84
- C7 -
2RMC
1
PPIC_MOUSE
G:
[22-172]
----------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
-
T
-
A
-
R
D
G
T
-
G
G
M
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
D
C
T
I
VNS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
84.63
45%
-91
- C7 -
2ESL
7
PPIC_HUMAN
F:
[30-180]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
-
T
-
G
-
D
-
G
T
-
G
G
V
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
N
C
S
I
INS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
84.21
42%
-84
- C7 -
2POY
1
?
A:
[31-181]
---------------------------
T
-----
P
-----
A
G
R
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
---
R
-----------
A
L
C
T
GEKGMGQ
S
G
-----------
K
P
-----------
L
-----------
C
--------
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
D
-
G
T
-
G
G
E
S
I
Y
----
G
-
K
F
R
D
E
-
N
-
F
V
Y
-
T
H
-
D
-
A
-
P
----
F
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
G
-
M
E
V
V
K
S
I
E
K
C
----
G
-
S
Q
--
N
G
K
P
T
K
S
V
C
I
---------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
84.18
45%
-89
- C7 -
2ESL
6
PPIC_HUMAN
A:
[30-180]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
T
G---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
I
T
-
T
-
G
-
D
-
G
T
-
G
G
V
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
N
C
S
I
I
N
S
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
83.87
46%
-85
- C7 -
2RMC
1
PPIC_MOUSE
C:
[22-172]
----------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
-
T
-
A
-
R
D
G
T
-
G
G
M
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
D
C
T
I
VNS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
83.80
42%
-83
- C7 -
2POY
2
?
C:
[31-181]
---------------------------
T
-----
P
-----
A
G
R
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
---
R
-----------
A
LCTGEKGMGQ
S
G
-----------
K
P
-----------
L
-----------
C
--------
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
D
-
G
T
-
G
G
E
S
I
Y
----
G
-
K
F
R
D
E
-
N
-
F
V
Y
-
T
H
-
D
-
A
-
P
----
F
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
G
-
M
E
V
V
K
S
I
E
K
C
----
G
-
S
Q
--
N
G
K
P
T
K
S
V
C
I
---------------------------------------------------------------------------------------------------------------------------
123
HHSearch
83.78
39%
-73
- C7 -
2HQ6
2
CWC27_HUMAN
A:
[21-179]
----------------
P
P
T
N
G
K
V
L
L
-
K
T
-----
T
-----
A
G
D
I
D
I
E
L
W
S
K
E
A
P
K
A
C
R
N
F
---
I
-----------
Q
----------
L
C
-----------
L
E
-----------
A
-----------
Y
--------
Y
D
N
T
I
F
H
R
V
V
P
G
F
I
V
Q
G
G
D
-
P
-
T
-
G
-
T
-
G
S
-
G
G
E
S
I
Y
----
G
A
P
F
K
D
E
-
F
-
H
S
R
-
L
R
F
N
-
R
-
R
----
G
L
V
A
M
A
N
A
-
G
----
S
H
D
N
G
S
Q
F
F
F
-
T
L
G
R
A
D
---------------------------
E
L
N
N
--------
K
H
T
I
F
G
K
V
T
G
D
T
V
Y
N
M
L
R
L
S
E
V
--
D
I
D
-
D
D
--
E
-
R
P
H
N
P
H
K
I
---
K
S
C
E
V
L
------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.68
46%
-85
- C7 -
2RMC
1
PPIC_MOUSE
A:
[22-172]
----------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
T
G---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
-
T
-
A
-
R
D
G
T
-
G
G
M
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
D
C
T
I
V
N
S
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
83.66
42%
-80
- C7 -
2POY
2
?
B:
[31-181]
---------------------------
T
-----
P
-----
A
G
R
I
T
M
E
L
F
A
D
K
V
P
I
T
A
E
N
F
---
R
-----------
A
L
C
T
GEKGMGQ
S
G
-----------
K
P
-----------
L
-----------
C
--------
Y
T
G
S
F
F
H
R
I
I
P
Q
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
D
-
G
T
-
G
G
E
S
I
Y
----
G
-
K
F
R
D
E
-
N
-
F
V
Y
-
T
H
-
D
-
A
-
P
----
F
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
G
-
M
E
V
V
K
S
I
E
K
C
----
G
-
S
Q
--
N
G
K
P
T
K
S
V
C
I
---------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.29
42%
-86
- C7 -
2IGW
2
CYP3_CAEEL
A:
[18-165]
----------------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
-
L
-----------
C
----------
T
G
-----------
E
N
-----------
G
IGKSGKPL---
H
--------
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
P
D
E
-
N
-
F
K
E
-
K
H
-
T
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
L
-
C
T
V
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
R
V
V
E
G
-
L
D
V
V
K
A
V
E
S
----
N
G
-
S
Q
--
S
G
K
P
V
K
D
C
M
I
---------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
83.20
40%
-69
- C7 -
2WFJ
3
PPIG_HUMAN
A:
[24-173]
----------------------------------------
G
R
V
V
F
E
L
F
S
D
V
C
P
K
T
C
E
N
F
---
R
C
L
C
T
GEKGTGK
S
----------
T
Q
-----------
K
P
-----------
L
-----------
H
--------
Y
K
S
C
L
F
H
R
V
V
K
D
F
M
V
Q
G
G
D
F
S
-
E
-
G
-
N
-
G
R
-
G
G
E
S
I
Y
----
G
G
F
F
E
D
E
-
S
-
F
A
V
-
K
H
-
N
-
K
-
E
----
F
L
L
S
M
A
N
R
-
G
----
K
D
T
N
G
S
Q
F
F
I
-
T
T
K
P
---------------------------
T
P
H
L
D
G
--------
H
H
V
V
F
G
Q
V
I
S
G
-
Q
E
V
V
R
E
I
E
N
Q
--
K
T
D
-
A
A
--
S
-
K
P
F
A
E
V
R
I
---------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
83.12
42%
-84
- C7 -
2IGV
1
CYP3_CAEEL
A:
[18-165]
----------------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
-
L
-----------
C
----------
T
G
-----------
E
N
-----------
G
IGKSGKPL---
H
--------
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
P
D
E
-
N
-
F
K
E
-
K
H
-
T
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
L
-
C
T
V
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
R
V
V
E
G
-
L
D
V
V
K
A
V
E
S
----
N
G
-
S
Q
--
S
G
K
P
V
K
D
C
M
I
---------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.10
46%
-84
- C7 -
2RMC
1
PPIC_MOUSE
E:
[22-172]
----------------------------------------
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
TG---------
E
K
-----------
G
-----------
Y
G-------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
-
T
-
A
-
R
D
G
T
-
G
G
M
S
I
Y
----
G
E
T
F
P
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
I
------
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
T
L
T
K
P
----------------------------
T
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
-
G
H
--
D
-
R
P
L
T
D
C
T
I
VNS
G
K
I
D
V
K
------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
82.91
42%
-86
- C7 -
1E8K
2
CYP3_CAEEL
A:
[18-165]
----------------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
-
L
-----------
C
----------
T
G
-----------
E
N
-----------
G
IGKSGKPL---
H
--------
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
P
D
E
-
N
-
F
K
E
-
K
H
-
T
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
L
-
C
T
V
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
R
V
V
E
G
-
L
D
V
V
K
A
V
E
S
----
N
G
-
S
Q
--
S
G
K
P
V
K
D
C
M
I
---------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
82.70
42%
-88
- C7 -
4JJM
2
?
A:
[21-166]
----------------------------------------
G
R
I
V
M
E
L
F
A
D
V
T
P
R
T
A
E
N
F
---
R
-----------
A
----------
L
C
T
GEKGIG----
K
S
-----------
G
KPL--------
H
--------
Y
K
G
S
S
F
H
R
V
I
P
G
F
M
C
Q
G
G
D
F
T
-
A
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
S
K
F
A
D
E
-
N
-
F
V
K
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
G
T
N
G
S
Q
F
F
V
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
Q
V
V
E
G
-
M
D
V
V
K
A
I
E
K
V
GS
S
S
G
-
R
T
--
N
-
K
P
V
--------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
82.45
42%
-83
- C7 -
1E3B
2
CYP3_CAEEL
A:
[18-165]
----------------------------------------
G
R
I
V
M
E
L
Y
D
D
V
V
P
K
T
A
G
N
F
R
A
-
L
-----------
C
----------
T
G
-----------
E
N
-----------
G
IGKSGKPL---
H
--------
F
K
G
S
K
F
H
R
I
I
P
N
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
P
D
E
-
N
-
F
K
E
-
K
H
-
T
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
L
-
C
T
V
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
R
V
V
E
G
-
L
D
V
V
K
A
V
E
S
----
N
G
-
S
Q
--
S
G
K
P
V
K
D
C
M
I
---------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
82.21
45%
-80
- C7 -
1H0P
1
CYP5_CAEEL
A:
[21-162]
----------------------------------------
G
R
I
V
I
G
L
F
G
K
T
V
P
K
T
A
T
N
F
---
I
-----------
E
----------
L
A
-----------
K
K
-----------
P
-----------
K
GEG-----
Y
P
G
S
K
F
H
R
V
I
A
D
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
D
-
G
T
-
G
G
R
S
I
Y
----
G
E
K
F
A
D
E
N
F
-
K
L
K
-
H
Y
-
G
-
A
------
G
W
L
S
M
A
N
A
-
G
----
A
D
T
N
G
S
Q
F
F
I
-
T
T
V
K
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
I
L
E
G
-
M
D
V
V
R
K
I
E
Q
T
--
E
K
L
-
P
G
--
D
-
R
P
K
Q
D
V
I
I
---------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
81.68
42%
-83
- C7 -
4JJM
1
?
B:
[21-166]
----------------------------------------
G
R
I
V
M
E
L
F
A
D
V
T
P
R
T
A
E
N
F
---
R
-----------
A
----------
L
C
TGEKGIG----
K
S
-----------
G
KPL--------
H
--------
Y
K
G
S
S
F
H
R
V
I
P
G
F
M
C
Q
G
G
D
F
T
-
A
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
S
K
F
A
D
E
-
N
-
F
V
K
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
G
T
N
G
S
Q
F
F
V
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
Q
V
V
E
G
-
M
D
V
V
K
A
I
E
K
V
GS
S
S
G
-
R
T
--
N
-
K
P
V
--------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.63
47%
-83
- C7 -
3EOV
1
?
B:
[26-166]
----------------------------------------
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
RQ-
L
-----------
C
----------
T
G
-----------
E
H
-----------
G
-----------
F
G-------
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
---
N
L
N
-
V
K
-
H
-
F
-
V
----
G
A
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
L
D
G
-
M
D
V
V
L
R
I
E
K
T
--
K
T
N
-
S
H
--
D
-
R
P
V
K
P
V
K
I
---------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.24
47%
-81
- C7 -
3EOV
1
?
A:
[26-166]
----------------------------------------
G
R
I
T
I
G
L
F
G
K
D
A
P
L
T
T
E
N
F
R
Q
-
L
-----------
C
----------
T
G
-----------
E
H
-----------
G
-----------
F
G-------
Y
K
D
S
I
F
H
R
V
I
Q
N
F
M
I
Q
G
G
D
F
T
-
N
-
F
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
---
N
L
N
-
V
K
-
H
-
F
-
V
----
G
A
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
A
P
---------------------------
T
P
W
L
D
G
--------
R
H
V
V
F
G
K
V
L
D
G
-
M
D
V
V
L
R
I
E
K
T
--
K
T
N
-
S
H
--
D
-
R
P
V
K
P
V
K
I
---------------------------------------------------------------------------------------------------------------------------
105
Fugue
81.15
43%
-58
- C7 -
2RMC
1
PPIC_MOUSE
A:
[1-182]
---------
K
R
G
P
S
V
T
D
K
V
F
F
D
V
R
I
G
D
K
-----
D
-----
V
G
R
I
V
I
G
L
F
G
N
V
V
P
K
T
V
E
N
F
---
V
-----------
A
----------
L
A
-----------
T
G
EKG--------
Y
-----------
G
--------
Y
K
G
S
I
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
-
F
T
A
-
R
-
D
-
G
T
-
G
G
M
S
I
Y
----
G
E
T
F
P
D
E
-
N
-
F
K
L
-
K
H
-
Y
-
G
-
I
----
G
W
V
S
M
A
N
A
-
G
----
P
D
T
N
G
S
Q
F
F
I
-
T
L
T
K
P
T
W
L
D
-------------------
G
----------------
K
H
V
V
F
G
K
V
L
D
G
-
M
T
V
V
H
S
I
E
L
Q
--
A
T
D
G-
H
--
D
-
R
P
L
T
D
C
T
I
---
V
N
S
G
K
I
D
V
K
T
P
F
V
VEVPDW-----------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
80.71
43%
-86
- C7 -
1CYN
1
PPIB_HUMAN
A:
[20-161]
----------------------------------------
G
R
V
I
F
G
L
F
G
K
T
V
P
K
T
V
D
N
F
---
V
A
L
A
--------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
N
S
K
F
H
R
V
I
K
D
F
M
I
Q
G
G
D
F
T
-
R
-
G
-
D
-
G
T
-
G
G
K
S
I
Y
----
G
E
R
F
P
D
E
-------
N
F
-
K
-
L
-
K
HYGP
G
W
V
S
M
A
N
A
-
G
----
K
D
T
N
G
S
Q
F
F
I
-
T
T
V
K
---------------------------
T
A
W
L
D
G
--------
K
H
V
V
F
G
K
V
L
E
G
-
M
E
V
V
R
K
V
E
S
T
--
K
T
D
-
S
R
--
D
-
K
P
L
K
D
V
I
I
---------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
80.58
45%
-88
- C7 -
3PMP
1
?
A:
[17-141]
----------------------------------------
G
R
I
V
F
K
L
Y
D
E
A
V
P
K
T
A
K
N
F
R
E
-
L
-----------
A
----------
T
G
-----------
Q
H
-----------
G
-----------
F
G-------
Y
K
D
S
I
F
H
R
V
I
P
Q
F
M
L
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
-
N
-
F
Q
V
-
K
H
-
T
-
K
-
P
----
G
L
L
S
M
A
N
A
-
G
----
A
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
T
S
W
L
D
G
--------
K
H
V
V
F
G
E
V
I
E
G
-
L
D
I
V
R
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
79.49
40%
-75
- C7 -
3S6M
3
?
A:
[3-167]
-------------------
G
S
M
V
E
L
-
H
T
-----
N
-----
H
G
V
I
K
L
E
L
D
E
A
K
A
P
K
T
V
E
N
F
---
L
-----------
N
----------
Y
V
-----------
K
K
-----------
G
-----------
H
--------
Y
D
G
T
I
F
H
R
V
I
N
G
F
M
I
Q
G
G
G
-
F
-
E
-
P
-
G
-
L
K
-
Q
--
K
P
T
----
D
A
P
I
A
N
E
-
A
-
N
N
G
-
L
K
-
N
-
D
-
T
----
Y
T
I
A
M
A
R
T
N
D
----
P
H
S
A
T
A
Q
F
F
I
-
N
V
N
D
N
E
---------------------------
F
L
N
H
SSPTPQGW
G
Y
A
V
F
G
K
V
V
E
G
-
Q
D
I
V
D
K
I
K
A
V
--
K
T
G
-
S
-HQ
D
-
V
P
N
D
D
V
V
I
---
E
K
A
V
V
V
------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
79.42
45%
-82
- C7 -
4HY7
1
?
A:
[18-149]
----------------------------------------
G
R
I
V
M
E
L
Y
K
D
A
V
P
R
T
V
E
N
F
---
R
-----------
A
----------
L
C
T
GEKGVG----
K
S
-----------
G
KPL--------
H
--------
Y
K
G
S
A
F
H
R
V
I
P
D
F
M
C
Q
G
G
D
F
T
-
R
-
G
-
N
-
G
T
-
G
G
E
S
I
Y
----
G
E
K
F
A
D
E
-
K
-
F
V
H
-
K
H
-
T
-
K
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
V
P
---------------------------
C
N
W
L
D
G
--------
K
H
V
V
F
G
E
V
V
E
G
-
M
D
V
V
K
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
78.87
45%
-84
- C7 -
4TOT
4
PPIF_RAT
D:
[18-145]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
78.83
45%
-86
- C7 -
3PMP
1
?
B:
[17-141]
----------------------------------------
G
R
I
V
F
K
L
Y
D
E
A
V
P
K
T
A
K
N
F
RE-
L
-----------
A
----------
T
G
-----------
Q
H
-----------
G
-----------
F
G-------
Y
K
D
S
I
F
H
R
V
I
P
Q
F
M
L
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
A
D
E
-
N
-
F
Q
V
-
K
H
-
T
-
K
-
P
----
G
L
L
S
M
A
N
A
-
G
----
A
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
T
S
W
L
D
G
--------
K
H
V
V
F
G
E
V
I
E
G
-
L
D
I
V
R
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.80
45%
-81
- C7 -
1QNG
1
?
A:
[15-148]
---------------------------
S
-----
N
-----
A
G
R
I
I
F
E
L
F
S
D
I
T
P
R
T
C
E
N
F
---
R
A
L
C
T
GEKIG--
S
----------
R
G
-----------
K
N
-----------
L
-----------
H
--------
Y
K
N
S
I
F
H
R
I
I
P
Q
F
M
C
Q
G
G
D
I
T
-
N
-
G
-
N
-
G
S
-
G
G
E
S
I
Y
----
G
R
S
F
T
D
E
-------
N
F
-
N
-
M
-
K
HDQP
G
L
L
S
M
A
N
A
-
G
----
P
N
T
N
S
S
Q
F
F
I
-
T
L
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
E
G
-
M
N
V
V
R
E
M
--------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
78.74
45%
-84
- C7 -
4TOT
2
PPIF_RAT
C:
[18-145]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
78.66
45%
-85
- C7 -
4TOT
4
PPIF_RAT
B:
[18-145]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
A
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.62
45%
-83
- C7 -
1VDN
2
CYPH_YEAST
A:
[16-148]
----------------------------------------
G
R
V
V
F
K
L
Y
N
D
I
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
A
G
S
P
F
H
R
V
I
P
D
F
M
L
Q
G
G
D
F
T
-
A
-
G
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
G
K
F
P
D
E
-
N
-
F
K
K
-
H
H
-
D
-
R
-
P
----
G
L
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
T
T
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
E
V
V
D
G
-
Y
D
I
V
K
K
V
E
S
L
GS
P
S
G
------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.49
44%
-73
- C7 -
1QNH
1
?
B:
[15-148]
---------------------------
S
-----
N
-----
A
G
R
I
I
F
E
L
F
S
D
I
T
P
R
T
C
E
N
F
---
R
A
L
C
T
GEKIG--
S
----------
R
G
-----------
K
N
-----------
L
-----------
H
--------
Y
K
N
S
I
F
H
R
I
I
P
Q
F
M
C
Q
G
G
D
I
T
-
N
-
G
-
N
-
G
S
-
G
G
E
S
I
Y
----
G
R
S
F
T
D
E
-
N
-
F
N
M
-
K
H
-
D
-
Q
-
P
----
G
L
L
S
M
A
N
A
-
G
----
P
N
T
N
S
S
Q
F
L
I
-
T
L
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
E
G
-
M
N
V
V
R
E
M
--------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
78.14
46%
-79
- C7 -
3R54
1
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
78.10
46%
-76
- C7 -
3R56
2
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
77.94
46%
-79
- C7 -
3RDB
2
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
77.85
46%
-80
- C7 -
3RCF
2
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.83
44%
-78
- C7 -
1QNH
1
?
A:
[15-148]
---------------------------
S
-----
N
-----
A
G
R
I
I
F
E
L
F
S
D
I
T
P
R
T
C
E
N
F
---
R
A
L
C
T
GEKIG--
S
----------
R
G
-----------
K
N
-----------
L
-----------
H
--------
Y
K
N
S
I
F
H
R
I
I
P
Q
F
M
C
Q
G
G
D
I
T
-
N
-
G
-
N
-
G
S
-
G
G
E
S
I
Y
----
G
R
S
F
T
D
E
-
N
-
F
N
M
-
K
H
-
D
-
Q
-
P
----
G
L
L
S
M
A
N
A
-
G
----
P
N
T
N
S
S
Q
F
L
I
-
T
L
V
P
---------------------------
C
P
W
L
D
G
--------
K
H
V
V
F
G
K
V
I
E
G
-
M
N
V
V
R
E
M
--------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
77.81
46%
-79
- C7 -
3RCI
4
PPIF_HUMAN
X:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
77.67
46%
-79
- C7 -
3R59
1
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
77.51
46%
-78
- C7 -
4J58
2
PPIF_HUMAN
A:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
77.48
46%
-82
- C7 -
3R57
5
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
77.29
46%
-77
- C7 -
3R4G
5
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
77.27
46%
-80
- C7 -
3RDA
7
PPIF_HUMAN
X:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
77.23
44%
-81
- C7 -
4N1S
2
?
A:
[18-142]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
77.18
46%
-78
- C7 -
4J5A
2
PPIF_HUMAN
X:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
77.17
46%
-79
- C7 -
4ZSD
1
?
A:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
77.11
46%
-78
- C7 -
4ZSC
1
?
A:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
77.11
46%
-79
- C7 -
4O8H
2
PPIF_HUMAN
A:
[18-142]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
77.10
46%
-79
- C7 -
3RCL
2
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
77.05
46%
-84
- C7 -
2Z6W
1
PPIF_HUMAN
B:
[18-142]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
77.02
44%
-80
- C7 -
3RDD
1
PPIA_HUMAN
A:
[37-161]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
77.02
46%
-80
- C7 -
2BIU
4
PPIF_HUMAN
X:
[18-142]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
76.98
44%
-83
- C7 -
4N1P
3
?
A:
[18-142]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
76.92
46%
-77
- C7 -
4J5D
1
PPIF_HUMAN
X:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
76.83
46%
-78
- C7 -
3R49
2
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
76.59
44%
-79
- C7 -
4N1N
1
?
A:
[18-142]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
76.59
46%
-80
- C7 -
4J59
1
PPIF_HUMAN
A:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
76.56
44%
-83
- C7 -
4N1R
1
?
A:
[18-142]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
76.31
44%
-80
- C7 -
4N1O
5
?
A:
[18-142]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
76.29
46%
-78
- C7 -
4J5E
1
PPIF_HUMAN
X:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.18
46%
-77
- C7 -
3RCK
5
PPIF_HUMAN
X:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
76.14
46%
-77
- C7 -
3RDC
1
PPIF_HUMAN
A:
[19-143]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
76.07
46%
-77
- C7 -
4J5B
1
PPIF_HUMAN
A:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
75.84
46%
-79
- C7 -
2Z6W
3
PPIF_HUMAN
A:
[18-142]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
75.75
46%
-78
- C7 -
4J5C
1
PPIF_HUMAN
X:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
RAL
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
74.78
46%
-75
- C7 -
4XNC
1
?
A:
[17-141]
----------------------------------------
G
R
V
V
L
E
L
K
A
D
V
V
P
K
T
A
E
N
F
R
A
L
C
-----------
T
----------
G
E
-----------
K
G
-----------
F
-----------
G
--------
Y
K
G
S
T
F
H
R
V
I
P
S
F
M
C
Q
A
G
D
F
T
-
N
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
S
R
F
P
D
E
-
N
-
F
T
L
-
K
H
-
V
-
G
-
P
----
G
V
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
I
K
---------------------------
T
D
W
L
D
G
--------
K
H
V
V
F
G
H
V
I
E
G
-
M
D
V
V
K
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
74.77
44%
-76
- C7 -
4N1Q
1
?
A:
[18-142]
----------------------------------------
G
R
V
S
F
E
L
F
A
D
K
V
P
K
T
A
E
N
F
R
A
-
L
-----------
S
----------
T
G
-----------
E
K
-----------
G
-----------
F
G-------
Y
K
G
S
C
F
H
R
I
I
P
G
F
M
C
Q
G
G
D
F
T
-
R
-
H
-
N
-
G
T
-
G
G
K
S
I
Y
----
G
E
K
F
E
D
E
-
N
-
F
I
L
-
K
H
-
T
-
G
-
P
----
G
I
L
S
M
A
N
A
-
G
----
P
N
T
N
G
S
Q
F
F
I
-
C
T
A
K
---------------------------
T
E
W
L
D
G
--------
K
H
V
V
F
G
K
V
K
E
G
-
M
N
I
V
E
A
M
--------------------------------------------------------------------------------------------------------------------------------------------------